Col8a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Col8a1
Entrez Gene ID	12837
Full Name	collagen, type VIII, alpha 1
Synonyms	Col8a-1
General protein information	Preferred Names collagen, type VIII, alpha 1 Names collagen alpha-1(VIII) chain procollagen type VIII alpha 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C1.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_007739.2	NP_031765.2	collagen alpha-1(VIII) chain precursor

Pathways from BioSystems

Homologies

	COL8A1	XP_002802671.1
Mus musculus (house mouse)	Col8a1	NP_031765.2
Gallus gallus (chicken)	COL8A1	XP_004938297.1
Bos taurus (cattle)	COL8A1	NP_001094646.1
Danio rerio (zebrafish)	col8a1b	XP_690914.3
Homo sapiens (human)	COL8A1	NP_001841.2
Pan troglodytes (chimpanzee)	COL8A1	XP_001142044.1
Rattus norvegicus (Norway rat)	Col8a1	NP_001100570.1
Xenopus tropicalis (tropical clawed frog)	col8a1	XP_002941034.1
Canis lupus familiaris (dog)	COL8A1	XP_545072.3

Gene Ontology
Bibliography

Related articles in PubMed

Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
Mendelsohn AI, Dasen JS, Jessell TM
Neuron93(4)792-805.e4(2017 Feb)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.
Skrbic B, Engebretsen KV, Strand ME, Lunde IG, Herum KM, Marstein HS, Sjaastad I, Lunde PK, Carlson CR, Christensen G, Bj?rnstad JL, T?nnessen T
Cardiovascular research106(1)32-42(2015 Apr)

Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome.
Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T
Human molecular genetics23(23)6177-90(2014 Dec)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lack of collagen VIII reduces myofibroblast differentiation and fibrosis and promotes early mortality and left ventricle dilatation in response to pressure overload in mice.
Title: Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.

Type VIII collagen signals via beta1 integrin and RhoA to regulate MMP-2 expression and smooth muscle cell migration.
Title: Type VIII collagen signals via ?1 integrin and RhoA to regulate MMP-2 expression and smooth muscle cell migration.

Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.
Title: Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.

in contrast to diabetic wild-type mice EMT-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice
Title: Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy.

Type VIII collagen significantly modulates the effect of TGF-beta1 on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy.
Title: Type VIII collagen modulates TGF-?1-induced proliferation of mesangial cells.

The following Col8a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Col8a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13763	NM_007739.2 Latest version!	Mus musculus collagen, type VIII, alpha 1 (Col8a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$433.30 $619.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Col8a1 ( NM_007739.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031765.2 Mus musculus collagen, type VIII, alpha 1 (Col8a1), mRNA.

Price & Availability↑

CloneID	OMu13763
Clone ID Related Accession (Same CDS sequence)	NM_007739.2
Accession Version	NM_007739.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	collagen alpha-1(VIII) chain precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY289783.1, AK046370.1, AV334655.2 and AC162943.2. On Jul 26, 2006 this sequence version replaced NM_007739.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK032048.1, BC058281.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGTGC CACCCAGGCC TCTACAGCTG CTGGGAATAC TGTTCATCAT TTCCCTGAAC 
TCTGTCAGAC TCATTCAGGC CGGTGCCTAC TATGGAATCA AGCCTCTGCC ACCTCAAATC 
CCTCCTCAGA TACCACCACA AATTCCACAG TACCAGCCCT TGGGCCAGCA AGTCCCTCAC 
ATGCCTTTGG GCAAAGATGG CCTTTCCATG GGCAAGGAGA TGCCTCACAT GCAGTATGGC 
AAAGAGTACC CACACCTACC CCAATATATG AAGGAAATCC CACCTGTGCC AAGAATGGGC 
AAGGAAGTGG TGCCCAAAAA AGGCAAAGGA GAAGTACCGT TAGCCAGTTT GCGCGGAGAA 
CAAGGTCCCC GTGGAGAACC TGGACCAAGA GGACCACCTG GGCCGCCAGG TTTACCAGGT 
CATGGAATGC CTGGAATCAA AGGAAAACCA GGGCCCCAGG GATATCCAGG AATTGGAAAG 
CCCGGTATGC CTGGAATGCC TGGGAAGCCA GGAGCCATGG GAATGCCAGG GGCAAAAGGC 
GAAATTGGAC CCAAAGGGGA AATCGGACCT ATGGGAATCC CAGGGCCACA AGGGCCTCCA 
GGACCTCATG GACTTCCTGG CATCGGGAAA CCGGGTGGGC CAGGGTTACC AGGGCAACCA 
GGAGCAAAAG GTGAGAGGGG GCCCAAAGGA CCACCAGGAC CTCCCGGCCT TCAGGGTCCC 
AAAGGAGAGA AGGGCTTCGG GATGCCTGGC TTGCCAGGTC TGAAGGGTCC TCCAGGTATG 
CATGGCCCTC CTGGACCAGT TGGACTACCG GGAGTAGGAA AACCAGGAGT GACAGGCTTT 
CCTGGACCAC AGGGTCCCCT GGGGAAGCCA GGGCCTCCAG GGGAACCTGG ACCACAAGGC 
CTTATTGGTG TGCCAGGAGT TCAAGGACCT CCTGGGATGC CTGGAGTTGG AAAGCCAGGT 
CAGGATGGGA TCCCGGGCCA ACCAGGATTT CCGGGTGGTA AAGGGGAACA AGGATTGCCA 
GGGTTGCCTG GACCCCCAGG CCTCCCAGGG GTCGGAAAGC CAGGTTTCCC AGGACCCAAA 
GGGGACCGGG GTATTGGGGG TGTTCCTGGG GTTCTTGGGC CGAGAGGGGA AAAAGGACCC 
ATTGGTGCTC CTGGAATGGG GGGTCCACCT GGAGAGCCAG GCCTACCCGG TATCCCGGGT 
CCCATGGGCC CTCCAGGTGC TATTGGTTTC CCTGGACCCA AAGGAGAAGG TGGAGTTGTA 
GGACCACAGG GTCCACCAGG CCCCAAGGGA GAGCCTGGCC TCCAAGGCTT CCCTGGGAAG 
CCAGGTTTTC TTGGTGAAGT AGGTCCCCCT GGCATGAGGG GTTTGCCTGG TCCTATAGGA 
CCCAAGGGAG AAGGTGGTCA CAAAGGGTTG CCAGGGCTTC CCGGTGTTCC AGGGCTGCTT 
GGACCCAAAG GAGAACCTGG CATACCTGGG GATCAGGGTC TACAGGGTCC CCCAGGGATT 
CCAGGGATCG TAGGACCTAG TGGCCCTATT GGACCCCCTG GGATTCCGGG CCCCAAAGGA 
GAACCAGGCC TCCCAGGGCC CCCTGGGTTC CCTGGTGTAG GGAAGCCAGG AGTAGCAGGA 
CTTCATGGGC CCCCGGGGAA ACCTGGTGCC CTTGGGCCTC AAGGCCAGCC TGGCCTTCCT 
GGACCCCCAG GTCCTCCAGG ACCCCCAGGC CCTCCAGCTG TGATGCCTAC ACCATCACCC 
CAGGGAGAGT ATCTGCCAGA TATGGGACTA GGAATTGATG GGGTGAAACC TCCGCATGCC 
TATGCGGGCA AAAAGGGCAA ACACGGAGGG CCAGCCTATG AGATGCCTGC GTTTACTGCC 
GAGCTGACTG TACCTTTCCC ACCGGTGGGG GCCCCAGTGA AGTTTGACAA GCTGCTCTAC 
AACGGCAGAC AGAACTACAA TCCGCAGACA GGCATCTTCA CCTGTGAAGT CCCGGGTGTC 
TACTACTTTG CTTATCATGT TCACTGCAAG GGAGGCAACG TATGGGTTGC TCTCTTCAAG 
AACAACGAGC CCATGATGTA CACATACGAC GAGTACAAGA AGGGCTTTCT GGACCAAGCA 
TCTGGAAGCG CAGTACTGCT TCTCCGTCCC GGAGACCAGG TGTTTCTCCA AATGCCTTCA 
GAACAGGCTG CTGGACTCTA TGCCGGGCAA TATGTCCACT CCTCCTTTTC AGGATATTTA 
TTGTATCCCA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031765.2
CDS	221..2455
Translation	MAVPPRPLQLLGILFIISLNSVRLIQAGAYYGIKPLPPQIPPQIPPQIPQYQPLGQQVPHMPLGKDGLSMGKEMPHMQYGKEYPHLPQYMKEIPPVPRMGKEVVPKKGKGEVPLASLRGEQGPRGEPGPRGPPGPPGLPGHGMPGIKGKPGPQGYPGIGKPGMPGMPGKPGAMGMPGAKGEIGPKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGAKGERGPKGPPGPPGLQGPKGEKGFGMPGLPGLKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGPPGEPGPQGLIGVPGVQGPPGMPGVGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGVGKPGFPGPKGDRGIGGVPGVLGPRGEKGPIGAPGMGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGVVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEGGHKGLPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIVGPSGPIGPPGIPGPKGEPGLPGPPGFPGVGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPTPSPQGEYLPDMGLGIDGVKPPHAYAGKKGKHGGPAYEMPAFTAELTVPFPPVGAPVKFDKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPMMYTYDEYKKGFLDQASGSAVLLLRPGDQVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM

Target ORF information:

RefSeq Version	NM_007739.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus collagen, type VIII, alpha 1 (Col8a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007739.2

ORF Insert Sequence:

ATGGCTGTGC CACCCAGGCC TCTACAGCTG CTGGGAATAC TGTTCATCAT TTCCCTGAAC 
TCTGTCAGAC TCATTCAGGC CGGTGCCTAC TATGGAATCA AGCCTCTGCC ACCTCAAATC 
CCTCCTCAGA TACCACCACA AATTCCACAG TACCAGCCCT TGGGCCAGCA AGTCCCTCAC 
ATGCCTTTGG GCAAAGATGG CCTTTCCATG GGCAAGGAGA TGCCTCACAT GCAGTATGGC 
AAAGAGTACC CACACCTACC CCAATATATG AAGGAAATCC CACCTGTGCC AAGAATGGGC 
AAGGAAGTGG TGCCCAAAAA AGGCAAAGGA GAAGTACCGT TAGCCAGTTT GCGCGGAGAA 
CAAGGTCCCC GTGGAGAACC TGGACCAAGA GGACCACCTG GGCCGCCAGG TTTACCAGGT 
CATGGAATGC CTGGAATCAA AGGAAAACCA GGGCCCCAGG GATATCCAGG AATTGGAAAG 
CCCGGTATGC CTGGAATGCC TGGGAAGCCA GGAGCCATGG GAATGCCAGG GGCAAAAGGC 
GAAATTGGAC CCAAAGGGGA AATCGGACCT ATGGGAATCC CAGGGCCACA AGGGCCTCCA 
GGACCTCATG GACTTCCTGG CATCGGGAAA CCGGGTGGGC CAGGGTTACC AGGGCAACCA 
GGAGCAAAAG GTGAGAGGGG GCCCAAAGGA CCACCAGGAC CTCCCGGCCT TCAGGGTCCC 
AAAGGAGAGA AGGGCTTCGG GATGCCTGGC TTGCCAGGTC TGAAGGGTCC TCCAGGTATG 
CATGGCCCTC CTGGACCAGT TGGACTACCG GGAGTAGGAA AACCAGGAGT GACAGGCTTT 
CCTGGACCAC AGGGTCCCCT GGGGAAGCCA GGGCCTCCAG GGGAACCTGG ACCACAAGGC 
CTTATTGGTG TGCCAGGAGT TCAAGGACCT CCTGGGATGC CTGGAGTTGG AAAGCCAGGT 
CAGGATGGGA TCCCGGGCCA ACCAGGATTT CCGGGTGGTA AAGGGGAACA AGGATTGCCA 
GGGTTGCCTG GACCCCCAGG CCTCCCAGGG GTCGGAAAGC CAGGTTTCCC AGGACCCAAA 
GGGGACCGGG GTATTGGGGG TGTTCCTGGG GTTCTTGGGC CGAGAGGGGA AAAAGGACCC 
ATTGGTGCTC CTGGAATGGG GGGTCCACCT GGAGAGCCAG GCCTACCCGG TATCCCGGGT 
CCCATGGGCC CTCCAGGTGC TATTGGTTTC CCTGGACCCA AAGGAGAAGG TGGAGTTGTA 
GGACCACAGG GTCCACCAGG CCCCAAGGGA GAGCCTGGCC TCCAAGGCTT CCCTGGGAAG 
CCAGGTTTTC TTGGTGAAGT AGGTCCCCCT GGCATGAGGG GTTTGCCTGG TCCTATAGGA 
CCCAAGGGAG AAGGTGGTCA CAAAGGGTTG CCAGGGCTTC CCGGTGTTCC AGGGCTGCTT 
GGACCCAAAG GAGAACCTGG CATACCTGGG GATCAGGGTC TACAGGGTCC CCCAGGGATT 
CCAGGGATCG TAGGACCTAG TGGCCCTATT GGACCCCCTG GGATTCCGGG CCCCAAAGGA 
GAACCAGGCC TCCCAGGGCC CCCTGGGTTC CCTGGTGTAG GGAAGCCAGG AGTAGCAGGA 
CTTCATGGGC CCCCGGGGAA ACCTGGTGCC CTTGGGCCTC AAGGCCAGCC TGGCCTTCCT 
GGACCCCCAG GTCCTCCAGG ACCCCCAGGC CCTCCAGCTG TGATGCCTAC ACCATCACCC 
CAGGGAGAGT ATCTGCCAGA TATGGGACTA GGAATTGATG GGGTGAAACC TCCGCATGCC 
TATGCGGGCA AAAAGGGCAA ACACGGAGGG CCAGCCTATG AGATGCCTGC GTTTACTGCC 
GAGCTGACTG TACCTTTCCC ACCGGTGGGG GCCCCAGTGA AGTTTGACAA GCTGCTCTAC 
AACGGCAGAC AGAACTACAA TCCGCAGACA GGCATCTTCA CCTGTGAAGT CCCGGGTGTC 
TACTACTTTG CTTATCATGT TCACTGCAAG GGAGGCAACG TATGGGTTGC TCTCTTCAAG 
AACAACGAGC CCATGATGTA CACATACGAC GAGTACAAGA AGGGCTTTCT GGACCAAGCA 
TCTGGAAGCG CAGTACTGCT TCTCCGTCCC GGAGACCAGG TGTTTCTCCA AATGCCTTCA 
GAACAGGCTG CTGGACTCTA TGCCGGGCAA TATGTCCACT CCTCCTTTTC AGGATATTTA 
TTGTATCCCA TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
Neuron93(4)792-805.e4(2017 Feb)
Mendelsohn AI,Dasen JS,Jessell TM

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.
Cardiovascular research106(1)32-42(2015 Apr)
Skrbic B,Engebretsen KV,Strand ME,Lunde IG,Herum KM,Marstein HS,Sjaastad I,Lunde PK,Carlson CR,Christensen G,Bj?rnstad JL,T?nnessen T

Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome.
Human molecular genetics23(23)6177-90(2014 Dec)
Hellbach N,Weise SC,Vezzali R,Wahane SD,Heidrich S,Roidl D,Pruszak J,Esser JS,Vogel T

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Col8a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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