Cox5b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cox5b
Entrez Gene ID	12859
Full Name	cytochrome c oxidase subunit Vb
General protein information	Preferred Names cytochrome c oxidase subunit Vb Names cytochrome c oxidase subunit 5B, mitochondrial cytochrome c oxidase polypeptide Vb
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_009942.2	NP_034072.2	cytochrome c oxidase subunit 5B, mitochondrial

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	zgc:86599	NP_001002163.1
Xenopus tropicalis (tropical clawed frog)	cox5b.1	NP_001016250.1
Mus musculus (house mouse)	LOC102638382	XP_006531622.1
Mus musculus (house mouse)	Cox5b	NP_034072.2

Gene Ontology
Bibliography

Related articles in PubMed

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.
Wang F, Xu C, Reece EA, Li X, Wu Y, Harman C, Yu J, Dong D, Wang C, Yang P, Zhong J, Yang P
Nature communications815182(2017 May)

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology216(3)675-693(2017 Mar)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P
Cell metabolism19(4)593-604(2014 Apr)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that the mitochondria from CcO Vb knock-down cells generated increased reactive oxygen species.
Title: Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production.

gene expression of the Cox subunits, Cox5a, 5b, and 6b1 is not required for embryo developmental events up to the blastocyst stage
Title: Gene expression of cox5a, 5b, or 6b1 and their roles in preimplantation mouse embryos.

The following Cox5b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cox5b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18079	NM_009942.2 Latest version!	Mus musculus cytochrome c oxidase subunit 5B (Cox5b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cox5b ( NM_009942.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034072.2 Mus musculus cytochrome c oxidase subunit 5B (Cox5b), mRNA.

Price & Availability↑

CloneID	OMu18079
Clone ID Related Accession (Same CDS sequence)	NM_009942.2
Accession Version	NM_009942.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Mus musculus(house mouse)
Product	cytochrome c oxidase subunit 5B, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ075429.1, AK135174.1 and BU757937.1. On Aug 19, 2006 this sequence version replaced NM_009942.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF741094.1, BG808840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCAA GGTTACTTCG CGGAGTGGGC GCTTTGGCGG CGCAGGCCCT GAGGGCCCAC 
GGCCCCCGTG GCGCGGCCGT GACCCGCTCC ATGGCTTCTG GAGGTGGTGT CCCCACTGAT 
GAGGAGCAGG CTACTGGGCT GGAGAGGGAG ATCATGATAG CAGCACAGAA GGGACTGGAC 
CCATACAATA TGCTACCTCC AAAGGCAGCT TCAGGCACCA AGGAAGACCC TAATCTAGTC 
CCGTCCATCA GCAACAAGAG AATAGTGGGC TGCATCTGTG AAGAGGACAA CTGTACTGTC 
ATCTGGTTTT GGCTGCACAA AGGCGAGAGT CAGCGATGCC CCAACTGTGG AACCCATTAC 
AAGCTGGTGC CCCACCAAAT GGCCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034072.2
CDS	101..490
Translation	MASRLLRGVGALAAQALRAHGPRGAAVTRSMASGGGVPTDEEQATGLEREIMIAAQKGLDPYNMLPPKAASGTKEDPNLVPSISNKRIVGCICEEDNCTVIWFWLHKGESQRCPNCGTHYKLVPHQMAH

Target ORF information:

RefSeq Version	NM_009942.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c oxidase subunit 5B (Cox5b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009942.2

ORF Insert Sequence:

ATGGCTTCAA GGTTACTTCG CGGAGTGGGC GCTTTGGCGG CGCAGGCCCT GAGGGCCCAC 
GGCCCCCGTG GCGCGGCCGT GACCCGCTCC ATGGCTTCTG GAGGTGGTGT CCCCACTGAT 
GAGGAGCAGG CTACTGGGCT GGAGAGGGAG ATCATGATAG CAGCACAGAA GGGACTGGAC 
CCATACAATA TGCTACCTCC AAAGGCAGCT TCAGGCACCA AGGAAGACCC TAATCTAGTC 
CCGTCCATCA GCAACAAGAG AATAGTGGGC TGCATCTGTG AAGAGGACAA CTGTACTGTC 
ATCTGGTTTT GGCTGCACAA AGGCGAGAGT CAGCGATGCC CCAACTGTGG AACCCATTAC 
AAGCTGGTGC CCCACCAAAT GGCCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.
Nature communications815182(2017 May)
Wang F,Xu C,Reece EA,Li X,Wu Y,Harman C,Yu J,Dong D,Wang C,Yang P,Zhong J,Yang P

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
The Journal of cell biology216(3)675-693(2017 Mar)
Schatton D,Pla-Martin D,Marx MC,Hansen H,Mourier A,Nemazanyy I,Pessia A,Zentis P,Corona T,Kondylis V,Barth E,Schauss AC,Velagapudi V,Rugarli EI

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
Cell metabolism19(4)593-604(2014 Apr)
Harms MJ,Ishibashi J,Wang W,Lim HW,Goyama S,Sato T,Kurokawa M,Won KJ,Seale P

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

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Cox5b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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