Ddn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ddn
Entrez Gene ID	13199
Full Name	dendrin
Synonyms	Gm748
General protein information	Preferred Names dendrin Names dendrin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 F1\|15 54.69 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013741.1	NP_001013763.1	dendrin

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DDN	XP_003313775.1
Canis lupus familiaris (dog)	DDN	XP_851155.1
Bos taurus (cattle)	DDN	NP_001095771.1
Homo sapiens (human)	DDN	NP_055901.2
Rattus norvegicus (Norway rat)	Ddn	NP_112255.1
Mus musculus (house mouse)	Ddn	NP_001013763.1
	DDN	XP_001105260.1

Gene Ontology
Bibliography

Related articles in PubMed

Dendrin ablation prolongs life span by delaying kidney failure.
Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, Campbell KN
The American journal of pathology185(8)2143-57(2015 Aug)

Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.
Xiao Z, Rodriguez PQ, He L, Betsholtz C, Tryggvason K, Patrakka J
PloS one8(12)e83133(2013)

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, M?ller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohm?ller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J
The Journal of clinical investigation121(10)3965-80(2011 Oct)

Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.
Dun?r F, Patrakka J, Xiao Z, Larsson J, Vlamis-Gardikas A, Pettersson E, Tryggvason K, Hultenby K, Wernerson A
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association23(8)2504-11(2008 Aug)

Nephrin is involved in podocyte maturation but not survival during glomerular development.
Don? SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K
Kidney international73(6)697-704(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ablation of the podocyte death-promoting protein dendrin delays onset of end-stage kidney disease, thereby expanding the life span of mice lacking the adapter protein CD2AP. Ablation of dendrin delays onset and severity of proteinuria and podocyte loss.
Title: Dendrin ablation prolongs life span by delaying kidney failure.

Dendrin is dispensable for the function of the normal glomerular filtration barrier, and it interacts with Wtip and Gadd45a.
Title: Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.

relocation of dendrin from the slit diaphragm to the podocyte nucleus in adriamycin-induced glomerulosclerosis
Title: Dendrin location in podocytes is associated with disease progression in animal and human glomerulopathy.

In glomerulogenesis, dendrin mRNA and protein appeared first at the early capillary loop stage. It was concentrated to the pre-podocytes on the basal side of podocalyxin, an apical cell membrane marker.
Title: Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.

Nuclear relocation of dendrin promotes apoptosis of podocytes.
Title: Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes.

The following Ddn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ddn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11539	NM_001013741.1 Latest version!	Mus musculus dendrin (Ddn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ddn ( NM_001013741.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001013763.1 Mus musculus dendrin (Ddn), mRNA.

Price & Availability↑

CloneID	OMu11539
Clone ID Related Accession (Same CDS sequence)	NM_001013741.1
Accession Version	NM_001013741.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2133bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	dendrin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK158894.1 and AK122363.1. On or before Mar 2, 2008 this sequence version replaced XM_001476216.1, XM_001480765.1, XM_619356.3. ##Evidence-Data-START## Transcript exon combination :: AK122363.1, AK158894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGATG GCCCGTTATT CTCCGAGGGG CCCGACAGCC CCCGGGAGCT CCAGGATGAG 
GAGTCCGGCA GCTGCCTCTG GGTGCAGAAG TCCAAGCTGT TGGTGATTGA AGTGAAGACT 
ATTTCCTGTC ATTATAGTCG TCGCGCTCCT TCTCGACAGT CCATGGACAT CCAGGCCAGC 
TACTGGGCCC GTGGGCCCCA GAGCCGCACG TGTAGGCTGC GCCCGGGATC CCCTGAGCCG 
CCACCCCGCC GACCCTGGGC CTCCAGGGTG CTGCAGGAGG CAACCAACTG GCGGGCGGGC 
CCCCCCGCCG AGGTCCGAGC CCGGGAACAA GAGAAAAGAA AGGCGGCGTC GCAGGAGCGG 
GAGGCCAAGG AGACCGAGAG AAAAAGGCGC AAGGCTGGCG GGGCCCGACG GAGTCCCCTA 
GGTCAGCCCC GCCCAGAGCC CCGGAACGCC CTTCGGGCAG CCCAACCTAC AGGGTTTCCA 
GTTTTCTCCA GACCAGAGCG CTTCGGGCAG GTGGGGCGAG CGCCCCGACC ATCCGTGCTC 
CCGCAGGGTG ACCCAGGGGT TGCATGGGCG GGGCCATGGG GAGGCAGAAG GCCAGGGCCC 
CCTAGCTACG AGGCTCACCT GCTGTTGAGA GGCTCTGCAG GCACAGCCCC AAGGCGCCGC 
TGGGACCGGC CGCCACCCTA TGTGGCTCCA CCTTCTTATG AAGGTCCCCA CAGGACCCTG 
GGGACTAAGC GAGGCCCGGA GCTCTCCCGG GCGCCCACCT CATCAGCCCC AGTTCCAGCC 
ACCACCAGGA CAGAGGGAGG GCGCACGAAG AAGAGGCTGG ATCCTCGAAT CTACCGGGAT 
GTTCTAGGAG CTTGGGGTCT CAGACAGGGA CGGGGACTCT TAGGAGGTGC TCCAGGCTGT 
ACAGCAGCCA GAGCTAGGCC AGAGTCTTGC AAAGGGGCTA TAGAGAAAAG CTCAGGCCTA 
GTTGCTGCTG GCCTGAACAG TGCTGGCGAT AGTCATTCCC AAGGCAAAAC GACTGGCGGT 
CCAGGCACGG ACGCAGCTCT CTCTAGGTCC GCGATCAGCA GCCCACCTCG TCCTGTTCCC 
AGGTCCAGGC AGCACCTCAG GGGGTCAAGG AAAGGGAAAG AAGGAAGTGA GCAGATATGG 
CTTCCCACGT GTTGGCTTGC CTCCCCTAAA AAGCCTCCAG TTAGGCACAG CCAGACGCTC 
CCTAGACCCT GGGCTCCTGG AGGCACCGGG TGGAAAGAGT CCCTGGGTCA AAGAGAGGGG 
GCAGAACATG AGACCCTGGA AGTTTGGAAG GTGACCCGCC GTGCCCACAC CCTGCCCCGC 
ATTTCCCGAG GTCCCGCTGG TAGAGAAGGC ATCTTTGTCA TTGACGCCAC ATGCGTGGTG 
ATAAAGTCCC AGTACGTTCC GACCCCTCGA ACCCAGCAGG GTCAGCTCGT GCCCTCTGGG 
GAGTCGTGCA GTGTGAGCGA CAGCCTTAGT CAACCCAAGC CCTGTCACGA GGAGGAGGGC 
GAGGGGGCCG CTGCCAACCC TTCAGTTTGC CAAAAGCGAC TGTTGAGCAG TCGAGTCTTA 
AACCAACCGA GCGAGGGTCG CGAGTGCGAG GCCGAGGTCG GACAGCAGGG GGATTCTTCA 
TTGGAGGAGC GCTCCTCCAG CGGTTTGGGG TTCCCTGTCG GAGAAGTGAA CCCGCGAGAC 
GCCCCCACGC AGCCAGGTAG CCAAGAGCAC CCGACCTTAG GCCCAGCGGC TCCGGTATGC 
GCCGGCAGCT TGAAGGGCTC AGAAGCGGCT GGTGTCCCGC GGCGCGCGGG CGGGGGCTGG 
GCGCGGACTC CAGGGCCCTA CGCCGGGGCG TTGCGAGAAG CCGTGTCCCG CATCCGCCGC 
CACACCGCCC CAGATTCGGA CTCAGACGAA GCGGAGGATC TCAGCGTCCA TAGCGGCTCC 
TCTGATGGAA GCGACACAGA CGCCCCAGGC GCCTCCTGGC GGAATGAGAG GACCCTGCCT 
GCGCTTGGGA ACACCCGGCC CAGGGAAGGC GGGAAGACAG CAGGGCTGAG CGACAGTATC 
CGGGAGATTG TGGATGTCAT CAGTCAAACC GAGGAAGGCT TCATCCGAGA GGACACCAGG 
AAAACGCCAC AGGGAAATAG AGAGAGGGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013763.1
CDS	113..2245
Translation	MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQSMDIQASYWARGPQSRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPEPRNALRAAQPTGFPVFSRPERFGQVGRAPRPSVLPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCTAARARPESCKGAIEKSSGLVAAGLNSAGDSHSQGKTTGGPGTDAALSRSAISSPPRPVPRSRQHLRGSRKGKEGSEQIWLPTCWLASPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGAEHETLEVWKVTRRAHTLPRISRGPAGREGIFVIDATCVVIKSQYVPTPRTQQGQLVPSGESCSVSDSLSQPKPCHEEEGEGAAANPSVCQKRLLSSRVLNQPSEGRECEAEVGQQGDSSLEERSSSGLGFPVGEVNPRDAPTQPGSQEHPTLGPAAPVCAGSLKGSEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEAEDLSVHSGSSDGSDTDAPGASWRNERTLPALGNTRPREGGKTAGLSDSIREIVDVISQTEEGFIREDTRKTPQGNRERE

Target ORF information:

RefSeq Version	NM_001013741.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dendrin (Ddn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013741.1

ORF Insert Sequence:

ATGCTGGATG GCCCGTTATT CTCCGAGGGG CCCGACAGCC CCCGGGAGCT CCAGGATGAG 
GAGTCCGGCA GCTGCCTCTG GGTGCAGAAG TCCAAGCTGT TGGTGATTGA AGTGAAGACT 
ATTTCCTGTC ATTATAGTCG TCGCGCTCCT TCTCGACAGT CCATGGACAT CCAGGCCAGC 
TACTGGGCCC GTGGGCCCCA GAGCCGCACG TGTAGGCTGC GCCCGGGATC CCCTGAGCCG 
CCACCCCGCC GACCCTGGGC CTCCAGGGTG CTGCAGGAGG CAACCAACTG GCGGGCGGGC 
CCCCCCGCCG AGGTCCGAGC CCGGGAACAA GAGAAAAGAA AGGCGGCGTC GCAGGAGCGG 
GAGGCCAAGG AGACCGAGAG AAAAAGGCGC AAGGCTGGCG GGGCCCGACG GAGTCCCCTA 
GGTCAGCCCC GCCCAGAGCC CCGGAACGCC CTTCGGGCAG CCCAACCTAC AGGGTTTCCA 
GTTTTCTCCA GACCAGAGCG CTTCGGGCAG GTGGGGCGAG CGCCCCGACC ATCCGTGCTC 
CCGCAGGGTG ACCCAGGGGT TGCATGGGCG GGGCCATGGG GAGGCAGAAG GCCAGGGCCC 
CCTAGCTACG AGGCTCACCT GCTGTTGAGA GGCTCTGCAG GCACAGCCCC AAGGCGCCGC 
TGGGACCGGC CGCCACCCTA TGTGGCTCCA CCTTCTTATG AAGGTCCCCA CAGGACCCTG 
GGGACTAAGC GAGGCCCGGA GCTCTCCCGG GCGCCCACCT CATCAGCCCC AGTTCCAGCC 
ACCACCAGGA CAGAGGGAGG GCGCACGAAG AAGAGGCTGG ATCCTCGAAT CTACCGGGAT 
GTTCTAGGAG CTTGGGGTCT CAGACAGGGA CGGGGACTCT TAGGAGGTGC TCCAGGCTGT 
ACAGCAGCCA GAGCTAGGCC AGAGTCTTGC AAAGGGGCTA TAGAGAAAAG CTCAGGCCTA 
GTTGCTGCTG GCCTGAACAG TGCTGGCGAT AGTCATTCCC AAGGCAAAAC GACTGGCGGT 
CCAGGCACGG ACGCAGCTCT CTCTAGGTCC GCGATCAGCA GCCCACCTCG TCCTGTTCCC 
AGGTCCAGGC AGCACCTCAG GGGGTCAAGG AAAGGGAAAG AAGGAAGTGA GCAGATATGG 
CTTCCCACGT GTTGGCTTGC CTCCCCTAAA AAGCCTCCAG TTAGGCACAG CCAGACGCTC 
CCTAGACCCT GGGCTCCTGG AGGCACCGGG TGGAAAGAGT CCCTGGGTCA AAGAGAGGGG 
GCAGAACATG AGACCCTGGA AGTTTGGAAG GTGACCCGCC GTGCCCACAC CCTGCCCCGC 
ATTTCCCGAG GTCCCGCTGG TAGAGAAGGC ATCTTTGTCA TTGACGCCAC ATGCGTGGTG 
ATAAAGTCCC AGTACGTTCC GACCCCTCGA ACCCAGCAGG GTCAGCTCGT GCCCTCTGGG 
GAGTCGTGCA GTGTGAGCGA CAGCCTTAGT CAACCCAAGC CCTGTCACGA GGAGGAGGGC 
GAGGGGGCCG CTGCCAACCC TTCAGTTTGC CAAAAGCGAC TGTTGAGCAG TCGAGTCTTA 
AACCAACCGA GCGAGGGTCG CGAGTGCGAG GCCGAGGTCG GACAGCAGGG GGATTCTTCA 
TTGGAGGAGC GCTCCTCCAG CGGTTTGGGG TTCCCTGTCG GAGAAGTGAA CCCGCGAGAC 
GCCCCCACGC AGCCAGGTAG CCAAGAGCAC CCGACCTTAG GCCCAGCGGC TCCGGTATGC 
GCCGGCAGCT TGAAGGGCTC AGAAGCGGCT GGTGTCCCGC GGCGCGCGGG CGGGGGCTGG 
GCGCGGACTC CAGGGCCCTA CGCCGGGGCG TTGCGAGAAG CCGTGTCCCG CATCCGCCGC 
CACACCGCCC CAGATTCGGA CTCAGACGAA GCGGAGGATC TCAGCGTCCA TAGCGGCTCC 
TCTGATGGAA GCGACACAGA CGCCCCAGGC GCCTCCTGGC GGAATGAGAG GACCCTGCCT 
GCGCTTGGGA ACACCCGGCC CAGGGAAGGC GGGAAGACAG CAGGGCTGAG CGACAGTATC 
CGGGAGATTG TGGATGTCAT CAGTCAAACC GAGGAAGGCT TCATCCGAGA GGACACCAGG 
AAAACGCCAC AGGGAAATAG AGAGAGGGAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dendrin ablation prolongs life span by delaying kidney failure.
The American journal of pathology185(8)2143-57(2015 Aug)
Weins A,Wong JS,Basgen JM,Gupta R,Daehn I,Casagrande L,Lessman D,Schwartzman M,Meliambro K,Patrakka J,Shaw A,Tryggvason K,He JC,Nicholas SB,Mundel P,Campbell KN

Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.
PloS one8(12)e83133(2013)
Xiao Z,Rodriguez PQ,He L,Betsholtz C,Tryggvason K,Patrakka J

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
The Journal of clinical investigation121(10)3965-80(2011 Oct)
Yaddanapudi S,Altintas MM,Kistler AD,Fernandez I,M?ller CC,Wei C,Peev V,Flesche JB,Forst AL,Li J,Patrakka J,Xiao Z,Grahammer F,Schiffer M,Lohm?ller T,Reinheckel T,Gu C,Huber TB,Ju W,Bitzer M,Rastaldi MP,Ruiz P,Tryggvason K,Shaw AS,Faul C,Sever S,Reiser J

Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association23(8)2504-11(2008 Aug)
Dun?r F,Patrakka J,Xiao Z,Larsson J,Vlamis-Gardikas A,Pettersson E,Tryggvason K,Hultenby K,Wernerson A

Nephrin is involved in podocyte maturation but not survival during glomerular development.
Kidney international73(6)697-704(2008 Mar)
Don? SC,Takemoto M,He L,Sun Y,Hultenby K,Betsholtz C,Tryggvason K

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Ddn cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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