Dsc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dsc1
Entrez Gene ID	13505
Full Name	desmocollin 1
Synonyms	1110020A10Rik,AI507491
General protein information	Preferred Names desmocollin 1 Names desmocollin-1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 A2
Summary	This gene encodes a member of the cadherin family of proteins that mediates adhesion in desmosomes. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional protein. Mice lacking the encoded protein exhibit epidermal fragility together with defects of epidermal barrier and differentiation. The neonatal mice lacking the encoded protein exhibit epidermal lesions and older mice develop chronic dermatitis. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001291804.1	NP_001278733.1	desmocollin-1 isoform 1 preproprotein
NM_013504.5	NP_038532.3	desmocollin-1 isoform 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dsc1	NP_038532.3
Danio rerio (zebrafish)	dsc2l	XP_688578.4
Homo sapiens (human)	DSC1	NP_077739.1
Pan troglodytes (chimpanzee)	DSC1	XP_512078.2
Canis lupus familiaris (dog)	DSC1	XP_547623.3
Bos taurus (cattle)	DSC1	NP_776469.1
Rattus norvegicus (Norway rat)	Dsc1	XP_006254505.1
	DSC1	XP_001098098.2

Gene Ontology
Bibliography

Related articles in PubMed

BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality.
Ikawa-Yoshida A, Matsumoto T, Okano S, Aoyagi Y, Matsubara Y, Furuyama T, Nakatsu Y, Tsuzuki T, Onimaru M, Ohkusa T, Nomura M, Maehara Y
Scientific reports632399(2016 Aug)

Variable impact of chronic stress on spatial learning and memory in BXD mice.
Shea CJ, Carhuatanta KA, Wagner J, Bechmann N, Moore R, Herman JP, Jankord R
Physiology & behavior15069-77(2015 Oct)

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.
Ferone G, Mollo MR, Thomason HA, Antonini D, Zhou H, Ambrosio R, De Rosa L, Salvatore D, Getsios S, van Bokhoven H, Dixon J, Missero C
Human molecular genetics22(3)531-43(2013 Feb)

Assessment of splice variant-specific functions of desmocollin 1 in the skin.
Cheng X, Mihindukulasuriya K, Den Z, Kowalczyk AP, Calkins CC, Ishiko A, Shimizu A, Koch PJ
Molecular and cellular biology24(1)154-63(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dsc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dsc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19062	NM_013504.5 Latest version!	Mus musculus desmocollin 1 (Dsc1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00
OMu19059	NM_001291804.1 Latest version!	Mus musculus desmocollin 1 (Dsc1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dsc1 ( NM_013504.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038532.3 Mus musculus desmocollin 1 (Dsc1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19062
Clone ID Related Accession (Same CDS sequence)	NM_013504.5
Accession Version	NM_013504.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2499bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	desmocollin-1 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK079441.1, BC109161.1 and AC132314.3. On Apr 29, 2014 this sequence version replaced NM_013504.4. Transcript Variant: This variant (2, also known as Dsc1b) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK079441.1, AK081826.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTGG CCTGTGCTGC CCCAGGGAGC ACCTTCTCTA AGCAGCTCCT TTTCTTTCTC 
CTGGTTCTGG TATTATTTTG TGATGCCTGT CAAAAAGTTT CCCTTCACGT TCCCTCTCAT 
CTTAAGGCTG AAACACCTGT AGGCAAAGTG AATCTGGAAG AGTGTCTCAA ATCACCCAGC 
CTGATCCTGT CCAGTGACCC AGCCTTCAGA ATTCTAGAAG ACGGCACAAT TTACACAACA 
CATGACCTGC TTTTGTCTTC TGAAAAGAGG GGGTTCTCCA TCTTGCTCTC AGATGGTCAA 
GGGCAGGAAC AAAAGAAGCT AGAAGTTGTA CTGTCAGCAA GAGAAAAAAA GGTTTTTAGG 
AAAAGACATA CCAAAGAGCC AGTACACAAC CGCAGTAAGA GAAGATGGGC TCCTATTCCA 
TGTTCACTGA TGGAGAACTC TTTGGGTCCA TTTCCACAAC ACATTCAGCA GATCCAATCT 
GATGCTGCCC AGAATTACAC CATCTTTTAC TCTATCAGTG GACCAGGAGT AGACAAAGAG 
CCTTACAATT TGTTCTACAT AGAGAAAGAC ACCGGGGACA TCTATTGTAC CCGAAGCATT 
GACCGTGAAC AGTATGACCA ATTTTTGGTA TATGGATATG CAACAACTGC TGATGGCTAT 
GCCCCAGACT ACCCTCTCCC CCTGCTGTTT AAGGTTGAAG ATGACAATGA CAATGCCCCA 
TATTTTGAAA CCAAATTAAC AGTTTTTAGT GTGCCTGAAA ATTGCCGATC TGGAACTTCA 
GTGGGACAAG TGACTGCCAT AGACAAGGAT GAGCCAGGAA CTCTACACAC TCGTCTGAAG 
TACAAAATCT TACAACAAAT CCCAGACCAG CCAAAGCACT TCTCCATCCA CCCAGACACA 
GGTGTGATCA CTACCACCAC ACCTTTACTG GACAGAGAGA AATGTGACAC TTACAAGCTA 
GTGATGGAGG TACGAGACAT GGGGGGCCAG CCCTTTGGTC TGTTCACCAC AGGAACAATC 
ACCATCTCAC TGGAGGATGA GAATGACAAC TCGCCATACT TCACCCAAAC TTCTTATACT 
ACAGAAGTAG AAGAAAACAG AATTGATGTT GAGATTCTGA GAATGGTGGT GCACGACCAA 
GATTTGCCCA ACACCCCCCA CTCGAAGGCG GTATACACAA TCCTAAAGGG GAACGAAAAC 
GGGAACTTCA AAATCACAAC GGATCCAAAT ACAAATGAAG GGGTCTTGTG TGTTGTCAAG 
CCACTGAACT ATGAAGTCAG CCGCCAAGTC ACTCTGCAAA TTGGTGTCCT TAATGAAGCC 
CAGTTCACTA ACGCTGCCAA CGCACAACCA CCAACAATGT GCACCACAAC TGTCACTGTG 
AAAATTAAAG ACAGAGATGA GGGCCCTGAG TGCCAGCCAC CAGTCAAAGT CATTCAGAGC 
AAAGATGGAC TGCCAGCGGG CCAAGAGCTC CTGGGCTACA AAGCGGTGGA CCCAGAGACA 
AGCAGTGGTG AAGGCTTAAG GTATGAGATG GTAGGAGATG AAGATAATTG GTTTGAGATT 
AACAAAATCA CCGGAGACTT GAGAACTGTG AAAGTACTGG ACAGAGAGTC GAAGTTTGTG 
AAAAACAACC AGTACAATAT TTCAGTAGTG GCGACAGATA CAGCTGGCCG ATCTTGCACA 
GGAACACTGG TAGTTCTTCT GGAAGATTTT AATGACCACC CACCACAGAT TGACAAGGAA 
GTGACCATTT GTCAGCAGGA GAAGGATTTT GCTGTTTTGG AACCTATAGA TTTAGATGGG 
CCAGATAATG GTCCACCTTT TCAGTTCCTT CTGGATAATT CTTCCAGCAA ACTTTGGACT 
CTAGAATCAC AGGATGGTAA ACGTGCCATT CTTCGTCAAC GACACAATCT TAATTATAAC 
TATTATTCTG TGCCAATCCA AATACAAGAC AGGCATGGTT TTTCCGCAAA ACATGTATTA 
TCAGTGCGAG TGTGTGACTG TACAACTCCA ACAGAATGTA GAATGGCTGT TAAGGAAGAG 
AGGGATGCTA AACCAAATAT AATCCTTGGG AAATGGGCCA TTCTTGCCAT GGTCCTGGGC 
TCTGCATTGC TACTGTGCAT TTTGTTTACA TGCTTCTGTG TGACCACTAC CAAGAGAACA 
GTCAAGAAAT GCTTCCCAGA TGATGTAGCT CAGCAAAATT TAATTGTATC AAATACTGAA 
GGACCAGGAG AAGAAGTGAC GGAAGCCAAT ATTAGACTCC CCACACAGAC AGCCAACATC 
TGTGATACAA GCATGTCTGT TGGGACTCTT GGTGGTCAAG GAATCAAAAC ACAGCAAAGT 
TTTGAGATGG TCAAAGGAGG CCACACCTTG GAGTCCCACA AGGGAGGAGT GCTAGGAGCA 
GCAGAGCCTG GCCGATATGC TTACACAGAC TGGCAAACTT TCACTCAACC TCGGCTTGGT 
GAAGAATCCA TTAGAGGACA CACTCTGATT AAAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038532.3
CDS	218..2716
Translation	MAVACAAPGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQSDAAQNYTIFYSISGPGVDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDQPKHFSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPYFTQTSYTTEVEENRIDVEILRMVVHDQDLPNTPHSKAVYTILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLNEAQFTNAANAQPPTMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMVGDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATDTAGRSCTGTLVVLLEDFNDHPPQIDKEVTICQQEKDFAVLEPIDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTTPTECRMAVKEERDAKPNIILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTANICDTSMSVGTLGGQGIKTQQSFEMVKGGHTLESHKGGVLGAAEPGRYAYTDWQTFTQPRLGEESIRGHTLIKN

Target ORF information:

RefSeq Version	NM_013504.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmocollin 1 (Dsc1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013504.5

ORF Insert Sequence:

ATGGCTGTGG CCTGTGCTGC CCCAGGGAGC ACCTTCTCTA AGCAGCTCCT TTTCTTTCTC 
CTGGTTCTGG TATTATTTTG TGATGCCTGT CAAAAAGTTT CCCTTCACGT TCCCTCTCAT 
CTTAAGGCTG AAACACCTGT AGGCAAAGTG AATCTGGAAG AGTGTCTCAA ATCACCCAGC 
CTGATCCTGT CCAGTGACCC AGCCTTCAGA ATTCTAGAAG ACGGCACAAT TTACACAACA 
CATGACCTGC TTTTGTCTTC TGAAAAGAGG GGGTTCTCCA TCTTGCTCTC AGATGGTCAA 
GGGCAGGAAC AAAAGAAGCT AGAAGTTGTA CTGTCAGCAA GAGAAAAAAA GGTTTTTAGG 
AAAAGACATA CCAAAGAGCC AGTACACAAC CGCAGTAAGA GAAGATGGGC TCCTATTCCA 
TGTTCACTGA TGGAGAACTC TTTGGGTCCA TTTCCACAAC ACATTCAGCA GATCCAATCT 
GATGCTGCCC AGAATTACAC CATCTTTTAC TCTATCAGTG GACCAGGAGT AGACAAAGAG 
CCTTACAATT TGTTCTACAT AGAGAAAGAC ACCGGGGACA TCTATTGTAC CCGAAGCATT 
GACCGTGAAC AGTATGACCA ATTTTTGGTA TATGGATATG CAACAACTGC TGATGGCTAT 
GCCCCAGACT ACCCTCTCCC CCTGCTGTTT AAGGTTGAAG ATGACAATGA CAATGCCCCA 
TATTTTGAAA CCAAATTAAC AGTTTTTAGT GTGCCTGAAA ATTGCCGATC TGGAACTTCA 
GTGGGACAAG TGACTGCCAT AGACAAGGAT GAGCCAGGAA CTCTACACAC TCGTCTGAAG 
TACAAAATCT TACAACAAAT CCCAGACCAG CCAAAGCACT TCTCCATCCA CCCAGACACA 
GGTGTGATCA CTACCACCAC ACCTTTACTG GACAGAGAGA AATGTGACAC TTACAAGCTA 
GTGATGGAGG TACGAGACAT GGGGGGCCAG CCCTTTGGTC TGTTCACCAC AGGAACAATC 
ACCATCTCAC TGGAGGATGA GAATGACAAC TCGCCATACT TCACCCAAAC TTCTTATACT 
ACAGAAGTAG AAGAAAACAG AATTGATGTT GAGATTCTGA GAATGGTGGT GCACGACCAA 
GATTTGCCCA ACACCCCCCA CTCGAAGGCG GTATACACAA TCCTAAAGGG GAACGAAAAC 
GGGAACTTCA AAATCACAAC GGATCCAAAT ACAAATGAAG GGGTCTTGTG TGTTGTCAAG 
CCACTGAACT ATGAAGTCAG CCGCCAAGTC ACTCTGCAAA TTGGTGTCCT TAATGAAGCC 
CAGTTCACTA ACGCTGCCAA CGCACAACCA CCAACAATGT GCACCACAAC TGTCACTGTG 
AAAATTAAAG ACAGAGATGA GGGCCCTGAG TGCCAGCCAC CAGTCAAAGT CATTCAGAGC 
AAAGATGGAC TGCCAGCGGG CCAAGAGCTC CTGGGCTACA AAGCGGTGGA CCCAGAGACA 
AGCAGTGGTG AAGGCTTAAG GTATGAGATG GTAGGAGATG AAGATAATTG GTTTGAGATT 
AACAAAATCA CCGGAGACTT GAGAACTGTG AAAGTACTGG ACAGAGAGTC GAAGTTTGTG 
AAAAACAACC AGTACAATAT TTCAGTAGTG GCGACAGATA CAGCTGGCCG ATCTTGCACA 
GGAACACTGG TAGTTCTTCT GGAAGATTTT AATGACCACC CACCACAGAT TGACAAGGAA 
GTGACCATTT GTCAGCAGGA GAAGGATTTT GCTGTTTTGG AACCTATAGA TTTAGATGGG 
CCAGATAATG GTCCACCTTT TCAGTTCCTT CTGGATAATT CTTCCAGCAA ACTTTGGACT 
CTAGAATCAC AGGATGGTAA ACGTGCCATT CTTCGTCAAC GACACAATCT TAATTATAAC 
TATTATTCTG TGCCAATCCA AATACAAGAC AGGCATGGTT TTTCCGCAAA ACATGTATTA 
TCAGTGCGAG TGTGTGACTG TACAACTCCA ACAGAATGTA GAATGGCTGT TAAGGAAGAG 
AGGGATGCTA AACCAAATAT AATCCTTGGG AAATGGGCCA TTCTTGCCAT GGTCCTGGGC 
TCTGCATTGC TACTGTGCAT TTTGTTTACA TGCTTCTGTG TGACCACTAC CAAGAGAACA 
GTCAAGAAAT GCTTCCCAGA TGATGTAGCT CAGCAAAATT TAATTGTATC AAATACTGAA 
GGACCAGGAG AAGAAGTGAC GGAAGCCAAT ATTAGACTCC CCACACAGAC AGCCAACATC 
TGTGATACAA GCATGTCTGT TGGGACTCTT GGTGGTCAAG GAATCAAAAC ACAGCAAAGT 
TTTGAGATGG TCAAAGGAGG CCACACCTTG GAGTCCCACA AGGGAGGAGT GCTAGGAGCA 
GCAGAGCCTG GCCGATATGC TTACACAGAC TGGCAAACTT TCACTCAACC TCGGCTTGGT 
GAAGAATCCA TTAGAGGACA CACTCTGATT AAAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dsc1 ( NM_001291804.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001278733.1 Mus musculus desmocollin 1 (Dsc1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19059
Clone ID Related Accession (Same CDS sequence)	NM_001291804.1
Accession Version	NM_001291804.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2661bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	desmocollin-1 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK079441.1, BC109162.1 and AC132314.3. On Apr 29, 2014 this sequence version replaced XM_006525591.1. Transcript Variant: This variant (1, also known as Dsc1a) represents the shorter transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC109162.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTGG CCTGTGCTGC CCCAGGGAGC ACCTTCTCTA AGCAGCTCCT TTTCTTTCTC 
CTGGTTCTGG TATTATTTTG TGATGCCTGT CAAAAAGTTT CCCTTCACGT TCCCTCTCAT 
CTTAAGGCTG AAACACCTGT AGGCAAAGTG AATCTGGAAG AGTGTCTCAA ATCACCCAGC 
CTGATCCTGT CCAGTGACCC AGCCTTCAGA ATTCTAGAAG ACGGCACAAT TTACACAACA 
CATGACCTGC TTTTGTCTTC TGAAAAGAGG GGGTTCTCCA TCTTGCTCTC AGATGGTCAA 
GGGCAGGAAC AAAAGAAGCT AGAAGTTGTA CTGTCAGCAA GAGAAAAAAA GGTTTTTAGG 
AAAAGACATA CCAAAGAGCC AGTACACAAC CGCAGTAAGA GAAGATGGGC TCCTATTCCA 
TGTTCACTGA TGGAGAACTC TTTGGGTCCA TTTCCACAAC ACATTCAGCA GATCCAATCT 
GATGCTGCCC AGAATTACAC CATCTTTTAC TCTATCAGTG GACCAGGAGT AGACAAAGAG 
CCTTACAATT TGTTCTACAT AGAGAAAGAC ACCGGGGACA TCTATTGTAC CCGAAGCATT 
GACCGTGAAC AGTATGACCA ATTTTTGGTA TATGGATATG CAACAACTGC TGATGGCTAT 
GCCCCAGACT ACCCTCTCCC CCTGCTGTTT AAGGTTGAAG ATGACAATGA CAATGCCCCA 
TATTTTGAAA CCAAATTAAC AGTTTTTAGT GTGCCTGAAA ATTGCCGATC TGGAACTTCA 
GTGGGACAAG TGACTGCCAT AGACAAGGAT GAGCCAGGAA CTCTACACAC TCGTCTGAAG 
TACAAAATCT TACAACAAAT CCCAGACCAG CCAAAGCACT TCTCCATCCA CCCAGACACA 
GGTGTGATCA CTACCACCAC ACCTTTACTG GACAGAGAGA AATGTGACAC TTACAAGCTA 
GTGATGGAGG TACGAGACAT GGGGGGCCAG CCCTTTGGTC TGTTCACCAC AGGAACAATC 
ACCATCTCAC TGGAGGATGA GAATGACAAC TCGCCATACT TCACCCAAAC TTCTTATACT 
ACAGAAGTAG AAGAAAACAG AATTGATGTT GAGATTCTGA GAATGGTGGT GCACGACCAA 
GATTTGCCCA ACACCCCCCA CTCGAAGGCG GTATACACAA TCCTAAAGGG GAACGAAAAC 
GGGAACTTCA AAATCACAAC GGATCCAAAT ACAAATGAAG GGGTCTTGTG TGTTGTCAAG 
CCACTGAACT ATGAAGTCAG CCGCCAAGTC ACTCTGCAAA TTGGTGTCCT TAATGAAGCC 
CAGTTCACTA ACGCTGCCAA CGCACAACCA CCAACAATGT GCACCACAAC TGTCACTGTG 
AAAATTAAAG ACAGAGATGA GGGCCCTGAG TGCCAGCCAC CAGTCAAAGT CATTCAGAGC 
AAAGATGGAC TGCCAGCGGG CCAAGAGCTC CTGGGCTACA AAGCGGTGGA CCCAGAGACA 
AGCAGTGGTG AAGGCTTAAG GTATGAGATG GTAGGAGATG AAGATAATTG GTTTGAGATT 
AACAAAATCA CCGGAGACTT GAGAACTGTG AAAGTACTGG ACAGAGAGTC GAAGTTTGTG 
AAAAACAACC AGTACAATAT TTCAGTAGTG GCGACAGATA CAGCTGGCCG ATCTTGCACA 
GGAACACTGG TAGTTCTTCT GGAAGATTTT AATGACCACC CACCACAGAT TGACAAGGAA 
GTGACCATTT GTCAGCAGGA GAAGGATTTT GCTGTTTTGG AACCTATAGA TTTAGATGGG 
CCAGATAATG GTCCACCTTT TCAGTTCCTT CTGGATAATT CTTCCAGCAA ACTTTGGACT 
CTAGAATCAC AGGATGGTAA ACGTGCCATT CTTCGTCAAC GACACAATCT TAATTATAAC 
TATTATTCTG TGCCAATCCA AATACAAGAC AGGCATGGTT TTTCCGCAAA ACATGTATTA 
TCAGTGCGAG TGTGTGACTG TACAACTCCA ACAGAATGTA GAATGGCTGT TAAGGAAGAG 
AGGGATGCTA AACCAAATAT AATCCTTGGG AAATGGGCCA TTCTTGCCAT GGTCCTGGGC 
TCTGCATTGC TACTGTGCAT TTTGTTTACA TGCTTCTGTG TGACCACTAC CAAGAGAACA 
GTCAAGAAAT GCTTCCCAGA TGATGTAGCT CAGCAAAATT TAATTGTATC AAATACTGAA 
GGACCAGGAG AAGAAGTGAC GGAAGCCAAT ATTAGACTCC CCACACAGAC AGCCAACATC 
TGTGATACAA GCATGTCTGT TGGGACTCTT GGTGGTCAAG GAATCAAAAC ACAGCAAAGT 
TTTGAGATGG TCAAAGGAGG CCACACCTTG GAGTCCCACA AGGGAGGAGT GCTAGGAGCA 
GCAGAGCCTG GCCGATATGC TTACACAGAC TGGCAAACTT TCACTCAACC TCGGCTTGGT 
GAAAAGGTGT ATTTGTGTGG GCAAGCTGAA GAACACAAGC ATTGTGAAGA CTACGTTCGC 
CCATATAACT ATGAAGGCAA AGGCTCCATG GCTGGCTCTG TGGGCTGCTG CAGTGATCGG 
CAGGAGGAAG AAGGGCTAGA GTTTTTAGAT CAATTGGAAC CAAAATTTAG GACATTAGCA 
AAGACATGTG TGAAGAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001278733.1
CDS	218..2878
Translation	MAVACAAPGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQSDAAQNYTIFYSISGPGVDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDQPKHFSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPYFTQTSYTTEVEENRIDVEILRMVVHDQDLPNTPHSKAVYTILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLNEAQFTNAANAQPPTMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMVGDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATDTAGRSCTGTLVVLLEDFNDHPPQIDKEVTICQQEKDFAVLEPIDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTTPTECRMAVKEERDAKPNIILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTANICDTSMSVGTLGGQGIKTQQSFEMVKGGHTLESHKGGVLGAAEPGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCEDYVRPYNYEGKGSMAGSVGCCSDRQEEEGLEFLDQLEPKFRTLAKTCVKK

Target ORF information:

RefSeq Version	NM_001291804.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmocollin 1 (Dsc1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001291804.1

ORF Insert Sequence:

ATGGCTGTGG CCTGTGCTGC CCCAGGGAGC ACCTTCTCTA AGCAGCTCCT TTTCTTTCTC 
CTGGTTCTGG TATTATTTTG TGATGCCTGT CAAAAAGTTT CCCTTCACGT TCCCTCTCAT 
CTTAAGGCTG AAACACCTGT AGGCAAAGTG AATCTGGAAG AGTGTCTCAA ATCACCCAGC 
CTGATCCTGT CCAGTGACCC AGCCTTCAGA ATTCTAGAAG ACGGCACAAT TTACACAACA 
CATGACCTGC TTTTGTCTTC TGAAAAGAGG GGGTTCTCCA TCTTGCTCTC AGATGGTCAA 
GGGCAGGAAC AAAAGAAGCT AGAAGTTGTA CTGTCAGCAA GAGAAAAAAA GGTTTTTAGG 
AAAAGACATA CCAAAGAGCC AGTACACAAC CGCAGTAAGA GAAGATGGGC TCCTATTCCA 
TGTTCACTGA TGGAGAACTC TTTGGGTCCA TTTCCACAAC ACATTCAGCA GATCCAATCT 
GATGCTGCCC AGAATTACAC CATCTTTTAC TCTATCAGTG GACCAGGAGT AGACAAAGAG 
CCTTACAATT TGTTCTACAT AGAGAAAGAC ACCGGGGACA TCTATTGTAC CCGAAGCATT 
GACCGTGAAC AGTATGACCA ATTTTTGGTA TATGGATATG CAACAACTGC TGATGGCTAT 
GCCCCAGACT ACCCTCTCCC CCTGCTGTTT AAGGTTGAAG ATGACAATGA CAATGCCCCA 
TATTTTGAAA CCAAATTAAC AGTTTTTAGT GTGCCTGAAA ATTGCCGATC TGGAACTTCA 
GTGGGACAAG TGACTGCCAT AGACAAGGAT GAGCCAGGAA CTCTACACAC TCGTCTGAAG 
TACAAAATCT TACAACAAAT CCCAGACCAG CCAAAGCACT TCTCCATCCA CCCAGACACA 
GGTGTGATCA CTACCACCAC ACCTTTACTG GACAGAGAGA AATGTGACAC TTACAAGCTA 
GTGATGGAGG TACGAGACAT GGGGGGCCAG CCCTTTGGTC TGTTCACCAC AGGAACAATC 
ACCATCTCAC TGGAGGATGA GAATGACAAC TCGCCATACT TCACCCAAAC TTCTTATACT 
ACAGAAGTAG AAGAAAACAG AATTGATGTT GAGATTCTGA GAATGGTGGT GCACGACCAA 
GATTTGCCCA ACACCCCCCA CTCGAAGGCG GTATACACAA TCCTAAAGGG GAACGAAAAC 
GGGAACTTCA AAATCACAAC GGATCCAAAT ACAAATGAAG GGGTCTTGTG TGTTGTCAAG 
CCACTGAACT ATGAAGTCAG CCGCCAAGTC ACTCTGCAAA TTGGTGTCCT TAATGAAGCC 
CAGTTCACTA ACGCTGCCAA CGCACAACCA CCAACAATGT GCACCACAAC TGTCACTGTG 
AAAATTAAAG ACAGAGATGA GGGCCCTGAG TGCCAGCCAC CAGTCAAAGT CATTCAGAGC 
AAAGATGGAC TGCCAGCGGG CCAAGAGCTC CTGGGCTACA AAGCGGTGGA CCCAGAGACA 
AGCAGTGGTG AAGGCTTAAG GTATGAGATG GTAGGAGATG AAGATAATTG GTTTGAGATT 
AACAAAATCA CCGGAGACTT GAGAACTGTG AAAGTACTGG ACAGAGAGTC GAAGTTTGTG 
AAAAACAACC AGTACAATAT TTCAGTAGTG GCGACAGATA CAGCTGGCCG ATCTTGCACA 
GGAACACTGG TAGTTCTTCT GGAAGATTTT AATGACCACC CACCACAGAT TGACAAGGAA 
GTGACCATTT GTCAGCAGGA GAAGGATTTT GCTGTTTTGG AACCTATAGA TTTAGATGGG 
CCAGATAATG GTCCACCTTT TCAGTTCCTT CTGGATAATT CTTCCAGCAA ACTTTGGACT 
CTAGAATCAC AGGATGGTAA ACGTGCCATT CTTCGTCAAC GACACAATCT TAATTATAAC 
TATTATTCTG TGCCAATCCA AATACAAGAC AGGCATGGTT TTTCCGCAAA ACATGTATTA 
TCAGTGCGAG TGTGTGACTG TACAACTCCA ACAGAATGTA GAATGGCTGT TAAGGAAGAG 
AGGGATGCTA AACCAAATAT AATCCTTGGG AAATGGGCCA TTCTTGCCAT GGTCCTGGGC 
TCTGCATTGC TACTGTGCAT TTTGTTTACA TGCTTCTGTG TGACCACTAC CAAGAGAACA 
GTCAAGAAAT GCTTCCCAGA TGATGTAGCT CAGCAAAATT TAATTGTATC AAATACTGAA 
GGACCAGGAG AAGAAGTGAC GGAAGCCAAT ATTAGACTCC CCACACAGAC AGCCAACATC 
TGTGATACAA GCATGTCTGT TGGGACTCTT GGTGGTCAAG GAATCAAAAC ACAGCAAAGT 
TTTGAGATGG TCAAAGGAGG CCACACCTTG GAGTCCCACA AGGGAGGAGT GCTAGGAGCA 
GCAGAGCCTG GCCGATATGC TTACACAGAC TGGCAAACTT TCACTCAACC TCGGCTTGGT 
GAAAAGGTGT ATTTGTGTGG GCAAGCTGAA GAACACAAGC ATTGTGAAGA CTACGTTCGC 
CCATATAACT ATGAAGGCAA AGGCTCCATG GCTGGCTCTG TGGGCTGCTG CAGTGATCGG 
CAGGAGGAAG AAGGGCTAGA GTTTTTAGAT CAATTGGAAC CAAAATTTAG GACATTAGCA 
AAGACATGTG TGAAGAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality.
Scientific reports632399(2016 Aug)
Ikawa-Yoshida A,Matsumoto T,Okano S,Aoyagi Y,Matsubara Y,Furuyama T,Nakatsu Y,Tsuzuki T,Onimaru M,Ohkusa T,Nomura M,Maehara Y

Variable impact of chronic stress on spatial learning and memory in BXD mice.
Physiology & behavior15069-77(2015 Oct)
Shea CJ,Carhuatanta KA,Wagner J,Bechmann N,Moore R,Herman JP,Jankord R

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.
Human molecular genetics22(3)531-43(2013 Feb)
Ferone G,Mollo MR,Thomason HA,Antonini D,Zhou H,Ambrosio R,De Rosa L,Salvatore D,Getsios S,van Bokhoven H,Dixon J,Missero C

Assessment of splice variant-specific functions of desmocollin 1 in the skin.
Molecular and cellular biology24(1)154-63(2004 Jan)
Cheng X,Mihindukulasuriya K,Den Z,Kowalczyk AP,Calkins CC,Ishiko A,Shimizu A,Koch PJ

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Dsc1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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