Cox5a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cox5a
Entrez Gene ID	12858
Full Name	cytochrome c oxidase subunit Va
Synonyms	AA959768,CcOX
General protein information	Preferred Names cytochrome c oxidase subunit Va Names cytochrome c oxidase subunit 5A, mitochondrial cytochrome c oxidase polypeptide Va
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 B

mRNA and Protein(s)

mRNA	Protein	Name
XM_030244034.1	XP_030099894.1	cytochrome c oxidase subunit 5A, mitochondrial isoform X1
NM_007747.2	NP_031773.2	cytochrome c oxidase subunit 5A, mitochondrial precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	COX5A	XP_003641852.1
Danio rerio (zebrafish)	LOC100537689	XP_003201496.1
Homo sapiens (human)	COX5A	NP_004246.2
	COX5A	NP_001035369.1
Bos taurus (cattle)	COX5A	NP_001002891.1
Mus musculus (house mouse)	Cox5a	NP_031773.2
Xenopus tropicalis (tropical clawed frog)	cox5a	NP_001017049.1
Pan troglodytes (chimpanzee)	COX5A	NP_001112385.1
Caenorhabditis elegans (roundworm)	cco-2	NP_499681.1
Canis lupus familiaris (dog)	COX5A	XP_535544.1
Danio rerio (zebrafish)	cox5aa	NP_001019574.1
Drosophila melanogaster (fruit fly)	CoVa	NP_001262488.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011159	XP_309490.3
Rattus norvegicus (Norway rat)	Cox5a	NP_665726.1

Gene Ontology
Bibliography

Related articles in PubMed

Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
XiYang YB, Wang YC, Zhao Y, Ru J, Lu BT, Zhang YN, Wang NC, Hu WY, Liu J, Yang JW, Wang ZJ, Hao CG, Feng ZT, Xiao ZC, Dong W, Quan XZ, Zhang LF, Wang TH
Molecular neurobiology53(2)955-67(2016 Mar)

IKK? and alternative NF-?B regulate PGC-1? to promote oxidative muscle metabolism.
Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PM, Guttridge DC
The Journal of cell biology196(4)497-511(2012 Feb)

SCaMC-1Like a member of the mitochondrial carrier (MC) family preferentially expressed in testis and localized in mitochondria and chromatoid body.
Amigo I, Traba J, Satr?stegui J, del Arco A
PloS one7(7)e40470(2012)

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y
PloS one7(12)e51621(2012)

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Yang H, Brosel S, Acin-Perez R, Slavkovich V, Nishino I, Khan R, Goldberg IJ, Graziano J, Manfredi G, Schon EA
Human molecular genetics19(1)170-80(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SCN2B could play an important role in the aging-related cognitive deterioration, which is associated with the regulations of COX5A and FGF-2.
Title: Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.

gene expression of the Cox subunits, Cox5a, 5b, and 6b1 is not required for embryo developmental events up to the blastocyst stage
Title: Gene expression of cox5a, 5b, or 6b1 and their roles in preimplantation mouse embryos.

Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury
Title: Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.

The following Cox5a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cox5a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14823	NM_007747.2 Latest version!	Mus musculus cytochrome c oxidase subunit 5A (Cox5a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OMu14823	XM_030244034.1 Latest version!	Mus musculus cytochrome c oxidase subunit 5A (Cox5a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cox5a ( NM_007747.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031773.2 Mus musculus cytochrome c oxidase subunit 5A (Cox5a), mRNA.

Price & Availability↑

CloneID	OMu14823
Clone ID Related Accession (Same CDS sequence)	XM_030244034.1 , NM_007747.2
Accession Version	NM_007747.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	cytochrome c oxidase subunit 5A, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY259203.1, AK018723.1 and CO044753.1. On Aug 12, 2006 this sequence version replaced NM_007747.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF578606.1, BU848057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTCGCCG CTGCCCTCCG TCGCTGTACC GCAGCCGCGG CTGCCCGAGG CCTCCTGCAC 
CCCGCCTCGG CTCCCAGCCC CGCCGCCGCT GTCTGTTCCA TTCGCTGCTA TTCTCATGGG 
TCACACGAGA CAGATGAGGA GTTTGATGCT CGCTGGGTGA CATATTTCAA CAAGCCAGAC 
ATTGATGCCT GGGAATTGCG TAAAGGGATG AATACACTTG TTGGCTATGA TCTGGTTCCT 
GAGCCCAAAA TCATTGATGC TGCATTGCGA GCATGTAGAC GGTTAAATGA TTTTGCTAGT 
GCTGTTCGCA TCTTGGAGGT TGTTAAGGAC AAAGCAGGAC CTCATAAGGA AATCTATCCC 
TATGTCATCC AGGAACTTAG ACCAACTTTA AATGAATTGG GAATCTCCAC TCCAGAGGAG 
CTGGGCCTTG ACAAAGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031773.2
CDS	97..537
Translation	MLAAALRRCTAAAAARGLLHPASAPSPAAAVCSIRCYSHGSHETDEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV

Target ORF information:

RefSeq Version	NM_007747.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c oxidase subunit 5A (Cox5a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007747.2

ORF Insert Sequence:

ATGCTCGCCG CTGCCCTCCG TCGCTGTACC GCAGCCGCGG CTGCCCGAGG CCTCCTGCAC 
CCCGCCTCGG CTCCCAGCCC CGCCGCCGCT GTCTGTTCCA TTCGCTGCTA TTCTCATGGG 
TCACACGAGA CAGATGAGGA GTTTGATGCT CGCTGGGTGA CATATTTCAA CAAGCCAGAC 
ATTGATGCCT GGGAATTGCG TAAAGGGATG AATACACTTG TTGGCTATGA TCTGGTTCCT 
GAGCCCAAAA TCATTGATGC TGCATTGCGA GCATGTAGAC GGTTAAATGA TTTTGCTAGT 
GCTGTTCGCA TCTTGGAGGT TGTTAAGGAC AAAGCAGGAC CTCATAAGGA AATCTATCCC 
TATGTCATCC AGGAACTTAG ACCAACTTTA AATGAATTGG GAATCTCCAC TCCAGAGGAG 
CTGGGCCTTG ACAAAGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cox5a ( XM_030244034.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030099894.1 Mus musculus cytochrome c oxidase subunit 5A (Cox5a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu14823
Clone ID Related Accession (Same CDS sequence)	XM_030244034.1 , NM_007747.2
Accession Version	XM_030244034.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	cytochrome c oxidase subunit 5A, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCGCCG CTGCCCTCCG TCGCTGTACC GCAGCCGCGG CTGCCCGAGG CCTCCTGCAC 
CCCGCCTCGG CTCCCAGCCC CGCCGCCGCT GTCTGTTCCA TTCGCTGCTA TTCTCATGGG 
TCACACGAGA CAGATGAGGA GTTTGATGCT CGCTGGGTGA CATATTTCAA CAAGCCAGAC 
ATTGATGCCT GGGAATTGCG TAAAGGGATG AATACACTTG TTGGCTATGA TCTGGTTCCT 
GAGCCCAAAA TCATTGATGC TGCATTGCGA GCATGTAGAC GGTTAAATGA TTTTGCTAGT 
GCTGTTCGCA TCTTGGAGGT TGTTAAGGAC AAAGCAGGAC CTCATAAGGA AATCTATCCC 
TATGTCATCC AGGAACTTAG ACCAACTTTA AATGAATTGG GAATCTCCAC TCCAGAGGAG 
CTGGGCCTTG ACAAAGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030099894.1
CDS	905..1345
Translation	MLAAALRRCTAAAAARGLLHPASAPSPAAAVCSIRCYSHGSHETDEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV

Target ORF information:

RefSeq Version	XM_030244034.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c oxidase subunit 5A (Cox5a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030244034.1

ORF Insert Sequence:

ATGCTCGCCG CTGCCCTCCG TCGCTGTACC GCAGCCGCGG CTGCCCGAGG CCTCCTGCAC 
CCCGCCTCGG CTCCCAGCCC CGCCGCCGCT GTCTGTTCCA TTCGCTGCTA TTCTCATGGG 
TCACACGAGA CAGATGAGGA GTTTGATGCT CGCTGGGTGA CATATTTCAA CAAGCCAGAC 
ATTGATGCCT GGGAATTGCG TAAAGGGATG AATACACTTG TTGGCTATGA TCTGGTTCCT 
GAGCCCAAAA TCATTGATGC TGCATTGCGA GCATGTAGAC GGTTAAATGA TTTTGCTAGT 
GCTGTTCGCA TCTTGGAGGT TGTTAAGGAC AAAGCAGGAC CTCATAAGGA AATCTATCCC 
TATGTCATCC AGGAACTTAG ACCAACTTTA AATGAATTGG GAATCTCCAC TCCAGAGGAG 
CTGGGCCTTG ACAAAGTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
Molecular neurobiology53(2)955-67(2016 Mar)
XiYang YB,Wang YC,Zhao Y,Ru J,Lu BT,Zhang YN,Wang NC,Hu WY,Liu J,Yang JW,Wang ZJ,Hao CG,Feng ZT,Xiao ZC,Dong W,Quan XZ,Zhang LF,Wang TH

IKK? and alternative NF-?B regulate PGC-1? to promote oxidative muscle metabolism.
The Journal of cell biology196(4)497-511(2012 Feb)
Bakkar N,Ladner K,Canan BD,Liyanarachchi S,Bal NC,Pant M,Periasamy M,Li Q,Janssen PM,Guttridge DC

SCaMC-1Like a member of the mitochondrial carrier (MC) family preferentially expressed in testis and localized in mitochondria and chromatoid body.
PloS one7(7)e40470(2012)
Amigo I,Traba J,Satr?stegui J,del Arco A

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
PloS one7(12)e51621(2012)
Brody MJ,Hacker TA,Patel JR,Feng L,Sadoshima J,Tevosian SG,Balijepalli RC,Moss RL,Lee Y

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Human molecular genetics19(1)170-80(2010 Jan)
Yang H,Brosel S,Acin-Perez R,Slavkovich V,Nishino I,Khan R,Goldberg IJ,Graziano J,Manfredi G,Schon EA

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Cox5a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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