Cybb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cybb
Entrez Gene ID	13058
Full Name	cytochrome b-245, beta polypeptide
Synonyms	C88302,CGD91-phox,Cgd,Cyd,Nox2,gp91-1,gp91phox
General protein information	Preferred Names cytochrome b-245, beta polypeptide Names cytochrome b-245 heavy chain NADPH oxidase 2 cytochrome b558 subunit beta heme-binding membrane glycoprotein gp91phox neutrophil cytochrome b 91 kDa polypeptide p22 phagocyte B-cytochrome
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X A1.1
Summary	This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006527565.3	XP_006527628.1	cytochrome b-245 heavy chain isoform X1
XM_006527565.2	XP_006527628.1	cytochrome b-245 heavy chain isoform X1
NM_007807.5	NP_031833.3	cytochrome b-245 heavy chain

Pathways from BioSystems

Homologies

Homo sapiens (human)	CYBB	NP_000388.2
Bos taurus (cattle)	CYBB	NP_776460.1
Danio rerio (zebrafish)	cybb	NP_956708.1
Canis lupus familiaris (dog)	CYBB	NP_001093761.1
Gallus gallus (chicken)	CYBB	NP_001093756.1
Arabidopsis thaliana (thale cress)	AT1G19230	NP_173357.1
Oryza sativa (rice)	Os08g0453700	NP_001061956.1
Pan troglodytes (chimpanzee)	LOC465566	XP_521002.2
	CYBB	XP_001083654.1
Rattus norvegicus (Norway rat)	Cybb	NP_076455.1
Magnaporthe oryzae (rice blast fungus)	MGG_06559	XP_003716981.1
Mus musculus (house mouse)	Cybb	NP_031833.3
Neurospora crassa	NCU10775	XP_001728356.1
Oryza sativa (rice)	Os09g0438000	NP_001063267.1
Xenopus tropicalis (tropical clawed frog)	cybb	NP_001025689.1

Gene Ontology
Bibliography

Related articles in PubMed

NOX2?: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages.
Harrison CB, Selemidis S, Guida E, King PT, Sobey CG, Drummond GR
PloS one7(10)e48326(2012)

The many roles of NOX2 NADPH oxidase-derived ROS in immunity.
Lam GY, Huang J, Brumell JH
Seminars in immunopathology32(4)415-30(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mice deficient in reactive oxygen species production by NOX2 due to the absence of the gp91 subunit had significantly more severe pathology in the later stages of infection with Leishmania amazonensis
Title: NOX2-Derived Reactive Oxygen Species Control Inflammation during

These data suggest that endothelial SHIP2 is required to maintain normal systemic glucose homeostasis and prevent oxidative stress-induced endothelial dysfunction.
Title: Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.

Acute myeloid leukemia cells -derived NOX2 drives transfer of mitochondria via the generation of superoxide.
Title: NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

Virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.
Title: Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

NOX2 signaling in macrophages participates in the pathogenesis of obesity, and reinforce a key role for macrophage inflammation in diet-induced metabolic and neurologic decline
Title: Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet.

The following Cybb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cybb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19798	NM_007807.5 Latest version!	Mus musculus cytochrome b-245, beta polypeptide (Cybb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OMu19798	XM_006527565.3 Latest version!	Mus musculus cytochrome b-245, beta polypeptide (Cybb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
View Old Accession Versions >>
OMu19798	XM_006527565.2	Mus musculus cytochrome b-245, beta polypeptide (Cybb), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cybb ( NM_007807.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031833.3 Mus musculus cytochrome b-245, beta polypeptide (Cybb), mRNA.

Price & Availability↑

CloneID	OMu19798
Clone ID Related Accession (Same CDS sequence)	XM_006527565.3 , XM_006527565.2 , NM_007807.5
Accession Version	NM_007807.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	cytochrome b-245 heavy chain
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY194282.1, AK152257.1 and AL671864.6. On May 31, 2013 this sequence version replaced NM_007807.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042838.1, AK033570.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAACT GGGCTGTGAA TGAAGGACTC TCCATCTTTG TCATTCTGGT GTGGTTGGGG 
CTGAATGTCT TCCTCTTTAT CAACTACTAC AAGGTTTATG ATGATGGGCC TAAGTATAAT 
TATACTCGAA AACTCCTTGG GTCAGCACTG GCTCTGGCCC GGGCACCTGC AGCCTGCCTG 
AATTTCAACT GTATGCTGAT CCTGCTGCCA GTGTGTCGAA ATCTGCTCTC CTTTCTCAGG 
GGTTCCAGTG CGTGTTGCTC GACAAGGATT CGAAGACAAC TGGACAGGAA CCTCACTTTC 
CATAAGATGG TAGCTTGGAT GATAGCACTG CACACCGCCA TCCACACAAT TGCACATCTC 
TTCAACGTTG AGTGGTGTGT GAATGCCAGA GTCGGGATTT CTGACCGGTA TTCAATAGCT 
CTCTCTGACA TCGGTGACAA TGAGAACGAA GAGTATCTCA ATTTTGCTAG AGAAAAAATC 
AAGAACCCTG AAGGGGGCCT GTATGTGGCC GTGACTCGGT TGGCTGGGAT CACAGGAATT 
GTCATCACAC TGTGTCTCAT ATTGATTATC ACATCCTCTA CCAAAACCAT TCGGAGGTCT 
TATTTTGAAG TGTTCTGGTA TACACACCAT CTCTTTGTGA TCTTCTTCAT CGGCCTTGCC 
ATCCATGGAG CTGAACGAAT TGTACGTGGA CAGACTGCGG AGAGTTTGGA AGAGCATAAT 
TTAGATATCT GTGCAGACAA AATCGAAGAA TGGGGAAAAA TAAAGGAGTG CCCAGTACCA 
AAGTTCGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCTAT GTTCCTGTAC 
CTTTGTGAGA GGTTGGTTCG GTTTTGGCGA TCTCAGCAAA AGGTGGTCAT CACCAAGGTG 
GTCACCCACC CTTTCAAAAC CATTGAGCTT CAGATGAAGA AGAAGGGATT CAAGATGGAG 
GTGGGACAGT ACATTTTTGT CAAGTGCCCC AAGGTATCCA AGTTAGAATG GCACCCATTC 
ACACTGACCT CTGCTCCTGA GGAAGACTTT TTTAGCATCC ATATCCGTAT TGTGGGAGAC 
TGGACGGAGG GGCTATTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTCCA AGATGCCTGG 
AAACTACCTA AGATAGCAGT TGATGGACCC TTTGGTACAG CCAGTGAAGA TGTGTTCAGC 
TATGAGGTGG TGATGTTAGT GGGAGCCGGG ATTGGAGTCA CGCCCTTTGC CTCCATTCTC 
AAGTCTGTCT GGTACAAATA TTGTGATAAT GCCACCAGTC TGAAACTCAA AAAGATCTAC 
TTCTACTGGC TGTGCAGGGA CACGCATGCC TTTGAGTGGT TTGCAGACCT GCTGCAGCTG 
CTGGAGACCC AGATGCAGGA AAGGAACAAT GCCAACTTCC TCAGCTACAA TATCTACCTT 
ACTGGCTGGG ATGAATCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT 
GTGATCACAG GCCTAAAACA GAAGACTCTG TATGGACGGC CCAACTGGGA TAACGAGTTC 
AAGACCATTG CAAGTGAACA CCCTAACACC ACAATAGGCG TTTTCCTGTG TGGCCCTGAA 
GCCTTGGCTG AAACTCTCAG TAAACAGAGC ATCTCCAACT CAGAATCCGG CCCGCGTGGA 
GTCCACTTCA TTTTCAACAA GGAAAACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031833.3
CDS	75..1787
Translation	MGNWAVNEGLSIFVILVWLGLNVFLFINYYKVYDDGPKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGISDRYSIALSDIGDNENEEYLNFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLEEHNLDICADKIEEWGKIKECPVPKFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERNNANFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHPNTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

Target ORF information:

RefSeq Version	NM_007807.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome b-245, beta polypeptide (Cybb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007807.5

ORF Insert Sequence:

ATGGGGAACT GGGCTGTGAA TGAAGGACTC TCCATCTTTG TCATTCTGGT GTGGTTGGGG 
CTGAATGTCT TCCTCTTTAT CAACTACTAC AAGGTTTATG ATGATGGGCC TAAGTATAAT 
TATACTCGAA AACTCCTTGG GTCAGCACTG GCTCTGGCCC GGGCACCTGC AGCCTGCCTG 
AATTTCAACT GTATGCTGAT CCTGCTGCCA GTGTGTCGAA ATCTGCTCTC CTTTCTCAGG 
GGTTCCAGTG CGTGTTGCTC GACAAGGATT CGAAGACAAC TGGACAGGAA CCTCACTTTC 
CATAAGATGG TAGCTTGGAT GATAGCACTG CACACCGCCA TCCACACAAT TGCACATCTC 
TTCAACGTTG AGTGGTGTGT GAATGCCAGA GTCGGGATTT CTGACCGGTA TTCAATAGCT 
CTCTCTGACA TCGGTGACAA TGAGAACGAA GAGTATCTCA ATTTTGCTAG AGAAAAAATC 
AAGAACCCTG AAGGGGGCCT GTATGTGGCC GTGACTCGGT TGGCTGGGAT CACAGGAATT 
GTCATCACAC TGTGTCTCAT ATTGATTATC ACATCCTCTA CCAAAACCAT TCGGAGGTCT 
TATTTTGAAG TGTTCTGGTA TACACACCAT CTCTTTGTGA TCTTCTTCAT CGGCCTTGCC 
ATCCATGGAG CTGAACGAAT TGTACGTGGA CAGACTGCGG AGAGTTTGGA AGAGCATAAT 
TTAGATATCT GTGCAGACAA AATCGAAGAA TGGGGAAAAA TAAAGGAGTG CCCAGTACCA 
AAGTTCGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCTAT GTTCCTGTAC 
CTTTGTGAGA GGTTGGTTCG GTTTTGGCGA TCTCAGCAAA AGGTGGTCAT CACCAAGGTG 
GTCACCCACC CTTTCAAAAC CATTGAGCTT CAGATGAAGA AGAAGGGATT CAAGATGGAG 
GTGGGACAGT ACATTTTTGT CAAGTGCCCC AAGGTATCCA AGTTAGAATG GCACCCATTC 
ACACTGACCT CTGCTCCTGA GGAAGACTTT TTTAGCATCC ATATCCGTAT TGTGGGAGAC 
TGGACGGAGG GGCTATTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTCCA AGATGCCTGG 
AAACTACCTA AGATAGCAGT TGATGGACCC TTTGGTACAG CCAGTGAAGA TGTGTTCAGC 
TATGAGGTGG TGATGTTAGT GGGAGCCGGG ATTGGAGTCA CGCCCTTTGC CTCCATTCTC 
AAGTCTGTCT GGTACAAATA TTGTGATAAT GCCACCAGTC TGAAACTCAA AAAGATCTAC 
TTCTACTGGC TGTGCAGGGA CACGCATGCC TTTGAGTGGT TTGCAGACCT GCTGCAGCTG 
CTGGAGACCC AGATGCAGGA AAGGAACAAT GCCAACTTCC TCAGCTACAA TATCTACCTT 
ACTGGCTGGG ATGAATCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT 
GTGATCACAG GCCTAAAACA GAAGACTCTG TATGGACGGC CCAACTGGGA TAACGAGTTC 
AAGACCATTG CAAGTGAACA CCCTAACACC ACAATAGGCG TTTTCCTGTG TGGCCCTGAA 
GCCTTGGCTG AAACTCTCAG TAAACAGAGC ATCTCCAACT CAGAATCCGG CCCGCGTGGA 
GTCCACTTCA TTTTCAACAA GGAAAACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cybb ( XM_006527565.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006527628.1 Mus musculus cytochrome b-245, beta polypeptide (Cybb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19798
Clone ID Related Accession (Same CDS sequence)	XM_006527565.3 , XM_006527565.2 , NM_007807.5
Accession Version	XM_006527565.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	cytochrome b-245 heavy chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006527565.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGAACT GGGCTGTGAA TGAAGGACTC TCCATCTTTG TCATTCTGGT GTGGTTGGGG 
CTGAATGTCT TCCTCTTTAT CAACTACTAC AAGGTTTATG ATGATGGGCC TAAGTATAAT 
TATACTCGAA AACTCCTTGG GTCAGCACTG GCTCTGGCCC GGGCACCTGC AGCCTGCCTG 
AATTTCAACT GTATGCTGAT CCTGCTGCCA GTGTGTCGAA ATCTGCTCTC CTTTCTCAGG 
GGTTCCAGTG CGTGTTGCTC GACAAGGATT CGAAGACAAC TGGACAGGAA CCTCACTTTC 
CATAAGATGG TAGCTTGGAT GATAGCACTG CACACCGCCA TCCACACAAT TGCACATCTC 
TTCAACGTTG AGTGGTGTGT GAATGCCAGA GTCGGGATTT CTGACCGGTA TTCAATAGCT 
CTCTCTGACA TCGGTGACAA TGAGAACGAA GAGTATCTCA ATTTTGCTAG AGAAAAAATC 
AAGAACCCTG AAGGGGGCCT GTATGTGGCC GTGACTCGGT TGGCTGGGAT CACAGGAATT 
GTCATCACAC TGTGTCTCAT ATTGATTATC ACATCCTCTA CCAAAACCAT TCGGAGGTCT 
TATTTTGAAG TGTTCTGGTA TACACACCAT CTCTTTGTGA TCTTCTTCAT CGGCCTTGCC 
ATCCATGGAG CTGAACGAAT TGTACGTGGA CAGACTGCGG AGAGTTTGGA AGAGCATAAT 
TTAGATATCT GTGCAGACAA AATCGAAGAA TGGGGAAAAA TAAAGGAGTG CCCAGTACCA 
AAGTTCGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCTAT GTTCCTGTAC 
CTTTGTGAGA GGTTGGTTCG GTTTTGGCGA TCTCAGCAAA AGGTGGTCAT CACCAAGGTG 
GTCACCCACC CTTTCAAAAC CATTGAGCTT CAGATGAAGA AGAAGGGATT CAAGATGGAG 
GTGGGACAGT ACATTTTTGT CAAGTGCCCC AAGGTATCCA AGTTAGAATG GCACCCATTC 
ACACTGACCT CTGCTCCTGA GGAAGACTTT TTTAGCATCC ATATCCGTAT TGTGGGAGAC 
TGGACGGAGG GGCTATTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTCCA AGATGCCTGG 
AAACTACCTA AGATAGCAGT TGATGGACCC TTTGGTACAG CCAGTGAAGA TGTGTTCAGC 
TATGAGGTGG TGATGTTAGT GGGAGCCGGG ATTGGAGTCA CGCCCTTTGC CTCCATTCTC 
AAGTCTGTCT GGTACAAATA TTGTGATAAT GCCACCAGTC TGAAACTCAA AAAGATCTAC 
TTCTACTGGC TGTGCAGGGA CACGCATGCC TTTGAGTGGT TTGCAGACCT GCTGCAGCTG 
CTGGAGACCC AGATGCAGGA AAGGAACAAT GCCAACTTCC TCAGCTACAA TATCTACCTT 
ACTGGCTGGG ATGAATCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT 
GTGATCACAG GCCTAAAACA GAAGACTCTG TATGGACGGC CCAACTGGGA TAACGAGTTC 
AAGACCATTG CAAGTGAACA CCCTAACACC ACAATAGGCG TTTTCCTGTG TGGCCCTGAA 
GCCTTGGCTG AAACTCTCAG TAAACAGAGC ATCTCCAACT CAGAATCCGG CCCGCGTGGA 
GTCCACTTCA TTTTCAACAA GGAAAACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006527628.1
CDS	107..1819
Translation	MGNWAVNEGLSIFVILVWLGLNVFLFINYYKVYDDGPKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGISDRYSIALSDIGDNENEEYLNFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLEEHNLDICADKIEEWGKIKECPVPKFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERNNANFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHPNTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

Target ORF information:

RefSeq Version	XM_006527565.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome b-245, beta polypeptide (Cybb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006527565.3

ORF Insert Sequence:

ATGGGGAACT GGGCTGTGAA TGAAGGACTC TCCATCTTTG TCATTCTGGT GTGGTTGGGG 
CTGAATGTCT TCCTCTTTAT CAACTACTAC AAGGTTTATG ATGATGGGCC TAAGTATAAT 
TATACTCGAA AACTCCTTGG GTCAGCACTG GCTCTGGCCC GGGCACCTGC AGCCTGCCTG 
AATTTCAACT GTATGCTGAT CCTGCTGCCA GTGTGTCGAA ATCTGCTCTC CTTTCTCAGG 
GGTTCCAGTG CGTGTTGCTC GACAAGGATT CGAAGACAAC TGGACAGGAA CCTCACTTTC 
CATAAGATGG TAGCTTGGAT GATAGCACTG CACACCGCCA TCCACACAAT TGCACATCTC 
TTCAACGTTG AGTGGTGTGT GAATGCCAGA GTCGGGATTT CTGACCGGTA TTCAATAGCT 
CTCTCTGACA TCGGTGACAA TGAGAACGAA GAGTATCTCA ATTTTGCTAG AGAAAAAATC 
AAGAACCCTG AAGGGGGCCT GTATGTGGCC GTGACTCGGT TGGCTGGGAT CACAGGAATT 
GTCATCACAC TGTGTCTCAT ATTGATTATC ACATCCTCTA CCAAAACCAT TCGGAGGTCT 
TATTTTGAAG TGTTCTGGTA TACACACCAT CTCTTTGTGA TCTTCTTCAT CGGCCTTGCC 
ATCCATGGAG CTGAACGAAT TGTACGTGGA CAGACTGCGG AGAGTTTGGA AGAGCATAAT 
TTAGATATCT GTGCAGACAA AATCGAAGAA TGGGGAAAAA TAAAGGAGTG CCCAGTACCA 
AAGTTCGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCTAT GTTCCTGTAC 
CTTTGTGAGA GGTTGGTTCG GTTTTGGCGA TCTCAGCAAA AGGTGGTCAT CACCAAGGTG 
GTCACCCACC CTTTCAAAAC CATTGAGCTT CAGATGAAGA AGAAGGGATT CAAGATGGAG 
GTGGGACAGT ACATTTTTGT CAAGTGCCCC AAGGTATCCA AGTTAGAATG GCACCCATTC 
ACACTGACCT CTGCTCCTGA GGAAGACTTT TTTAGCATCC ATATCCGTAT TGTGGGAGAC 
TGGACGGAGG GGCTATTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTCCA AGATGCCTGG 
AAACTACCTA AGATAGCAGT TGATGGACCC TTTGGTACAG CCAGTGAAGA TGTGTTCAGC 
TATGAGGTGG TGATGTTAGT GGGAGCCGGG ATTGGAGTCA CGCCCTTTGC CTCCATTCTC 
AAGTCTGTCT GGTACAAATA TTGTGATAAT GCCACCAGTC TGAAACTCAA AAAGATCTAC 
TTCTACTGGC TGTGCAGGGA CACGCATGCC TTTGAGTGGT TTGCAGACCT GCTGCAGCTG 
CTGGAGACCC AGATGCAGGA AAGGAACAAT GCCAACTTCC TCAGCTACAA TATCTACCTT 
ACTGGCTGGG ATGAATCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT 
GTGATCACAG GCCTAAAACA GAAGACTCTG TATGGACGGC CCAACTGGGA TAACGAGTTC 
AAGACCATTG CAAGTGAACA CCCTAACACC ACAATAGGCG TTTTCCTGTG TGGCCCTGAA 
GCCTTGGCTG AAACTCTCAG TAAACAGAGC ATCTCCAACT CAGAATCCGG CCCGCGTGGA 
GTCCACTTCA TTTTCAACAA GGAAAACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cybb ( XM_006527565.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006527628.1 Mus musculus cytochrome b-245, beta polypeptide (Cybb), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19798
Clone ID Related Accession (Same CDS sequence)	XM_006527565.3 , XM_006527565.2 , NM_007807.5
Accession Version	XM_006527565.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	cytochrome b-245 heavy chain isoform X1
Comment

ATGGGGAACT GGGCTGTGAA TGAAGGACTC TCCATCTTTG TCATTCTGGT GTGGTTGGGG 
CTGAATGTCT TCCTCTTTAT CAACTACTAC AAGGTTTATG ATGATGGGCC TAAGTATAAT 
TATACTCGAA AACTCCTTGG GTCAGCACTG GCTCTGGCCC GGGCACCTGC AGCCTGCCTG 
AATTTCAACT GTATGCTGAT CCTGCTGCCA GTGTGTCGAA ATCTGCTCTC CTTTCTCAGG 
GGTTCCAGTG CGTGTTGCTC GACAAGGATT CGAAGACAAC TGGACAGGAA CCTCACTTTC 
CATAAGATGG TAGCTTGGAT GATAGCACTG CACACCGCCA TCCACACAAT TGCACATCTC 
TTCAACGTTG AGTGGTGTGT GAATGCCAGA GTCGGGATTT CTGACCGGTA TTCAATAGCT 
CTCTCTGACA TCGGTGACAA TGAGAACGAA GAGTATCTCA ATTTTGCTAG AGAAAAAATC 
AAGAACCCTG AAGGGGGCCT GTATGTGGCC GTGACTCGGT TGGCTGGGAT CACAGGAATT 
GTCATCACAC TGTGTCTCAT ATTGATTATC ACATCCTCTA CCAAAACCAT TCGGAGGTCT 
TATTTTGAAG TGTTCTGGTA TACACACCAT CTCTTTGTGA TCTTCTTCAT CGGCCTTGCC 
ATCCATGGAG CTGAACGAAT TGTACGTGGA CAGACTGCGG AGAGTTTGGA AGAGCATAAT 
TTAGATATCT GTGCAGACAA AATCGAAGAA TGGGGAAAAA TAAAGGAGTG CCCAGTACCA 
AAGTTCGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCTAT GTTCCTGTAC 
CTTTGTGAGA GGTTGGTTCG GTTTTGGCGA TCTCAGCAAA AGGTGGTCAT CACCAAGGTG 
GTCACCCACC CTTTCAAAAC CATTGAGCTT CAGATGAAGA AGAAGGGATT CAAGATGGAG 
GTGGGACAGT ACATTTTTGT CAAGTGCCCC AAGGTATCCA AGTTAGAATG GCACCCATTC 
ACACTGACCT CTGCTCCTGA GGAAGACTTT TTTAGCATCC ATATCCGTAT TGTGGGAGAC 
TGGACGGAGG GGCTATTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTCCA AGATGCCTGG 
AAACTACCTA AGATAGCAGT TGATGGACCC TTTGGTACAG CCAGTGAAGA TGTGTTCAGC 
TATGAGGTGG TGATGTTAGT GGGAGCCGGG ATTGGAGTCA CGCCCTTTGC CTCCATTCTC 
AAGTCTGTCT GGTACAAATA TTGTGATAAT GCCACCAGTC TGAAACTCAA AAAGATCTAC 
TTCTACTGGC TGTGCAGGGA CACGCATGCC TTTGAGTGGT TTGCAGACCT GCTGCAGCTG 
CTGGAGACCC AGATGCAGGA AAGGAACAAT GCCAACTTCC TCAGCTACAA TATCTACCTT 
ACTGGCTGGG ATGAATCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT 
GTGATCACAG GCCTAAAACA GAAGACTCTG TATGGACGGC CCAACTGGGA TAACGAGTTC 
AAGACCATTG CAAGTGAACA CCCTAACACC ACAATAGGCG TTTTCCTGTG TGGCCCTGAA 
GCCTTGGCTG AAACTCTCAG TAAACAGAGC ATCTCCAACT CAGAATCCGG CCCGCGTGGA 
GTCCACTTCA TTTTCAACAA GGAAAACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_006527628.1

Translation

MGNWAVNEGLSIFVILVWLGLNVFLFINYYKVYDDGPKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRIRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGISDRYSIALSDIGDNENEEYLNFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLEEHNLDICADKIEEWGKIKECPVPKFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCDNATSLKLKKIYFYWLCRDTHAFEWFADLLQLLETQMQERNNANFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASEHPNTTIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

Target ORF information:

RefSeq Version	XM_006527565.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus cytochrome b-245, beta polypeptide (Cybb), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006527565.2

ORF Insert Sequence:

ATGGGGAACT GGGCTGTGAA TGAAGGACTC TCCATCTTTG TCATTCTGGT GTGGTTGGGG 
CTGAATGTCT TCCTCTTTAT CAACTACTAC AAGGTTTATG ATGATGGGCC TAAGTATAAT 
TATACTCGAA AACTCCTTGG GTCAGCACTG GCTCTGGCCC GGGCACCTGC AGCCTGCCTG 
AATTTCAACT GTATGCTGAT CCTGCTGCCA GTGTGTCGAA ATCTGCTCTC CTTTCTCAGG 
GGTTCCAGTG CGTGTTGCTC GACAAGGATT CGAAGACAAC TGGACAGGAA CCTCACTTTC 
CATAAGATGG TAGCTTGGAT GATAGCACTG CACACCGCCA TCCACACAAT TGCACATCTC 
TTCAACGTTG AGTGGTGTGT GAATGCCAGA GTCGGGATTT CTGACCGGTA TTCAATAGCT 
CTCTCTGACA TCGGTGACAA TGAGAACGAA GAGTATCTCA ATTTTGCTAG AGAAAAAATC 
AAGAACCCTG AAGGGGGCCT GTATGTGGCC GTGACTCGGT TGGCTGGGAT CACAGGAATT 
GTCATCACAC TGTGTCTCAT ATTGATTATC ACATCCTCTA CCAAAACCAT TCGGAGGTCT 
TATTTTGAAG TGTTCTGGTA TACACACCAT CTCTTTGTGA TCTTCTTCAT CGGCCTTGCC 
ATCCATGGAG CTGAACGAAT TGTACGTGGA CAGACTGCGG AGAGTTTGGA AGAGCATAAT 
TTAGATATCT GTGCAGACAA AATCGAAGAA TGGGGAAAAA TAAAGGAGTG CCCAGTACCA 
AAGTTCGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCTAT GTTCCTGTAC 
CTTTGTGAGA GGTTGGTTCG GTTTTGGCGA TCTCAGCAAA AGGTGGTCAT CACCAAGGTG 
GTCACCCACC CTTTCAAAAC CATTGAGCTT CAGATGAAGA AGAAGGGATT CAAGATGGAG 
GTGGGACAGT ACATTTTTGT CAAGTGCCCC AAGGTATCCA AGTTAGAATG GCACCCATTC 
ACACTGACCT CTGCTCCTGA GGAAGACTTT TTTAGCATCC ATATCCGTAT TGTGGGAGAC 
TGGACGGAGG GGCTATTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTCCA AGATGCCTGG 
AAACTACCTA AGATAGCAGT TGATGGACCC TTTGGTACAG CCAGTGAAGA TGTGTTCAGC 
TATGAGGTGG TGATGTTAGT GGGAGCCGGG ATTGGAGTCA CGCCCTTTGC CTCCATTCTC 
AAGTCTGTCT GGTACAAATA TTGTGATAAT GCCACCAGTC TGAAACTCAA AAAGATCTAC 
TTCTACTGGC TGTGCAGGGA CACGCATGCC TTTGAGTGGT TTGCAGACCT GCTGCAGCTG 
CTGGAGACCC AGATGCAGGA AAGGAACAAT GCCAACTTCC TCAGCTACAA TATCTACCTT 
ACTGGCTGGG ATGAATCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT 
GTGATCACAG GCCTAAAACA GAAGACTCTG TATGGACGGC CCAACTGGGA TAACGAGTTC 
AAGACCATTG CAAGTGAACA CCCTAACACC ACAATAGGCG TTTTCCTGTG TGGCCCTGAA 
GCCTTGGCTG AAACTCTCAG TAAACAGAGC ATCTCCAACT CAGAATCCGG CCCGCGTGGA 
GTCCACTTCA TTTTCAACAA GGAAAACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NOX2?: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages.
PloS one7(10)e48326(2012)
Harrison CB,Selemidis S,Guida E,King PT,Sobey CG,Drummond GR

The many roles of NOX2 NADPH oxidase-derived ROS in immunity.
Seminars in immunopathology32(4)415-30(2010 Dec)
Lam GY,Huang J,Brumell JH

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Cybb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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