Dgcr6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dgcr6
Entrez Gene ID	13353
Full Name	DiGeorge syndrome critical region gene 6
General protein information	Preferred Names DiGeorge syndrome critical region gene 6 Names protein DGCR6 DiGeorge syndrome chromosome region 6 diGeorge syndrome critical region 6 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A3\|16 11.19 cM
Summary	This gene encodes a protein that is similar to the gonadal protein in Drosophila (fruit fly). The encoded protein is thought to play a role in migration of neural crest cells during development. Deletions in the human gene are associated with DiGeorge syndrome (or velocardiofacial syndrome) which has many clinical features including cardiac abnormalities, cleft palate, atypical facial features, hypocalcemia, hypoparathyroidism and defective development or congenital absence of the thymus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006521759.2	XP_006521822.1	protein DGCR6 isoform X1
NM_001289813.1	NP_001276742.1	protein DGCR6 isoform 1
XM_030248957.1	XP_030104817.1	protein DGCR6 isoform X1
NM_010047.4	NP_034177.1	protein DGCR6 isoform 3
NM_001289814.1	NP_001276743.1	protein DGCR6 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Dgcr6	NP_001100550.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012393	XP_320165.3
Drosophila melanogaster (fruit fly)	gdl	NP_001261877.1
Pan troglodytes (chimpanzee)	DGCR6	XP_003953868.1
	DGCR6	XP_001082214.1
Mus musculus (house mouse)	Dgcr6	NP_034177.1

Gene Ontology
Bibliography

Related articles in PubMed

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.
Paronett EM, Meechan DW, Karpinski BA, LaMantia AS, Maynard TM
Cerebral cortex (New York, N.Y. : 1991)25(10)3977-93(2015 Oct)

Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome.
Karpinski BA, Maynard TM, Fralish MS, Nuwayhid S, Zohn IE, Moody SA, LaMantia AS
Disease models & mechanisms7(2)245-57(2014 Feb)

A comprehensive analysis of 22q11 gene expression in the developing and adult brain.
Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS
Proceedings of the National Academy of Sciences of the United States of America100(24)14433-8(2003 Nov)

Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.
Edelmann L, Stankiewicz P, Spiteri E, Pandita RK, Shaffer L, Lupski JR, Morrow BE, Lupski J
Genome research11(2)208-17(2001 Feb)

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.
Puech A, Saint-Jore B, Merscher S, Russell RG, Cherif D, Sirotkin H, Xu H, Factor S, Kucherlapati R, Skoultchi AI
Proceedings of the National Academy of Sciences of the United States of America97(18)10090-5(2000 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dgcr6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dgcr6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18393	NM_001289813.1 Latest version!	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu18430	NM_010047.4 Latest version!	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu18454	NM_001289814.1 Latest version!	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu51846	XM_006521759.2 Latest version!	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu18454	XM_030248957.1 Latest version!	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dgcr6 ( NM_001289813.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276742.1 Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18393
Clone ID Related Accession (Same CDS sequence)	NM_001289813.1
Accession Version	NM_001289813.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	protein DGCR6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087064.27, BE945982.1, AK019346.1 and BY594536.1. On or before Feb 1, 2014 this sequence version replaced XM_006536792.1, XM_006521757.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW990646.1, AW476080.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCGCT ATGCGGCCGC CGGGGATGAG GCGGCGGATC GGGCCCGGCA GCAGGAGCGG 
CACTACCAGC TGCTGTCAGC ACTACAGAGC CTGGTCAAGG AGCTGCCCAG CTCCTTTCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC TTGGCCCTGG CGCTGCTCGA CGGAACGGTG 
TTTGAAATCG TGCAGGGTCT TCTGGAGATT CAGCACCTCA CTGAGAAGAG CCTCTACAAC 
CAGAGACTGC GGCTGCAGAA CGAACACCGA GTGCTCAGAC AGACTCTAAG GCAGAAGCAC 
CTGGAAGCCC AGCAGTCCTG CCGGCCCCAC AACTTGCCAG TGCTCCAGGC AGCTCAGCAG 
CGTGAGCTGG AGTCATGGCA GGCCATGGAA CATCGGATCC GGGAGGAGCA GCAGGCTATG 
GACCGAAAGA TTGTCCTGGA GCTGGACCGG AAGGTTGCCG ACCAGCAGAG CACACTGGAG 
AAGGCAGGGG TAGCTGGTTT CTACGTGACC ACCAATCCTC AGGAGCTGAC GCTGCAGATG 
AACCTATTGG AACTCATCAG GAAGCTGCAG CAGAGGGGCT GCCAAGTGGG AAAGGCAGCT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276742.1
CDS	88..693
Translation	MDRYAAAGDEAADRARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELESWQAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGKAAL

Target ORF information:

RefSeq Version	NM_001289813.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289813.1

ORF Insert Sequence:

ATGGACCGCT ATGCGGCCGC CGGGGATGAG GCGGCGGATC GGGCCCGGCA GCAGGAGCGG 
CACTACCAGC TGCTGTCAGC ACTACAGAGC CTGGTCAAGG AGCTGCCCAG CTCCTTTCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC TTGGCCCTGG CGCTGCTCGA CGGAACGGTG 
TTTGAAATCG TGCAGGGTCT TCTGGAGATT CAGCACCTCA CTGAGAAGAG CCTCTACAAC 
CAGAGACTGC GGCTGCAGAA CGAACACCGA GTGCTCAGAC AGACTCTAAG GCAGAAGCAC 
CTGGAAGCCC AGCAGTCCTG CCGGCCCCAC AACTTGCCAG TGCTCCAGGC AGCTCAGCAG 
CGTGAGCTGG AGTCATGGCA GGCCATGGAA CATCGGATCC GGGAGGAGCA GCAGGCTATG 
GACCGAAAGA TTGTCCTGGA GCTGGACCGG AAGGTTGCCG ACCAGCAGAG CACACTGGAG 
AAGGCAGGGG TAGCTGGTTT CTACGTGACC ACCAATCCTC AGGAGCTGAC GCTGCAGATG 
AACCTATTGG AACTCATCAG GAAGCTGCAG CAGAGGGGCT GCCAAGTGGG AAAGGCAGCT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dgcr6 ( NM_010047.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034177.1 Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu18430
Clone ID Related Accession (Same CDS sequence)	NM_010047.4
Accession Version	NM_010047.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	protein DGCR6 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK019346.1, AC087064.27 and BY594536.1. On Feb 1, 2014 this sequence version replaced NM_010047.3. Transcript Variant: This variant (3) represents the use of an alternate promoter and has multiple differences compared to variant 1. These differences result in a different 5' UTR and cause translation initiation at an alternate start codon compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK160342.1, AK019346.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTAGAGA GCATGGCACC AGCCAGCTCC TTTCAGCAGC GCCTGTCCTA CACCACGCTC 
AGCGACTTGG CCCTGGCGCT GCTCGACGGA ACGGTGTTTG AAATCGTGCA GGGTCTTCTG 
GAGATTCAGC ACCTCACTGA GAAGAGCCTC TACAACCAGA GACTGCGGCT GCAGAACGAA 
CACCGAGTGC TCAGACAGAC TCTAAGGCAG AAGCACCTGG AAGCCCAGCA GTCCTGCCGG 
CCCCACAACT TGCCAGTGCT CCAGGCAGCT CAGCAGCGTG AGCTGGAGGC CATGGAACAT 
CGGATCCGGG AGGAGCAGCA GGCTATGGAC CGAAAGATTG TCCTGGAGCT GGACCGGAAG 
GTTGCCGACC AGCAGAGCAC ACTGGAGAAG GCAGGGGTAG CTGGTTTCTA CGTGACCACC 
AATCCTCAGG AGCTGACGCT GCAGATGAAC CTATTGGAAC TCATCAGGAA GCTGCAGCAG 
AGGGGCTGCC AAGTGGGAAA GGCAGCTCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034177.1
CDS	369..881
Translation	MVESMAPASSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGKAAL

Target ORF information:

RefSeq Version	NM_010047.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010047.4

ORF Insert Sequence:

ATGGTAGAGA GCATGGCACC AGCCAGCTCC TTTCAGCAGC GCCTGTCCTA CACCACGCTC 
AGCGACTTGG CCCTGGCGCT GCTCGACGGA ACGGTGTTTG AAATCGTGCA GGGTCTTCTG 
GAGATTCAGC ACCTCACTGA GAAGAGCCTC TACAACCAGA GACTGCGGCT GCAGAACGAA 
CACCGAGTGC TCAGACAGAC TCTAAGGCAG AAGCACCTGG AAGCCCAGCA GTCCTGCCGG 
CCCCACAACT TGCCAGTGCT CCAGGCAGCT CAGCAGCGTG AGCTGGAGGC CATGGAACAT 
CGGATCCGGG AGGAGCAGCA GGCTATGGAC CGAAAGATTG TCCTGGAGCT GGACCGGAAG 
GTTGCCGACC AGCAGAGCAC ACTGGAGAAG GCAGGGGTAG CTGGTTTCTA CGTGACCACC 
AATCCTCAGG AGCTGACGCT GCAGATGAAC CTATTGGAAC TCATCAGGAA GCTGCAGCAG 
AGGGGCTGCC AAGTGGGAAA GGCAGCTCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dgcr6 ( NM_001289814.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276743.1 Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18454
Clone ID Related Accession (Same CDS sequence)	XM_030248957.1 , NM_001289814.1
Accession Version	NM_001289814.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	protein DGCR6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087064.27. On or before Feb 1, 2014 this sequence version replaced XM_006536793.1, XM_006521758.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF021031.1, CA980516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCGCT ATGCGGCCGC CGGGGATGAG GCGGCGGATC GGGCCCGGCA GCAGGAGCGG 
CACTACCAGC TGCTGTCAGC ACTACAGAGC CTGGTCAAGG AGCTGCCCAG CTCCTTTCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC TTGGCCCTGG CGCTGCTCGA CGGAACGGTG 
TTTGAAATCG TGCAGGGTCT TCTGGAGATT CAGCACCTCA CTGAGAAGAG CCTCTACAAC 
CAGAGACTGC GGCTGCAGAA CGAACACCGA GTGCTCAGAC AGACTCTAAG GCAGAAGCAC 
CTGGAAGCCC AGCAGTCCTG CCGGCCCCAC AACTTGCCAG TGCTCCAGGC AGCTCAGCAG 
CGTGAGCTGG AGGCCATGGA ACATCGGATC CGGGAGGAGC AGCAGGCTAT GGACCGAAAG 
ATTGTCCTGG AGCTGGACCG GAAGGTTGCC GACCAGCAGA GCACACTGGA GAAGGCAGGG 
GTAGCTGGTT TCTACGTGAC CACCAATCCT CAGGAGCTGA CGCTGCAGAT GAACCTATTG 
GAACTCATCA GGAAGCTGCA GCAGAGGGGC TGCCAAGTGG GAAAGGCAGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276743.1
CDS	88..684
Translation	MDRYAAAGDEAADRARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGKAAL

Target ORF information:

RefSeq Version	NM_001289814.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289814.1

ORF Insert Sequence:

ATGGACCGCT ATGCGGCCGC CGGGGATGAG GCGGCGGATC GGGCCCGGCA GCAGGAGCGG 
CACTACCAGC TGCTGTCAGC ACTACAGAGC CTGGTCAAGG AGCTGCCCAG CTCCTTTCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC TTGGCCCTGG CGCTGCTCGA CGGAACGGTG 
TTTGAAATCG TGCAGGGTCT TCTGGAGATT CAGCACCTCA CTGAGAAGAG CCTCTACAAC 
CAGAGACTGC GGCTGCAGAA CGAACACCGA GTGCTCAGAC AGACTCTAAG GCAGAAGCAC 
CTGGAAGCCC AGCAGTCCTG CCGGCCCCAC AACTTGCCAG TGCTCCAGGC AGCTCAGCAG 
CGTGAGCTGG AGGCCATGGA ACATCGGATC CGGGAGGAGC AGCAGGCTAT GGACCGAAAG 
ATTGTCCTGG AGCTGGACCG GAAGGTTGCC GACCAGCAGA GCACACTGGA GAAGGCAGGG 
GTAGCTGGTT TCTACGTGAC CACCAATCCT CAGGAGCTGA CGCTGCAGAT GAACCTATTG 
GAACTCATCA GGAAGCTGCA GCAGAGGGGC TGCCAAGTGG GAAAGGCAGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dgcr6 ( XM_006521759.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006521822.1 Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu51846
Clone ID Related Accession (Same CDS sequence)	XM_006521759.2
Accession Version	XM_006521759.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	protein DGCR6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006521759.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGCC CTGGGCGCGC ACCTCCAAGG TCAGCACCAC TTGGGAGCTC AGCGAGCCCC 
TATTTCTTCT CCCTAGGACA AAGCGCTTAC AAGCAGTCTC CCTGGTGGGT GGAGCGCGTC 
TTATTGTGCC TGACGCACCA CGGTGAACGG CCGGAGACCG ACCGGAGGGG CGGGGCGCAT 
GCGTCGTTCG CGCTGGAGAA TGACGTGAGG GGGCGGGGCG CGCCGGGGCA CCCTAGGAGA 
CCGAGTAGAG GGGCGGCGGG GGACCGCGCG GTAAACCGCG CGATGGACCG CTATGCGGCC 
GCCGGGGATG AGGCGGCGGA TCGGGCCCGG CAGCAGGAGC GGCACTACCA GCTGCTGTCA 
GCACTACAGA GCCTGGTCAA GGAGCTGCCC AGCTCCTTTC AGCAGCGCCT GTCCTACACC 
ACGCTCAGCG ACTTGGCCCT GGCGCTGCTC GACGGAACGG TGTTTGAAAT CGTGCAGGGT 
CTTCTGGAGA TTCAGCACCT CACTGAGAAG AGCCTCTACA ACCAGAGACT GCGGCTGCAG 
AACGAACACC GAGTGCTCAG ACAGACTCTA AGGCAGAAGC ACCTGGAAGC CCAGCAGTCC 
TGCCGGCCCC ACAACTTGCC AGTGCTCCAG GCAGCTCAGC AGCGTGAGCT GGAGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006521822.1
CDS	134..793
Translation	MQSPGRAPPRSAPLGSSASPYFFSLGQSAYKQSPWWVERVLLCLTHHGERPETDRRGGAHASFALENDVRGRGAPGHPRRPSRGAAGDRAVNRAMDRYAAAGDEAADRARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELEP

Target ORF information:

RefSeq Version	XM_006521759.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006521759.2

ORF Insert Sequence:

ATGCAGAGCC CTGGGCGCGC ACCTCCAAGG TCAGCACCAC TTGGGAGCTC AGCGAGCCCC 
TATTTCTTCT CCCTAGGACA AAGCGCTTAC AAGCAGTCTC CCTGGTGGGT GGAGCGCGTC 
TTATTGTGCC TGACGCACCA CGGTGAACGG CCGGAGACCG ACCGGAGGGG CGGGGCGCAT 
GCGTCGTTCG CGCTGGAGAA TGACGTGAGG GGGCGGGGCG CGCCGGGGCA CCCTAGGAGA 
CCGAGTAGAG GGGCGGCGGG GGACCGCGCG GTAAACCGCG CGATGGACCG CTATGCGGCC 
GCCGGGGATG AGGCGGCGGA TCGGGCCCGG CAGCAGGAGC GGCACTACCA GCTGCTGTCA 
GCACTACAGA GCCTGGTCAA GGAGCTGCCC AGCTCCTTTC AGCAGCGCCT GTCCTACACC 
ACGCTCAGCG ACTTGGCCCT GGCGCTGCTC GACGGAACGG TGTTTGAAAT CGTGCAGGGT 
CTTCTGGAGA TTCAGCACCT CACTGAGAAG AGCCTCTACA ACCAGAGACT GCGGCTGCAG 
AACGAACACC GAGTGCTCAG ACAGACTCTA AGGCAGAAGC ACCTGGAAGC CCAGCAGTCC 
TGCCGGCCCC ACAACTTGCC AGTGCTCCAG GCAGCTCAGC AGCGTGAGCT GGAGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dgcr6 ( XM_030248957.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030104817.1 Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu18454
Clone ID Related Accession (Same CDS sequence)	XM_030248957.1 , NM_001289814.1
Accession Version	XM_030248957.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protein DGCR6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCGCT ATGCGGCCGC CGGGGATGAG GCGGCGGATC GGGCCCGGCA GCAGGAGCGG 
CACTACCAGC TGCTGTCAGC ACTACAGAGC CTGGTCAAGG AGCTGCCCAG CTCCTTTCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC TTGGCCCTGG CGCTGCTCGA CGGAACGGTG 
TTTGAAATCG TGCAGGGTCT TCTGGAGATT CAGCACCTCA CTGAGAAGAG CCTCTACAAC 
CAGAGACTGC GGCTGCAGAA CGAACACCGA GTGCTCAGAC AGACTCTAAG GCAGAAGCAC 
CTGGAAGCCC AGCAGTCCTG CCGGCCCCAC AACTTGCCAG TGCTCCAGGC AGCTCAGCAG 
CGTGAGCTGG AGGCCATGGA ACATCGGATC CGGGAGGAGC AGCAGGCTAT GGACCGAAAG 
ATTGTCCTGG AGCTGGACCG GAAGGTTGCC GACCAGCAGA GCACACTGGA GAAGGCAGGG 
GTAGCTGGTT TCTACGTGAC CACCAATCCT CAGGAGCTGA CGCTGCAGAT GAACCTATTG 
GAACTCATCA GGAAGCTGCA GCAGAGGGGC TGCCAAGTGG GAAAGGCAGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030104817.1
CDS	586..1182
Translation	MDRYAAAGDEAADRARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGKAAL

Target ORF information:

RefSeq Version	XM_030248957.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus DiGeorge syndrome critical region gene 6 (Dgcr6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030248957.1

ORF Insert Sequence:

ATGGACCGCT ATGCGGCCGC CGGGGATGAG GCGGCGGATC GGGCCCGGCA GCAGGAGCGG 
CACTACCAGC TGCTGTCAGC ACTACAGAGC CTGGTCAAGG AGCTGCCCAG CTCCTTTCAG 
CAGCGCCTGT CCTACACCAC GCTCAGCGAC TTGGCCCTGG CGCTGCTCGA CGGAACGGTG 
TTTGAAATCG TGCAGGGTCT TCTGGAGATT CAGCACCTCA CTGAGAAGAG CCTCTACAAC 
CAGAGACTGC GGCTGCAGAA CGAACACCGA GTGCTCAGAC AGACTCTAAG GCAGAAGCAC 
CTGGAAGCCC AGCAGTCCTG CCGGCCCCAC AACTTGCCAG TGCTCCAGGC AGCTCAGCAG 
CGTGAGCTGG AGGCCATGGA ACATCGGATC CGGGAGGAGC AGCAGGCTAT GGACCGAAAG 
ATTGTCCTGG AGCTGGACCG GAAGGTTGCC GACCAGCAGA GCACACTGGA GAAGGCAGGG 
GTAGCTGGTT TCTACGTGAC CACCAATCCT CAGGAGCTGA CGCTGCAGAT GAACCTATTG 
GAACTCATCA GGAAGCTGCA GCAGAGGGGC TGCCAAGTGG GAAAGGCAGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.
Cerebral cortex (New York, N.Y. : 1991)25(10)3977-93(2015 Oct)
Paronett EM,Meechan DW,Karpinski BA,LaMantia AS,Maynard TM

Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome.
Disease models & mechanisms7(2)245-57(2014 Feb)
Karpinski BA,Maynard TM,Fralish MS,Nuwayhid S,Zohn IE,Moody SA,LaMantia AS

A comprehensive analysis of 22q11 gene expression in the developing and adult brain.
Proceedings of the National Academy of Sciences of the United States of America100(24)14433-8(2003 Nov)
Maynard TM,Haskell GT,Peters AZ,Sikich L,Lieberman JA,LaMantia AS

Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.
Genome research11(2)208-17(2001 Feb)
Edelmann L,Stankiewicz P,Spiteri E,Pandita RK,Shaffer L,Lupski JR,Morrow BE,Lupski J

Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.
Proceedings of the National Academy of Sciences of the United States of America97(18)10090-5(2000 Aug)
Puech A,Saint-Jore B,Merscher S,Russell RG,Cherif D,Sirotkin H,Xu H,Factor S,Kucherlapati R,Skoultchi AI

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Dgcr6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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