Adam24 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam24
Entrez Gene ID	13526
Full Name	a disintegrin and metallopeptidase domain 24 (testase 1)
Synonyms	Dtgn5
General protein information	Preferred Names a disintegrin and metallopeptidase domain 24 (testase 1) Names disintegrin and metalloproteinase domain-containing protein 24 a disintegrin and metalloproteinase domain 24 (testase 1) disintegrin 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A4
Summary	This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. Male mice lacking the encoded protein exhibit reduced fertility due to the higher incidence of polyspermic embryos. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006509261.1	XP_006509324.1	disintegrin and metalloproteinase domain-containing protein 24 isoform X1
NM_010086.5	NP_034216.3	disintegrin and metalloproteinase domain-containing protein 24 preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Adam24	XP_224892.1
Mus musculus (house mouse)	Adam24	NP_034216.3

Gene Ontology
Bibliography

Related articles in PubMed

Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.
Grayson P, Civetta A
BMC evolutionary biology13217(2013 Sep)

Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice.
Zhu GZ, Gupta S, Myles DG, Primakoff P
Molecular reproduction and development76(11)1106-14(2009 Nov)

Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
Han C, Choi E, Park I, Lee B, Jin S, Kim DH, Nishimura H, Cho C
Biology of reproduction80(5)1001-8(2009 May)

Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P
Developmental dynamics : an official publication of the American Association of Anatomists238(5)1033-41(2009 May)

Testase 1 (ADAM 24) a plasma membrane-anchored sperm protease implicated in sperm function during epididymal maturation or fertilization.
Zhu GZ, Myles DG, Primakoff P
Journal of cell science114(Pt 9)1787-94(2001 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings suggest that testase 1 is a sperm plasma membrane component which contributes to the prevention of polyspermy at the level of the oocyte plasma membrane.
Title: Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice.

The following Adam24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05494	NM_010086.5 Latest version!	Mus musculus a disintegrin and metallopeptidase domain 24 (testase 1) (Adam24), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu05494	XM_006509261.1 Latest version!	Mus musculus a disintegrin and metallopeptidase domain 24 (testase 1) (Adam24), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam24 ( NM_010086.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034216.3 Mus musculus a disintegrin and metallopeptidase domain 24 (testase 1) (Adam24), mRNA.

Price & Availability↑

CloneID	OMu05494
Clone ID Related Accession (Same CDS sequence)	XM_006509261.1 , NM_010086.5
Accession Version	NM_010086.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2286bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	disintegrin and metalloproteinase domain-containing protein 24 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BB616396.1, AK029528.1 and AK133199.1. On May 12, 2016 this sequence version replaced NM_010086.4. ##Evidence-Data-START## Transcript exon combination :: AK029528.1, BB614583.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGGTGGCTA TGAGTGAGGC TCTGGTTCAT GCAAGGATCA CTCTCCTTCA GGCATGGTTG 
AGGATGCTGC TCTTTTCTTC TGTATGGCCC CCGACTTGGT GTGCTGAATA CAAAGGCCCT 
CCAGAGACAG TGAAACCCTT GAGGGTAATT GTCTCTAGTA AAGACATGAG TCTTGCAGGC 
TGGATGTCCT ATAGTCTGTA CTTTGGAGGC CAGAGACACA TTATCTCCAT GAAATCCAAG 
AATTTTTTGG AATCCAGACA GCTCCCTGTG TTCACATACA ATGACCAAGG TGTCCTCTTT 
GAGGACAGAC CTTTTGTCCA AAATGACTGT TATTATCTTG GTTTTGTGGA TGGAGATCTA 
GAATCCATGG CTGCTCTTAC CACCTGTTTT GGGGGCTTTC AAGGAATATT ACAGATAAAT 
GACACAGCTT ATGAAATTAA GCCCAAGAGC CCCTCTTCCA CATTTGAACA TCTGCTTTAC 
AAGATAGACA GTGAGAAAAC TCAATTACGC CCCATGAGAT GTGGATTAAC AGATGAAGAA 
ATAGCAGGGC AAGTGAGACT TCAAGAAAAT GGTAAGTCCA CTAGAATGCA AAGCATCTAT 
GGGTCATGGT GGTCTCATGG ATTGTATATT AAACTGGCAT TGGTTATAGA CCATGAACAA 
TACCTTTATC GAAAAAAAAA TACTTCTCTT GTGATAAGAG ATGTATTAAG CATTATGCAG 
GGAATAAATC TCTTCTTACT TTCAGTGGAT ATTAATGTGG TTTTACTTGG ACTTACTATC 
TGGACTAATG GAAATCCTAT ACCAGTGCAA GATATATATG CTCTTTTGCC AGCATTTTGT 
ACGTGGAAGG GAACAAACCT TGATTCTCAG ATACCATATG ATATTGCACA TCTCTTTGTG 
AATTATACTT TTAGTAACTA TTTTGGCATA GCCTATGTAG GAACTGTATG TGATAAGACA 
TTTGGTTGTG GAATTGATAG TATCGCTGAA GATGATTTCC TTACCATTGG ACATATTGTG 
GCACATGAGA TAGGTCACAA TTTGGGCATG TCACATGATG GGATACTTTG TACTTGCGGA 
GAAGAATCAT GTTTAATGTC TGCTACAATG GATAGTTCCC AAAAACTCAG CAACTGTAGT 
TATGAAGTCT TGTGGGCACA CATGATCAAT AAAAGCTGCA TACATAGAGA GCCCAGACCT 
TCTGATATTT TCCAATTGAA GGTCTGTGGG AATGGTATAG TTGAAGAAGG TGAGCAGTGT 
GACTGTGGAA GCTCTGAAAA CTGTAGACGT AATCGCTGTT GTATGCCTAG CTGTACTCTG 
AGGTCTAAAG CTAAATGTGA TACTGGACTA TGTTGTAACC GCAAATGCCA AATCCAGCCA 
TCTGGCACTC TGTGTAGAGC TCGGGAGAAT GAATGTGACC TTCCAGAATG GTGCAATGGA 
ACCTCACATG AGTGCCCTGA AGACTTGTTT GTACAGGATG GGACCTCTTG CCCTGGTGAT 
GGCTACTGCT ATGAAAAAAG ATGTAACAGC CACGATGTCC ACTGTCAGAG AGTTTTTGGC 
CAGCTTGCCA TGAAAGCATC GGATAGCTGT TACAAGGAAC TCAATACTCG TGGTGATCGT 
TTTGGTAACT GTGGCTTCAT AAACAACGAG TATGTGAGAT GTGAGATCTC AGACATCCTC 
TGTGGGAGGA TTCAATGTGA CAAAGTGGGA ACACTTCCTA TCCTGCAGAA TCATTATACT 
ATTCACTGGA CTCATTTTAA TAGTGTTTCC TGCTGGAGTA CTGACTACCA TTTGGGGATG 
AAAATTGCTG ACCTCGGTGA CATAAAAGAT GGCACAAACT GTGGTCCACA GCATGTGTGC 
ATTGCCAGAA AGTGTGTTAA TAAGCCAAGT TGGGTAAATG ATTGTACACC AGAGACCTGC 
AACATGAAAG GAGTCTGCAA TAATAAGCAG CACTGCCATT GTGATGTTGG CTGGAGCCCA 
CCAAACTGCC AGGAAACTGG CACCGGAGGA AGTATTGACA GTGGTTCTCC TGGAAACGAA 
GTTTATGAAG ATGAAGTTGT GAGCAAGAAG GATGCCCCAG AAAAACCTAA CGTCATAATT 
TGGTTATTAC CTATTATTTG TGTGGCTGTA GTTTTATCTG TATTGTTTTG CTTGTCTGGG 
GCCACTAAAA AATCACGTGA AGCAGCAGCA AGTCAACCAG CAGAGGAGAG AGTTAAACCA 
CCATATGAAG GGGCTGAACC CTCATATGAG ACAGTTAAAC CACCGGATGA ATGGGCTAAC 
CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034216.3
CDS	183..2468
Translation	MVAMSEALVHARITLLQAWLRMLLFSSVWPPTWCAEYKGPPETVKPLRVIVSSKDMSLAGWMSYSLYFGGQRHIISMKSKNFLESRQLPVFTYNDQGVLFEDRPFVQNDCYYLGFVDGDLESMAALTTCFGGFQGILQINDTAYEIKPKSPSSTFEHLLYKIDSEKTQLRPMRCGLTDEEIAGQVRLQENGKSTRMQSIYGSWWSHGLYIKLALVIDHEQYLYRKKNTSLVIRDVLSIMQGINLFLLSVDINVVLLGLTIWTNGNPIPVQDIYALLPAFCTWKGTNLDSQIPYDIAHLFVNYTFSNYFGIAYVGTVCDKTFGCGIDSIAEDDFLTIGHIVAHEIGHNLGMSHDGILCTCGEESCLMSATMDSSQKLSNCSYEVLWAHMINKSCIHREPRPSDIFQLKVCGNGIVEEGEQCDCGSSENCRRNRCCMPSCTLRSKAKCDTGLCCNRKCQIQPSGTLCRARENECDLPEWCNGTSHECPEDLFVQDGTSCPGDGYCYEKRCNSHDVHCQRVFGQLAMKASDSCYKELNTRGDRFGNCGFINNEYVRCEISDILCGRIQCDKVGTLPILQNHYTIHWTHFNSVSCWSTDYHLGMKIADLGDIKDGTNCGPQHVCIARKCVNKPSWVNDCTPETCNMKGVCNNKQHCHCDVGWSPPNCQETGTGGSIDSGSPGNEVYEDEVVSKKDAPEKPNVIIWLLPIICVAVVLSVLFCLSGATKKSREAAASQPAEERVKPPYEGAEPSYETVKPPDEWANP

Target ORF information:

RefSeq Version	NM_010086.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin and metallopeptidase domain 24 (testase 1) (Adam24), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010086.5

ORF Insert Sequence:

ATGGTGGCTA TGAGTGAGGC TCTGGTTCAT GCAAGGATCA CTCTCCTTCA GGCATGGTTG 
AGGATGCTGC TCTTTTCTTC TGTATGGCCC CCGACTTGGT GTGCTGAATA CAAAGGCCCT 
CCAGAGACAG TGAAACCCTT GAGGGTAATT GTCTCTAGTA AAGACATGAG TCTTGCAGGC 
TGGATGTCCT ATAGTCTGTA CTTTGGAGGC CAGAGACACA TTATCTCCAT GAAATCCAAG 
AATTTTTTGG AATCCAGACA GCTCCCTGTG TTCACATACA ATGACCAAGG TGTCCTCTTT 
GAGGACAGAC CTTTTGTCCA AAATGACTGT TATTATCTTG GTTTTGTGGA TGGAGATCTA 
GAATCCATGG CTGCTCTTAC CACCTGTTTT GGGGGCTTTC AAGGAATATT ACAGATAAAT 
GACACAGCTT ATGAAATTAA GCCCAAGAGC CCCTCTTCCA CATTTGAACA TCTGCTTTAC 
AAGATAGACA GTGAGAAAAC TCAATTACGC CCCATGAGAT GTGGATTAAC AGATGAAGAA 
ATAGCAGGGC AAGTGAGACT TCAAGAAAAT GGTAAGTCCA CTAGAATGCA AAGCATCTAT 
GGGTCATGGT GGTCTCATGG ATTGTATATT AAACTGGCAT TGGTTATAGA CCATGAACAA 
TACCTTTATC GAAAAAAAAA TACTTCTCTT GTGATAAGAG ATGTATTAAG CATTATGCAG 
GGAATAAATC TCTTCTTACT TTCAGTGGAT ATTAATGTGG TTTTACTTGG ACTTACTATC 
TGGACTAATG GAAATCCTAT ACCAGTGCAA GATATATATG CTCTTTTGCC AGCATTTTGT 
ACGTGGAAGG GAACAAACCT TGATTCTCAG ATACCATATG ATATTGCACA TCTCTTTGTG 
AATTATACTT TTAGTAACTA TTTTGGCATA GCCTATGTAG GAACTGTATG TGATAAGACA 
TTTGGTTGTG GAATTGATAG TATCGCTGAA GATGATTTCC TTACCATTGG ACATATTGTG 
GCACATGAGA TAGGTCACAA TTTGGGCATG TCACATGATG GGATACTTTG TACTTGCGGA 
GAAGAATCAT GTTTAATGTC TGCTACAATG GATAGTTCCC AAAAACTCAG CAACTGTAGT 
TATGAAGTCT TGTGGGCACA CATGATCAAT AAAAGCTGCA TACATAGAGA GCCCAGACCT 
TCTGATATTT TCCAATTGAA GGTCTGTGGG AATGGTATAG TTGAAGAAGG TGAGCAGTGT 
GACTGTGGAA GCTCTGAAAA CTGTAGACGT AATCGCTGTT GTATGCCTAG CTGTACTCTG 
AGGTCTAAAG CTAAATGTGA TACTGGACTA TGTTGTAACC GCAAATGCCA AATCCAGCCA 
TCTGGCACTC TGTGTAGAGC TCGGGAGAAT GAATGTGACC TTCCAGAATG GTGCAATGGA 
ACCTCACATG AGTGCCCTGA AGACTTGTTT GTACAGGATG GGACCTCTTG CCCTGGTGAT 
GGCTACTGCT ATGAAAAAAG ATGTAACAGC CACGATGTCC ACTGTCAGAG AGTTTTTGGC 
CAGCTTGCCA TGAAAGCATC GGATAGCTGT TACAAGGAAC TCAATACTCG TGGTGATCGT 
TTTGGTAACT GTGGCTTCAT AAACAACGAG TATGTGAGAT GTGAGATCTC AGACATCCTC 
TGTGGGAGGA TTCAATGTGA CAAAGTGGGA ACACTTCCTA TCCTGCAGAA TCATTATACT 
ATTCACTGGA CTCATTTTAA TAGTGTTTCC TGCTGGAGTA CTGACTACCA TTTGGGGATG 
AAAATTGCTG ACCTCGGTGA CATAAAAGAT GGCACAAACT GTGGTCCACA GCATGTGTGC 
ATTGCCAGAA AGTGTGTTAA TAAGCCAAGT TGGGTAAATG ATTGTACACC AGAGACCTGC 
AACATGAAAG GAGTCTGCAA TAATAAGCAG CACTGCCATT GTGATGTTGG CTGGAGCCCA 
CCAAACTGCC AGGAAACTGG CACCGGAGGA AGTATTGACA GTGGTTCTCC TGGAAACGAA 
GTTTATGAAG ATGAAGTTGT GAGCAAGAAG GATGCCCCAG AAAAACCTAA CGTCATAATT 
TGGTTATTAC CTATTATTTG TGTGGCTGTA GTTTTATCTG TATTGTTTTG CTTGTCTGGG 
GCCACTAAAA AATCACGTGA AGCAGCAGCA AGTCAACCAG CAGAGGAGAG AGTTAAACCA 
CCATATGAAG GGGCTGAACC CTCATATGAG ACAGTTAAAC CACCGGATGA ATGGGCTAAC 
CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Adam24 ( XM_006509261.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006509324.1 Mus musculus a disintegrin and metallopeptidase domain 24 (testase 1) (Adam24), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu05494
Clone ID Related Accession (Same CDS sequence)	XM_006509261.1 , NM_010086.5
Accession Version	XM_006509261.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2286bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	disintegrin and metalloproteinase domain-containing protein 24 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGCTA TGAGTGAGGC TCTGGTTCAT GCAAGGATCA CTCTCCTTCA GGCATGGTTG 
AGGATGCTGC TCTTTTCTTC TGTATGGCCC CCGACTTGGT GTGCTGAATA CAAAGGCCCT 
CCAGAGACAG TGAAACCCTT GAGGGTAATT GTCTCTAGTA AAGACATGAG TCTTGCAGGC 
TGGATGTCCT ATAGTCTGTA CTTTGGAGGC CAGAGACACA TTATCTCCAT GAAATCCAAG 
AATTTTTTGG AATCCAGACA GCTCCCTGTG TTCACATACA ATGACCAAGG TGTCCTCTTT 
GAGGACAGAC CTTTTGTCCA AAATGACTGT TATTATCTTG GTTTTGTGGA TGGAGATCTA 
GAATCCATGG CTGCTCTTAC CACCTGTTTT GGGGGCTTTC AAGGAATATT ACAGATAAAT 
GACACAGCTT ATGAAATTAA GCCCAAGAGC CCCTCTTCCA CATTTGAACA TCTGCTTTAC 
AAGATAGACA GTGAGAAAAC TCAATTACGC CCCATGAGAT GTGGATTAAC AGATGAAGAA 
ATAGCAGGGC AAGTGAGACT TCAAGAAAAT GGTAAGTCCA CTAGAATGCA AAGCATCTAT 
GGGTCATGGT GGTCTCATGG ATTGTATATT AAACTGGCAT TGGTTATAGA CCATGAACAA 
TACCTTTATC GAAAAAAAAA TACTTCTCTT GTGATAAGAG ATGTATTAAG CATTATGCAG 
GGAATAAATC TCTTCTTACT TTCAGTGGAT ATTAATGTGG TTTTACTTGG ACTTACTATC 
TGGACTAATG GAAATCCTAT ACCAGTGCAA GATATATATG CTCTTTTGCC AGCATTTTGT 
ACGTGGAAGG GAACAAACCT TGATTCTCAG ATACCATATG ATATTGCACA TCTCTTTGTG 
AATTATACTT TTAGTAACTA TTTTGGCATA GCCTATGTAG GAACTGTATG TGATAAGACA 
TTTGGTTGTG GAATTGATAG TATCGCTGAA GATGATTTCC TTACCATTGG ACATATTGTG 
GCACATGAGA TAGGTCACAA TTTGGGCATG TCACATGATG GGATACTTTG TACTTGCGGA 
GAAGAATCAT GTTTAATGTC TGCTACAATG GATAGTTCCC AAAAACTCAG CAACTGTAGT 
TATGAAGTCT TGTGGGCACA CATGATCAAT AAAAGCTGCA TACATAGAGA GCCCAGACCT 
TCTGATATTT TCCAATTGAA GGTCTGTGGG AATGGTATAG TTGAAGAAGG TGAGCAGTGT 
GACTGTGGAA GCTCTGAAAA CTGTAGACGT AATCGCTGTT GTATGCCTAG CTGTACTCTG 
AGGTCTAAAG CTAAATGTGA TACTGGACTA TGTTGTAACC GCAAATGCCA AATCCAGCCA 
TCTGGCACTC TGTGTAGAGC TCGGGAGAAT GAATGTGACC TTCCAGAATG GTGCAATGGA 
ACCTCACATG AGTGCCCTGA AGACTTGTTT GTACAGGATG GGACCTCTTG CCCTGGTGAT 
GGCTACTGCT ATGAAAAAAG ATGTAACAGC CACGATGTCC ACTGTCAGAG AGTTTTTGGC 
CAGCTTGCCA TGAAAGCATC GGATAGCTGT TACAAGGAAC TCAATACTCG TGGTGATCGT 
TTTGGTAACT GTGGCTTCAT AAACAACGAG TATGTGAGAT GTGAGATCTC AGACATCCTC 
TGTGGGAGGA TTCAATGTGA CAAAGTGGGA ACACTTCCTA TCCTGCAGAA TCATTATACT 
ATTCACTGGA CTCATTTTAA TAGTGTTTCC TGCTGGAGTA CTGACTACCA TTTGGGGATG 
AAAATTGCTG ACCTCGGTGA CATAAAAGAT GGCACAAACT GTGGTCCACA GCATGTGTGC 
ATTGCCAGAA AGTGTGTTAA TAAGCCAAGT TGGGTAAATG ATTGTACACC AGAGACCTGC 
AACATGAAAG GAGTCTGCAA TAATAAGCAG CACTGCCATT GTGATGTTGG CTGGAGCCCA 
CCAAACTGCC AGGAAACTGG CACCGGAGGA AGTATTGACA GTGGTTCTCC TGGAAACGAA 
GTTTATGAAG ATGAAGTTGT GAGCAAGAAG GATGCCCCAG AAAAACCTAA CGTCATAATT 
TGGTTATTAC CTATTATTTG TGTGGCTGTA GTTTTATCTG TATTGTTTTG CTTGTCTGGG 
GCCACTAAAA AATCACGTGA AGCAGCAGCA AGTCAACCAG CAGAGGAGAG AGTTAAACCA 
CCATATGAAG GGGCTGAACC CTCATATGAG ACAGTTAAAC CACCGGATGA ATGGGCTAAC 
CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006509324.1
CDS	198..2483
Translation	MVAMSEALVHARITLLQAWLRMLLFSSVWPPTWCAEYKGPPETVKPLRVIVSSKDMSLAGWMSYSLYFGGQRHIISMKSKNFLESRQLPVFTYNDQGVLFEDRPFVQNDCYYLGFVDGDLESMAALTTCFGGFQGILQINDTAYEIKPKSPSSTFEHLLYKIDSEKTQLRPMRCGLTDEEIAGQVRLQENGKSTRMQSIYGSWWSHGLYIKLALVIDHEQYLYRKKNTSLVIRDVLSIMQGINLFLLSVDINVVLLGLTIWTNGNPIPVQDIYALLPAFCTWKGTNLDSQIPYDIAHLFVNYTFSNYFGIAYVGTVCDKTFGCGIDSIAEDDFLTIGHIVAHEIGHNLGMSHDGILCTCGEESCLMSATMDSSQKLSNCSYEVLWAHMINKSCIHREPRPSDIFQLKVCGNGIVEEGEQCDCGSSENCRRNRCCMPSCTLRSKAKCDTGLCCNRKCQIQPSGTLCRARENECDLPEWCNGTSHECPEDLFVQDGTSCPGDGYCYEKRCNSHDVHCQRVFGQLAMKASDSCYKELNTRGDRFGNCGFINNEYVRCEISDILCGRIQCDKVGTLPILQNHYTIHWTHFNSVSCWSTDYHLGMKIADLGDIKDGTNCGPQHVCIARKCVNKPSWVNDCTPETCNMKGVCNNKQHCHCDVGWSPPNCQETGTGGSIDSGSPGNEVYEDEVVSKKDAPEKPNVIIWLLPIICVAVVLSVLFCLSGATKKSREAAASQPAEERVKPPYEGAEPSYETVKPPDEWANP

Target ORF information:

RefSeq Version	XM_006509261.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin and metallopeptidase domain 24 (testase 1) (Adam24), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509261.1

ORF Insert Sequence:

ATGGTGGCTA TGAGTGAGGC TCTGGTTCAT GCAAGGATCA CTCTCCTTCA GGCATGGTTG 
AGGATGCTGC TCTTTTCTTC TGTATGGCCC CCGACTTGGT GTGCTGAATA CAAAGGCCCT 
CCAGAGACAG TGAAACCCTT GAGGGTAATT GTCTCTAGTA AAGACATGAG TCTTGCAGGC 
TGGATGTCCT ATAGTCTGTA CTTTGGAGGC CAGAGACACA TTATCTCCAT GAAATCCAAG 
AATTTTTTGG AATCCAGACA GCTCCCTGTG TTCACATACA ATGACCAAGG TGTCCTCTTT 
GAGGACAGAC CTTTTGTCCA AAATGACTGT TATTATCTTG GTTTTGTGGA TGGAGATCTA 
GAATCCATGG CTGCTCTTAC CACCTGTTTT GGGGGCTTTC AAGGAATATT ACAGATAAAT 
GACACAGCTT ATGAAATTAA GCCCAAGAGC CCCTCTTCCA CATTTGAACA TCTGCTTTAC 
AAGATAGACA GTGAGAAAAC TCAATTACGC CCCATGAGAT GTGGATTAAC AGATGAAGAA 
ATAGCAGGGC AAGTGAGACT TCAAGAAAAT GGTAAGTCCA CTAGAATGCA AAGCATCTAT 
GGGTCATGGT GGTCTCATGG ATTGTATATT AAACTGGCAT TGGTTATAGA CCATGAACAA 
TACCTTTATC GAAAAAAAAA TACTTCTCTT GTGATAAGAG ATGTATTAAG CATTATGCAG 
GGAATAAATC TCTTCTTACT TTCAGTGGAT ATTAATGTGG TTTTACTTGG ACTTACTATC 
TGGACTAATG GAAATCCTAT ACCAGTGCAA GATATATATG CTCTTTTGCC AGCATTTTGT 
ACGTGGAAGG GAACAAACCT TGATTCTCAG ATACCATATG ATATTGCACA TCTCTTTGTG 
AATTATACTT TTAGTAACTA TTTTGGCATA GCCTATGTAG GAACTGTATG TGATAAGACA 
TTTGGTTGTG GAATTGATAG TATCGCTGAA GATGATTTCC TTACCATTGG ACATATTGTG 
GCACATGAGA TAGGTCACAA TTTGGGCATG TCACATGATG GGATACTTTG TACTTGCGGA 
GAAGAATCAT GTTTAATGTC TGCTACAATG GATAGTTCCC AAAAACTCAG CAACTGTAGT 
TATGAAGTCT TGTGGGCACA CATGATCAAT AAAAGCTGCA TACATAGAGA GCCCAGACCT 
TCTGATATTT TCCAATTGAA GGTCTGTGGG AATGGTATAG TTGAAGAAGG TGAGCAGTGT 
GACTGTGGAA GCTCTGAAAA CTGTAGACGT AATCGCTGTT GTATGCCTAG CTGTACTCTG 
AGGTCTAAAG CTAAATGTGA TACTGGACTA TGTTGTAACC GCAAATGCCA AATCCAGCCA 
TCTGGCACTC TGTGTAGAGC TCGGGAGAAT GAATGTGACC TTCCAGAATG GTGCAATGGA 
ACCTCACATG AGTGCCCTGA AGACTTGTTT GTACAGGATG GGACCTCTTG CCCTGGTGAT 
GGCTACTGCT ATGAAAAAAG ATGTAACAGC CACGATGTCC ACTGTCAGAG AGTTTTTGGC 
CAGCTTGCCA TGAAAGCATC GGATAGCTGT TACAAGGAAC TCAATACTCG TGGTGATCGT 
TTTGGTAACT GTGGCTTCAT AAACAACGAG TATGTGAGAT GTGAGATCTC AGACATCCTC 
TGTGGGAGGA TTCAATGTGA CAAAGTGGGA ACACTTCCTA TCCTGCAGAA TCATTATACT 
ATTCACTGGA CTCATTTTAA TAGTGTTTCC TGCTGGAGTA CTGACTACCA TTTGGGGATG 
AAAATTGCTG ACCTCGGTGA CATAAAAGAT GGCACAAACT GTGGTCCACA GCATGTGTGC 
ATTGCCAGAA AGTGTGTTAA TAAGCCAAGT TGGGTAAATG ATTGTACACC AGAGACCTGC 
AACATGAAAG GAGTCTGCAA TAATAAGCAG CACTGCCATT GTGATGTTGG CTGGAGCCCA 
CCAAACTGCC AGGAAACTGG CACCGGAGGA AGTATTGACA GTGGTTCTCC TGGAAACGAA 
GTTTATGAAG ATGAAGTTGT GAGCAAGAAG GATGCCCCAG AAAAACCTAA CGTCATAATT 
TGGTTATTAC CTATTATTTG TGTGGCTGTA GTTTTATCTG TATTGTTTTG CTTGTCTGGG 
GCCACTAAAA AATCACGTGA AGCAGCAGCA AGTCAACCAG CAGAGGAGAG AGTTAAACCA 
CCATATGAAG GGGCTGAACC CTCATATGAG ACAGTTAAAC CACCGGATGA ATGGGCTAAC 
CCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.
BMC evolutionary biology13217(2013 Sep)
Grayson P,Civetta A

Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice.
Molecular reproduction and development76(11)1106-14(2009 Nov)
Zhu GZ,Gupta S,Myles DG,Primakoff P

Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
Biology of reproduction80(5)1001-8(2009 May)
Han C,Choi E,Park I,Lee B,Jin S,Kim DH,Nishimura H,Cho C

Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Developmental dynamics : an official publication of the American Association of Anatomists238(5)1033-41(2009 May)
Combes AN,Lesieur E,Harley VR,Sinclair AH,Little MH,Wilhelm D,Koopman P

Testase 1 (ADAM 24) a plasma membrane-anchored sperm protease implicated in sperm function during epididymal maturation or fertilization.
Journal of cell science114(Pt 9)1787-94(2001 May)
Zhu GZ,Myles DG,Primakoff P

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Adam24 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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