Klk1b22 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klk1b22
Entrez Gene ID	13646
Full Name	kallikrein 1-related peptidase b22
Synonyms	EGF-BP A,Egfbp-1,Egfbp1,Klk22,mGk-22
General protein information	Preferred Names kallikrein 1-related peptidase b22 Names kallikrein 1-related peptidase b22 beta-NGF-endopeptidase epidermal growth factor-binding protein type A glandular kallikrein K22 nerve growth factor beta chain endopeptidase tissue kallikrein 22
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 28.61 cM
Summary	This gene encodes the beta subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded preproprotein undergoes proteolytic processing to generate a functional, mature peptide. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010114.1	NP_034244.1	kallikrein 1-related peptidase b22 precursor
NM_010114.2	NP_034244.1	kallikrein 1-related peptidase b22 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klk1b5	NP_032482.1
Mus musculus (house mouse)	Klk1b1	NP_034775.1
Mus musculus (house mouse)	Klk1b3	NP_032719.1
Mus musculus (house mouse)	Klk1b24	NP_034773.1
Mus musculus (house mouse)	Klk1b26	NP_034774.1
Mus musculus (house mouse)	Klk1b4	NP_035045.2
Mus musculus (house mouse)	Klk1b22	NP_034244.1
Mus musculus (house mouse)	Klk1b8	NP_032483.1
Mus musculus (house mouse)	Klk1b21	NP_034772.1
Mus musculus (house mouse)	Klk1b27	NP_064664.1
Homo sapiens (human)	KLK3	NP_001639.1
Mus musculus (house mouse)	Klk1b16	NP_032480.1
Mus musculus (house mouse)	Klk1b11	NP_034770.1
	KLK3	NP_001036241.1
Mus musculus (house mouse)	Klk1	NP_034769.4
Mus musculus (house mouse)	Klk1b9	NP_034246.1

Gene Ontology
Bibliography

Related articles in PubMed

Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.
Chen JQ, Mori H, Cardiff RD, Trott JF, Hovey RC, Hubbard NE, Engelberg JA, Tepper CG, Willis BJ, Khan IH, Ravindran RK, Chan SR, Schreiber RD, Borowsky AD
PloS one10(6)e0129895(2015)

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM
Biological chemistry387(6)637-41(2006 Jun)

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Olsson AY, Lilja H, Lundwall A
Genomics84(1)147-56(2004 Jul)

Organization and evolution of the glandular kallikrein locus in Mus musculus.
Olsson AY, Lundwall A
Biochemical and biophysical research communications299(2)305-11(2002 Nov)

Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).
Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K
Biochimica et biophysica acta1382(1)55-64(1998 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Klk1b22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klk1b22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu05562	NM_010114.2 Latest version!	Mus musculus kallikrein 1-related peptidase b22 (Klk1b22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu05562	NM_010114.1	Mus musculus kallikrein 1-related peptidase b22 (Klk1b22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klk1b22 ( NM_010114.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034244.1 Mus musculus kallikrein 1-related peptidase b22 (Klk1b22), mRNA.

Price & Availability↑

CloneID	OMu05562
Clone ID Related Accession (Same CDS sequence)	NM_010114.1 , NM_010114.2
Accession Version	NM_010114.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	kallikrein 1-related peptidase b22 precursor
Comment

ATGAGGTTCC TGATCCTGTT CCTAACCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATACTTGG AGGATTTAAA TGTGAGAAGA ATTCCCAACC CTGGCAGGTG 
GCTGTGTACT ACTTAGATGA GTACCTATGC GGGGGAGTCC TGTTGGACCG CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGAAGACAAG TATAATATTT GGCTGGGCAA AAACAAGCTA 
TTCCAAGATG AACCCTCTGC TCAGCACCGA TTGGTCAGCA AAAGCTTCCC TCATCCTGAC 
TTCAACATGA GCCTCCTCCA AAGTGTACCT ACTGGGGCCG ACTTAAGCAA TGACCTGATG 
CTGCTCCGCC TCAGCAAGCC TGCTGACATC ACAGATGTTG TGAAGCCCAT CGACCTGCCC 
ACTACGGAGC CCAAGCTGGG GAGCACATGC CTAGCCTCAG GCTGGGGCAG CATTAACCAG 
TTAATATACC AAAACCCAAA TGATCTCCAG TGTGTGTCCA TCAAGCTCCA TCCTAATGAG 
GTCTGTGTGA AAGCCCATAT ACTGAAGGTG ACAGATGTCA TGCTGTGTGC AGGAGAGATG 
AATGGAGGCA AAGACACTTG TAAGGGAGAC TCAGGAGGCC CACTGATCTG TGATGGTGTT 
CTACAAGGTA TCACATCATG GGGCTCTACC CCATGTGGTG AACCCAATGC ACCGGCCATC 
TACACCAAAC TTATTAAGTT TACCTCCTGG ATAAAAGACA CTATGGCCAA AAACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034244.1
Translation	MRFLILFLTLSLGGIDAAPPVQSRILGGFKCEKNSQPWQVAVYYLDEYLCGGVLLDRNWVLTAAHCYEDKYNIWLGKNKLFQDEPSAQHRLVSKSFPHPDFNMSLLQSVPTGADLSNDLMLLRLSKPADITDVVKPIDLPTTEPKLGSTCLASGWGSINQLIYQNPNDLQCVSIKLHPNEVCVKAHILKVTDVMLCAGEMNGGKDTCKGDSGGPLICDGVLQGITSWGSTPCGEPNAPAIYTKLIKFTSWIKDTMAKNP

Target ORF information:

RefSeq Version	NM_010114.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus kallikrein 1-related peptidase b22 (Klk1b22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010114.1

ORF Insert Sequence:

ATGAGGTTCC TGATCCTGTT CCTAACCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATACTTGG AGGATTTAAA TGTGAGAAGA ATTCCCAACC CTGGCAGGTG 
GCTGTGTACT ACTTAGATGA GTACCTATGC GGGGGAGTCC TGTTGGACCG CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGAAGACAAG TATAATATTT GGCTGGGCAA AAACAAGCTA 
TTCCAAGATG AACCCTCTGC TCAGCACCGA TTGGTCAGCA AAAGCTTCCC TCATCCTGAC 
TTCAACATGA GCCTCCTCCA AAGTGTACCT ACTGGGGCCG ACTTAAGCAA TGACCTGATG 
CTGCTCCGCC TCAGCAAGCC TGCTGACATC ACAGATGTTG TGAAGCCCAT CGACCTGCCC 
ACTACGGAGC CCAAGCTGGG GAGCACATGC CTAGCCTCAG GCTGGGGCAG CATTAACCAG 
TTAATATACC AAAACCCAAA TGATCTCCAG TGTGTGTCCA TCAAGCTCCA TCCTAATGAG 
GTCTGTGTGA AAGCCCATAT ACTGAAGGTG ACAGATGTCA TGCTGTGTGC AGGAGAGATG 
AATGGAGGCA AAGACACTTG TAAGGGAGAC TCAGGAGGCC CACTGATCTG TGATGGTGTT 
CTACAAGGTA TCACATCATG GGGCTCTACC CCATGTGGTG AACCCAATGC ACCGGCCATC 
TACACCAAAC TTATTAAGTT TACCTCCTGG ATAAAAGACA CTATGGCCAA AAACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klk1b22 ( NM_010114.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034244.1 Mus musculus kallikrein 1-related peptidase b22 (Klk1b22), mRNA.

Price & Availability↑

CloneID	OMu05562
Clone ID Related Accession (Same CDS sequence)	NM_010114.1 , NM_010114.2
Accession Version	NM_010114.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	kallikrein 1-related peptidase b22 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC124176.3. On Feb 23, 2016 this sequence version replaced NM_010114.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC106155.1, BF302117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGTTCC TGATCCTGTT CCTAACCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATACTTGG AGGATTTAAA TGTGAGAAGA ATTCCCAACC CTGGCAGGTG 
GCTGTGTACT ACTTAGATGA GTACCTATGC GGGGGAGTCC TGTTGGACCG CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGAAGACAAG TATAATATTT GGCTGGGCAA AAACAAGCTA 
TTCCAAGATG AACCCTCTGC TCAGCACCGA TTGGTCAGCA AAAGCTTCCC TCATCCTGAC 
TTCAACATGA GCCTCCTCCA AAGTGTACCT ACTGGGGCCG ACTTAAGCAA TGACCTGATG 
CTGCTCCGCC TCAGCAAGCC TGCTGACATC ACAGATGTTG TGAAGCCCAT CGACCTGCCC 
ACTACGGAGC CCAAGCTGGG GAGCACATGC CTAGCCTCAG GCTGGGGCAG CATTAACCAG 
TTAATATACC AAAACCCAAA TGATCTCCAG TGTGTGTCCA TCAAGCTCCA TCCTAATGAG 
GTCTGTGTGA AAGCCCATAT ACTGAAGGTG ACAGATGTCA TGCTGTGTGC AGGAGAGATG 
AATGGAGGCA AAGACACTTG TAAGGGAGAC TCAGGAGGCC CACTGATCTG TGATGGTGTT 
CTACAAGGTA TCACATCATG GGGCTCTACC CCATGTGGTG AACCCAATGC ACCGGCCATC 
TACACCAAAC TTATTAAGTT TACCTCCTGG ATAAAAGACA CTATGGCCAA AAACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034244.1
CDS	30..809
Translation	MRFLILFLTLSLGGIDAAPPVQSRILGGFKCEKNSQPWQVAVYYLDEYLCGGVLLDRNWVLTAAHCYEDKYNIWLGKNKLFQDEPSAQHRLVSKSFPHPDFNMSLLQSVPTGADLSNDLMLLRLSKPADITDVVKPIDLPTTEPKLGSTCLASGWGSINQLIYQNPNDLQCVSIKLHPNEVCVKAHILKVTDVMLCAGEMNGGKDTCKGDSGGPLICDGVLQGITSWGSTPCGEPNAPAIYTKLIKFTSWIKDTMAKNP

Target ORF information:

RefSeq Version	NM_010114.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus kallikrein 1-related peptidase b22 (Klk1b22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010114.2

ORF Insert Sequence:

ATGAGGTTCC TGATCCTGTT CCTAACCCTG TCCCTAGGAG GGATTGATGC TGCACCTCCT 
GTCCAGTCTC GAATACTTGG AGGATTTAAA TGTGAGAAGA ATTCCCAACC CTGGCAGGTG 
GCTGTGTACT ACTTAGATGA GTACCTATGC GGGGGAGTCC TGTTGGACCG CAACTGGGTT 
CTCACAGCTG CCCACTGCTA TGAAGACAAG TATAATATTT GGCTGGGCAA AAACAAGCTA 
TTCCAAGATG AACCCTCTGC TCAGCACCGA TTGGTCAGCA AAAGCTTCCC TCATCCTGAC 
TTCAACATGA GCCTCCTCCA AAGTGTACCT ACTGGGGCCG ACTTAAGCAA TGACCTGATG 
CTGCTCCGCC TCAGCAAGCC TGCTGACATC ACAGATGTTG TGAAGCCCAT CGACCTGCCC 
ACTACGGAGC CCAAGCTGGG GAGCACATGC CTAGCCTCAG GCTGGGGCAG CATTAACCAG 
TTAATATACC AAAACCCAAA TGATCTCCAG TGTGTGTCCA TCAAGCTCCA TCCTAATGAG 
GTCTGTGTGA AAGCCCATAT ACTGAAGGTG ACAGATGTCA TGCTGTGTGC AGGAGAGATG 
AATGGAGGCA AAGACACTTG TAAGGGAGAC TCAGGAGGCC CACTGATCTG TGATGGTGTT 
CTACAAGGTA TCACATCATG GGGCTCTACC CCATGTGGTG AACCCAATGC ACCGGCCATC 
TACACCAAAC TTATTAAGTT TACCTCCTGG ATAAAAGACA CTATGGCCAA AAACCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.
PloS one10(6)e0129895(2015)
Chen JQ,Mori H,Cardiff RD,Trott JF,Hovey RC,Hubbard NE,Engelberg JA,Tepper CG,Willis BJ,Khan IH,Ravindran RK,Chan SR,Schreiber RD,Borowsky AD

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.
Biological chemistry387(6)637-41(2006 Jun)
Lundwall A,Band V,Blaber M,Clements JA,Courty Y,Diamandis EP,Fritz H,Lilja H,Malm J,Maltais LJ,Olsson AY,Petraki C,Scorilas A,Sotiropoulou G,Stenman UH,Stephan C,Talieri M,Yousef GM

Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen.
Genomics84(1)147-56(2004 Jul)
Olsson AY,Lilja H,Lundwall A

Organization and evolution of the glandular kallikrein locus in Mus musculus.
Biochemical and biophysical research communications299(2)305-11(2002 Nov)
Olsson AY,Lundwall A

Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22).
Biochimica et biophysica acta1382(1)55-64(1998 Jan)
Kikkawa Y,Yamanaka N,Tada J,Kanamori N,Tsumura K,Hosoi K

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Klk1b22 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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