Cyp17a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyp17a1
Entrez Gene ID	13074
Full Name	cytochrome P450, family 17, subfamily a, polypeptide 1
Synonyms	Cyp17,p450c17
General protein information	Preferred Names cytochrome P450, family 17, subfamily a, polypeptide 1 Names steroid 17-alpha-hydroxylase/17,20 lyase 17-alpha-hydroxyprogesterone aldolase CYPXVII cytochrome P450 17A1 cytochrome P450, 17 cytochrome P450, 17a1 cytochrome P450-C17 cytochrome P450c17 steroid 17-alpha hydroxylase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 C3\|19 38.97 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007809.3	NP_031835.3	steroid 17-alpha-hydroxylase/17,20 lyase precursor

Pathways from BioSystems

Homologies

	CYP17A1	NP_001035322.1
Arabidopsis thaliana (thale cress)	CYP706A3	NP_199275.1
Canis lupus familiaris (dog)	CYP17A1	XP_535000.3
Arabidopsis thaliana (thale cress)	CYP706A4	NP_192967.1
Arabidopsis thaliana (thale cress)	CYP706A2	NP_194002.1
Homo sapiens (human)	CYP17A1	NP_000093.1
Bos taurus (cattle)	CYP17A1	NP_776729.1
Arabidopsis thaliana (thale cress)	CYP706A6	NP_192969.4
Arabidopsis thaliana (thale cress)	CYP706A5	NP_192968.3
Arabidopsis thaliana (thale cress)	CYP706A1	NP_567665.2
Mus musculus (house mouse)	Cyp17a1	NP_031835.3
Oryza sativa (rice)	Os08g0547900	NP_001062431.2
Pan troglodytes (chimpanzee)	CYP17A1	NP_001009052.1
Rattus norvegicus (Norway rat)	Cyp17a1	NP_036885.1
Arabidopsis thaliana (thale cress)	CYP706A7	NP_192970.1
Oryza sativa (rice)	Os01g0700500	NP_001043985.2

Gene Ontology
Bibliography

Related articles in PubMed

MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Shawki HH, Oishi H, Usui T, Kitadate Y, Basha WA, Abdellatif AM, Hasegawa K, Okada R, Mochida K, El-Shemy HA, Muratani M, Ogura A, Yoshida S, Takahashi S
PloS one13(1)e0190800(2018)

Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2.
Bagheri-Fam S, Bird AD, Zhao L, Ryan JM, Yong M, Wilhelm D, Koopman P, Eswarakumar VP, Harley VR
Endocrinology158(11)3832-3843(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

through mouse-to-human search and validation, we found that CYP17A1 is overexpressed in hepatocellular carcinomas and it has great potentiality as a noninvasive marker for hepatocellular carcinoma detection
Title: Transcriptome Analysis of WHV/c-myc Transgenic Mice Implicates Cytochrome P450 Enzyme 17A1 as a Promising Biomarker for Hepatocellular Carcinoma.

Demonstration of the physiologic importance of cytochrome b5 activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.
Title: Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.

TRalpha/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 transactivation on these promoters.
Title: Differential regulation of steroidogenic enzyme genes by TR? signaling in testicular Leydig cells.

ata indicate that androgen receptor (AR) regulation on Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Title: Androgen receptor binding sites identified in mouse testis.

Data suggest that immune-activation of testicular interstitial macrophages may cause inhibition of P450c17 gene expression in Leydig cells.
Title: The role of cytokines in the regulation of Leydig cell P450c17 gene expression.

The following Cyp17a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp17a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16756	NM_007809.3 Latest version!	Mus musculus cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyp17a1 ( NM_007809.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031835.3 Mus musculus cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), mRNA.

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CloneID	OMu16756
Clone ID Related Accession (Same CDS sequence)	NM_007809.3
Accession Version	NM_007809.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1524bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	steroid 17-alpha-hydroxylase/17,20 lyase precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD552634.1, M64863.1 and AK134376.1. On Nov 22, 2007 this sequence version replaced NM_007809.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132830.1, BC064793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGGAAC TTGTGGGTCT CTTGCTGCTC ATCCTGGCCT ATTTCTTTTG GCCCAAGTCA 
AAGACACCTA ATGCCAAGTT CCCCAGGAGC CTTCCATTCC TGCCCCTGGT GGGTAGTCTA 
CCGTTTCTCC CCAGACGTGG TCATATGCAT GCCAACTTCT TCAAGCTGCA GGAAAAGTAT 
GGTCCCATCT ATTCTCTTCG CCTGGGTACC ACAACTGCAG TGATTGTCGG TCACTATCAG 
CTGGCCAGAG AAGTGCTCGT GAAGAAGGGG AAAGAATTCT CTGGTCGGCC CCAGATGGTG 
ACTCTAGGCC TCTTGTCGGA CCAAGGAAAA GGCGTCGCCT TTGCGGATAG TAGTAGCTCC 
TGGCAGCTGC ACCGGAAGCT GGTATTCAGC ACCTTTTCCC TGTTCAGGGA TGACCAGAAA 
CTGGAGAAGA TGATATGTCA GGAAGCCAAC TCACTGTGTG ACTTGATACT TACATACGAC 
GGGGAGTCCC GAGATCTGTC TACGCTCATC TTCAAGTCAG TAATCAATAT CATCTGTACC 
ATCTGCTTCA ACATCTCTTT TGAGAACAAG GATCCGATAC TGACTACCAT ACAGACCTTT 
ACAGAGGGTA TTGTGGATGT CCTGGGCCAC AGCGATCTGG TGGACATATT CCCGTGGTTG 
AAGATTTTTC CCAATAAAAA CTTGGAAATG ATAAAGGAAC ACACTAAAAT TCGAGAAAAA 
ACACTGGTTG AAATGTTTGA AAAATGCAAG GAGAAATTCA ATAGTGAATC TCTCTCCAGC 
CTGACAGACA TTCTGATACA AGCCAAGATG AATGCAGAAA ATAATAACAC TGGGGAAGGC 
CAGGACCCAA GTGTGTTCTC AGATAAGCAT ATCCTTGTCA CGGTGGGAGA CATCTTTGGG 
GCAGGCATAG AGACAACTAG CTCTGTGCTG AACTGGATCC TGGCTTTCCT GGTGCACAAT 
CCTGAGGTGA AGAGGAAGAT CCAAAAGGAG ATTGACCAGT ATGTAGGCTT CAGTCGAACA 
CCGTCTTTCA ATGACCGGAC TCACCTCCTC ATGCTGGAGG CCACTATCCG AGAAGTGCTT 
CGTATCAGGC CGGTGGCCCC CTTGCTCATC CCACACAAGG CTAACATTGA CTCCAGCATT 
GGAGAGTTTG CCATCCCGAA GGACACACAT GTGATCATCA ATCTCTGGGC ACTGCATCAC 
GATAAAAATG AATGGGACCA GCCAGATCGG TTTATGCCTG AGCGCTTCTT AGATCCAACA 
GGAAGCCATC TCATTACACC CACACCCAGT TATTTGCCCT TCGGAGCTGG TCCCCGATCG 
TGCATTGGAG AGGCTCTGGC CCGGCAGGAG CTCTTTATCT TCATGGCCTT GCTGCTGCAG 
AGGTTTGACT TTGATGTGTC AGATGACAAA CAGCTGCCCT GTCTGGTGGG TGACCCCAAG 
GTGGTCTTTC TGATCGACCC TTTCAAAGTG AAAATCACAG TGCGACAAGC ATGGAAGGAT 
GCACAGGTTG AGGTTAGCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031835.3
CDS	158..1681
Translation	MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLPRRGHMHANFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTLGLLSDQGKGVAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYDGESRDLSTLIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFPWLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNNTGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKQLPCLVGDPKVVFLIDPFKVKITVRQAWKDAQVEVST

Target ORF information:

RefSeq Version	NM_007809.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007809.3

ORF Insert Sequence:

ATGTGGGAAC TTGTGGGTCT CTTGCTGCTC ATCCTGGCCT ATTTCTTTTG GCCCAAGTCA 
AAGACACCTA ATGCCAAGTT CCCCAGGAGC CTTCCATTCC TGCCCCTGGT GGGTAGTCTA 
CCGTTTCTCC CCAGACGTGG TCATATGCAT GCCAACTTCT TCAAGCTGCA GGAAAAGTAT 
GGTCCCATCT ATTCTCTTCG CCTGGGTACC ACAACTGCAG TGATTGTCGG TCACTATCAG 
CTGGCCAGAG AAGTGCTCGT GAAGAAGGGG AAAGAATTCT CTGGTCGGCC CCAGATGGTG 
ACTCTAGGCC TCTTGTCGGA CCAAGGAAAA GGCGTCGCCT TTGCGGATAG TAGTAGCTCC 
TGGCAGCTGC ACCGGAAGCT GGTATTCAGC ACCTTTTCCC TGTTCAGGGA TGACCAGAAA 
CTGGAGAAGA TGATATGTCA GGAAGCCAAC TCACTGTGTG ACTTGATACT TACATACGAC 
GGGGAGTCCC GAGATCTGTC TACGCTCATC TTCAAGTCAG TAATCAATAT CATCTGTACC 
ATCTGCTTCA ACATCTCTTT TGAGAACAAG GATCCGATAC TGACTACCAT ACAGACCTTT 
ACAGAGGGTA TTGTGGATGT CCTGGGCCAC AGCGATCTGG TGGACATATT CCCGTGGTTG 
AAGATTTTTC CCAATAAAAA CTTGGAAATG ATAAAGGAAC ACACTAAAAT TCGAGAAAAA 
ACACTGGTTG AAATGTTTGA AAAATGCAAG GAGAAATTCA ATAGTGAATC TCTCTCCAGC 
CTGACAGACA TTCTGATACA AGCCAAGATG AATGCAGAAA ATAATAACAC TGGGGAAGGC 
CAGGACCCAA GTGTGTTCTC AGATAAGCAT ATCCTTGTCA CGGTGGGAGA CATCTTTGGG 
GCAGGCATAG AGACAACTAG CTCTGTGCTG AACTGGATCC TGGCTTTCCT GGTGCACAAT 
CCTGAGGTGA AGAGGAAGAT CCAAAAGGAG ATTGACCAGT ATGTAGGCTT CAGTCGAACA 
CCGTCTTTCA ATGACCGGAC TCACCTCCTC ATGCTGGAGG CCACTATCCG AGAAGTGCTT 
CGTATCAGGC CGGTGGCCCC CTTGCTCATC CCACACAAGG CTAACATTGA CTCCAGCATT 
GGAGAGTTTG CCATCCCGAA GGACACACAT GTGATCATCA ATCTCTGGGC ACTGCATCAC 
GATAAAAATG AATGGGACCA GCCAGATCGG TTTATGCCTG AGCGCTTCTT AGATCCAACA 
GGAAGCCATC TCATTACACC CACACCCAGT TATTTGCCCT TCGGAGCTGG TCCCCGATCG 
TGCATTGGAG AGGCTCTGGC CCGGCAGGAG CTCTTTATCT TCATGGCCTT GCTGCTGCAG 
AGGTTTGACT TTGATGTGTC AGATGACAAA CAGCTGCCCT GTCTGGTGGG TGACCCCAAG 
GTGGTCTTTC TGATCGACCC TTTCAAAGTG AAAATCACAG TGCGACAAGC ATGGAAGGAT 
GCACAGGTTG AGGTTAGCAC CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
PloS one13(1)e0190800(2018)
Shawki HH,Oishi H,Usui T,Kitadate Y,Basha WA,Abdellatif AM,Hasegawa K,Okada R,Mochida K,El-Shemy HA,Muratani M,Ogura A,Yoshida S,Takahashi S

Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2.
Endocrinology158(11)3832-3843(2017 Nov)
Bagheri-Fam S,Bird AD,Zhao L,Ryan JM,Yong M,Wilhelm D,Koopman P,Eswarakumar VP,Harley VR

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Cyp17a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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