Epc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Epc1
Entrez Gene ID	13831
Full Name	enhancer of polycomb homolog 1
Synonyms	2400007E14Rik,5730566F07Rik,A930032N02Rik,mir-1893
General protein information	Preferred Names enhancer of polycomb homolog 1 Names enhancer of polycomb homolog 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 A1

mRNA and Protein(s)

mRNA	Protein	Name
NM_027497.3	NP_081773.1	enhancer of polycomb homolog 1 isoform 2
NM_007935.2	NP_031961.1	enhancer of polycomb homolog 1 isoform 1
NM_001276350.1	NP_001263279.1	enhancer of polycomb homolog 1 isoform 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	EPC1	XP_003433746.1
Rattus norvegicus (Norway rat)	Epc1	XP_003751752.1
Xenopus tropicalis (tropical clawed frog)	epc1	NP_001090648.1
Homo sapiens (human)	EPC1	NP_079485.1
Pan troglodytes (chimpanzee)	EPC1	XP_507733.3
Bos taurus (cattle)	EPC1	NP_001179739.1
Mus musculus (house mouse)	Epc1	NP_081773.1
Gallus gallus (chicken)	EPC1	XP_418573.2
Danio rerio (zebrafish)	epc1	XP_695062.2

Gene Ontology
Bibliography

Related articles in PubMed

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.
Dong Y, Isono KI, Ohbo K, Endo TA, Ohara O, Maekawa M, Toyama Y, Ito C, Toshimori K, Helin K, Ogonuki N, Inoue K, Ogura A, Yamagata K, Kitabayashi I, Koseki H
Molecular and cellular biology37(19)(2017 Oct)

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Gineste C, De Winter JM, Kohl C, Witt CC, Giannesini B, Brohm K, Le Fur Y, Gretz N, Vilmen C, Pecchi E, Jubeau M, Cozzone PJ, Stienen GJ, Granzier H, Labeit S, Ottenheijm CA, Bendahan D, Gondin J
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)

Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation.
Joung H, Kwon JS, Kim JR, Shin S, Kang W, Ahn Y, Kook H, Kee HJ
Atherosclerosis222(1)84-91(2012 May)

Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb1.
Kee HJ, Kim JR, Joung H, Choe N, Lee SE, Eom GH, Kim JC, Geyer SH, Jijiwa M, Kato T, Kawai K, Weninger WJ, Seo SB, Nam KI, Jeong MH, Takahashi M, Kook H
Cell death and differentiation19(1)121-31(2012 Jan)

miRBase: integrating microRNA annotation and deep-sequencing data.
Kozomara A, Griffiths-Jones S
Nucleic acids research39(Database issue)D152-7(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results report that EPC1 and TIP60 are co-expressed in male germ cells. Genetic ablation of either Epc1 or Tip60 disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development.
Title: EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.

results indicate that Epc1 induces vascular smooth muscle differentiation by interacting with myocardin to induce serum response factor-dependent smooth muscle genes; propose that Epc1 acts as a novel negative regulator of neointima formation after carotid injury
Title: Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation.

Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin promoter, binding of SRF to the serum response element, and muscle-specific gene induction were blocked by RFP.
Title: Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb1.

Epc1 is required for skeletal muscle differentiation by recruiting both SRF and p300 to the SRE of muscle-specific gene promoters
Title: Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation.

Epc1 plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop is required for the full activity.
Title: Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation.

The following Epc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Epc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu16924	NM_001276350.1 Latest version!	Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu01071	NM_007935.2 Latest version!	Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu04292	NM_027497.3 Latest version!	Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$482.30 $689.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Epc1 ( NM_001276350.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001263279.1 Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu16924
Clone ID Related Accession (Same CDS sequence)	NM_001276350.1
Accession Version	NM_001276350.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 186bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	enhancer of polycomb homolog 1 isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139300.4, AK040254.1, BC038636.1, BC055805.1, BB343428.1 and AV356347.1. Transcript Variant: This variant (3) lacks several exons in the central and 3' coding regions and includes an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 2. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC059708.1, AK010295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTAAAC TGTCGTTTCG GGCGCGGGCG CTGGACGCCT CGAAGCCGCT GCCGGTCTTC 
CGCTGTGAGG ATCTGCCCGA CCTGCACGAA TACGCCTCGA TAAACCGGGC CGTGCCGCAG 
ATGCCCACCG GGATGGAGAA GGAAGAGGAG TCGGTACAGC CACTTATACA GGGTGCAGTG 
TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263279.1
CDS	243..428
Translation	MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESVQPLIQGAVC

Target ORF information:

RefSeq Version	NM_001276350.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276350.1

ORF Insert Sequence:

ATGAGTAAAC TGTCGTTTCG GGCGCGGGCG CTGGACGCCT CGAAGCCGCT GCCGGTCTTC 
CGCTGTGAGG ATCTGCCCGA CCTGCACGAA TACGCCTCGA TAAACCGGGC CGTGCCGCAG 
ATGCCCACCG GGATGGAGAA GGAAGAGGAG TCGGTACAGC CACTTATACA GGGTGCAGTG 
TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Epc1 ( NM_007935.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031961.1 Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu01071
Clone ID Related Accession (Same CDS sequence)	NM_007935.2
Accession Version	NM_007935.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2292bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	enhancer of polycomb homolog 1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM936825.1, AK148194.1, AK149317.1, BB207261.2, AI849475.1 and DV652878.1. On Feb 1, 2013 this sequence version replaced NM_007935.1. Transcript Variant: This variant (1) differs in the 5' UTR and in the 5' coding region, compared to variant 2. It encodes isoform 1 which is shorter and has a distinct N-terminus, compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF079765.1, AK148194.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACACC ATCTTCAGCG GGCTATTTCT GCACAGCAGG TGTACGGCGA GAAGCGGGAT 
AACATGGTTA TTCCAGTTCC TGAAGCAGAG AGTAACATCG CTTACTATGA GTCCATATAC 
CCTGGGGAGT TCAGGATGCC AAAGCAGCTC ATTCACATAC AGCCTTTTAG CTTGGACGCT 
GAACAGCCTG ATTACGATCT GGATTCTGAA GATGAAGTAT TTGTGAATAA ACTGAAGAAG 
AAAATGGACA TCTGCCCATT GCAGTTTGAG GAGATGATTG ACCGGCTAGA AAAAGGCAGC 
GGTCAGCAGC CAGTCAGTCT GCAGGAAGCC AAACTACTTC TAAAAGAAGA TGATGAGTTA 
ATTAGAGAAG TTTATGAATA CTGGATTAAA AAGAGGAAAA CCTGCCGGGG GTCATCACTT 
ATCCCGTTGG TAAAACAGGA AAAGCGAGAT GGTTCTAGCA CAAATGATCC TTACGTGGCT 
TTTAGAAGAC GAACTGAGAA AATGCAAACT CGGAAAAACC GTAAGAATGA TGAAGCCTCA 
TATGAGAAAA TGCTCAAGCT GCGCCGCGAT CTCAGCCGGG CTGTCACCAT CCTGGAAATG 
ATCAAGAGAC GGGAGAAGAG TAAACGGGAG CTGCTGCACC TGACCCTGGA AATCATGGAG 
AAGAGGTATA ATTTAGGTGA CTATAGTGGA GAGATCATGT CTGAGGTCAT GGCACAGAGA 
CAGCCAGTGA AGCCTACTTA TGCCATCCCC ATCATCCCGA TTACTAACAG CAGCCAGTTC 
AAACACCAGG ATGCCACGGA CTCGAAGGAG TTCAAAGTTA ACAAGCAAGA TAAGGCTGAT 
CTTATCCGGC CGAAGCGCAA ATATGAAAAG AAGCCCAAAG TCTTACCCCC ATCTGCTGCC 
GCCCCTCAGC AGCAGAGTCC TGCTGCACTG CCAGGCTTCA GTGCTAAAGA CTTAAACCAG 
TACGACTTCC CCAGCTCAGA TGAAGAGCCT CTGTCACAGG TTTTGTCTGG CTCTTCGGAA 
GCTGAGGAAG AGAATGACCC TGATGGCCCT TTTGCTTTCC GTAGGAAAGC AGGCTGTCAG 
TACTATGCTC CTCATTTAGA CCAAACTGGC AACTGGCCCT GGACTAGCCC TAAAGATGGA 
GGCCTGGGGG ATGTGCGATA TAGATATTGC TTAACTACTC TCACCGTACC CCAGAGGTGT 
CTTGGATTTG CACGAAGACG GGTCGGACGT GGTGGAAGGG TCGTGCTGGA CAGAGCGCAT 
TCAGACTATG ACAGTATGTT TCACCACCTG GATTTGGACA TGCTTTCCTC ACCACAACCT 
TCTCCAGTCA ATCAGTTTGC CAATACCTCA GAACCCAATA CCTCGGACAG ATCTTCCTCT 
AAAGACCTCA GTCAGATACT AGTCGATATC AAATCATGTA GATGGCGGCA CTTTAGGCCT 
CGGACACCAT CCCTGCCTGA CAGTGACAGT GGTGAACTCT CCAGTAGAAA GTTACACAGG 
AGTATCAGTC GAGCAGGAGC AGCACAGCCT GGGGCCCACA CGTGCAGCAC CTCCACCCAG 
AACAGAAGTA GCAGTGGCTC AGCACACTGT GCATTCACAG CCGAACAGTA CCAGCAGCAC 
CAGCAGCAGC TGGCACTCAT GCAGCAGCAG CAGCTTGCGC AGACTCAGCA GCAGCAGCAA 
GCAAATAGTA GTTCCTCTGC CGCCGCGCAA CAGGGTTTTG TTTCTAAGAC GTTGGACTCT 
GCTAGTGCAC AGTTTGCTGC TTCTGCTTTG ATGACGTCGG AACAGCTGCT GGGGTTCAAG 
GTGAAGGATG ATGTGGTGCT CGGGCTCGGG GTGAATGGCG TCCTTCCTGC CTCAGGAGTA 
TACAAGGGCT TACACCTCAG TAGCACTACA CCAACGGCAC TTGTACATAC GAGTCCTTCG 
ACAGCAGGTT CAACTTTGTT ACAGCCTTCA AATATTACAC AGACTTCGGG TTCCCACAGC 
TCACTGAGTC ACCAAGTAAC TGCTGCCAGC TCTGCAACAA CTCAGGTTCT GTTTGGGAAC 
AACATCCGAT TAACTGTCCC CTCATCTGTC CCCACTGTCA ACTCTGTCAC CCCAATAAAC 
GCACGGCATA TACCTAGGAC TTTAAGTGCT GTTCCGCCAT CTGCCTTAAA GCTGGCTGCT 
GCAGCAAATT GTCAAGTTTC CAAGGTCCCC TCCTCATCCT CTGTAGATTC AGTTCCAAGG 
GAAAATCATG AATCGGAAAA GCCAGCACTG AACAACATAG CAGACAACAC AGTAGCAATG 
GAGGTGACGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031961.1
CDS	242..2533
Translation	MEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFRMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGSSLIPLVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDATDSKEFKVNKQDKADLIRPKRKYEKKPKVLPPSAAAPQQQSPAALPGFSAKDLNQYDFPSSDEEPLSQVLSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCLGFARRRVGRGGRVVLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTSEPNTSDRSSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGAAQPGAHTCSTSTQNRSSSGSAHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQQANSSSSAAAQQGFVSKTLDSASAQFAASALMTSEQLLGFKVKDDVVLGLGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTAASSATTQVLFGNNIRLTVPSSVPTVNSVTPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT

Target ORF information:

RefSeq Version	NM_007935.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007935.2

ORF Insert Sequence:

ATGGAACACC ATCTTCAGCG GGCTATTTCT GCACAGCAGG TGTACGGCGA GAAGCGGGAT 
AACATGGTTA TTCCAGTTCC TGAAGCAGAG AGTAACATCG CTTACTATGA GTCCATATAC 
CCTGGGGAGT TCAGGATGCC AAAGCAGCTC ATTCACATAC AGCCTTTTAG CTTGGACGCT 
GAACAGCCTG ATTACGATCT GGATTCTGAA GATGAAGTAT TTGTGAATAA ACTGAAGAAG 
AAAATGGACA TCTGCCCATT GCAGTTTGAG GAGATGATTG ACCGGCTAGA AAAAGGCAGC 
GGTCAGCAGC CAGTCAGTCT GCAGGAAGCC AAACTACTTC TAAAAGAAGA TGATGAGTTA 
ATTAGAGAAG TTTATGAATA CTGGATTAAA AAGAGGAAAA CCTGCCGGGG GTCATCACTT 
ATCCCGTTGG TAAAACAGGA AAAGCGAGAT GGTTCTAGCA CAAATGATCC TTACGTGGCT 
TTTAGAAGAC GAACTGAGAA AATGCAAACT CGGAAAAACC GTAAGAATGA TGAAGCCTCA 
TATGAGAAAA TGCTCAAGCT GCGCCGCGAT CTCAGCCGGG CTGTCACCAT CCTGGAAATG 
ATCAAGAGAC GGGAGAAGAG TAAACGGGAG CTGCTGCACC TGACCCTGGA AATCATGGAG 
AAGAGGTATA ATTTAGGTGA CTATAGTGGA GAGATCATGT CTGAGGTCAT GGCACAGAGA 
CAGCCAGTGA AGCCTACTTA TGCCATCCCC ATCATCCCGA TTACTAACAG CAGCCAGTTC 
AAACACCAGG ATGCCACGGA CTCGAAGGAG TTCAAAGTTA ACAAGCAAGA TAAGGCTGAT 
CTTATCCGGC CGAAGCGCAA ATATGAAAAG AAGCCCAAAG TCTTACCCCC ATCTGCTGCC 
GCCCCTCAGC AGCAGAGTCC TGCTGCACTG CCAGGCTTCA GTGCTAAAGA CTTAAACCAG 
TACGACTTCC CCAGCTCAGA TGAAGAGCCT CTGTCACAGG TTTTGTCTGG CTCTTCGGAA 
GCTGAGGAAG AGAATGACCC TGATGGCCCT TTTGCTTTCC GTAGGAAAGC AGGCTGTCAG 
TACTATGCTC CTCATTTAGA CCAAACTGGC AACTGGCCCT GGACTAGCCC TAAAGATGGA 
GGCCTGGGGG ATGTGCGATA TAGATATTGC TTAACTACTC TCACCGTACC CCAGAGGTGT 
CTTGGATTTG CACGAAGACG GGTCGGACGT GGTGGAAGGG TCGTGCTGGA CAGAGCGCAT 
TCAGACTATG ACAGTATGTT TCACCACCTG GATTTGGACA TGCTTTCCTC ACCACAACCT 
TCTCCAGTCA ATCAGTTTGC CAATACCTCA GAACCCAATA CCTCGGACAG ATCTTCCTCT 
AAAGACCTCA GTCAGATACT AGTCGATATC AAATCATGTA GATGGCGGCA CTTTAGGCCT 
CGGACACCAT CCCTGCCTGA CAGTGACAGT GGTGAACTCT CCAGTAGAAA GTTACACAGG 
AGTATCAGTC GAGCAGGAGC AGCACAGCCT GGGGCCCACA CGTGCAGCAC CTCCACCCAG 
AACAGAAGTA GCAGTGGCTC AGCACACTGT GCATTCACAG CCGAACAGTA CCAGCAGCAC 
CAGCAGCAGC TGGCACTCAT GCAGCAGCAG CAGCTTGCGC AGACTCAGCA GCAGCAGCAA 
GCAAATAGTA GTTCCTCTGC CGCCGCGCAA CAGGGTTTTG TTTCTAAGAC GTTGGACTCT 
GCTAGTGCAC AGTTTGCTGC TTCTGCTTTG ATGACGTCGG AACAGCTGCT GGGGTTCAAG 
GTGAAGGATG ATGTGGTGCT CGGGCTCGGG GTGAATGGCG TCCTTCCTGC CTCAGGAGTA 
TACAAGGGCT TACACCTCAG TAGCACTACA CCAACGGCAC TTGTACATAC GAGTCCTTCG 
ACAGCAGGTT CAACTTTGTT ACAGCCTTCA AATATTACAC AGACTTCGGG TTCCCACAGC 
TCACTGAGTC ACCAAGTAAC TGCTGCCAGC TCTGCAACAA CTCAGGTTCT GTTTGGGAAC 
AACATCCGAT TAACTGTCCC CTCATCTGTC CCCACTGTCA ACTCTGTCAC CCCAATAAAC 
GCACGGCATA TACCTAGGAC TTTAAGTGCT GTTCCGCCAT CTGCCTTAAA GCTGGCTGCT 
GCAGCAAATT GTCAAGTTTC CAAGGTCCCC TCCTCATCCT CTGTAGATTC AGTTCCAAGG 
GAAAATCATG AATCGGAAAA GCCAGCACTG AACAACATAG CAGACAACAC AGTAGCAATG 
GAGGTGACGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Epc1 ( NM_027497.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081773.1 Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04292
Clone ID Related Accession (Same CDS sequence)	NM_027497.3
Accession Version	NM_027497.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2442bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	enhancer of polycomb homolog 1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC139300.4, AK040254.1 and AF079765.1. On Feb 1, 2013 this sequence version replaced NM_027497.2. Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.68288.1, SRR1660817.201437.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTAAAC TGTCGTTTCG GGCGCGGGCG CTGGACGCCT CGAAGCCGCT GCCGGTCTTC 
CGCTGTGAGG ATCTGCCCGA CCTGCACGAA TACGCCTCGA TAAACCGGGC CGTGCCGCAG 
ATGCCCACCG GGATGGAGAA GGAAGAGGAG TCGGAACACC ATCTTCAGCG GGCTATTTCT 
GCACAGCAGG TGTACGGCGA GAAGCGGGAT AACATGGTTA TTCCAGTTCC TGAAGCAGAG 
AGTAACATCG CTTACTATGA GTCCATATAC CCTGGGGAGT TCAGGATGCC AAAGCAGCTC 
ATTCACATAC AGCCTTTTAG CTTGGACGCT GAACAGCCTG ATTACGATCT GGATTCTGAA 
GATGAAGTAT TTGTGAATAA ACTGAAGAAG AAAATGGACA TCTGCCCATT GCAGTTTGAG 
GAGATGATTG ACCGGCTAGA AAAAGGCAGC GGTCAGCAGC CAGTCAGTCT GCAGGAAGCC 
AAACTACTTC TAAAAGAAGA TGATGAGTTA ATTAGAGAAG TTTATGAATA CTGGATTAAA 
AAGAGGAAAA CCTGCCGGGG GTCATCACTT ATCCCGTTGG TAAAACAGGA AAAGCGAGAT 
GGTTCTAGCA CAAATGATCC TTACGTGGCT TTTAGAAGAC GAACTGAGAA AATGCAAACT 
CGGAAAAACC GTAAGAATGA TGAAGCCTCA TATGAGAAAA TGCTCAAGCT GCGCCGCGAT 
CTCAGCCGGG CTGTCACCAT CCTGGAAATG ATCAAGAGAC GGGAGAAGAG TAAACGGGAG 
CTGCTGCACC TGACCCTGGA AATCATGGAG AAGAGGTATA ATTTAGGTGA CTATAGTGGA 
GAGATCATGT CTGAGGTCAT GGCACAGAGA CAGCCAGTGA AGCCTACTTA TGCCATCCCC 
ATCATCCCGA TTACTAACAG CAGCCAGTTC AAACACCAGG ATGCCACGGA CTCGAAGGAG 
TTCAAAGTTA ACAAGCAAGA TAAGGCTGAT CTTATCCGGC CGAAGCGCAA ATATGAAAAG 
AAGCCCAAAG TCTTACCCCC ATCTGCTGCC GCCCCTCAGC AGCAGAGTCC TGCTGCACTG 
CCAGGCTTCA GTGCTAAAGA CTTAAACCAG TACGACTTCC CCAGCTCAGA TGAAGAGCCT 
CTGTCACAGG TTTTGTCTGG CTCTTCGGAA GCTGAGGAAG AGAATGACCC TGATGGCCCT 
TTTGCTTTCC GTAGGAAAGC AGGCTGTCAG TACTATGCTC CTCATTTAGA CCAAACTGGC 
AACTGGCCCT GGACTAGCCC TAAAGATGGA GGCCTGGGGG ATGTGCGATA TAGATATTGC 
TTAACTACTC TCACCGTACC CCAGAGGTGT CTTGGATTTG CACGAAGACG GGTCGGACGT 
GGTGGAAGGG TCGTGCTGGA CAGAGCGCAT TCAGACTATG ACAGTATGTT TCACCACCTG 
GATTTGGACA TGCTTTCCTC ACCACAACCT TCTCCAGTCA ATCAGTTTGC CAATACCTCA 
GAACCCAATA CCTCGGACAG ATCTTCCTCT AAAGACCTCA GTCAGATACT AGTCGATATC 
AAATCATGTA GATGGCGGCA CTTTAGGCCT CGGACACCAT CCCTGCCTGA CAGTGACAGT 
GGTGAACTCT CCAGTAGAAA GTTACACAGG AGTATCAGTC GAGCAGGAGC AGCACAGCCT 
GGGGCCCACA CGTGCAGCAC CTCCACCCAG AACAGAAGTA GCAGTGGCTC AGCACACTGT 
GCATTCACAG CCGAACAGTA CCAGCAGCAC CAGCAGCAGC TGGCACTCAT GCAGCAGCAG 
CAGCTTGCGC AGACTCAGCA GCAGCAGCAA GCAAATAGTA GTTCCTCTGC CGCCGCGCAA 
CAGGGTTTTG TTTCTAAGAC GTTGGACTCT GCTAGTGCAC AGTTTGCTGC TTCTGCTTTG 
ATGACGTCGG AACAGCTGCT GGGGTTCAAG GTGAAGGATG ATGTGGTGCT CGGGCTCGGG 
GTGAATGGCG TCCTTCCTGC CTCAGGAGTA TACAAGGGCT TACACCTCAG TAGCACTACA 
CCAACGGCAC TTGTACATAC GAGTCCTTCG ACAGCAGGTT CAACTTTGTT ACAGCCTTCA 
AATATTACAC AGACTTCGGG TTCCCACAGC TCACTGAGTC ACCAAGTAAC TGCTGCCAGC 
TCTGCAACAA CTCAGGTTCT GTTTGGGAAC AACATCCGAT TAACTGTCCC CTCATCTGTC 
CCCACTGTCA ACTCTGTCAC CCCAATAAAC GCACGGCATA TACCTAGGAC TTTAAGTGCT 
GTTCCGCCAT CTGCCTTAAA GCTGGCTGCT GCAGCAAATT GTCAAGTTTC CAAGGTCCCC 
TCCTCATCCT CTGTAGATTC AGTTCCAAGG GAAAATCATG AATCGGAAAA GCCAGCACTG 
AACAACATAG CAGACAACAC AGTAGCAATG GAGGTGACGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081773.1
CDS	243..2684
Translation	MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFRMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGSSLIPLVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDATDSKEFKVNKQDKADLIRPKRKYEKKPKVLPPSAAAPQQQSPAALPGFSAKDLNQYDFPSSDEEPLSQVLSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCLGFARRRVGRGGRVVLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTSEPNTSDRSSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGAAQPGAHTCSTSTQNRSSSGSAHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQQANSSSSAAAQQGFVSKTLDSASAQFAASALMTSEQLLGFKVKDDVVLGLGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTAASSATTQVLFGNNIRLTVPSSVPTVNSVTPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT

Target ORF information:

RefSeq Version	NM_027497.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus enhancer of polycomb homolog 1 (Epc1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027497.3

ORF Insert Sequence:

ATGAGTAAAC TGTCGTTTCG GGCGCGGGCG CTGGACGCCT CGAAGCCGCT GCCGGTCTTC 
CGCTGTGAGG ATCTGCCCGA CCTGCACGAA TACGCCTCGA TAAACCGGGC CGTGCCGCAG 
ATGCCCACCG GGATGGAGAA GGAAGAGGAG TCGGAACACC ATCTTCAGCG GGCTATTTCT 
GCACAGCAGG TGTACGGCGA GAAGCGGGAT AACATGGTTA TTCCAGTTCC TGAAGCAGAG 
AGTAACATCG CTTACTATGA GTCCATATAC CCTGGGGAGT TCAGGATGCC AAAGCAGCTC 
ATTCACATAC AGCCTTTTAG CTTGGACGCT GAACAGCCTG ATTACGATCT GGATTCTGAA 
GATGAAGTAT TTGTGAATAA ACTGAAGAAG AAAATGGACA TCTGCCCATT GCAGTTTGAG 
GAGATGATTG ACCGGCTAGA AAAAGGCAGC GGTCAGCAGC CAGTCAGTCT GCAGGAAGCC 
AAACTACTTC TAAAAGAAGA TGATGAGTTA ATTAGAGAAG TTTATGAATA CTGGATTAAA 
AAGAGGAAAA CCTGCCGGGG GTCATCACTT ATCCCGTTGG TAAAACAGGA AAAGCGAGAT 
GGTTCTAGCA CAAATGATCC TTACGTGGCT TTTAGAAGAC GAACTGAGAA AATGCAAACT 
CGGAAAAACC GTAAGAATGA TGAAGCCTCA TATGAGAAAA TGCTCAAGCT GCGCCGCGAT 
CTCAGCCGGG CTGTCACCAT CCTGGAAATG ATCAAGAGAC GGGAGAAGAG TAAACGGGAG 
CTGCTGCACC TGACCCTGGA AATCATGGAG AAGAGGTATA ATTTAGGTGA CTATAGTGGA 
GAGATCATGT CTGAGGTCAT GGCACAGAGA CAGCCAGTGA AGCCTACTTA TGCCATCCCC 
ATCATCCCGA TTACTAACAG CAGCCAGTTC AAACACCAGG ATGCCACGGA CTCGAAGGAG 
TTCAAAGTTA ACAAGCAAGA TAAGGCTGAT CTTATCCGGC CGAAGCGCAA ATATGAAAAG 
AAGCCCAAAG TCTTACCCCC ATCTGCTGCC GCCCCTCAGC AGCAGAGTCC TGCTGCACTG 
CCAGGCTTCA GTGCTAAAGA CTTAAACCAG TACGACTTCC CCAGCTCAGA TGAAGAGCCT 
CTGTCACAGG TTTTGTCTGG CTCTTCGGAA GCTGAGGAAG AGAATGACCC TGATGGCCCT 
TTTGCTTTCC GTAGGAAAGC AGGCTGTCAG TACTATGCTC CTCATTTAGA CCAAACTGGC 
AACTGGCCCT GGACTAGCCC TAAAGATGGA GGCCTGGGGG ATGTGCGATA TAGATATTGC 
TTAACTACTC TCACCGTACC CCAGAGGTGT CTTGGATTTG CACGAAGACG GGTCGGACGT 
GGTGGAAGGG TCGTGCTGGA CAGAGCGCAT TCAGACTATG ACAGTATGTT TCACCACCTG 
GATTTGGACA TGCTTTCCTC ACCACAACCT TCTCCAGTCA ATCAGTTTGC CAATACCTCA 
GAACCCAATA CCTCGGACAG ATCTTCCTCT AAAGACCTCA GTCAGATACT AGTCGATATC 
AAATCATGTA GATGGCGGCA CTTTAGGCCT CGGACACCAT CCCTGCCTGA CAGTGACAGT 
GGTGAACTCT CCAGTAGAAA GTTACACAGG AGTATCAGTC GAGCAGGAGC AGCACAGCCT 
GGGGCCCACA CGTGCAGCAC CTCCACCCAG AACAGAAGTA GCAGTGGCTC AGCACACTGT 
GCATTCACAG CCGAACAGTA CCAGCAGCAC CAGCAGCAGC TGGCACTCAT GCAGCAGCAG 
CAGCTTGCGC AGACTCAGCA GCAGCAGCAA GCAAATAGTA GTTCCTCTGC CGCCGCGCAA 
CAGGGTTTTG TTTCTAAGAC GTTGGACTCT GCTAGTGCAC AGTTTGCTGC TTCTGCTTTG 
ATGACGTCGG AACAGCTGCT GGGGTTCAAG GTGAAGGATG ATGTGGTGCT CGGGCTCGGG 
GTGAATGGCG TCCTTCCTGC CTCAGGAGTA TACAAGGGCT TACACCTCAG TAGCACTACA 
CCAACGGCAC TTGTACATAC GAGTCCTTCG ACAGCAGGTT CAACTTTGTT ACAGCCTTCA 
AATATTACAC AGACTTCGGG TTCCCACAGC TCACTGAGTC ACCAAGTAAC TGCTGCCAGC 
TCTGCAACAA CTCAGGTTCT GTTTGGGAAC AACATCCGAT TAACTGTCCC CTCATCTGTC 
CCCACTGTCA ACTCTGTCAC CCCAATAAAC GCACGGCATA TACCTAGGAC TTTAAGTGCT 
GTTCCGCCAT CTGCCTTAAA GCTGGCTGCT GCAGCAAATT GTCAAGTTTC CAAGGTCCCC 
TCCTCATCCT CTGTAGATTC AGTTCCAAGG GAAAATCATG AATCGGAAAA GCCAGCACTG 
AACAACATAG CAGACAACAC AGTAGCAATG GAGGTGACGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.
Molecular and cellular biology37(19)(2017 Oct)
Dong Y,Isono KI,Ohbo K,Endo TA,Ohara O,Maekawa M,Toyama Y,Ito C,Toshimori K,Helin K,Ogonuki N,Inoue K,Ogura A,Yamagata K,Kitabayashi I,Koseki H

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Neuromuscular disorders : NMD23(4)357-69(2013 Apr)
Gineste C,De Winter JM,Kohl C,Witt CC,Giannesini B,Brohm K,Le Fur Y,Gretz N,Vilmen C,Pecchi E,Jubeau M,Cozzone PJ,Stienen GJ,Granzier H,Labeit S,Ottenheijm CA,Bendahan D,Gondin J

Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation.
Atherosclerosis222(1)84-91(2012 May)
Joung H,Kwon JS,Kim JR,Shin S,Kang W,Ahn Y,Kook H,Kee HJ

Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb1.
Cell death and differentiation19(1)121-31(2012 Jan)
Kee HJ,Kim JR,Joung H,Choe N,Lee SE,Eom GH,Kim JC,Geyer SH,Jijiwa M,Kato T,Kawai K,Weninger WJ,Seo SB,Nam KI,Jeong MH,Takahashi M,Kook H

miRBase: integrating microRNA annotation and deep-sequencing data.
Nucleic acids research39(Database issue)D152-7(2011 Jan)
Kozomara A,Griffiths-Jones S

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Epc1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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