Col6a2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Col6a2
Entrez Gene ID	12834
Full Name	collagen, type VI, alpha 2
Synonyms	Col6a-2
General protein information	Preferred Names collagen, type VI, alpha 2 Names collagen alpha-2(VI) chain procollagen, type VI, alpha 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C1\|10 39.32 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_146007.2	NP_666119.1	collagen alpha-2(VI) chain isoform 1 precursor
NM_001347207.1	NP_001334136.1	collagen alpha-2(VI) chain isoform 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	COL6A2	XP_531504.3
Gallus gallus (chicken)	COL6A2	NP_990679.1
Homo sapiens (human)	COL6A2	NP_001840.3
Mus musculus (house mouse)	Col6a2	NP_666119.1
Xenopus tropicalis (tropical clawed frog)	LOC100145523	NP_001120436.1
Danio rerio (zebrafish)	col6a2	XP_696164.2
	COL6A2	XP_001099130.2
Rattus norvegicus (Norway rat)	Col6a2	NP_001094211.1

Gene Ontology
Bibliography

Related articles in PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the ?-sarcoglycan-null mouse.
de Greef JC, Hamlyn R, Jensen BS, O'Campo Landa R, Levy JR, Kobuke K, Campbell KP
Human molecular genetics25(7)1357-69(2016 Apr)

A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease.
Soret R, Mennetrey M, Bergeron KF, Dariel A, Neunlist M, Grunder F, Faure C, Silversides DW, Pilon N,
The Journal of clinical investigation125(12)4483-96(2015 Dec)

Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.
Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR
Matrix biology : journal of the International Society for Matrix Biology4256-73(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

gamma-sarcoglycan-null/Col6a2Deltaex5 (Col6a2 deficient) mice exhibit reduced muscle pathology compared with gamma-sarcoglycan-null mice. Specifically, fewer muscle fibers are degenerating, fiber size varies less. Surprisingly, in spite of this reduction in muscle pathology, muscle function is not significantly improved.
Title: Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the ?-sarcoglycan-null mouse.

The following Col6a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Col6a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu44179	NM_001347207.1 Latest version!	Mus musculus collagen, type VI, alpha 2 (Col6a2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OMu21255	NM_146007.2 Latest version!	Mus musculus collagen, type VI, alpha 2 (Col6a2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$608.30 $869.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Col6a2 ( NM_001347207.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334136.1 Mus musculus collagen, type VI, alpha 2 (Col6a2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu44179
Clone ID Related Accession (Same CDS sequence)	NM_001347207.1
Accession Version	NM_001347207.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	collagen alpha-2(VI) chain isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153892.12, AK042826.1, CB249309.1, CN670932.1, CK619862.1, CD804788.1, AK132540.1 and AW487891.1. On Nov 18, 2016 this sequence version replaced XM_006513177.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK132540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTACTA TCAAGATGCT CCAGGGTCCT CTTTCTGTGC TCCTGATTGG GGGACTCTTG 
GGGGTCCTCC ATGCCCAGCA GCAGGAAGCC ATCTCACCCC AGGAGCAGGA AGCTGTCTCA 
CCAGACATCT CCACCACTGA AAGGAACAAC AATTGTCCAG AGAAGGCCGA CTGCCCAGTC 
AACGTGTATT TCGTGTTGGA CACCTCAGAG AGCGTGGCCA TGCAGTCCCC GACAGACAGC 
CTGCTCTATC ATATGCAGCA GTTCGTACCG CAGTTTATCA GCCAGCTGCA GAACGAGTTC 
TACCTGGACC AGGTGGCCCT GAGCTGGCGC TACGGTGGTC TACACTTCTC GGACCAAGTG 
GAGGTGTTCA GCCCACCGGG CAGTGACCGG GCCTCCTTCA CTAAGAGCCT ACAAGGCATC 
CGCTCCTTCC GCAGGGGCAC CTTCACTGAC TGTGCATTGG CTAACATGAC GCAGCAGATC 
CGGCAGCACG TAGGCAAGGG GGTGGTCAAC TTCGCCGTGG TCATCACTGA CGGCCACGTC 
ACGGGCAGTC CGTGTGGGGG CATCAAGATG CAGGCTGAGC GTGCCCGTGA AGAGGGCATC 
CGGCTCTTCG CTGTGGCCCC TAACAGGAAC CTAAACGAAC AAGGCCTGAG GGACATCGCT 
AACTCTCCAC ATGAGCTCTA CCGTAACAAC TACGCCACCA TGCGACCCGA CTCTACCGAG 
ATTGACCAGG ACACCATCAA CCGCATCATC AAGGTCATGA AACATGAAGC CTATGGAGAG 
TGCTACAAGG TGAGCTGCCT GGAGATTCCT GGACCCCACG GACCCAAGGG TTACCGAGGA 
CAGAAGGGTG CCAAGGGCAA CATGGGTGAA CCAGGAGAGC CTGGACAGAA AGGACGACAG 
GGAGACCCCG GCATCGAAGG CCCCATTGGA TTCCCGGGAC CGAAGGGTGT GCCTGGCTTC 
AAGGGAGAGA AGGGTGAATT TGGATCGGAT GGTCGGAAGG GAGCGCCTGG CCTAGCTGGC 
AAGAATGGAA CAGATGGACA GAAGGGCAAA CTGGGCCGCA TTGGGCCTCC TGGTTGCAAG 
GGAGACCCCG GAAGTCGGGG CCCCGATGGA TACCCTGGAG AAGCTGGAAG CCCAGGCGAG 
CGAGGAGACC AGGGTGCCAA GGGGGACTCT GGCCGCCCAG GACGCAGGGG ACCACCAGGA 
GATCCTGGAG ACAAAGGAAG CAAGGGATAT CAAGGCAACA ACGGAGCCCC TGGAAGCCCG 
GGAGTGAAAG GAGGCAAGGG AGGGCCTGGC CCCCGTGGAC CAAAAGGAGA GCCTGGACGC 
AGAGGAGACC CCGGGACCAA GGGCGGCCCC GGCAGCGATG GTCCAAAGGG AGAGAAGGGA 
GACCCTGGTC CTGAGGGGCC TCGAGGCCTG GCTGGAGAAG TTGGCAGTAA AGGAGCCAAG 
GGAGACAGAG GTTTGCCTGG ACCCAGAGGC CCCCAGGGGG CTCTTGGAGA GCCAGGAAAG 
CAGGGATCTC GAGGAGACCC TGGTGACGCC GGACCTCGAG GGGATTCAGG ACAGCCGGGC 
CCCAAGGGCG ATCCTGGAAG GCCTGGATTC AGCTACCCGG GACCTCGAGG GACACCCGGT 
GAAAAAGGCG AGCCCGGTCC ACCAGGCCCT GAGGGAGGCC GAGGAGACTT TGGTCTGAAA 
GGAACACCCG GACGGAAGGG AGATAAAGGG GAGCCAGCTG ATCCTGGTCC CCCTGGTGAA 
CCTGGCCCTC GGGGGCCAAG AGGAATCCCA GGACCTGAGG GAGAACCCGG CCCTCCAGGA 
GACCCTGGTC TCACGGAATG TGATGTCATG ACCTATGTGA GGGAGACCTG TGGATGCTGC 
GACTGTGAGA AGCGCTGTGG TGCCCTGGAT GTGGTCTTCG TCATCGACAG TTCTGAGAGT 
ATTGGCTACA CCAACTTCAC CTTGGAGAAG AACTTTGTCA TCAATGTGGT CAACAGGCTA 
GGTGCCATTG CCAAGGACCC CAAGTCAGAA ACAGGCACAC GTGTGGGTGT GGTGCAGTAC 
AGCCACGAGG GCACCTTTGA GGCCATCCGG CTGGACGACG AGCGAGTCAA CTCCCTGTCT 
AGTTTCAAGG AGGCTGTCAA AAACCTTGAA TGGATCGCCG GTGGCACTTG GACGCCCTCT 
GCCCTCAAGT TTGCCTATAA TCAGCTCATC AAAGAAAGCC GGCGCCAGAA GACCCGGGTG 
TTCGCAGTGG TCATCACGGA TGGGCGCCAT GACCCCCGAG ATGATGACCT CAATCTTCGG 
GCACTGTGTG ACCGAGATGT CACTGTGACA GCCATTGGCA TCGGTGACAT GTTCCACGAG 
ACTCATGAGA GTGAGAACCT CTACTCCATT GCCTGTGACA AGCCACAGCA AGTGCGCAAC 
ATGACGCTGT TCTCTGACCT GGTGGCCGAG AAGTTCATCG ATGACATGGA AGACGTCCTT 
TGTCCAGACC CCCAGATCGT GTGTCCAGAA CTTCCCTGCC AAACAGATGA ACCATGGCCT 
GGGAACAAGC CCCCGGTCAC CTTCCTCCGC ACGGAAGAGG GTCCGGACCC CACCTTCCCC 
AAGACCATCC CCCTGATCCA GCAGTTGCTA AACGCCACGG AGTTCACACA GAATCCAGCT 
GCCTACTCCC AACTGGTAGC TGTGATGGTC TACACCGCCG AGAGGGCCAA GTTCTCCACA 
GGGGTCGAGC GGCAGGACTG GATGCAGCTG TTCATTGACA CCTTTAAACT GGTGCACAGG 
GATATCACAG GGGACCCAGA GAGCGTGCTG GCACTCTGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334136.1
CDS	394..3195
Translation	MTTIKMLQGPLSVLLIGGLLGVLHAQQQEAISPQEQEAVSPDISTTERNNNCPEKADCPVNVYFVLDTSESVAMQSPTDSLLYHMQQFVPQFISQLQNEFYLDQVALSWRYGGLHFSDQVEVFSPPGSDRASFTKSLQGIRSFRRGTFTDCALANMTQQIRQHVGKGVVNFAVVITDGHVTGSPCGGIKMQAERAREEGIRLFAVAPNRNLNEQGLRDIANSPHELYRNNYATMRPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPHGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGSDGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGSRGPDGYPGEAGSPGERGDQGAKGDSGRPGRRGPPGDPGDKGSKGYQGNNGAPGSPGVKGGKGGPGPRGPKGEPGRRGDPGTKGGPGSDGPKGEKGDPGPEGPRGLAGEVGSKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGTPGEKGEPGPPGPEGGRGDFGLKGTPGRKGDKGEPADPGPPGEPGPRGPRGIPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIRLDDERVNSLSSFKEAVKNLEWIAGGTWTPSALKFAYNQLIKESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDMFHETHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQIVCPELPCQTDEPWPGNKPPVTFLRTEEGPDPTFPKTIPLIQQLLNATEFTQNPAAYSQLVAVMVYTAERAKFSTGVERQDWMQLFIDTFKLVHRDITGDPESVLALC

Target ORF information:

RefSeq Version	NM_001347207.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus collagen, type VI, alpha 2 (Col6a2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347207.1

ORF Insert Sequence:

ATGACTACTA TCAAGATGCT CCAGGGTCCT CTTTCTGTGC TCCTGATTGG GGGACTCTTG 
GGGGTCCTCC ATGCCCAGCA GCAGGAAGCC ATCTCACCCC AGGAGCAGGA AGCTGTCTCA 
CCAGACATCT CCACCACTGA AAGGAACAAC AATTGTCCAG AGAAGGCCGA CTGCCCAGTC 
AACGTGTATT TCGTGTTGGA CACCTCAGAG AGCGTGGCCA TGCAGTCCCC GACAGACAGC 
CTGCTCTATC ATATGCAGCA GTTCGTACCG CAGTTTATCA GCCAGCTGCA GAACGAGTTC 
TACCTGGACC AGGTGGCCCT GAGCTGGCGC TACGGTGGTC TACACTTCTC GGACCAAGTG 
GAGGTGTTCA GCCCACCGGG CAGTGACCGG GCCTCCTTCA CTAAGAGCCT ACAAGGCATC 
CGCTCCTTCC GCAGGGGCAC CTTCACTGAC TGTGCATTGG CTAACATGAC GCAGCAGATC 
CGGCAGCACG TAGGCAAGGG GGTGGTCAAC TTCGCCGTGG TCATCACTGA CGGCCACGTC 
ACGGGCAGTC CGTGTGGGGG CATCAAGATG CAGGCTGAGC GTGCCCGTGA AGAGGGCATC 
CGGCTCTTCG CTGTGGCCCC TAACAGGAAC CTAAACGAAC AAGGCCTGAG GGACATCGCT 
AACTCTCCAC ATGAGCTCTA CCGTAACAAC TACGCCACCA TGCGACCCGA CTCTACCGAG 
ATTGACCAGG ACACCATCAA CCGCATCATC AAGGTCATGA AACATGAAGC CTATGGAGAG 
TGCTACAAGG TGAGCTGCCT GGAGATTCCT GGACCCCACG GACCCAAGGG TTACCGAGGA 
CAGAAGGGTG CCAAGGGCAA CATGGGTGAA CCAGGAGAGC CTGGACAGAA AGGACGACAG 
GGAGACCCCG GCATCGAAGG CCCCATTGGA TTCCCGGGAC CGAAGGGTGT GCCTGGCTTC 
AAGGGAGAGA AGGGTGAATT TGGATCGGAT GGTCGGAAGG GAGCGCCTGG CCTAGCTGGC 
AAGAATGGAA CAGATGGACA GAAGGGCAAA CTGGGCCGCA TTGGGCCTCC TGGTTGCAAG 
GGAGACCCCG GAAGTCGGGG CCCCGATGGA TACCCTGGAG AAGCTGGAAG CCCAGGCGAG 
CGAGGAGACC AGGGTGCCAA GGGGGACTCT GGCCGCCCAG GACGCAGGGG ACCACCAGGA 
GATCCTGGAG ACAAAGGAAG CAAGGGATAT CAAGGCAACA ACGGAGCCCC TGGAAGCCCG 
GGAGTGAAAG GAGGCAAGGG AGGGCCTGGC CCCCGTGGAC CAAAAGGAGA GCCTGGACGC 
AGAGGAGACC CCGGGACCAA GGGCGGCCCC GGCAGCGATG GTCCAAAGGG AGAGAAGGGA 
GACCCTGGTC CTGAGGGGCC TCGAGGCCTG GCTGGAGAAG TTGGCAGTAA AGGAGCCAAG 
GGAGACAGAG GTTTGCCTGG ACCCAGAGGC CCCCAGGGGG CTCTTGGAGA GCCAGGAAAG 
CAGGGATCTC GAGGAGACCC TGGTGACGCC GGACCTCGAG GGGATTCAGG ACAGCCGGGC 
CCCAAGGGCG ATCCTGGAAG GCCTGGATTC AGCTACCCGG GACCTCGAGG GACACCCGGT 
GAAAAAGGCG AGCCCGGTCC ACCAGGCCCT GAGGGAGGCC GAGGAGACTT TGGTCTGAAA 
GGAACACCCG GACGGAAGGG AGATAAAGGG GAGCCAGCTG ATCCTGGTCC CCCTGGTGAA 
CCTGGCCCTC GGGGGCCAAG AGGAATCCCA GGACCTGAGG GAGAACCCGG CCCTCCAGGA 
GACCCTGGTC TCACGGAATG TGATGTCATG ACCTATGTGA GGGAGACCTG TGGATGCTGC 
GACTGTGAGA AGCGCTGTGG TGCCCTGGAT GTGGTCTTCG TCATCGACAG TTCTGAGAGT 
ATTGGCTACA CCAACTTCAC CTTGGAGAAG AACTTTGTCA TCAATGTGGT CAACAGGCTA 
GGTGCCATTG CCAAGGACCC CAAGTCAGAA ACAGGCACAC GTGTGGGTGT GGTGCAGTAC 
AGCCACGAGG GCACCTTTGA GGCCATCCGG CTGGACGACG AGCGAGTCAA CTCCCTGTCT 
AGTTTCAAGG AGGCTGTCAA AAACCTTGAA TGGATCGCCG GTGGCACTTG GACGCCCTCT 
GCCCTCAAGT TTGCCTATAA TCAGCTCATC AAAGAAAGCC GGCGCCAGAA GACCCGGGTG 
TTCGCAGTGG TCATCACGGA TGGGCGCCAT GACCCCCGAG ATGATGACCT CAATCTTCGG 
GCACTGTGTG ACCGAGATGT CACTGTGACA GCCATTGGCA TCGGTGACAT GTTCCACGAG 
ACTCATGAGA GTGAGAACCT CTACTCCATT GCCTGTGACA AGCCACAGCA AGTGCGCAAC 
ATGACGCTGT TCTCTGACCT GGTGGCCGAG AAGTTCATCG ATGACATGGA AGACGTCCTT 
TGTCCAGACC CCCAGATCGT GTGTCCAGAA CTTCCCTGCC AAACAGATGA ACCATGGCCT 
GGGAACAAGC CCCCGGTCAC CTTCCTCCGC ACGGAAGAGG GTCCGGACCC CACCTTCCCC 
AAGACCATCC CCCTGATCCA GCAGTTGCTA AACGCCACGG AGTTCACACA GAATCCAGCT 
GCCTACTCCC AACTGGTAGC TGTGATGGTC TACACCGCCG AGAGGGCCAA GTTCTCCACA 
GGGGTCGAGC GGCAGGACTG GATGCAGCTG TTCATTGACA CCTTTAAACT GGTGCACAGG 
GATATCACAG GGGACCCAGA GAGCGTGCTG GCACTCTGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Col6a2 ( NM_146007.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666119.1 Mus musculus collagen, type VI, alpha 2 (Col6a2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu21255
Clone ID Related Accession (Same CDS sequence)	NM_146007.2
Accession Version	NM_146007.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3105bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	collagen alpha-2(VI) chain isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ159755.1, AK128938.1, X65582.1 and CJ313132.1. On Dec 29, 2007 this sequence version replaced NM_146007.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128938.1, BC034414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END##

ATGACTACTA TCAAGATGCT CCAGGGTCCT CTTTCTGTGC TCCTGATTGG GGGACTCTTG 
GGGGTCCTCC ATGCCCAGCA GCAGGAAGCC ATCTCACCCC AGGAGCAGGA AGCTGTCTCA 
CCAGACATCT CCACCACTGA AAGGAACAAC AATTGTCCAG AGAAGGCCGA CTGCCCAGTC 
AACGTGTATT TCGTGTTGGA CACCTCAGAG AGCGTGGCCA TGCAGTCCCC GACAGACAGC 
CTGCTCTATC ATATGCAGCA GTTCGTACCG CAGTTTATCA GCCAGCTGCA GAACGAGTTC 
TACCTGGACC AGGTGGCCCT GAGCTGGCGC TACGGTGGTC TACACTTCTC GGACCAAGTG 
GAGGTGTTCA GCCCACCGGG CAGTGACCGG GCCTCCTTCA CTAAGAGCCT ACAAGGCATC 
CGCTCCTTCC GCAGGGGCAC CTTCACTGAC TGTGCATTGG CTAACATGAC GCAGCAGATC 
CGGCAGCACG TAGGCAAGGG GGTGGTCAAC TTCGCCGTGG TCATCACTGA CGGCCACGTC 
ACGGGCAGTC CGTGTGGGGG CATCAAGATG CAGGCTGAGC GTGCCCGTGA AGAGGGCATC 
CGGCTCTTCG CTGTGGCCCC TAACAGGAAC CTAAACGAAC AAGGCCTGAG GGACATCGCT 
AACTCTCCAC ATGAGCTCTA CCGTAACAAC TACGCCACCA TGCGACCCGA CTCTACCGAG 
ATTGACCAGG ACACCATCAA CCGCATCATC AAGGTCATGA AACATGAAGC CTATGGAGAG 
TGCTACAAGG TGAGCTGCCT GGAGATTCCT GGACCCCACG GACCCAAGGG TTACCGAGGA 
CAGAAGGGTG CCAAGGGCAA CATGGGTGAA CCAGGAGAGC CTGGACAGAA AGGACGACAG 
GGAGACCCCG GCATCGAAGG CCCCATTGGA TTCCCGGGAC CGAAGGGTGT GCCTGGCTTC 
AAGGGAGAGA AGGGTGAATT TGGATCGGAT GGTCGGAAGG GAGCGCCTGG CCTAGCTGGC 
AAGAATGGAA CAGATGGACA GAAGGGCAAA CTGGGCCGCA TTGGGCCTCC TGGTTGCAAG 
GGAGACCCCG GAAGTCGGGG CCCCGATGGA TACCCTGGAG AAGCTGGAAG CCCAGGCGAG 
CGAGGAGACC AGGGTGCCAA GGGGGACTCT GGCCGCCCAG GACGCAGGGG ACCACCAGGA 
GATCCTGGAG ACAAAGGAAG CAAGGGATAT CAAGGCAACA ACGGAGCCCC TGGAAGCCCG 
GGAGTGAAAG GAGGCAAGGG AGGGCCTGGC CCCCGTGGAC CAAAAGGAGA GCCTGGACGC 
AGAGGAGACC CCGGGACCAA GGGCGGCCCC GGCAGCGATG GTCCAAAGGG AGAGAAGGGA 
GACCCTGGTC CTGAGGGGCC TCGAGGCCTG GCTGGAGAAG TTGGCAGTAA AGGAGCCAAG 
GGAGACAGAG GTTTGCCTGG ACCCAGAGGC CCCCAGGGGG CTCTTGGAGA GCCAGGAAAG 
CAGGGATCTC GAGGAGACCC TGGTGACGCC GGACCTCGAG GGGATTCAGG ACAGCCGGGC 
CCCAAGGGCG ATCCTGGAAG GCCTGGATTC AGCTACCCGG GACCTCGAGG GACACCCGGT 
GAAAAAGGCG AGCCCGGTCC ACCAGGCCCT GAGGGAGGCC GAGGAGACTT TGGTCTGAAA 
GGAACACCCG GACGGAAGGG AGATAAAGGG GAGCCAGCTG ATCCTGGTCC CCCTGGTGAA 
CCTGGCCCTC GGGGGCCAAG AGGAATCCCA GGACCTGAGG GAGAACCCGG CCCTCCAGGA 
GACCCTGGTC TCACGGAATG TGATGTCATG ACCTATGTGA GGGAGACCTG TGGATGCTGC 
GACTGTGAGA AGCGCTGTGG TGCCCTGGAT GTGGTCTTCG TCATCGACAG TTCTGAGAGT 
ATTGGCTACA CCAACTTCAC CTTGGAGAAG AACTTTGTCA TCAATGTGGT CAACAGGCTA 
GGTGCCATTG CCAAGGACCC CAAGTCAGAA ACAGGCACAC GTGTGGGTGT GGTGCAGTAC 
AGCCACGAGG GCACCTTTGA GGCCATCCGG CTGGACGACG AGCGAGTCAA CTCCCTGTCT 
AGTTTCAAGG AGGCTGTCAA AAACCTTGAA TGGATCGCCG GTGGCACTTG GACGCCCTCT 
GCCCTCAAGT TTGCCTATAA TCAGCTCATC AAAGAAAGCC GGCGCCAGAA GACCCGGGTG 
TTCGCAGTGG TCATCACGGA TGGGCGCCAT GACCCCCGAG ATGATGACCT CAATCTTCGG 
GCACTGTGTG ACCGAGATGT CACTGTGACA GCCATTGGCA TCGGTGACAT GTTCCACGAG 
ACTCATGAGA GTGAGAACCT CTACTCCATT GCCTGTGACA AGCCACAGCA AGTGCGCAAC 
ATGACGCTGT TCTCTGACCT GGTGGCCGAG AAGTTCATCG ATGACATGGA AGACGTCCTT 
TGTCCAGACC CCCAGATCGT GTGTCCAGAA CTTCCCTGCC AAACAGAGCT CTATGTGGCC 
CAGTGCACAC AACGGCCCGT GGACATTGTC TTCCTGCTGG ATGGCTCGGA GCGGCTGGGC 
GAGCAGAACT TCCACAAGGT GCGGCGCTTC GTGGAGGACG TGTCCCGGCG CCTGACTCTG 
GCCCGGAGGG ATGATGACCC ACTCAACGCC CGCATGGCTC TGTTGCAATA TGGCAGCCAG 
AATCAGCAAC AGGTGGCCTT CCCACTGACC TACAACGTGA CCACCATCCA CGAGGCCCTG 
GAGAGGGCCA CCTACCTCAA TTCCTTTTCT CACGTGGGCA CGGGCATCGT ACACGCCATC 
AACAACGTGG TGCGGGGGGC ACGGGGTGGG GCGCGGCGCC ACGCAGAGCT CTCCTTCGTC 
TTCCTCACGG ACGGTGTCAC CGGCAATGAC AGCCTGGAGG AGTCAGTGCA CTCTATGCGT 
AAGCAGAACG TGGTGCCCAC TGTGGTCGCT GTGGGCGGCG ACGTGGACAT GGATGTGCTT 
ACTAAGATCA GCCTGGGTGA CAGGGCGGCC ATCTTCCGGG AGAAAGACTT TGACAGTCTG 
GCCCAGCCCA GCTTCTTTGA CAGGTTCATC CGCTGGATCT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666119.1
CDS	168..3272
Translation	MTTIKMLQGPLSVLLIGGLLGVLHAQQQEAISPQEQEAVSPDISTTERNNNCPEKADCPVNVYFVLDTSESVAMQSPTDSLLYHMQQFVPQFISQLQNEFYLDQVALSWRYGGLHFSDQVEVFSPPGSDRASFTKSLQGIRSFRRGTFTDCALANMTQQIRQHVGKGVVNFAVVITDGHVTGSPCGGIKMQAERAREEGIRLFAVAPNRNLNEQGLRDIANSPHELYRNNYATMRPDSTEIDQDTINRIIKVMKHEAYGECYKVSCLEIPGPHGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGSDGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGSRGPDGYPGEAGSPGERGDQGAKGDSGRPGRRGPPGDPGDKGSKGYQGNNGAPGSPGVKGGKGGPGPRGPKGEPGRRGDPGTKGGPGSDGPKGEKGDPGPEGPRGLAGEVGSKGAKGDRGLPGPRGPQGALGEPGKQGSRGDPGDAGPRGDSGQPGPKGDPGRPGFSYPGPRGTPGEKGEPGPPGPEGGRGDFGLKGTPGRKGDKGEPADPGPPGEPGPRGPRGIPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIRLDDERVNSLSSFKEAVKNLEWIAGGTWTPSALKFAYNQLIKESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDMFHETHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQIVCPELPCQTELYVAQCTQRPVDIVFLLDGSERLGEQNFHKVRRFVEDVSRRLTLARRDDDPLNARMALLQYGSQNQQQVAFPLTYNVTTIHEALERATYLNSFSHVGTGIVHAINNVVRGARGGARRHAELSFVFLTDGVTGNDSLEESVHSMRKQNVVPTVVAVGGDVDMDVLTKISLGDRAAIFREKDFDSLAQPSFFDRFIRWIC

Target ORF information:

RefSeq Version	NM_146007.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus collagen, type VI, alpha 2 (Col6a2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146007.2

ORF Insert Sequence:

ATGACTACTA TCAAGATGCT CCAGGGTCCT CTTTCTGTGC TCCTGATTGG GGGACTCTTG 
GGGGTCCTCC ATGCCCAGCA GCAGGAAGCC ATCTCACCCC AGGAGCAGGA AGCTGTCTCA 
CCAGACATCT CCACCACTGA AAGGAACAAC AATTGTCCAG AGAAGGCCGA CTGCCCAGTC 
AACGTGTATT TCGTGTTGGA CACCTCAGAG AGCGTGGCCA TGCAGTCCCC GACAGACAGC 
CTGCTCTATC ATATGCAGCA GTTCGTACCG CAGTTTATCA GCCAGCTGCA GAACGAGTTC 
TACCTGGACC AGGTGGCCCT GAGCTGGCGC TACGGTGGTC TACACTTCTC GGACCAAGTG 
GAGGTGTTCA GCCCACCGGG CAGTGACCGG GCCTCCTTCA CTAAGAGCCT ACAAGGCATC 
CGCTCCTTCC GCAGGGGCAC CTTCACTGAC TGTGCATTGG CTAACATGAC GCAGCAGATC 
CGGCAGCACG TAGGCAAGGG GGTGGTCAAC TTCGCCGTGG TCATCACTGA CGGCCACGTC 
ACGGGCAGTC CGTGTGGGGG CATCAAGATG CAGGCTGAGC GTGCCCGTGA AGAGGGCATC 
CGGCTCTTCG CTGTGGCCCC TAACAGGAAC CTAAACGAAC AAGGCCTGAG GGACATCGCT 
AACTCTCCAC ATGAGCTCTA CCGTAACAAC TACGCCACCA TGCGACCCGA CTCTACCGAG 
ATTGACCAGG ACACCATCAA CCGCATCATC AAGGTCATGA AACATGAAGC CTATGGAGAG 
TGCTACAAGG TGAGCTGCCT GGAGATTCCT GGACCCCACG GACCCAAGGG TTACCGAGGA 
CAGAAGGGTG CCAAGGGCAA CATGGGTGAA CCAGGAGAGC CTGGACAGAA AGGACGACAG 
GGAGACCCCG GCATCGAAGG CCCCATTGGA TTCCCGGGAC CGAAGGGTGT GCCTGGCTTC 
AAGGGAGAGA AGGGTGAATT TGGATCGGAT GGTCGGAAGG GAGCGCCTGG CCTAGCTGGC 
AAGAATGGAA CAGATGGACA GAAGGGCAAA CTGGGCCGCA TTGGGCCTCC TGGTTGCAAG 
GGAGACCCCG GAAGTCGGGG CCCCGATGGA TACCCTGGAG AAGCTGGAAG CCCAGGCGAG 
CGAGGAGACC AGGGTGCCAA GGGGGACTCT GGCCGCCCAG GACGCAGGGG ACCACCAGGA 
GATCCTGGAG ACAAAGGAAG CAAGGGATAT CAAGGCAACA ACGGAGCCCC TGGAAGCCCG 
GGAGTGAAAG GAGGCAAGGG AGGGCCTGGC CCCCGTGGAC CAAAAGGAGA GCCTGGACGC 
AGAGGAGACC CCGGGACCAA GGGCGGCCCC GGCAGCGATG GTCCAAAGGG AGAGAAGGGA 
GACCCTGGTC CTGAGGGGCC TCGAGGCCTG GCTGGAGAAG TTGGCAGTAA AGGAGCCAAG 
GGAGACAGAG GTTTGCCTGG ACCCAGAGGC CCCCAGGGGG CTCTTGGAGA GCCAGGAAAG 
CAGGGATCTC GAGGAGACCC TGGTGACGCC GGACCTCGAG GGGATTCAGG ACAGCCGGGC 
CCCAAGGGCG ATCCTGGAAG GCCTGGATTC AGCTACCCGG GACCTCGAGG GACACCCGGT 
GAAAAAGGCG AGCCCGGTCC ACCAGGCCCT GAGGGAGGCC GAGGAGACTT TGGTCTGAAA 
GGAACACCCG GACGGAAGGG AGATAAAGGG GAGCCAGCTG ATCCTGGTCC CCCTGGTGAA 
CCTGGCCCTC GGGGGCCAAG AGGAATCCCA GGACCTGAGG GAGAACCCGG CCCTCCAGGA 
GACCCTGGTC TCACGGAATG TGATGTCATG ACCTATGTGA GGGAGACCTG TGGATGCTGC 
GACTGTGAGA AGCGCTGTGG TGCCCTGGAT GTGGTCTTCG TCATCGACAG TTCTGAGAGT 
ATTGGCTACA CCAACTTCAC CTTGGAGAAG AACTTTGTCA TCAATGTGGT CAACAGGCTA 
GGTGCCATTG CCAAGGACCC CAAGTCAGAA ACAGGCACAC GTGTGGGTGT GGTGCAGTAC 
AGCCACGAGG GCACCTTTGA GGCCATCCGG CTGGACGACG AGCGAGTCAA CTCCCTGTCT 
AGTTTCAAGG AGGCTGTCAA AAACCTTGAA TGGATCGCCG GTGGCACTTG GACGCCCTCT 
GCCCTCAAGT TTGCCTATAA TCAGCTCATC AAAGAAAGCC GGCGCCAGAA GACCCGGGTG 
TTCGCAGTGG TCATCACGGA TGGGCGCCAT GACCCCCGAG ATGATGACCT CAATCTTCGG 
GCACTGTGTG ACCGAGATGT CACTGTGACA GCCATTGGCA TCGGTGACAT GTTCCACGAG 
ACTCATGAGA GTGAGAACCT CTACTCCATT GCCTGTGACA AGCCACAGCA AGTGCGCAAC 
ATGACGCTGT TCTCTGACCT GGTGGCCGAG AAGTTCATCG ATGACATGGA AGACGTCCTT 
TGTCCAGACC CCCAGATCGT GTGTCCAGAA CTTCCCTGCC AAACAGAGCT CTATGTGGCC 
CAGTGCACAC AACGGCCCGT GGACATTGTC TTCCTGCTGG ATGGCTCGGA GCGGCTGGGC 
GAGCAGAACT TCCACAAGGT GCGGCGCTTC GTGGAGGACG TGTCCCGGCG CCTGACTCTG 
GCCCGGAGGG ATGATGACCC ACTCAACGCC CGCATGGCTC TGTTGCAATA TGGCAGCCAG 
AATCAGCAAC AGGTGGCCTT CCCACTGACC TACAACGTGA CCACCATCCA CGAGGCCCTG 
GAGAGGGCCA CCTACCTCAA TTCCTTTTCT CACGTGGGCA CGGGCATCGT ACACGCCATC 
AACAACGTGG TGCGGGGGGC ACGGGGTGGG GCGCGGCGCC ACGCAGAGCT CTCCTTCGTC 
TTCCTCACGG ACGGTGTCAC CGGCAATGAC AGCCTGGAGG AGTCAGTGCA CTCTATGCGT 
AAGCAGAACG TGGTGCCCAC TGTGGTCGCT GTGGGCGGCG ACGTGGACAT GGATGTGCTT 
ACTAAGATCA GCCTGGGTGA CAGGGCGGCC ATCTTCCGGG AGAAAGACTT TGACAGTCTG 
GCCCAGCCCA GCTTCTTTGA CAGGTTCATC CGCTGGATCT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the ?-sarcoglycan-null mouse.
Human molecular genetics25(7)1357-69(2016 Apr)
de Greef JC,Hamlyn R,Jensen BS,O'Campo Landa R,Levy JR,Kobuke K,Campbell KP

A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease.
The Journal of clinical investigation125(12)4483-96(2015 Dec)
Soret R,Mennetrey M,Bergeron KF,Dariel A,Neunlist M,Grunder F,Faure C,Silversides DW,Pilon N,

Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.
Matrix biology : journal of the International Society for Matrix Biology4256-73(2015 Mar)
Besschetnova TY,Ichimura T,Katebi N,St Croix B,Bonventre JV,Olsen BR

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Col6a2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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