CDK5R1 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDK5R1
Entrez Gene ID	12569
Full Name	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Synonyms	Cdk5r,D11Bwg0379e,p25,p35
General protein information	Preferred Names cyclin-dependent kinase 5, regulatory subunit 1 (p35) Names cyclin-dependent kinase 5 activator 1 CDK5 activator 1 TPKII regulatory subunit cyclin-dependent kinase 5 regulatory subunit 1 cyclin-dependent kinase 5, regulatory subunit (p35) 1
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 11 Map Location: 11 B5\|11 47.94 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009871.3	NP_034001.1	cyclin-dependent kinase 5 activator 1
NM_009871.2	NP_034001.1	cyclin-dependent kinase 5 activator 1

Pathways from BioSystems

Homologies

	CDK5R1	XP_001113136.1
Bos taurus (cattle)	CDK5R1	NP_776937.2
Rattus norvegicus (Norway rat)	Cdk5r1	NP_446343.1
Xenopus tropicalis (tropical clawed frog)	cdk5r1	XP_002935561.1
Canis lupus familiaris (dog)	CDK5R1	XP_005624877.1
Homo sapiens (human)	CDK5R1	NP_003876.1
Pan troglodytes (chimpanzee)	CDK5R1	XP_001158783.2
Mus musculus (house mouse)	Cdk5r1	NP_034001.1
Danio rerio (zebrafish)	cdk5r1b	NP_001002515.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.
Hall BE, Prochazkova M, Sapio MR, Minetos P, Kurochkina N, Binukumar BK, Amin ND, Terse A, Joseph J, Raithel SJ, Mannes AJ, Pant HC, Chung MK, Iadarola MJ, Kulkarni AB
Scientific reports8(1)1177(2018 Jan)

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.
Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tsai LH
The Journal of neuroscience : the official journal of the Society for Neuroscience37(41)9917-9924(2017 Oct)

p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease.
Park KHJ, Franciosi S, Parrant K, Lu G, Leavitt BR
Neuroscience35279-87(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of endothelial NO plays an important role in the generation of p25 and resulting tau phosphorylation in neuronal tissue. Endothelial nitric oxide synthase (eNOS)-deficient (eNOS-/-) mice display increased levels of p25, an aberrant activator of cyclin-dependent kinase 5, which is one of the primary kinases responsible for tau hyperphosphorylation, and a statistically higher p25/p35 ratio.
Title: Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer's Disease.

It suggests that ectopic increase of Cdk5 kinase activity through conversion of p35 to p25 is involved in the process of neuronal death induced by hypoxia.
Title: Increase of p25 associated with cortical neuronal death induced by hypoxia.

These data suggest p35 and p39 have specific and overlapping roles in oligodendrocyte development, some of which may be independent of Cdk5 activation.
Title: The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination.

Cdk5 (cyclin-dependent kinase 5) requires p35 regulatory subunit (Cdk5r1) for activation; data suggest Cdk5r1 stability regulates Cdk5 activity in neurons; Cdk5r1 is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.
Title: Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination.

The transiently active CDK5-p35 complexes limited the LPS-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3)
Title: The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production.

The following CDK5R1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK5R1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22188	NM_009871.3 Latest version!	Mus musculus cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu22188	NM_009871.2	Mus musculus cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDK5R1 ( NM_009871.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_034001.1 Mus musculus cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), mRNA.

Price & Availability↑

CloneID	OMu22188
Clone ID Related Accession (Same CDS sequence)	NM_009871.3 , NM_009871.2
Accession Version	NM_009871.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinase 5 activator 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK142868.1 and BC046823.1. On Jan 19, 2017 this sequence version replaced NM_009871.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK142868.1, BC050768.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCACGG TGCTGTCCCT ATCCCCCAGC TATCGGAAGG CCACACTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA CACGGCCGTG CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGGC ACTCCATCAT CTCGGTGCTG CCTTGGAAGA GGATCGTGGC GGTGTCAGCG 
AAGAAGAAGA ACTCCAAGAA GGCGCAGCCC AACAGCAGCT ACCAGAGCAA CATCGCGCAT 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCCTGTGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCGCCGG CTCAGCCGCC CGCACCCCCA GCCAGCCAGC TTTCTGGCTC CCAGACTGGG 
GTCTCCTCTT CTGTCAAGAA GGCCCCGCAC CCTGCCATCA CCTCTGCAGG GACACCCAAA 
CGGGTCATCG TCCAGGCGTC CACTAGTGAG CTGCTGCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACTTGTCC CCAACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CCCTGCTTCT GCAGGGCTGG CAGGACCAGG GTTTCATCAC ACCGGCCAAT 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTCATCTCCT CTGAGGTGGG CTCCGACCAT 
GAGCTCCAGG CTGTCCTGCT GACCTGTCTG TACCTCTCCT ATTCCTACAT GGGCAATGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTA GAGAGCTGTA AGGAAGCCTT TTGGGACCGT 
TGCCTCTCAG TTATCAACCT CATGAGCTCC AAGATGCTGC AGATCAATGC CGACCCACAC 
TATTTCACAC AAGTGTTCTC TGACTTGAAG AATGAGAGCG GTCAGGAGGA CAAGAAGCGA 
CTCCTCCTGG GGCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034001.1
CDS	487..1410
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKAQPNSSYQSNIAHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSSVKKAPHPAITSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	NM_009871.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009871.3

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT ATCCCCCAGC TATCGGAAGG CCACACTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA CACGGCCGTG CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGGC ACTCCATCAT CTCGGTGCTG CCTTGGAAGA GGATCGTGGC GGTGTCAGCG 
AAGAAGAAGA ACTCCAAGAA GGCGCAGCCC AACAGCAGCT ACCAGAGCAA CATCGCGCAT 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCCTGTGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCGCCGG CTCAGCCGCC CGCACCCCCA GCCAGCCAGC TTTCTGGCTC CCAGACTGGG 
GTCTCCTCTT CTGTCAAGAA GGCCCCGCAC CCTGCCATCA CCTCTGCAGG GACACCCAAA 
CGGGTCATCG TCCAGGCGTC CACTAGTGAG CTGCTGCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACTTGTCC CCAACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CCCTGCTTCT GCAGGGCTGG CAGGACCAGG GTTTCATCAC ACCGGCCAAT 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTCATCTCCT CTGAGGTGGG CTCCGACCAT 
GAGCTCCAGG CTGTCCTGCT GACCTGTCTG TACCTCTCCT ATTCCTACAT GGGCAATGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTA GAGAGCTGTA AGGAAGCCTT TTGGGACCGT 
TGCCTCTCAG TTATCAACCT CATGAGCTCC AAGATGCTGC AGATCAATGC CGACCCACAC 
TATTTCACAC AAGTGTTCTC TGACTTGAAG AATGAGAGCG GTCAGGAGGA CAAGAAGCGA 
CTCCTCCTGG GGCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDK5R1 ( NM_009871.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_034001.1 Mus musculus cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), mRNA.

Price & Availability↑

CloneID	OMu22188
Clone ID Related Accession (Same CDS sequence)	NM_009871.3 , NM_009871.2
Accession Version	NM_009871.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2014-05-23
Organism	Mus musculus(House mouse)
Product	cyclin-dependent kinase 5 activator 1
Comment

ATGGGCACGG TGCTGTCCCT ATCCCCCAGC TATCGGAAGG CCACACTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA CACGGCCGTG CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGGC ACTCCATCAT CTCGGTGCTG CCTTGGAAGA GGATCGTGGC GGTGTCAGCG 
AAGAAGAAGA ACTCCAAGAA GGCGCAGCCC AACAGCAGCT ACCAGAGCAA CATCGCGCAT 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCCTGTGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCGCCGG CTCAGCCGCC CGCACCCCCA GCCAGCCAGC TTTCTGGCTC CCAGACTGGG 
GTCTCCTCTT CTGTCAAGAA GGCCCCGCAC CCTGCCATCA CCTCTGCAGG GACACCCAAA 
CGGGTCATCG TCCAGGCGTC CACTAGTGAG CTGCTGCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACTTGTCC CCAACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CCCTGCTTCT GCAGGGCTGG CAGGACCAGG GTTTCATCAC ACCGGCCAAT 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTCATCTCCT CTGAGGTGGG CTCCGACCAT 
GAGCTCCAGG CTGTCCTGCT GACCTGTCTG TACCTCTCCT ATTCCTACAT GGGCAATGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTA GAGAGCTGTA AGGAAGCCTT TTGGGACCGT 
TGCCTCTCAG TTATCAACCT CATGAGCTCC AAGATGCTGC AGATCAATGC CGACCCACAC 
TATTTCACAC AAGTGTTCTC TGACTTGAAG AATGAGAGCG GTCAGGAGGA CAAGAAGCGA 
CTCCTCCTGG GGCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034001.1
Translation	MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKAQPNSSYQSNIAHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSSVKKAPHPAITSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR

Target ORF information:

RefSeq Version	NM_009871.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009871.2

ORF Insert Sequence:

ATGGGCACGG TGCTGTCCCT ATCCCCCAGC TATCGGAAGG CCACACTGTT TGAGGATGGC 
GCGGCCACCG TGGGCCACTA CACGGCCGTG CAGAACAGCA AGAACGCCAA GGACAAGAAC 
CTGAAGCGGC ACTCCATCAT CTCGGTGCTG CCTTGGAAGA GGATCGTGGC GGTGTCAGCG 
AAGAAGAAGA ACTCCAAGAA GGCGCAGCCC AACAGCAGCT ACCAGAGCAA CATCGCGCAT 
CTCAACAATG AGAACCTGAA GAAGTCGCTG TCCTGTGCCA ACCTGTCCAC ATTCGCCCAG 
CCCCCGCCGG CTCAGCCGCC CGCACCCCCA GCCAGCCAGC TTTCTGGCTC CCAGACTGGG 
GTCTCCTCTT CTGTCAAGAA GGCCCCGCAC CCTGCCATCA CCTCTGCAGG GACACCCAAA 
CGGGTCATCG TCCAGGCGTC CACTAGTGAG CTGCTGCGCT GCCTGGGTGA GTTTCTCTGC 
CGCCGGTGCT ACCGCCTGAA GCACTTGTCC CCAACGGACC CCGTGCTCTG GCTGCGCAGC 
GTGGACCGCT CCCTGCTTCT GCAGGGCTGG CAGGACCAGG GTTTCATCAC ACCGGCCAAT 
GTGGTCTTCC TCTACATGCT CTGCAGGGAT GTCATCTCCT CTGAGGTGGG CTCCGACCAT 
GAGCTCCAGG CTGTCCTGCT GACCTGTCTG TACCTCTCCT ATTCCTACAT GGGCAATGAG 
ATCTCCTACC CGCTCAAGCC CTTCCTGGTA GAGAGCTGTA AGGAAGCCTT TTGGGACCGT 
TGCCTCTCAG TTATCAACCT CATGAGCTCC AAGATGCTGC AGATCAATGC CGACCCACAC 
TATTTCACAC AAGTGTTCTC TGACTTGAAG AATGAGAGCG GTCAGGAGGA CAAGAAGCGA 
CTCCTCCTGG GGCTGGATCG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.
Scientific reports8(1)1177(2018 Jan)
Hall BE,Prochazkova M,Sapio MR,Minetos P,Kurochkina N,Binukumar BK,Amin ND,Terse A,Joseph J,Raithel SJ,Mannes AJ,Pant HC,Chung MK,Iadarola MJ,Kulkarni AB

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(41)9917-9924(2017 Oct)
Seo J,Kritskiy O,Watson LA,Barker SJ,Dey D,Raja WK,Lin YT,Ko T,Cho S,Penney J,Silva MC,Sheridan SD,Lucente D,Gusella JF,Dickerson BC,Haggarty SJ,Tsai LH

p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease.
Neuroscience35279-87(2017 Jun)
Park KHJ,Franciosi S,Parrant K,Lu G,Leavitt BR

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CDK5R1 cDNA ORF clone, Mus musculus(House mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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