Adam26a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam26a
Entrez Gene ID	13525
Full Name	a disintegrin and metallopeptidase domain 26A (testase 3)
Synonyms	Adam26,Dtgn4
General protein information	Preferred Names a disintegrin and metallopeptidase domain 26A (testase 3) Names disintegrin and metalloproteinase domain-containing protein 26A a disintegrin and metalloprotease domain 26 disintegrin 4 testase 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 A4
Summary	This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during the late stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to two other ADAM genes on chromosome 8. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010085.3	NP_034215.2	disintegrin and metalloproteinase domain-containing protein 26A preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Adam26a	NP_034215.2
Mus musculus (house mouse)	Adam26b	NP_001009547.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC
PLoS genetics12(2)e1005691(2016 Feb)

Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.
Grayson P, Civetta A
BMC evolutionary biology13217(2013 Sep)

Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
Han C, Choi E, Park I, Lee B, Jin S, Kim DH, Nishimura H, Cho C
Biology of reproduction80(5)1001-8(2009 May)

Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization.
Zhu GZ, Lin Y, Myles DG, Primakoff P
Gene234(2)227-37(1999 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Adam26a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam26a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05493	NM_010085.3 Latest version!	Mus musculus a disintegrin and metallopeptidase domain 26A (testase 3) (Adam26a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam26a ( NM_010085.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034215.2 Mus musculus a disintegrin and metallopeptidase domain 26A (testase 3) (Adam26a), mRNA.

Price & Availability↑

CloneID	OMu05493
Clone ID Related Accession (Same CDS sequence)	NM_010085.3
Accession Version	NM_010085.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2094bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	disintegrin and metalloproteinase domain-containing protein 26A preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK029756.1 and AC131115.3. On May 12, 2016 this sequence version replaced NM_010085.2. ##Evidence-Data-START## Transcript exon combination :: AF167404.1, AK029756.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCCTTA AGTTCTGCCT GTGGACGATG TTCTTCTTCT CTGCATGGTC ACCAATTGGA 
CATGCTAAGT ACAGTAGCCT TCTAGAAGTA GTGACACCCT TGAGGGTCAC TGTCACTAGA 
GGAAATAATA TTTCACCAGG TTGGCTGTCC TATAGCCTGA ACATTGGGGG GCAGAGGCAC 
ATAATCACTA TGAAACCCAA GAAAAACTTG ATATCCAGAA ACTTCTTATT ATTCACTTAT 
AGTGACCAAG GTGATCTCCT TGAACAACAC CATTTTGTGC AGAATGACTG CTATTACCAT 
GGCTATGTGG ATGAAGACCT AGAGTCCCCG GTCATTGTCA ACACCTGTTT TGGAAGTTTG 
CAAGGCACAC TAGAGATAAA TGGCACAAGT TATGAAATCA TGCCCAAGAG CTCAACGTCA 
ACATTTGAAC ATCTGGTTTA CAAAATGGAC AGTGGGGATT CAGAATCATC TCCCATGAGA 
TGTGGGTTAT CAGAAGAGGA AACAGCACAA CAAACGAAGC TACAAGAAAG CAATGCCCCC 
ACACTTTTAC AAATTCCCTA TGAGAATTGG TGGACCCACC ACAGGTTTAT TGAATATTTT 
GTAGTACTAG ACCATAAACA ATATGTTCAT AGAAATAACA ATATCACAAC TTGTATTCAA 
GATATGTTGC AAATAGTCAA TGGAGTAAAT GGTTATTATC TTCAAATAGA TACTGATGTG 
GTTTTAACCA CTCTTGAAGT ATGGAATGAA AAAAACTATA TCAATGTAGA ACTCAGTATA 
TTTAAAGTCC TTGGTGATTT CTGTACTTGG AAGCAAAACA TGTTTGGCAA TCGCATTAGA 
CATGATATCA TACACCTTTT AGTCAGACAG GGATATGGTT TATATTTAGG GTTAGCTTAT 
TTAGCTGACG TTTGTACACC TTATAATTGT GGAGTTAGCA GTGTCCTTTC TGATGTAATG 
TCAGACATGG CACACATTGT AGCACACGAG ATGGGGCATA ACTTCGGTAT GAAACATGAT 
GGAATTGGAT GTACTTGTGG GTTAAAAGAC TGTCTAATGG CCCCATATAA AACAAATTCT 
CCAAAATTCA GCAACTGTAG TTATGAAGAA ATGTATTCAG TTGTTACCAA ACGAAGTTGC 
TTATATGATA TTCCAGAAGC ACTAGTAACA AACCTGACCG TGTGTGGGAA TAAGGTGGTT 
GAAGAAGGAG AGCAGTGTGA TTGTGGGAAC TCTGAATCCT GTTTACAAGA TCCTTGCTGT 
AGCAGCGACT GTGTTCTCAA ACCTGGTGCT CAATGTGCTT TTGGACTTTG TTGCAAAAAT 
TGCCAGTTCC TTAAAGCAGG CACTGTGTGT AGAAAAGAGA AAAATGAGTG TGACCTTCCA 
GAGTGGTGCA ATGGAACTTC AGCTGAGTGT CCAGGAGATG TGTATAAAGC AGACGGAATC 
CCTTGCAGTG GTGAGGGCTA TTGCTATAAA ATGGAATGTC ATCAACGTGA TGAGCAGTGT 
CGGAAGATTT TTGGCAATGG AAGTAGAAGT GCAGATGAAA TTTGCTACAT GGAAATGAAC 
AGACAGGGTG ACCGCTTTGG GAACTGTGGC AATGATAGCT CTACATATAG AACATGCCAA 
ATTGCTGATG TACTCTGTGG GCAAATTCAG TGTGAGAATG TGATACAACT TCCCCAAAGG 
AGAAACCATG AAACAGTGCA TTATACTCAC TTCAGTAATA TCACCTGCTG GACTATGGAC 
TATCATTTTG GGATCACCAT AGATGATATT GGAGCTGTGA GCGATGGCAC AGCTTATGCT 
CCAGACCATA TATGTGTTGA CAGAAAGTGT GTCAGCAAGT CTGTTCTGGT AAGTAACTGT 
TCACCACAGT TATACCATAT GCAAGGAATC TGCAATAATA AACAACACTG CCATTGTGGT 
GTCACATGGA AACCACCAGA CTGTCAAAAA CGTGGCCATG GAGGTAGTAT AGACAGTGGA 
CCACCTCCAT TGCCTTTATC TCATTCCAAA TGGATTGTGT ACATCCTTAT TGTTTTAGAT 
GTGTGTATTG TTATCATAAT TTATTTATTT TCTTTTTATA AGTTAAGCAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034215.2
CDS	316..2409
Translation	MFLKFCLWTMFFFSAWSPIGHAKYSSLLEVVTPLRVTVTRGNNISPGWLSYSLNIGGQRHIITMKPKKNLISRNFLLFTYSDQGDLLEQHHFVQNDCYYHGYVDEDLESPVIVNTCFGSLQGTLEINGTSYEIMPKSSTSTFEHLVYKMDSGDSESSPMRCGLSEEETAQQTKLQESNAPTLLQIPYENWWTHHRFIEYFVVLDHKQYVHRNNNITTCIQDMLQIVNGVNGYYLQIDTDVVLTTLEVWNEKNYINVELSIFKVLGDFCTWKQNMFGNRIRHDIIHLLVRQGYGLYLGLAYLADVCTPYNCGVSSVLSDVMSDMAHIVAHEMGHNFGMKHDGIGCTCGLKDCLMAPYKTNSPKFSNCSYEEMYSVVTKRSCLYDIPEALVTNLTVCGNKVVEEGEQCDCGNSESCLQDPCCSSDCVLKPGAQCAFGLCCKNCQFLKAGTVCRKEKNECDLPEWCNGTSAECPGDVYKADGIPCSGEGYCYKMECHQRDEQCRKIFGNGSRSADEICYMEMNRQGDRFGNCGNDSSTYRTCQIADVLCGQIQCENVIQLPQRRNHETVHYTHFSNITCWTMDYHFGITIDDIGAVSDGTAYAPDHICVDRKCVSKSVLVSNCSPQLYHMQGICNNKQHCHCGVTWKPPDCQKRGHGGSIDSGPPPLPLSHSKWIVYILIVLDVCIVIIIYLFSFYKLSK

Target ORF information:

RefSeq Version	NM_010085.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus a disintegrin and metallopeptidase domain 26A (testase 3) (Adam26a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010085.3

ORF Insert Sequence:

ATGTTCCTTA AGTTCTGCCT GTGGACGATG TTCTTCTTCT CTGCATGGTC ACCAATTGGA 
CATGCTAAGT ACAGTAGCCT TCTAGAAGTA GTGACACCCT TGAGGGTCAC TGTCACTAGA 
GGAAATAATA TTTCACCAGG TTGGCTGTCC TATAGCCTGA ACATTGGGGG GCAGAGGCAC 
ATAATCACTA TGAAACCCAA GAAAAACTTG ATATCCAGAA ACTTCTTATT ATTCACTTAT 
AGTGACCAAG GTGATCTCCT TGAACAACAC CATTTTGTGC AGAATGACTG CTATTACCAT 
GGCTATGTGG ATGAAGACCT AGAGTCCCCG GTCATTGTCA ACACCTGTTT TGGAAGTTTG 
CAAGGCACAC TAGAGATAAA TGGCACAAGT TATGAAATCA TGCCCAAGAG CTCAACGTCA 
ACATTTGAAC ATCTGGTTTA CAAAATGGAC AGTGGGGATT CAGAATCATC TCCCATGAGA 
TGTGGGTTAT CAGAAGAGGA AACAGCACAA CAAACGAAGC TACAAGAAAG CAATGCCCCC 
ACACTTTTAC AAATTCCCTA TGAGAATTGG TGGACCCACC ACAGGTTTAT TGAATATTTT 
GTAGTACTAG ACCATAAACA ATATGTTCAT AGAAATAACA ATATCACAAC TTGTATTCAA 
GATATGTTGC AAATAGTCAA TGGAGTAAAT GGTTATTATC TTCAAATAGA TACTGATGTG 
GTTTTAACCA CTCTTGAAGT ATGGAATGAA AAAAACTATA TCAATGTAGA ACTCAGTATA 
TTTAAAGTCC TTGGTGATTT CTGTACTTGG AAGCAAAACA TGTTTGGCAA TCGCATTAGA 
CATGATATCA TACACCTTTT AGTCAGACAG GGATATGGTT TATATTTAGG GTTAGCTTAT 
TTAGCTGACG TTTGTACACC TTATAATTGT GGAGTTAGCA GTGTCCTTTC TGATGTAATG 
TCAGACATGG CACACATTGT AGCACACGAG ATGGGGCATA ACTTCGGTAT GAAACATGAT 
GGAATTGGAT GTACTTGTGG GTTAAAAGAC TGTCTAATGG CCCCATATAA AACAAATTCT 
CCAAAATTCA GCAACTGTAG TTATGAAGAA ATGTATTCAG TTGTTACCAA ACGAAGTTGC 
TTATATGATA TTCCAGAAGC ACTAGTAACA AACCTGACCG TGTGTGGGAA TAAGGTGGTT 
GAAGAAGGAG AGCAGTGTGA TTGTGGGAAC TCTGAATCCT GTTTACAAGA TCCTTGCTGT 
AGCAGCGACT GTGTTCTCAA ACCTGGTGCT CAATGTGCTT TTGGACTTTG TTGCAAAAAT 
TGCCAGTTCC TTAAAGCAGG CACTGTGTGT AGAAAAGAGA AAAATGAGTG TGACCTTCCA 
GAGTGGTGCA ATGGAACTTC AGCTGAGTGT CCAGGAGATG TGTATAAAGC AGACGGAATC 
CCTTGCAGTG GTGAGGGCTA TTGCTATAAA ATGGAATGTC ATCAACGTGA TGAGCAGTGT 
CGGAAGATTT TTGGCAATGG AAGTAGAAGT GCAGATGAAA TTTGCTACAT GGAAATGAAC 
AGACAGGGTG ACCGCTTTGG GAACTGTGGC AATGATAGCT CTACATATAG AACATGCCAA 
ATTGCTGATG TACTCTGTGG GCAAATTCAG TGTGAGAATG TGATACAACT TCCCCAAAGG 
AGAAACCATG AAACAGTGCA TTATACTCAC TTCAGTAATA TCACCTGCTG GACTATGGAC 
TATCATTTTG GGATCACCAT AGATGATATT GGAGCTGTGA GCGATGGCAC AGCTTATGCT 
CCAGACCATA TATGTGTTGA CAGAAAGTGT GTCAGCAAGT CTGTTCTGGT AAGTAACTGT 
TCACCACAGT TATACCATAT GCAAGGAATC TGCAATAATA AACAACACTG CCATTGTGGT 
GTCACATGGA AACCACCAGA CTGTCAAAAA CGTGGCCATG GAGGTAGTAT AGACAGTGGA 
CCACCTCCAT TGCCTTTATC TCATTCCAAA TGGATTGTGT ACATCCTTAT TGTTTTAGAT 
GTGTGTATTG TTATCATAAT TTATTTATTT TCTTTTTATA AGTTAAGCAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
PLoS genetics12(2)e1005691(2016 Feb)
West DB,Engelhard EK,Adkisson M,Nava AJ,Kirov JV,Cipollone A,Willis B,Rapp J,de Jong PJ,Lloyd KC

Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.
BMC evolutionary biology13217(2013 Sep)
Grayson P,Civetta A

Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice.
Biology of reproduction80(5)1001-8(2009 May)
Han C,Choi E,Park I,Lee B,Jin S,Kim DH,Nishimura H,Cho C

Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization.
Gene234(2)227-37(1999 Jul)
Zhu GZ,Lin Y,Myles DG,Primakoff P

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Adam26a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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