DSG2 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	DSG2
Entrez Gene ID	13511
Full Name	desmoglein 2
Synonyms	AA408168,D18Ertd293e
General protein information	Preferred Names desmoglein 2 Names desmoglein-2
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 18 Map Location: 18 A2\|18 11.42 cM
Summary	This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein die in utero. Mutant mice lacking a part of the extracellular adhesive domain of the encoded protein develop cardiac fibrosis and dilation. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007883.3	NP_031909.2	desmoglein-2 preproprotein
NM_007883.2	NP_031909.2	desmoglein-2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	DSG2	NP_001934.2
Danio rerio (zebrafish)	LOC101882022	XP_005170207.1
Canis lupus familiaris (dog)	DSG2	XP_005622989.1
Bos taurus (cattle)	DSG2	NP_001179101.2
Mus musculus (house mouse)	Dsg2	NP_031909.2
Danio rerio (zebrafish)	si:ch73-74h11.1	XP_003200735.2
Rattus norvegicus (Norway rat)	Dsg2	XP_006254536.1
Danio rerio (zebrafish)	dsg2l	XP_005171176.1
Danio rerio (zebrafish)	dsg2	NP_001243566.1
Pan troglodytes (chimpanzee)	DSG2	XP_512079.2
	DSG2	XP_001098597.1
Gallus gallus (chicken)	DSG2	XP_426083.4
Xenopus tropicalis (tropical clawed frog)	dsg2	XP_002934177.2

Gene Ontology
Bibliography

Related articles in PubMed

Cardiomyocyte Hypertrophy in Arrhythmogenic Cardiomyopathy.
Ger?ek M, Ger?ek M, Kant S, Simsekyilmaz S, Kassner A, Milting H, Liehn EA, Leube RE, Krusche CA
The American journal of pathology187(4)752-766(2017 Apr)

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.
Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR
PloS one11(8)e0161465(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

generated a Dsg2 loss-of-function strain (Dsg2 (lo/lo)) and observed that, in response to reduced levels of Dsg2: (i) CD31(+) endothelial cells in the pancreas are hypertrophic and exhibit altered morphology, (ii) bone marrow-derived endothelial colony formation is impaired, (iii) ex vivo vascular sprouting from aortic rings is reduced, and (iv) vessel formation in vitro and in vivo is attenuated
Title: A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis.

Data suggest that loss of desmoglein 2 (Dsg2) compromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other desmosome-related arrhythmogenic cardiomyopathy (AC).
Title: Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function.

Dsg2 modulates Gli1 expression. Dsg2-mediated hyperproliferation, MEK/Erk1/2 activation, and accelerated squamous tumor development are enhanced on the Ptc1+/lacZ background.
Title: Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.

a novel pathway of CSTA regulation involving Dsg2
Title: Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion.

Data demonstrate that desmoglein-2 plays a critical role in cardiomyocyte cohesion and function.
Title: Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function.

The following DSG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DSG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu21170	NM_007883.3 Latest version!	Mus musculus desmoglein 2 (Dsg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$664.30 $949.00
View Old Accession Versions >>
OMu21170	NM_007883.2	Mus musculus desmoglein 2 (Dsg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$664.30 $949.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DSG2 ( NM_007883.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_031909.2 Mus musculus desmoglein 2 (Dsg2), mRNA.

Price & Availability↑

CloneID	OMu21170
Clone ID Related Accession (Same CDS sequence)	NM_007883.3 , NM_007883.2
Accession Version	NM_007883.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	desmoglein-2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC132091.3, AK029320.1 and BG092030.1. On Jan 30, 2016 this sequence version replaced NM_007883.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB072269.1, BC131653.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGGA GCCCGGGTGA CCGGTGCGCC CTGCTGCTGC TGGTGCAGCT GCTGGCGGTG 
GTCTGCTTGG ACTTTGGAAA CGGACTTCAC TTAGAGGTCT TCAGCCCAAG AAATGAAGGC 
AAACCGTTCC CTAAGCACAC TCACTTGGTT CGTCAAAAGA GGGCCTGGAT CACTGCCCCT 
GTGGCTCTGC GGGAGGGCGA AGACCTGTCC AGAAAGAACC CGATTGCCAA GATACACTCT 
GACCTTGCAG AAGAAAAAGG GATAAAAATC ACGTACAAGT ACACTGGGAA GGGAATTACA 
GAACCGCCTT TCGGCATATT CGTCTTTGAT AGAAACACAG GAGAACTGAA CATCACTAGC 
ATTCTTGACC GGGAAGAAAC ACCATATTTT CTGCTGACAG GCTATGCATT GGACTCCAGA 
GGAAACAACC TGGAAAAGCC CTTGGAACTA CGCATCAAAG TTCTGGACAT CAATGACAAC 
GAGCCAGTGT TCACACAGGA GGTCTTTGTT GGGTCCATTG AGGAATTGAG TGCAGCACAT 
ACACTTGTGA TGAAAATCAC CGCCACAGAT GCAGATGACC CGGAGACTCT GAATGCTAAA 
GTCTCCTACA GAATTGTCTC TCAGGAGCCT GCAAATAGTC ATATGTTCTA CCTAAATAAA 
GACACGGGGG AGATCTATAC GACCAGTTTT ACTTTGGACA GAGAGGAACA CAGCAGCTAT 
TCCTTGACGG TGGAAGCAAG AGATGGTAAC GGGCAGATAA CAGACAAGCC AGTCCAGCAA 
GCTCAAGTTC AGATCCGTAT ATTGGATGTC AATGACAATA TACCTGTGGT AGAAAACAAA 
ATGTATGAGG GGACAGTGGA AGAAAACCAG GTCAATGTAG AAGTCATGCG GATCAAAGTG 
ACCGATGCAG ATGAAGTGGG CTCTGATAAC TGGCTAGCAA ACTTTACATT TGCATCAGGA 
AATGAAGGGG GCTATTTCCA CATTGAGACT GACACACAGA CTAATGAAGG GATTGTGACC 
CTTGTCAAGG AAGTGGACTA TGAAGAAATG AAGAAGCTAG ACTTGAGCAT CATTGTCACT 
AACAAAGCAG CTTTCCACAA GTCCATTCTG AGCAAGTACA AGGCCACGCC CATTCCCATC 
ACTGTCAAGG TCAAGAACGT GGTTGAAGGC ATTCATTTCA AGAGCAGCGT AGTCTCTTTC 
CGAGCTAGTG AGGCAATGGA TAGATCCAGC CTCAGCAGGT CGATTGGAAA TTTTCAAGTT 
TTTGATGAAG ACACTGGTCA AGCAGCTAAA GTAACATATG TAAAAGTGCA AGACACTGAC 
AACTGGGTCT CTGTGGACTC CGTCACTTCA GAGATTAAGC TTGTAAAGAT TCCTGACTTT 
GAATCTAGAT ATGTCCAAAA TGGTACCTAC ACTGCAAAGG TTGTGGCCAT ATCCAAAGAA 
CATCCTCAAA AAACCATCAC TGGCACCATC GTTATCACTG TTGAAGACGT CAATGACAAT 
TGTCCCGTGC TGGTGGACTC TGTACGGAGT GTCTGTGAGG ATGAACCATA TGTGAATGTC 
ACTGCAGAGG ATTTGGATGG GGCCCAGAAC AGTGCGCCAT TCAGCTTCTC CATCATTGAC 
CAGCCTCCTG GAACGGCACA GAAGTGGAAA ATAACGCACC AGGAAAGTAC CAGTGTGCTG 
CTGCAGCAGA GCGAGCGGAA ACGCGGGAGA AGTGAGATTC CCTTCCTCAT TTCCGACAGC 
CAGGGCTTCA GCTGCCCCGA AAGGCAGGTC CTTCAGCTCA CTGTATGCGA GTGTCTGAAG 
GGCGGTGGCT GTGTGGCTGC ACAGTATGAC AACTACGTCG GGTTGGGCCC TGCCGCCATC 
GCTCTCATGA TTCTAGCACT CCTGCTCCTG CTCCTGGTGC CGCTCTTGCT GTTGATATGC 
CACTGTGGAG GGGGCGCCAA AGGCTTCACC CCCATTCCTG GGACAATAGA GATGCTGCAC 
CCTTGGAATA ATGAAGGGGC ACCTCCTGAG GACAAGGTGG TGCCATCGCT TCTGGTGGCC 
GATCATGCAG AGAGCTCGGC AGTGAGAGGC GGCGTAGGAG GTGCGATGCT CAAGGAAGGC 
ATGATGAAAG GCAGCAGCTC AGCTTCCGTT ACCAAAGGGC AGCATGAGCT GTCTGAGGTT 
GACGGAAGAT GGGAAGAACA CAGAAGCCTC CTCACCGCTG GGGCCACTCA CCATGTAAGG 
ACAGCAGGAA CCATCGCTGC CAACGAAGCC GTAAGGACAA GAGCCACGGG GTCTTCCAGA 
GACATGAGTG GGGCTCGAGG AGCCGTTGCC GTGAATGAGG AATTCTTAAG AAGTTACTTC 
ACAGAGAAAG CGGCCTCCTA CAATGGGGAA GACGACCTTC ACATGGCCAA AGACTGCCTT 
CTCGTTTACT CTCAGGAAGA CACGGCCTCC CTCCGAGGCT CGGTCGGGTG CTGCAGTTTC 
ATCGAGGGAG AACTCGATGA CCTGTTCCTG GATGATCTTG GCCTTAAATT CAAGACCCTA 
GCTGAAGTTT GCCTAGGTCG AAAGATCGAT CTGGATGTGG ACATTGAACA GAGGCAGAAG 
CCGGTCAGAG AAGCGAGCGT GAGTGCAGCT TCTGGCTCGC ACTATGAGCA AGCGGTAACC 
AGCTCAGAGA GCGCGTACTC CTCTAACACC GGCTTCCCCG CCCCCAAACC TCTGCACGAA 
GTGCACACAG AGAAAGTCAC ACAGGAAATC GTCACTGAGA GCTCTGTATC TTCCAGGCAG 
AGTCAGAAGG TAGTACCGCC ACCTGATCCT GTGGCTTCTG GTAATATTAT AGTGACGGAA 
ACTTCCTATG CCAAAGGCTC AGCAGTGCCA CCCAGCACTG TGCTCCTGGC TCCCAGACAG 
CCACAGAGCC TGATCGTGAC AGAGAGGGTG TATGCTCCAA CCTCCACCTT GGTGGATCAG 
CATTATGCCA ATGAAGAAAA AGTCCTTGTT ACCGAACGAG TGATCCAGCC TAATGGGGGC 
ATCCCTAAGC CCCTTGAGGT CACCCAGCAT CTGAAAGATG CACAGTATGT AATGGTGAGG 
GAAAGAGAGA GCATCCTTGC TCCCAGCTCA GGCGTGCAGC CCACTCTGGC AATGCCCAGC 
GTGGCAGCAG GAGGACAGAA TGTCACCGTG ACAGAAAGAA TACTAACTCC TGCTTCCACT 
CTGCAGTCCA GCTACCAGAT TCCCAGTGAA ACCTCCATCA CGGCTAGGAA CACTGTGCTC 
TCTAGTGTGG GAAGCATAGG TCCTCTGCCC AATTTAGATC TAGAGGAATC TGATCGTCCC 
AATTCTACTA TAACCACATC TTCCACCAGG GTCACCAAGC ATAGCACCAT GCAACATTCT 
TACTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031909.2
CDS	212..3580
Translation	MARSPGDRCALLLLVQLLAVVCLDFGNGLHLEVFSPRNEGKPFPKHTHLVRQKRAWITAPVALREGEDLSRKNPIAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDADDPETLNAKVSYRIVSQEPANSHMFYLNKDTGEIYTTSFTLDREEHSSYSLTVEARDGNGQITDKPVQQAQVQIRILDVNDNIPVVENKMYEGTVEENQVNVEVMRIKVTDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVTLVKEVDYEEMKKLDLSIIVTNKAAFHKSILSKYKATPIPITVKVKNVVEGIHFKSSVVSFRASEAMDRSSLSRSIGNFQVFDEDTGQAAKVTYVKVQDTDNWVSVDSVTSEIKLVKIPDFESRYVQNGTYTAKVVAISKEHPQKTITGTIVITVEDVNDNCPVLVDSVRSVCEDEPYVNVTAEDLDGAQNSAPFSFSIIDQPPGTAQKWKITHQESTSVLLQQSERKRGRSEIPFLISDSQGFSCPERQVLQLTVCECLKGGGCVAAQYDNYVGLGPAAIALMILALLLLLLVPLLLLICHCGGGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSLLVADHAESSAVRGGVGGAMLKEGMMKGSSSASVTKGQHELSEVDGRWEEHRSLLTAGATHHVRTAGTIAANEAVRTRATGSSRDMSGARGAVAVNEEFLRSYFTEKAASYNGEDDLHMAKDCLLVYSQEDTASLRGSVGCCSFIEGELDDLFLDDLGLKFKTLAEVCLGRKIDLDVDIEQRQKPVREASVSAASGSHYEQAVTSSESAYSSNTGFPAPKPLHEVHTEKVTQEIVTESSVSSRQSQKVVPPPDPVASGNIIVTETSYAKGSAVPPSTVLLAPRQPQSLIVTERVYAPTSTLVDQHYANEEKVLVTERVIQPNGGIPKPLEVTQHLKDAQYVMVRERESILAPSSGVQPTLAMPSVAAGGQNVTVTERILTPASTLQSSYQIPSETSITARNTVLSSVGSIGPLPNLDLEESDRPNSTITTSSTRVTKHSTMQHSYS

Target ORF information:

RefSeq Version	NM_007883.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmoglein 2 (Dsg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007883.3

ORF Insert Sequence:

ATGGCGCGGA GCCCGGGTGA CCGGTGCGCC CTGCTGCTGC TGGTGCAGCT GCTGGCGGTG 
GTCTGCTTGG ACTTTGGAAA CGGACTTCAC TTAGAGGTCT TCAGCCCAAG AAATGAAGGC 
AAACCGTTCC CTAAGCACAC TCACTTGGTT CGTCAAAAGA GGGCCTGGAT CACTGCCCCT 
GTGGCTCTGC GGGAGGGCGA AGACCTGTCC AGAAAGAACC CGATTGCCAA GATACACTCT 
GACCTTGCAG AAGAAAAAGG GATAAAAATC ACGTACAAGT ACACTGGGAA GGGAATTACA 
GAACCGCCTT TCGGCATATT CGTCTTTGAT AGAAACACAG GAGAACTGAA CATCACTAGC 
ATTCTTGACC GGGAAGAAAC ACCATATTTT CTGCTGACAG GCTATGCATT GGACTCCAGA 
GGAAACAACC TGGAAAAGCC CTTGGAACTA CGCATCAAAG TTCTGGACAT CAATGACAAC 
GAGCCAGTGT TCACACAGGA GGTCTTTGTT GGGTCCATTG AGGAATTGAG TGCAGCACAT 
ACACTTGTGA TGAAAATCAC CGCCACAGAT GCAGATGACC CGGAGACTCT GAATGCTAAA 
GTCTCCTACA GAATTGTCTC TCAGGAGCCT GCAAATAGTC ATATGTTCTA CCTAAATAAA 
GACACGGGGG AGATCTATAC GACCAGTTTT ACTTTGGACA GAGAGGAACA CAGCAGCTAT 
TCCTTGACGG TGGAAGCAAG AGATGGTAAC GGGCAGATAA CAGACAAGCC AGTCCAGCAA 
GCTCAAGTTC AGATCCGTAT ATTGGATGTC AATGACAATA TACCTGTGGT AGAAAACAAA 
ATGTATGAGG GGACAGTGGA AGAAAACCAG GTCAATGTAG AAGTCATGCG GATCAAAGTG 
ACCGATGCAG ATGAAGTGGG CTCTGATAAC TGGCTAGCAA ACTTTACATT TGCATCAGGA 
AATGAAGGGG GCTATTTCCA CATTGAGACT GACACACAGA CTAATGAAGG GATTGTGACC 
CTTGTCAAGG AAGTGGACTA TGAAGAAATG AAGAAGCTAG ACTTGAGCAT CATTGTCACT 
AACAAAGCAG CTTTCCACAA GTCCATTCTG AGCAAGTACA AGGCCACGCC CATTCCCATC 
ACTGTCAAGG TCAAGAACGT GGTTGAAGGC ATTCATTTCA AGAGCAGCGT AGTCTCTTTC 
CGAGCTAGTG AGGCAATGGA TAGATCCAGC CTCAGCAGGT CGATTGGAAA TTTTCAAGTT 
TTTGATGAAG ACACTGGTCA AGCAGCTAAA GTAACATATG TAAAAGTGCA AGACACTGAC 
AACTGGGTCT CTGTGGACTC CGTCACTTCA GAGATTAAGC TTGTAAAGAT TCCTGACTTT 
GAATCTAGAT ATGTCCAAAA TGGTACCTAC ACTGCAAAGG TTGTGGCCAT ATCCAAAGAA 
CATCCTCAAA AAACCATCAC TGGCACCATC GTTATCACTG TTGAAGACGT CAATGACAAT 
TGTCCCGTGC TGGTGGACTC TGTACGGAGT GTCTGTGAGG ATGAACCATA TGTGAATGTC 
ACTGCAGAGG ATTTGGATGG GGCCCAGAAC AGTGCGCCAT TCAGCTTCTC CATCATTGAC 
CAGCCTCCTG GAACGGCACA GAAGTGGAAA ATAACGCACC AGGAAAGTAC CAGTGTGCTG 
CTGCAGCAGA GCGAGCGGAA ACGCGGGAGA AGTGAGATTC CCTTCCTCAT TTCCGACAGC 
CAGGGCTTCA GCTGCCCCGA AAGGCAGGTC CTTCAGCTCA CTGTATGCGA GTGTCTGAAG 
GGCGGTGGCT GTGTGGCTGC ACAGTATGAC AACTACGTCG GGTTGGGCCC TGCCGCCATC 
GCTCTCATGA TTCTAGCACT CCTGCTCCTG CTCCTGGTGC CGCTCTTGCT GTTGATATGC 
CACTGTGGAG GGGGCGCCAA AGGCTTCACC CCCATTCCTG GGACAATAGA GATGCTGCAC 
CCTTGGAATA ATGAAGGGGC ACCTCCTGAG GACAAGGTGG TGCCATCGCT TCTGGTGGCC 
GATCATGCAG AGAGCTCGGC AGTGAGAGGC GGCGTAGGAG GTGCGATGCT CAAGGAAGGC 
ATGATGAAAG GCAGCAGCTC AGCTTCCGTT ACCAAAGGGC AGCATGAGCT GTCTGAGGTT 
GACGGAAGAT GGGAAGAACA CAGAAGCCTC CTCACCGCTG GGGCCACTCA CCATGTAAGG 
ACAGCAGGAA CCATCGCTGC CAACGAAGCC GTAAGGACAA GAGCCACGGG GTCTTCCAGA 
GACATGAGTG GGGCTCGAGG AGCCGTTGCC GTGAATGAGG AATTCTTAAG AAGTTACTTC 
ACAGAGAAAG CGGCCTCCTA CAATGGGGAA GACGACCTTC ACATGGCCAA AGACTGCCTT 
CTCGTTTACT CTCAGGAAGA CACGGCCTCC CTCCGAGGCT CGGTCGGGTG CTGCAGTTTC 
ATCGAGGGAG AACTCGATGA CCTGTTCCTG GATGATCTTG GCCTTAAATT CAAGACCCTA 
GCTGAAGTTT GCCTAGGTCG AAAGATCGAT CTGGATGTGG ACATTGAACA GAGGCAGAAG 
CCGGTCAGAG AAGCGAGCGT GAGTGCAGCT TCTGGCTCGC ACTATGAGCA AGCGGTAACC 
AGCTCAGAGA GCGCGTACTC CTCTAACACC GGCTTCCCCG CCCCCAAACC TCTGCACGAA 
GTGCACACAG AGAAAGTCAC ACAGGAAATC GTCACTGAGA GCTCTGTATC TTCCAGGCAG 
AGTCAGAAGG TAGTACCGCC ACCTGATCCT GTGGCTTCTG GTAATATTAT AGTGACGGAA 
ACTTCCTATG CCAAAGGCTC AGCAGTGCCA CCCAGCACTG TGCTCCTGGC TCCCAGACAG 
CCACAGAGCC TGATCGTGAC AGAGAGGGTG TATGCTCCAA CCTCCACCTT GGTGGATCAG 
CATTATGCCA ATGAAGAAAA AGTCCTTGTT ACCGAACGAG TGATCCAGCC TAATGGGGGC 
ATCCCTAAGC CCCTTGAGGT CACCCAGCAT CTGAAAGATG CACAGTATGT AATGGTGAGG 
GAAAGAGAGA GCATCCTTGC TCCCAGCTCA GGCGTGCAGC CCACTCTGGC AATGCCCAGC 
GTGGCAGCAG GAGGACAGAA TGTCACCGTG ACAGAAAGAA TACTAACTCC TGCTTCCACT 
CTGCAGTCCA GCTACCAGAT TCCCAGTGAA ACCTCCATCA CGGCTAGGAA CACTGTGCTC 
TCTAGTGTGG GAAGCATAGG TCCTCTGCCC AATTTAGATC TAGAGGAATC TGATCGTCCC 
AATTCTACTA TAACCACATC TTCCACCAGG GTCACCAAGC ATAGCACCAT GCAACATTCT 
TACTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG2 ( NM_007883.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_031909.2 Mus musculus desmoglein 2 (Dsg2), mRNA.

Price & Availability↑

CloneID	OMu21170
Clone ID Related Accession (Same CDS sequence)	NM_007883.3 , NM_007883.2
Accession Version	NM_007883.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	desmoglein-2 precursor
Comment

ATGGCGCGGA GCCCGGGTGA CCGGTGCGCC CTGCTGCTGC TGGTGCAGCT GCTGGCGGTG 
GTCTGCTTGG ACTTTGGAAA CGGACTTCAC TTAGAGGTCT TCAGCCCAAG AAATGAAGGC 
AAACCGTTCC CTAAGCACAC TCACTTGGTT CGTCAAAAGA GGGCCTGGAT CACTGCCCCT 
GTGGCTCTGC GGGAGGGCGA AGACCTGTCC AGAAAGAACC CGATTGCCAA GATACACTCT 
GACCTTGCAG AAGAAAAAGG GATAAAAATC ACGTACAAGT ACACTGGGAA GGGAATTACA 
GAACCGCCTT TCGGCATATT CGTCTTTGAT AGAAACACAG GAGAACTGAA CATCACTAGC 
ATTCTTGACC GGGAAGAAAC ACCATATTTT CTGCTGACAG GCTATGCATT GGACTCCAGA 
GGAAACAACC TGGAAAAGCC CTTGGAACTA CGCATCAAAG TTCTGGACAT CAATGACAAC 
GAGCCAGTGT TCACACAGGA GGTCTTTGTT GGGTCCATTG AGGAATTGAG TGCAGCACAT 
ACACTTGTGA TGAAAATCAC CGCCACAGAT GCAGATGACC CGGAGACTCT GAATGCTAAA 
GTCTCCTACA GAATTGTCTC TCAGGAGCCT GCAAATAGTC ATATGTTCTA CCTAAATAAA 
GACACGGGGG AGATCTATAC GACCAGTTTT ACTTTGGACA GAGAGGAACA CAGCAGCTAT 
TCCTTGACGG TGGAAGCAAG AGATGGTAAC GGGCAGATAA CAGACAAGCC AGTCCAGCAA 
GCTCAAGTTC AGATCCGTAT ATTGGATGTC AATGACAATA TACCTGTGGT AGAAAACAAA 
ATGTATGAGG GGACAGTGGA AGAAAACCAG GTCAATGTAG AAGTCATGCG GATCAAAGTG 
ACCGATGCAG ATGAAGTGGG CTCTGATAAC TGGCTAGCAA ACTTTACATT TGCATCAGGA 
AATGAAGGGG GCTATTTCCA CATTGAGACT GACACACAGA CTAATGAAGG GATTGTGACC 
CTTGTCAAGG AAGTGGACTA TGAAGAAATG AAGAAGCTAG ACTTGAGCAT CATTGTCACT 
AACAAAGCAG CTTTCCACAA GTCCATTCTG AGCAAGTACA AGGCCACGCC CATTCCCATC 
ACTGTCAAGG TCAAGAACGT GGTTGAAGGC ATTCATTTCA AGAGCAGCGT AGTCTCTTTC 
CGAGCTAGTG AGGCAATGGA TAGATCCAGC CTCAGCAGGT CGATTGGAAA TTTTCAAGTT 
TTTGATGAAG ACACTGGTCA AGCAGCTAAA GTAACATATG TAAAAGTGCA AGACACTGAC 
AACTGGGTCT CTGTGGACTC CGTCACTTCA GAGATTAAGC TTGTAAAGAT TCCTGACTTT 
GAATCTAGAT ATGTCCAAAA TGGTACCTAC ACTGCAAAGG TTGTGGCCAT ATCCAAAGAA 
CATCCTCAAA AAACCATCAC TGGCACCATC GTTATCACTG TTGAAGACGT CAATGACAAT 
TGTCCCGTGC TGGTGGACTC TGTACGGAGT GTCTGTGAGG ATGAACCATA TGTGAATGTC 
ACTGCAGAGG ATTTGGATGG GGCCCAGAAC AGTGCGCCAT TCAGCTTCTC CATCATTGAC 
CAGCCTCCTG GAACGGCACA GAAGTGGAAA ATAACGCACC AGGAAAGTAC CAGTGTGCTG 
CTGCAGCAGA GCGAGCGGAA ACGCGGGAGA AGTGAGATTC CCTTCCTCAT TTCCGACAGC 
CAGGGCTTCA GCTGCCCCGA AAGGCAGGTC CTTCAGCTCA CTGTATGCGA GTGTCTGAAG 
GGCGGTGGCT GTGTGGCTGC ACAGTATGAC AACTACGTCG GGTTGGGCCC TGCCGCCATC 
GCTCTCATGA TTCTAGCACT CCTGCTCCTG CTCCTGGTGC CGCTCTTGCT GTTGATATGC 
CACTGTGGAG GGGGCGCCAA AGGCTTCACC CCCATTCCTG GGACAATAGA GATGCTGCAC 
CCTTGGAATA ATGAAGGGGC ACCTCCTGAG GACAAGGTGG TGCCATCGCT TCTGGTGGCC 
GATCATGCAG AGAGCTCGGC AGTGAGAGGC GGCGTAGGAG GTGCGATGCT CAAGGAAGGC 
ATGATGAAAG GCAGCAGCTC AGCTTCCGTT ACCAAAGGGC AGCATGAGCT GTCTGAGGTT 
GACGGAAGAT GGGAAGAACA CAGAAGCCTC CTCACCGCTG GGGCCACTCA CCATGTAAGG 
ACAGCAGGAA CCATCGCTGC CAACGAAGCC GTAAGGACAA GAGCCACGGG GTCTTCCAGA 
GACATGAGTG GGGCTCGAGG AGCCGTTGCC GTGAATGAGG AATTCTTAAG AAGTTACTTC 
ACAGAGAAAG CGGCCTCCTA CAATGGGGAA GACGACCTTC ACATGGCCAA AGACTGCCTT 
CTCGTTTACT CTCAGGAAGA CACGGCCTCC CTCCGAGGCT CGGTCGGGTG CTGCAGTTTC 
ATCGAGGGAG AACTCGATGA CCTGTTCCTG GATGATCTTG GCCTTAAATT CAAGACCCTA 
GCTGAAGTTT GCCTAGGTCG AAAGATCGAT CTGGATGTGG ACATTGAACA GAGGCAGAAG 
CCGGTCAGAG AAGCGAGCGT GAGTGCAGCT TCTGGCTCGC ACTATGAGCA AGCGGTAACC 
AGCTCAGAGA GCGCGTACTC CTCTAACACC GGCTTCCCCG CCCCCAAACC TCTGCACGAA 
GTGCACACAG AGAAAGTCAC ACAGGAAATC GTCACTGAGA GCTCTGTATC TTCCAGGCAG 
AGTCAGAAGG TAGTACCGCC ACCTGATCCT GTGGCTTCTG GTAATATTAT AGTGACGGAA 
ACTTCCTATG CCAAAGGCTC AGCAGTGCCA CCCAGCACTG TGCTCCTGGC TCCCAGACAG 
CCACAGAGCC TGATCGTGAC AGAGAGGGTG TATGCTCCAA CCTCCACCTT GGTGGATCAG 
CATTATGCCA ATGAAGAAAA AGTCCTTGTT ACCGAACGAG TGATCCAGCC TAATGGGGGC 
ATCCCTAAGC CCCTTGAGGT CACCCAGCAT CTGAAAGATG CACAGTATGT AATGGTGAGG 
GAAAGAGAGA GCATCCTTGC TCCCAGCTCA GGCGTGCAGC CCACTCTGGC AATGCCCAGC 
GTGGCAGCAG GAGGACAGAA TGTCACCGTG ACAGAAAGAA TACTAACTCC TGCTTCCACT 
CTGCAGTCCA GCTACCAGAT TCCCAGTGAA ACCTCCATCA CGGCTAGGAA CACTGTGCTC 
TCTAGTGTGG GAAGCATAGG TCCTCTGCCC AATTTAGATC TAGAGGAATC TGATCGTCCC 
AATTCTACTA TAACCACATC TTCCACCAGG GTCACCAAGC ATAGCACCAT GCAACATTCT 
TACTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_031909.2

Translation

MARSPGDRCALLLLVQLLAVVCLDFGNGLHLEVFSPRNEGKPFPKHTHLVRQKRAWITAPVALREGEDLSRKNPIAKIHSDLAEEKGIKITYKYTGKGITEPPFGIFVFDRNTGELNITSILDREETPYFLLTGYALDSRGNNLEKPLELRIKVLDINDNEPVFTQEVFVGSIEELSAAHTLVMKITATDADDPETLNAKVSYRIVSQEPANSHMFYLNKDTGEIYTTSFTLDREEHSSYSLTVEARDGNGQITDKPVQQAQVQIRILDVNDNIPVVENKMYEGTVEENQVNVEVMRIKVTDADEVGSDNWLANFTFASGNEGGYFHIETDTQTNEGIVTLVKEVDYEEMKKLDLSIIVTNKAAFHKSILSKYKATPIPITVKVKNVVEGIHFKSSVVSFRASEAMDRSSLSRSIGNFQVFDEDTGQAAKVTYVKVQDTDNWVSVDSVTSEIKLVKIPDFESRYVQNGTYTAKVVAISKEHPQKTITGTIVITVEDVNDNCPVLVDSVRSVCEDEPYVNVTAEDLDGAQNSAPFSFSIIDQPPGTAQKWKITHQESTSVLLQQSERKRGRSEIPFLISDSQGFSCPERQVLQLTVCECLKGGGCVAAQYDNYVGLGPAAIALMILALLLLLLVPLLLLICHCGGGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSLLVADHAESSAVRGGVGGAMLKEGMMKGSSSASVTKGQHELSEVDGRWEEHRSLLTAGATHHVRTAGTIAANEAVRTRATGSSRDMSGARGAVAVNEEFLRSYFTEKAASYNGEDDLHMAKDCLLVYSQEDTASLRGSVGCCSFIEGELDDLFLDDLGLKFKTLAEVCLGRKIDLDVDIEQRQKPVREASVSAASGSHYEQAVTSSESAYSSNTGFPAPKPLHEVHTEKVTQEIVTESSVSSRQSQKVVPPPDPVASGNIIVTETSYAKGSAVPPSTVLLAPRQPQSLIVTERVYAPTSTLVDQHYANEEKVLVTERVIQPNGGIPKPLEVTQHLKDAQYVMVRERESILAPSSGVQPTLAMPSVAAGGQNVTVTERILTPASTLQSSYQIPSETSITARNTVLSSVGSIGPLPNLDLEESDRPNSTITTSSTRVTKHSTMQHSYS

Target ORF information:

RefSeq Version	NM_007883.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus desmoglein 2 (Dsg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007883.2

ORF Insert Sequence:

ATGGCGCGGA GCCCGGGTGA CCGGTGCGCC CTGCTGCTGC TGGTGCAGCT GCTGGCGGTG 
GTCTGCTTGG ACTTTGGAAA CGGACTTCAC TTAGAGGTCT TCAGCCCAAG AAATGAAGGC 
AAACCGTTCC CTAAGCACAC TCACTTGGTT CGTCAAAAGA GGGCCTGGAT CACTGCCCCT 
GTGGCTCTGC GGGAGGGCGA AGACCTGTCC AGAAAGAACC CGATTGCCAA GATACACTCT 
GACCTTGCAG AAGAAAAAGG GATAAAAATC ACGTACAAGT ACACTGGGAA GGGAATTACA 
GAACCGCCTT TCGGCATATT CGTCTTTGAT AGAAACACAG GAGAACTGAA CATCACTAGC 
ATTCTTGACC GGGAAGAAAC ACCATATTTT CTGCTGACAG GCTATGCATT GGACTCCAGA 
GGAAACAACC TGGAAAAGCC CTTGGAACTA CGCATCAAAG TTCTGGACAT CAATGACAAC 
GAGCCAGTGT TCACACAGGA GGTCTTTGTT GGGTCCATTG AGGAATTGAG TGCAGCACAT 
ACACTTGTGA TGAAAATCAC CGCCACAGAT GCAGATGACC CGGAGACTCT GAATGCTAAA 
GTCTCCTACA GAATTGTCTC TCAGGAGCCT GCAAATAGTC ATATGTTCTA CCTAAATAAA 
GACACGGGGG AGATCTATAC GACCAGTTTT ACTTTGGACA GAGAGGAACA CAGCAGCTAT 
TCCTTGACGG TGGAAGCAAG AGATGGTAAC GGGCAGATAA CAGACAAGCC AGTCCAGCAA 
GCTCAAGTTC AGATCCGTAT ATTGGATGTC AATGACAATA TACCTGTGGT AGAAAACAAA 
ATGTATGAGG GGACAGTGGA AGAAAACCAG GTCAATGTAG AAGTCATGCG GATCAAAGTG 
ACCGATGCAG ATGAAGTGGG CTCTGATAAC TGGCTAGCAA ACTTTACATT TGCATCAGGA 
AATGAAGGGG GCTATTTCCA CATTGAGACT GACACACAGA CTAATGAAGG GATTGTGACC 
CTTGTCAAGG AAGTGGACTA TGAAGAAATG AAGAAGCTAG ACTTGAGCAT CATTGTCACT 
AACAAAGCAG CTTTCCACAA GTCCATTCTG AGCAAGTACA AGGCCACGCC CATTCCCATC 
ACTGTCAAGG TCAAGAACGT GGTTGAAGGC ATTCATTTCA AGAGCAGCGT AGTCTCTTTC 
CGAGCTAGTG AGGCAATGGA TAGATCCAGC CTCAGCAGGT CGATTGGAAA TTTTCAAGTT 
TTTGATGAAG ACACTGGTCA AGCAGCTAAA GTAACATATG TAAAAGTGCA AGACACTGAC 
AACTGGGTCT CTGTGGACTC CGTCACTTCA GAGATTAAGC TTGTAAAGAT TCCTGACTTT 
GAATCTAGAT ATGTCCAAAA TGGTACCTAC ACTGCAAAGG TTGTGGCCAT ATCCAAAGAA 
CATCCTCAAA AAACCATCAC TGGCACCATC GTTATCACTG TTGAAGACGT CAATGACAAT 
TGTCCCGTGC TGGTGGACTC TGTACGGAGT GTCTGTGAGG ATGAACCATA TGTGAATGTC 
ACTGCAGAGG ATTTGGATGG GGCCCAGAAC AGTGCGCCAT TCAGCTTCTC CATCATTGAC 
CAGCCTCCTG GAACGGCACA GAAGTGGAAA ATAACGCACC AGGAAAGTAC CAGTGTGCTG 
CTGCAGCAGA GCGAGCGGAA ACGCGGGAGA AGTGAGATTC CCTTCCTCAT TTCCGACAGC 
CAGGGCTTCA GCTGCCCCGA AAGGCAGGTC CTTCAGCTCA CTGTATGCGA GTGTCTGAAG 
GGCGGTGGCT GTGTGGCTGC ACAGTATGAC AACTACGTCG GGTTGGGCCC TGCCGCCATC 
GCTCTCATGA TTCTAGCACT CCTGCTCCTG CTCCTGGTGC CGCTCTTGCT GTTGATATGC 
CACTGTGGAG GGGGCGCCAA AGGCTTCACC CCCATTCCTG GGACAATAGA GATGCTGCAC 
CCTTGGAATA ATGAAGGGGC ACCTCCTGAG GACAAGGTGG TGCCATCGCT TCTGGTGGCC 
GATCATGCAG AGAGCTCGGC AGTGAGAGGC GGCGTAGGAG GTGCGATGCT CAAGGAAGGC 
ATGATGAAAG GCAGCAGCTC AGCTTCCGTT ACCAAAGGGC AGCATGAGCT GTCTGAGGTT 
GACGGAAGAT GGGAAGAACA CAGAAGCCTC CTCACCGCTG GGGCCACTCA CCATGTAAGG 
ACAGCAGGAA CCATCGCTGC CAACGAAGCC GTAAGGACAA GAGCCACGGG GTCTTCCAGA 
GACATGAGTG GGGCTCGAGG AGCCGTTGCC GTGAATGAGG AATTCTTAAG AAGTTACTTC 
ACAGAGAAAG CGGCCTCCTA CAATGGGGAA GACGACCTTC ACATGGCCAA AGACTGCCTT 
CTCGTTTACT CTCAGGAAGA CACGGCCTCC CTCCGAGGCT CGGTCGGGTG CTGCAGTTTC 
ATCGAGGGAG AACTCGATGA CCTGTTCCTG GATGATCTTG GCCTTAAATT CAAGACCCTA 
GCTGAAGTTT GCCTAGGTCG AAAGATCGAT CTGGATGTGG ACATTGAACA GAGGCAGAAG 
CCGGTCAGAG AAGCGAGCGT GAGTGCAGCT TCTGGCTCGC ACTATGAGCA AGCGGTAACC 
AGCTCAGAGA GCGCGTACTC CTCTAACACC GGCTTCCCCG CCCCCAAACC TCTGCACGAA 
GTGCACACAG AGAAAGTCAC ACAGGAAATC GTCACTGAGA GCTCTGTATC TTCCAGGCAG 
AGTCAGAAGG TAGTACCGCC ACCTGATCCT GTGGCTTCTG GTAATATTAT AGTGACGGAA 
ACTTCCTATG CCAAAGGCTC AGCAGTGCCA CCCAGCACTG TGCTCCTGGC TCCCAGACAG 
CCACAGAGCC TGATCGTGAC AGAGAGGGTG TATGCTCCAA CCTCCACCTT GGTGGATCAG 
CATTATGCCA ATGAAGAAAA AGTCCTTGTT ACCGAACGAG TGATCCAGCC TAATGGGGGC 
ATCCCTAAGC CCCTTGAGGT CACCCAGCAT CTGAAAGATG CACAGTATGT AATGGTGAGG 
GAAAGAGAGA GCATCCTTGC TCCCAGCTCA GGCGTGCAGC CCACTCTGGC AATGCCCAGC 
GTGGCAGCAG GAGGACAGAA TGTCACCGTG ACAGAAAGAA TACTAACTCC TGCTTCCACT 
CTGCAGTCCA GCTACCAGAT TCCCAGTGAA ACCTCCATCA CGGCTAGGAA CACTGTGCTC 
TCTAGTGTGG GAAGCATAGG TCCTCTGCCC AATTTAGATC TAGAGGAATC TGATCGTCCC 
AATTCTACTA TAACCACATC TTCCACCAGG GTCACCAAGC ATAGCACCAT GCAACATTCT 
TACTCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cardiomyocyte Hypertrophy in Arrhythmogenic Cardiomyopathy.
The American journal of pathology187(4)752-766(2017 Apr)
Ger?ek M,Ger?ek M,Kant S,Simsekyilmaz S,Kassner A,Milting H,Liehn EA,Leube RE,Krusche CA

Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.
PloS one11(8)e0161465(2016)
Zhang L,Ferreyros M,Feng W,Hupe M,Crumrine DA,Chen J,Elias PM,Holleran WM,Niswander L,Hohl D,Williams T,Torchia EC,Roop DR

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DSG2 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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