Cenpa cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cenpa
Entrez Gene ID	12615
Full Name	centromere protein A
Synonyms	Cenp-A
General protein information	Preferred Names centromere protein A Names histone H3-like centromeric protein A centromere autoantigen A centrosomin A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 B1\|5 16.76 cM
Summary	Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015].

mRNA and Protein(s)

mRNA	Protein	Name
XM_011240699.2	XP_011239001.1	histone H3-like centromeric protein A isoform X1
XM_030254094.1	XP_030109954.1	histone H3-like centromeric protein A isoform X1
NM_001302131.1	NP_001289060.1	histone H3-like centromeric protein A isoform 2
NM_007681.3	NP_031707.1	histone H3-like centromeric protein A isoform 1
NM_001302132.1	NP_001289061.1	histone H3-like centromeric protein A isoform 3
NM_001302129.1	NP_001289058.1	histone H3-like centromeric protein A isoform 2
XM_011240699.3	XP_011239001.1	histone H3-like centromeric protein A isoform X2
NM_001302130.1	NP_001289059.1	histone H3-like centromeric protein A isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CENPA	XP_515346.2
	CENPA	XP_001087306.1
Gallus gallus (chicken)	CENPA	NP_001094507.1
Xenopus tropicalis (tropical clawed frog)	cenpa	NP_001016585.1
Canis lupus familiaris (dog)	CENPA	XP_532899.2
Mus musculus (house mouse)	Cenpa	NP_031707.1
Bos taurus (cattle)	LOC782601	XP_005225982.1
Homo sapiens (human)	CENPA	NP_001800.1
Bos taurus (cattle)	CENPA	NP_001192309.1
Rattus norvegicus (Norway rat)	Cenpa	NP_001100181.1

Gene Ontology
Bibliography

Related articles in PubMed

Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis.
Iwata-Otsubo A, Dawicki-McKenna JM, Akera T, Falk SJ, Chm?tal L, Yang K, Sullivan BA, Schultz RM, Lampson MA, Black BE
Current biology : CB27(15)2365-2373.e8(2017 Aug)

CENP-A regulates chromosome segregation during the first meiosis of mouse oocytes.
Li L, Qi ST, Sun QY, Chen SL
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban37(3)313-318(2017 Jun)

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition.
Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE
Nature communications815775(2017 Jun)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

Meioc maintains an extended meiotic prophase I in mice.
Soh YQS, Mikedis MM, Kojima M, Godfrey AK, de Rooij DG, Page DC
PLoS genetics13(4)e1006704(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data implicate the insulin-FoxM1/PLK1/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
Title: Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic ??Cell Proliferation.

evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.
Title: The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.

CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.
Title: CENP-A is essential for cardiac progenitor cell proliferation.

Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.
Title: CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells.

The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs or Ligase IV.
Title: Double-strand DNA breaks recruit the centromeric histone CENP-A.

The following Cenpa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cenpa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu67359	NM_001302130.1 Latest version!	Mus musculus centromere protein A (Cenpa), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu67359	NM_001302131.1 Latest version!	Mus musculus centromere protein A (Cenpa), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu67359	NM_001302129.1 Latest version!	Mus musculus centromere protein A (Cenpa), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu67360	NM_001302132.1 Latest version!	Mus musculus centromere protein A (Cenpa), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu00596	NM_007681.3 Latest version!	Mus musculus centromere protein A (Cenpa), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu67358	XM_011240699.3 Latest version!	Mus musculus centromere protein A (Cenpa), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu88719	XM_030254094.1 Latest version!	Mus musculus centromere protein A (Cenpa), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu67358	XM_011240699.2	Mus musculus centromere protein A (Cenpa), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cenpa ( NM_001302131.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001289060.1 Mus musculus centromere protein A (Cenpa), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu67359
Clone ID Related Accession (Same CDS sequence)	NM_001302131.1 , NM_001302129.1 , NM_001302130.1
Accession Version	NM_001302131.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY136144.1, AF012709.1, AK041138.1, AC105298.21, AK011399.1 and BQ748418.1. Transcript Variant: This variant (4) contains two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU519136.1, BI904218.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGGCAGCAGA AGCTTTCCTC ATCCACCTCT TTGAGGACGC CTACCTCCTC 
TCCTTACATG CTGGTCGGGT CACGCTTTTC CCCAAAGACA TTCAGTTGAC CAGGAGAATC 
CGAGGCTTCG AGGGCGGACT CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289060.1
CDS	413..739
Translation	MDGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP

Target ORF information:

RefSeq Version	NM_001302131.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302131.1

ORF Insert Sequence:

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGGCAGCAGA AGCTTTCCTC ATCCACCTCT TTGAGGACGC CTACCTCCTC 
TCCTTACATG CTGGTCGGGT CACGCTTTTC CCCAAAGACA TTCAGTTGAC CAGGAGAATC 
CGAGGCTTCG AGGGCGGACT CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cenpa ( NM_001302129.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001289058.1 Mus musculus centromere protein A (Cenpa), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu67359
Clone ID Related Accession (Same CDS sequence)	NM_001302131.1 , NM_001302129.1 , NM_001302130.1
Accession Version	NM_001302129.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY136144.1, AF012709.1, AK041138.1, AK011399.1, BQ748418.1 and AC105298.21. On Oct 3, 2014 this sequence version replaced XM_006503708.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK041138.1, AK040313.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGGCAGCAGA AGCTTTCCTC ATCCACCTCT TTGAGGACGC CTACCTCCTC 
TCCTTACATG CTGGTCGGGT CACGCTTTTC CCCAAAGACA TTCAGTTGAC CAGGAGAATC 
CGAGGCTTCG AGGGCGGACT CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289058.1
CDS	359..685
Translation	MDGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP

Target ORF information:

RefSeq Version	NM_001302129.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302129.1

ORF Insert Sequence:

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGGCAGCAGA AGCTTTCCTC ATCCACCTCT TTGAGGACGC CTACCTCCTC 
TCCTTACATG CTGGTCGGGT CACGCTTTTC CCCAAAGACA TTCAGTTGAC CAGGAGAATC 
CGAGGCTTCG AGGGCGGACT CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cenpa ( NM_001302130.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001289059.1 Mus musculus centromere protein A (Cenpa), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu67359
Clone ID Related Accession (Same CDS sequence)	NM_001302131.1 , NM_001302129.1 , NM_001302130.1
Accession Version	NM_001302130.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY136144.1, AF012709.1, AK041138.1, AC105298.21, AK011399.1 and BQ748418.1. Transcript Variant: This variant (3) contains two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a distinct shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGGCAGCAGA AGCTTTCCTC ATCCACCTCT TTGAGGACGC CTACCTCCTC 
TCCTTACATG CTGGTCGGGT CACGCTTTTC CCCAAAGACA TTCAGTTGAC CAGGAGAATC 
CGAGGCTTCG AGGGCGGACT CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289059.1
CDS	367..693
Translation	MDGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP

Target ORF information:

RefSeq Version	NM_001302130.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302130.1

ORF Insert Sequence:

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGGCAGCAGA AGCTTTCCTC ATCCACCTCT TTGAGGACGC CTACCTCCTC 
TCCTTACATG CTGGTCGGGT CACGCTTTTC CCCAAAGACA TTCAGTTGAC CAGGAGAATC 
CGAGGCTTCG AGGGCGGACT CCCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cenpa ( NM_001302132.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001289061.1 Mus musculus centromere protein A (Cenpa), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OMu67360
Clone ID Related Accession (Same CDS sequence)	NM_001302132.1
Accession Version	NM_001302132.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY136144.1, AF012709.1, AK011399.1, AA016357.1, AC105298.21 and BQ748418.1. Transcript Variant: This variant (5) lacks a 3' exon, which results in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AA016357.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGCTCT CAGACACTGC GCAGAAGACA GAAATTCATG 
TGGCTTAAGG AAATCAAGAC CCTGCAGAAG AGCACAGACC TCTTGTTCAG GAAGAAGCCT 
TTCAGCATGG TTGTTAGAGA AATATGTGAG AAGTTCAGCC GTGGTGTGGA TTTTTGGTGG 
CAAGCCCAGG CCTTGTTGGC CCTTCAGGAG ACATTACCTG GAAGCTTTTG GAGTTGCAGC 
TTGACAGTGG TGTCGGAGGA GCTGGCTGGG TTTTGCTGTT TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289061.1
CDS	144..488
Translation	MGPRRKPQTPRRRPSSPAPGPSRQSSSVGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQETLPGSFWSCSLTVVSEELAGFCCF

Target ORF information:

RefSeq Version	NM_001302132.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302132.1

ORF Insert Sequence:

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGCTCT CAGACACTGC GCAGAAGACA GAAATTCATG 
TGGCTTAAGG AAATCAAGAC CCTGCAGAAG AGCACAGACC TCTTGTTCAG GAAGAAGCCT 
TTCAGCATGG TTGTTAGAGA AATATGTGAG AAGTTCAGCC GTGGTGTGGA TTTTTGGTGG 
CAAGCCCAGG CCTTGTTGGC CCTTCAGGAG ACATTACCTG GAAGCTTTTG GAGTTGCAGC 
TTGACAGTGG TGTCGGAGGA GCTGGCTGGG TTTTGCTGTT TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cenpa ( XM_011240699.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239001.1 Mus musculus centromere protein A (Cenpa), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu67358
Clone ID Related Accession (Same CDS sequence)	XM_011240699.2 , XM_011240699.3
Accession Version	XM_011240699.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011240699.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGACTA AGGATTGAAC GCAGGGCCTT GTGTGTACAA 
GGCTCTCAGA CACTGCGCAG AAGACAGAAA TTCATGTGGC TTAAGGAAAT CAAGACCCTG 
CAGAAGAGCA CAGACCTCTT GTTCAGGAAG AAGCCTTTCA GCATGGTTGT TAGAGAAATA 
TGTGAGAAGT TCAGCCGTGG TGTGGATTTT TGGTGGCAAG CCCAGGCCTT GTTGGCCCTT 
CAGGAGGCAG CAGAAGCTTT CCTCATCCAC CTCTTTGAGG ACGCCTACCT CCTCTCCTTA 
CATGCTGGTC GGGTCACGCT TTTCCCCAAA GACATTCAGT TGACCAGGAG AATCCGAGGC 
TTCGAGGGCG GACTCCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239001.1
CDS	137..577
Translation	MGPRRKPQTPRRRPSSPAPGPSRQSSSVGLRIERRALCVQGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP

Target ORF information:

RefSeq Version	XM_011240699.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011240699.2

ORF Insert Sequence:

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGACTA AGGATTGAAC GCAGGGCCTT GTGTGTACAA 
GGCTCTCAGA CACTGCGCAG AAGACAGAAA TTCATGTGGC TTAAGGAAAT CAAGACCCTG 
CAGAAGAGCA CAGACCTCTT GTTCAGGAAG AAGCCTTTCA GCATGGTTGT TAGAGAAATA 
TGTGAGAAGT TCAGCCGTGG TGTGGATTTT TGGTGGCAAG CCCAGGCCTT GTTGGCCCTT 
CAGGAGGCAG CAGAAGCTTT CCTCATCCAC CTCTTTGAGG ACGCCTACCT CCTCTCCTTA 
CATGCTGGTC GGGTCACGCT TTTCCCCAAA GACATTCAGT TGACCAGGAG AATCCGAGGC 
TTCGAGGGCG GACTCCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cenpa ( NM_007681.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031707.1 Mus musculus centromere protein A (Cenpa), transcript variant 1, mRNA.

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CloneID	OMu00596
Clone ID Related Accession (Same CDS sequence)	NM_007681.3
Accession Version	NM_007681.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY136144.1, AF012709.1, AK011399.1, BQ748418.1 and AC105298.21. On Oct 3, 2014 this sequence version replaced NM_007681.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF012709.1, AK053763.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 24781148 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGCTCT CAGACACTGC GCAGAAGACA GAAATTCATG 
TGGCTTAAGG AAATCAAGAC CCTGCAGAAG AGCACAGACC TCTTGTTCAG GAAGAAGCCT 
TTCAGCATGG TTGTTAGAGA AATATGTGAG AAGTTCAGCC GTGGTGTGGA TTTTTGGTGG 
CAAGCCCAGG CCTTGTTGGC CCTTCAGGAG GCAGCAGAAG CTTTCCTCAT CCACCTCTTT 
GAGGACGCCT ACCTCCTCTC CTTACATGCT GGTCGGGTCA CGCTTTTCCC CAAAGACATT 
CAGTTGACCA GGAGAATCCG AGGCTTCGAG GGCGGACTCC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031707.1
CDS	144..548
Translation	MGPRRKPQTPRRRPSSPAPGPSRQSSSVGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP

Target ORF information:

RefSeq Version	NM_007681.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007681.3

ORF Insert Sequence:

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGCTCT CAGACACTGC GCAGAAGACA GAAATTCATG 
TGGCTTAAGG AAATCAAGAC CCTGCAGAAG AGCACAGACC TCTTGTTCAG GAAGAAGCCT 
TTCAGCATGG TTGTTAGAGA AATATGTGAG AAGTTCAGCC GTGGTGTGGA TTTTTGGTGG 
CAAGCCCAGG CCTTGTTGGC CCTTCAGGAG GCAGCAGAAG CTTTCCTCAT CCACCTCTTT 
GAGGACGCCT ACCTCCTCTC CTTACATGCT GGTCGGGTCA CGCTTTTCCC CAAAGACATT 
CAGTTGACCA GGAGAATCCG AGGCTTCGAG GGCGGACTCC CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cenpa ( XM_011240699.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011239001.1 Mus musculus centromere protein A (Cenpa), transcript variant X2, mRNA.

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CloneID	OMu67358
Clone ID Related Accession (Same CDS sequence)	XM_011240699.2 , XM_011240699.3
Accession Version	XM_011240699.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011240699.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGACTA AGGATTGAAC GCAGGGCCTT GTGTGTACAA 
GGCTCTCAGA CACTGCGCAG AAGACAGAAA TTCATGTGGC TTAAGGAAAT CAAGACCCTG 
CAGAAGAGCA CAGACCTCTT GTTCAGGAAG AAGCCTTTCA GCATGGTTGT TAGAGAAATA 
TGTGAGAAGT TCAGCCGTGG TGTGGATTTT TGGTGGCAAG CCCAGGCCTT GTTGGCCCTT 
CAGGAGGCAG CAGAAGCTTT CCTCATCCAC CTCTTTGAGG ACGCCTACCT CCTCTCCTTA 
CATGCTGGTC GGGTCACGCT TTTCCCCAAA GACATTCAGT TGACCAGGAG AATCCGAGGC 
TTCGAGGGCG GACTCCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011239001.1
CDS	153..593
Translation	MGPRRKPQTPRRRPSSPAPGPSRQSSSVGLRIERRALCVQGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP

Target ORF information:

RefSeq Version	XM_011240699.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011240699.3

ORF Insert Sequence:

ATGGGCCCGC GTCGCAAACC GCAGACCCCA AGGAGGAGAC CCTCCAGCCC GGCGCCTGGA 
CCCTCGCGAC AGAGCTCCAG TGTAGGACTA AGGATTGAAC GCAGGGCCTT GTGTGTACAA 
GGCTCTCAGA CACTGCGCAG AAGACAGAAA TTCATGTGGC TTAAGGAAAT CAAGACCCTG 
CAGAAGAGCA CAGACCTCTT GTTCAGGAAG AAGCCTTTCA GCATGGTTGT TAGAGAAATA 
TGTGAGAAGT TCAGCCGTGG TGTGGATTTT TGGTGGCAAG CCCAGGCCTT GTTGGCCCTT 
CAGGAGGCAG CAGAAGCTTT CCTCATCCAC CTCTTTGAGG ACGCCTACCT CCTCTCCTTA 
CATGCTGGTC GGGTCACGCT TTTCCCCAAA GACATTCAGT TGACCAGGAG AATCCGAGGC 
TTCGAGGGCG GACTCCCCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cenpa ( XM_030254094.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030109954.1 Mus musculus centromere protein A (Cenpa), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu88719
Clone ID Related Accession (Same CDS sequence)	XM_030254094.1
Accession Version	XM_030254094.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	histone H3-like centromeric protein A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGCCACGTCA GTGTTCTCTT CTGCCCAGGC AGCAGAAGCT TTCCTCATCC 
ACCTCTTTGA GGACGCCTAC CTCCTCTCCT TACATGCTGG TCGGGTCACG CTTTTCCCCA 
AAGACATTCA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030109954.1
CDS	352..666
Translation	MDGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEPRQCSLLPRQQKLSSSTSLRTPTSSPYMLVGSRFSPKTFS

Target ORF information:

RefSeq Version	XM_030254094.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus centromere protein A (Cenpa), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030254094.1

ORF Insert Sequence:

ATGGACGGCT CTCAGACACT GCGCAGAAGA CAGAAATTCA TGTGGCTTAA GGAAATCAAG 
ACCCTGCAGA AGAGCACAGA CCTCTTGTTC AGGAAGAAGC CTTTCAGCAT GGTTGTTAGA 
GAAATATGTG AGAAGTTCAG CCGTGGTGTG GATTTTTGGT GGCAAGCCCA GGCCTTGTTG 
GCCCTTCAGG AGCCACGTCA GTGTTCTCTT CTGCCCAGGC AGCAGAAGCT TTCCTCATCC 
ACCTCTTTGA GGACGCCTAC CTCCTCTCCT TACATGCTGG TCGGGTCACG CTTTTCCCCA 
AAGACATTCA GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis.
Current biology : CB27(15)2365-2373.e8(2017 Aug)
Iwata-Otsubo A,Dawicki-McKenna JM,Akera T,Falk SJ,Chm?tal L,Yang K,Sullivan BA,Schultz RM,Lampson MA,Black BE

CENP-A regulates chromosome segregation during the first meiosis of mouse oocytes.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban37(3)313-318(2017 Jun)
Li L,Qi ST,Sun QY,Chen SL

Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition.
Nature communications815775(2017 Jun)
Guo LY,Allu PK,Zandarashvili L,McKinley KL,Sekulic N,Dawicki-McKenna JM,Fachinetti D,Logsdon GA,Jamiolkowski RM,Cleveland DW,Cheeseman IM,Black BE

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

Meioc maintains an extended meiotic prophase I in mice.
PLoS genetics13(4)e1006704(2017 Apr)
Soh YQS,Mikedis MM,Kojima M,Godfrey AK,de Rooij DG,Page DC

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Cenpa cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

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ORF Insert Sequence:

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