Cpox cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cpox
Entrez Gene ID	12892
Full Name	coproporphyrinogen oxidase
Synonyms	CPX,Cpo,HCP,cac,nct
General protein information	Preferred Names coproporphyrinogen oxidase Names oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial COX Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX) clone 560 coprogen oxidase coproporphyrinogen-III oxidase, mitochondrial coproporphyrinogenase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C1.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_007757.2	NP_031783.2	oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CPOX	NP_000088.3
Rattus norvegicus (Norway rat)	Cpox	NP_001032172.1
Kluyveromyces lactis	KLLA0F18546g	XP_455911.1
Eremothecium gossypii	AGOS_AGR030C	NP_986695.1
Xenopus tropicalis (tropical clawed frog)	cpox	XP_002933115.1
	CPOX	XP_001088605.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004749	XP_318069.4
Saccharomyces cerevisiae (baker's yeast)	HEM13	NP_010329.1
Magnaporthe oryzae (rice blast fungus)	MGG_01061	XP_003717878.1
Gallus gallus (chicken)	CPOX	XP_416596.1
Neurospora crassa	NCU01546	XP_956249.2
Arabidopsis thaliana (thale cress)	LIN2	NP_171847.4
Oryza sativa (rice)	Os04g0610800	NP_001053833.1
Bos taurus (cattle)	CPOX	NP_001179322.1
Mus musculus (house mouse)	Cpox	NP_031783.2
Drosophila melanogaster (fruit fly)	Coprox	NP_524777.1
Schizosaccharomyces pombe (fission yeast)	hem13	NP_593150.1
Pan troglodytes (chimpanzee)	CPOX	XP_516615.2
Danio rerio (zebrafish)	cpox	NP_001035183.2

Gene Ontology
Bibliography

Related articles in PubMed

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.
Conway AJ, Brown FC, Fullinfaw RO, Kile BT, Jane SM, Curtis DJ
Disease models & mechanisms10(8)1005-1013(2017 Aug)

A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.
Shoji H, Kiniwa Y, Okuyama R, Yang M, Higuchi K, Mori M
Experimental animals64(2)171-9(2015)

Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.
Mori M, Gotoh S, Taketani S, Hiai H, Higuchi K
Experimental eye research11245-50(2013 Jul)

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.
Tallack MR, Whitington T, Yuen WS, Wainwright EN, Keys JR, Gardiner BB, Nourbakhsh E, Cloonan N, Grimmond SM, Bailey TL, Perkins AC
Genome research20(8)1052-63(2010 Aug)

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.
Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK
Proceedings of the National Academy of Sciences of the United States of America107(2)832-7(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The mechanisms by which impairment of CPOX leads to lens opacity in the NCT are elusive. However, our data illuminate a hitherto unanticipated involvement of the heme biosynthesis pathway in lens physiology.
Title: Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.

The following Cpox gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cpox cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18599	NM_007757.2 Latest version!	Mus musculus coproporphyrinogen oxidase (Cpox), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cpox ( NM_007757.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031783.2 Mus musculus coproporphyrinogen oxidase (Cpox), mRNA.

Price & Availability↑

CloneID	OMu18599
Clone ID Related Accession (Same CDS sequence)	NM_007757.2
Accession Version	NM_007757.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ142773.1, BY728426.1, CA535096.1, D16333.1 and AC159200.2. On Dec 1, 2007 this sequence version replaced NM_007757.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D16333.1, BC017680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTTGC GGCTGGGCCG CCTGGGTTCG GACCCCTGGT GGCGAGCGGT GCTGGGCGAC 
TATGCTCAGC TGCGCGCCGC GTCCCCGCGC TGCGCGTCCG CCCGCGTCTG CCAGCTGCCT 
GGCACGGCTG GTCCCCAGCC TCGCCGCGGG CTGGGCTACG GCCCCTGGGC TAGAGGCGGG 
TCCGGGCTGG GGACCCGGCT GGCCGCGACG CTGGCGGGGT TGGCAGGGCT GGCAGCCGCC 
GCCTTTGGGC ACGTGCAGCG GGCGGAGATG GTGCCCAAGA GCTCGGGGGC GCGGAGCCCC 
TCACCTGGAC GGCGGGAGGA GGACGGGGAC GAGCTGGCCC GCCGCTGCAG CACCTTCATG 
TCCTCGCCGG TGACCGAGCT GCGGGAGCTG CGGAGGAGGC CGGAGGACAT GAAGACCAAG 
ATGGAGCTGA TGATTATGGA GACCCAGGCT CAGGTGTGTC GGGCACTGGC GCAGGTAGAT 
GGCGTTGCCG ACTTCACTGT GGACCGGTGG GAGAGGAAAG AAGGAGGAGG TGGCATCACC 
TGTGTGCTTC AGGACGGGCG TGTGTTTGAA AAGGCCGGGG TGAGCATTTC CGTCGTTCAT 
GGGAATCTTT CTGAGGAAGC AGCGAACCAA ATGAGAGGCA GAGGCAAAAC TCTGAAGACG 
AAAGATAGTA AATTGCCATT TACTGCTATG GGTGTAAGTT CTGTGATTCA CCCCAAGAAT 
CCTTATGCGC CCACCATGCA TTTCAACTAC AGATACTTTG AAGTAGAGGA AGCTGACGGT 
AACACACACT GGTGGTTTGG GGGTGGCTGT GACCTCACAC CGACATACTT GAACCAAGAG 
GATGCTGTCC ATTTCCACCG TACTCTAAAG GAAGCTTGCG ATCAGCATGG GCCAGACATC 
TACCCAAAGT TTAAAAAATG GTGTGACGAC TACTTCTTTA TAGTTCACCG CGGGGAGCGG 
AGGGGCATCG GCGGCATCTT TTTTGACGAT CTTGACTCCC CCTCCAAGGA GGAGGCTTTC 
CGCTTCGTGA AGACGTGTGC TGAGGCTGTG GTCCCTTCCT ATGTTCCCAT TGTGAAGAAG 
CACTGCGATG ACTCCTACAC CCCCAGGGAC AAGCTGTGGC AGCAGCTGAG GAGAGGGCGG 
TATGTGGAGT TTAATCTGTT GTATGATCGG GGCACCAAGT TTGGCCTCTT TACTCCAGGA 
TCCAGGATCG AAAGTATCTT GATGTCTTTA CCTCTAACAG CAAGATGGGA GTACATGCAT 
TCTCCCCCAG AGAATTCCAA AGAAGCTGAA ATTCTGGAAG TGTTGCGCCA TCCAAAGGAC 
TGGGTGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031783.2
CDS	221..1552
Translation	MALRLGRLGSDPWWRAVLGDYAQLRAASPRCASARVCQLPGTAGPQPRRGLGYGPWARGGSGLGTRLAATLAGLAGLAAAAFGHVQRAEMVPKSSGARSPSPGRREEDGDELARRCSTFMSSPVTELRELRRRPEDMKTKMELMIMETQAQVCRALAQVDGVADFTVDRWERKEGGGGITCVLQDGRVFEKAGVSISVVHGNLSEEAANQMRGRGKTLKTKDSKLPFTAMGVSSVIHPKNPYAPTMHFNYRYFEVEEADGNTHWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIVHRGERRGIGGIFFDDLDSPSKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPRDKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWVH

Target ORF information:

RefSeq Version	NM_007757.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus coproporphyrinogen oxidase (Cpox), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007757.2

ORF Insert Sequence:

ATGGCCTTGC GGCTGGGCCG CCTGGGTTCG GACCCCTGGT GGCGAGCGGT GCTGGGCGAC 
TATGCTCAGC TGCGCGCCGC GTCCCCGCGC TGCGCGTCCG CCCGCGTCTG CCAGCTGCCT 
GGCACGGCTG GTCCCCAGCC TCGCCGCGGG CTGGGCTACG GCCCCTGGGC TAGAGGCGGG 
TCCGGGCTGG GGACCCGGCT GGCCGCGACG CTGGCGGGGT TGGCAGGGCT GGCAGCCGCC 
GCCTTTGGGC ACGTGCAGCG GGCGGAGATG GTGCCCAAGA GCTCGGGGGC GCGGAGCCCC 
TCACCTGGAC GGCGGGAGGA GGACGGGGAC GAGCTGGCCC GCCGCTGCAG CACCTTCATG 
TCCTCGCCGG TGACCGAGCT GCGGGAGCTG CGGAGGAGGC CGGAGGACAT GAAGACCAAG 
ATGGAGCTGA TGATTATGGA GACCCAGGCT CAGGTGTGTC GGGCACTGGC GCAGGTAGAT 
GGCGTTGCCG ACTTCACTGT GGACCGGTGG GAGAGGAAAG AAGGAGGAGG TGGCATCACC 
TGTGTGCTTC AGGACGGGCG TGTGTTTGAA AAGGCCGGGG TGAGCATTTC CGTCGTTCAT 
GGGAATCTTT CTGAGGAAGC AGCGAACCAA ATGAGAGGCA GAGGCAAAAC TCTGAAGACG 
AAAGATAGTA AATTGCCATT TACTGCTATG GGTGTAAGTT CTGTGATTCA CCCCAAGAAT 
CCTTATGCGC CCACCATGCA TTTCAACTAC AGATACTTTG AAGTAGAGGA AGCTGACGGT 
AACACACACT GGTGGTTTGG GGGTGGCTGT GACCTCACAC CGACATACTT GAACCAAGAG 
GATGCTGTCC ATTTCCACCG TACTCTAAAG GAAGCTTGCG ATCAGCATGG GCCAGACATC 
TACCCAAAGT TTAAAAAATG GTGTGACGAC TACTTCTTTA TAGTTCACCG CGGGGAGCGG 
AGGGGCATCG GCGGCATCTT TTTTGACGAT CTTGACTCCC CCTCCAAGGA GGAGGCTTTC 
CGCTTCGTGA AGACGTGTGC TGAGGCTGTG GTCCCTTCCT ATGTTCCCAT TGTGAAGAAG 
CACTGCGATG ACTCCTACAC CCCCAGGGAC AAGCTGTGGC AGCAGCTGAG GAGAGGGCGG 
TATGTGGAGT TTAATCTGTT GTATGATCGG GGCACCAAGT TTGGCCTCTT TACTCCAGGA 
TCCAGGATCG AAAGTATCTT GATGTCTTTA CCTCTAACAG CAAGATGGGA GTACATGCAT 
TCTCCCCCAG AGAATTCCAA AGAAGCTGAA ATTCTGGAAG TGTTGCGCCA TCCAAAGGAC 
TGGGTGCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.
Disease models & mechanisms10(8)1005-1013(2017 Aug)
Conway AJ,Brown FC,Fullinfaw RO,Kile BT,Jane SM,Curtis DJ

A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.
Experimental animals64(2)171-9(2015)
Shoji H,Kiniwa Y,Okuyama R,Yang M,Higuchi K,Mori M

Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.
Experimental eye research11245-50(2013 Jul)
Mori M,Gotoh S,Taketani S,Hiai H,Higuchi K

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.
Genome research20(8)1052-63(2010 Aug)
Tallack MR,Whitington T,Yuen WS,Wainwright EN,Keys JR,Gardiner BB,Nourbakhsh E,Cloonan N,Grimmond SM,Bailey TL,Perkins AC

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.
Proceedings of the National Academy of Sciences of the United States of America107(2)832-7(2010 Jan)
Mortensen M,Ferguson DJ,Edelmann M,Kessler B,Morten KJ,Komatsu M,Simon AK

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Cpox cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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