Cox4i1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cox4i1
Entrez Gene ID	12857
Full Name	cytochrome c oxidase subunit 4I1
Synonyms	AL024441,COX,COX IV-1,COXIV,Cox4,Cox4a,IV-1
General protein information	Preferred Names cytochrome c oxidase subunit 4I1 Names cytochrome c oxidase subunit 4 isoform 1, mitochondrial cytochrome c oxidase polypeptide IV cytochrome c oxidase subunit IV cytochrome c oxidase, subunit IVa
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 E1\|8 69.99 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001293559.1	NP_001280488.1	cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2
NM_009941.3	NP_034071.2	cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	COX4I1	NP_001852.1
Canis lupus familiaris (dog)	COX4I1	XP_536759.1
Mus musculus (house mouse)	Cox4i1	NP_034071.1
	LOC714951	XP_001113547.1
Bos taurus (cattle)	COX4I1	NP_001001439.1
Pan troglodytes (chimpanzee)	COX4I1	NP_001238844.1
	COX4I1	XP_001084054.1
Xenopus tropicalis (tropical clawed frog)	cox4i1	NP_001016479.1
Rattus norvegicus (Norway rat)	Cox4i1	NP_058898.1
Gallus gallus (chicken)	COX4I1	NP_001025748.1
Drosophila melanogaster (fruit fly)	CG10396	NP_610168.1
Danio rerio (zebrafish)	cox4i1	NP_999866.1

Gene Ontology
Bibliography

Related articles in PubMed

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim BE, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC
Human molecular genetics26(23)4617-4628(2017 Dec)

CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.
Gomez-Velazquez M, Badia-Careaga C, Lechuga-Vieco AV, Nieto-Arellano R, Tena JJ, Rollan I, Alvarez A, Torroja C, Caceres EF, Roy AR, Galjart N, Delgado-Olguin P, Sanchez-Cabo F, Enriquez JA, Gomez-Skarmeta JL, Manzanares M
PLoS genetics13(8)e1006985(2017 Aug)

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E
PLoS genetics13(4)e1006656(2017 Apr)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P
Skeletal muscle6(1)30(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

exercise training caused an increase in mRNA and protein levels of COXIV, whereas NAC intervention lowered the two so significantly that even exercise training could not reverse the effect of NAC intervention
Title: The effect of treadmill training and N-acetyl-l-cysteine intervention on biogenesis of cytochrome c oxidase (COX).

Data suggest that that obesity affects both sperm and seminal plasma composition; Cox4i1 mRNA is up-regulated in spermatozoa of obese mice compared to control mice.
Title: Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model.

Our data suggest that MPP(+) acts on astrocytes in a sex- and brain region-specific manner involving cytochrome c oxidase isoform expression in an impairment of energy production and elevated oxidative stress levels
Title: Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability.

Knockdown of small interfering RNA-mediated COX subunit IV decreases progesterone synthesis in steroidogenic cells.
Title: Decreased cytochrome c oxidase IV expression reduces steroidogenesis.

Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation.
Title: HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.

The following Cox4i1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cox4i1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23506	NM_001293559.1 Latest version!	Mus musculus cytochrome c oxidase subunit 4I1 (Cox4i1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu23507	NM_009941.3 Latest version!	Mus musculus cytochrome c oxidase subunit 4I1 (Cox4i1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cox4i1 ( NM_001293559.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001280488.1 Mus musculus cytochrome c oxidase subunit 4I1 (Cox4i1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu23506
Clone ID Related Accession (Same CDS sequence)	NM_001293559.1
Accession Version	NM_001293559.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AV469576.1, AK019276.1 and BE992841.1. On Jun 10, 2014 this sequence version replaced XM_006530639.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV469576.1, BG966284.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTGGCTT CCAGAGCGCT GAGCCTGATT GGCAAGAGAG CCATTTCTAC TTCGGTGTGC 
CTTCGAGCAC ATGGGAGTGT TGTGAAGAGT GAAGACTATG CTTTCCCCAC TTACGCTGAT 
CGGCGTGACT ACCCCTTGCC TGATGTGGCC CATGTCACGA TGCTGTCTGC CAGCCAGAAG 
GCGCTGAAGG AGAAGGAGAA GGCCGACTGG AGCAGCCTTT CCAGGGATGA GAAAGTTCAG 
TTGTACCGCA TCCAGTTTAA CGAGAGCTTC GCCGAGATGA ACAGGGGCAC CAATGAATGG 
AAGACAGTTG TGGGCATGGC CATGTTCTTC ATTGGCTTCA CTGCGCTCGT TCTGATTTGG 
GAGAAGAGCT ATGTGTATGG CCCCATCCCT CATACTTTCG ATCGTGACTG GGTGGCCATG 
CAGACCAAGC GAATGCTGGA CATGAAGGCC AACCCCATTC AGGGCTTCTC CGCCAAGTGG 
GACTATGACA AGAATGAGTG GAAGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001280488.1
CDS	58..567
Translation	MLASRALSLIGKRAISTSVCLRAHGSVVKSEDYAFPTYADRRDYPLPDVAHVTMLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK

Target ORF information:

RefSeq Version	NM_001293559.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c oxidase subunit 4I1 (Cox4i1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001293559.1

ORF Insert Sequence:

ATGTTGGCTT CCAGAGCGCT GAGCCTGATT GGCAAGAGAG CCATTTCTAC TTCGGTGTGC 
CTTCGAGCAC ATGGGAGTGT TGTGAAGAGT GAAGACTATG CTTTCCCCAC TTACGCTGAT 
CGGCGTGACT ACCCCTTGCC TGATGTGGCC CATGTCACGA TGCTGTCTGC CAGCCAGAAG 
GCGCTGAAGG AGAAGGAGAA GGCCGACTGG AGCAGCCTTT CCAGGGATGA GAAAGTTCAG 
TTGTACCGCA TCCAGTTTAA CGAGAGCTTC GCCGAGATGA ACAGGGGCAC CAATGAATGG 
AAGACAGTTG TGGGCATGGC CATGTTCTTC ATTGGCTTCA CTGCGCTCGT TCTGATTTGG 
GAGAAGAGCT ATGTGTATGG CCCCATCCCT CATACTTTCG ATCGTGACTG GGTGGCCATG 
CAGACCAAGC GAATGCTGGA CATGAAGGCC AACCCCATTC AGGGCTTCTC CGCCAAGTGG 
GACTATGACA AGAATGAGTG GAAGAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cox4i1 ( NM_009941.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034071.2 Mus musculus cytochrome c oxidase subunit 4I1 (Cox4i1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23507
Clone ID Related Accession (Same CDS sequence)	NM_009941.3
Accession Version	NM_009941.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY250039.1, AK012583.1 and BE992841.1. On or before Jun 11, 2014 this sequence version replaced XM_006530638.1, NM_009941.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA450881.1, BU562590.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTTCGCG GCTCCGTCTT GGTCTTCCGG TTGCGGGCCC CGTTCTTCCG GTCGCGAGCA 
CCCCAGGGTG TAGAGGGCGG TCGCGGCGGT CGCCTGGGCA GCGGTGGCAG AATGTTGGCT 
TCCAGAGCGC TGAGCCTGAT TGGCAAGAGA GCCATTTCTA CTTCGGTGTG CCTTCGAGCA 
CATGGGAGTG TTGTGAAGAG TGAAGACTAT GCTTTCCCCA CTTACGCTGA TCGGCGTGAC 
TACCCCTTGC CTGATGTGGC CCATGTCACG ATGCTGTCTG CCAGCCAGAA GGCGCTGAAG 
GAGAAGGAGA AGGCCGACTG GAGCAGCCTT TCCAGGGATG AGAAAGTTCA GTTGTACCGC 
ATCCAGTTTA ACGAGAGCTT CGCCGAGATG AACAGGGGCA CCAATGAATG GAAGACAGTT 
GTGGGCATGG CCATGTTCTT CATTGGCTTC ACTGCGCTCG TTCTGATTTG GGAGAAGAGC 
TATGTGTATG GCCCCATCCC TCATACTTTC GATCGTGACT GGGTGGCCAT GCAGACCAAG 
CGAATGCTGG ACATGAAGGC CAACCCCATT CAGGGCTTCT CCGCCAAGTG GGACTATGAC 
AAGAATGAGT GGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034071.2
CDS	22..642
Translation	MLRGSVLVFRLRAPFFRSRAPQGVEGGRGGRLGSGGRMLASRALSLIGKRAISTSVCLRAHGSVVKSEDYAFPTYADRRDYPLPDVAHVTMLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK

Target ORF information:

RefSeq Version	NM_009941.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cytochrome c oxidase subunit 4I1 (Cox4i1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009941.3

ORF Insert Sequence:

ATGCTTCGCG GCTCCGTCTT GGTCTTCCGG TTGCGGGCCC CGTTCTTCCG GTCGCGAGCA 
CCCCAGGGTG TAGAGGGCGG TCGCGGCGGT CGCCTGGGCA GCGGTGGCAG AATGTTGGCT 
TCCAGAGCGC TGAGCCTGAT TGGCAAGAGA GCCATTTCTA CTTCGGTGTG CCTTCGAGCA 
CATGGGAGTG TTGTGAAGAG TGAAGACTAT GCTTTCCCCA CTTACGCTGA TCGGCGTGAC 
TACCCCTTGC CTGATGTGGC CCATGTCACG ATGCTGTCTG CCAGCCAGAA GGCGCTGAAG 
GAGAAGGAGA AGGCCGACTG GAGCAGCCTT TCCAGGGATG AGAAAGTTCA GTTGTACCGC 
ATCCAGTTTA ACGAGAGCTT CGCCGAGATG AACAGGGGCA CCAATGAATG GAAGACAGTT 
GTGGGCATGG CCATGTTCTT CATTGGCTTC ACTGCGCTCG TTCTGATTTG GGAGAAGAGC 
TATGTGTATG GCCCCATCCC TCATACTTTC GATCGTGACT GGGTGGCCAT GCAGACCAAG 
CGAATGCTGG ACATGAAGGC CAACCCCATT CAGGGCTTCT CCGCCAAGTG GGACTATGAC 
AAGAATGAGT GGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Human molecular genetics26(23)4617-4628(2017 Dec)
Baker ZN,Jett K,Boulet A,Hossain A,Cobine PA,Kim BE,El Zawily AM,Lee L,Tibbits GF,Petris MJ,Leary SC

CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.
PLoS genetics13(8)e1006985(2017 Aug)
Gomez-Velazquez M,Badia-Careaga C,Lechuga-Vieco AV,Nieto-Arellano R,Tena JJ,Rollan I,Alvarez A,Torroja C,Caceres EF,Roy AR,Galjart N,Delgado-Olguin P,Sanchez-Cabo F,Enriquez JA,Gomez-Skarmeta JL,Manzanares M

Novel insights into SLC25A46-related pathologies in a genetic mouse model.
PLoS genetics13(4)e1006656(2017 Apr)
Terzenidou ME,Segklia A,Kano T,Papastefanaki F,Karakostas A,Charalambous M,Ioakeimidis F,Papadaki M,Kloukina I,Chrysanthou-Piterou M,Samiotaki M,Panayotou G,Matsas R,Douni E

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.
Skeletal muscle6(1)30(2016)
Sakakibara I,Wurmser M,Dos Santos M,Santolini M,Ducommun S,Davaze R,Guernec A,Sakamoto K,Maire P

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Cox4i1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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