Cdh15 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdh15
Entrez Gene ID	12555
Full Name	cadherin 15
Synonyms	AI323380,Cdh14,Mcad
General protein information	Preferred Names cadherin 15 Names cadherin-15 M-cadherin cadherin-14 muscle cadherin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 E1\|8 71.99 cM
Summary	This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Based on the expression of this gene in skeletal muscle, satellite cells and cerebellum, it was postulated that the encoded protein may be important for muscle development and regeneration. Mice lacking the encoded protein appear normal and display no discernible defects in skeletal musculature. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007662.2	NP_031688.2	cadherin-15 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDH15	NP_004924.1
Bos taurus (cattle)	CDH15	NP_001095536.1
Canis lupus familiaris (dog)	CDH15	XP_536750.3
Rattus norvegicus (Norway rat)	Cdh15	NP_997496.1
Xenopus tropicalis (tropical clawed frog)	cdh15	XP_002933722.2
Mus musculus (house mouse)	Cdh15	NP_031688.2
Pan troglodytes (chimpanzee)	CDH15	XP_003315293.1
Danio rerio (zebrafish)	cdh15	NP_997771.1

Gene Ontology
Bibliography

Related articles in PubMed

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.
Lib?-Philippot B, Michel V, Boutet de Monvel J, Le Gal S, Dupont T, Avan P, M?tin C, Michalski N, Petit C
Proceedings of the National Academy of Sciences of the United States of America114(30)7765-7774(2017 Jul)

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.
Lu J, Xu Q, Ji M, Guo X, Xu X, Fargo DC, Li X
EMBO reports18(5)841-857(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Treatment of satellite cells with M-cadherin in vitro stimulates cell division, whereas addition of anti-M-cadherin antibodies reduces the cell division rate.
Title: M-cadherin-mediated intercellular interactions activate satellite cell division.

The recruitment of M-cadherin to lipid rafts during pre-fusion myogenesis events depended on interaction with p120 catenin, whereas the organization of microrafts was controlled by a small G protein, Rac1.
Title: Regulation of pre-fusion events: recruitment of M-cadherin to microrafts organized at fusion-competent sites of myogenic cells.

M-cadherin-mediated signaling attenuates beta-catenin phosphorylation.
Title: M-cadherin-inhibited phosphorylation of ?-catenin augments differentiation of mouse myoblasts.

Inhibition of GSK-3beta activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation.
Title: Suppression of GSK-3? activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation.

These data suggest that Toxoplasma gondii is able to down regulate M-cadherin expression, leading to molecular modifications in the host cell surface that interfere with membrane fusion and consequently affect the myogenesis process.
Title: Toxoplasma gondii down modulates cadherin expression in skeletal muscle cells inhibiting myogenesis.

The following Cdh15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdh15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00555	NM_007662.2 Latest version!	Mus musculus cadherin 15 (Cdh15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdh15 ( NM_007662.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031688.2 Mus musculus cadherin 15 (Cdh15), mRNA.

Price & Availability↑

CloneID	OMu00555
Clone ID Related Accession (Same CDS sequence)	NM_007662.2
Accession Version	NM_007662.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2355bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	cadherin-15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC167359.4 and AC132287.3. On Dec 27, 2006 this sequence version replaced NM_007662.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M74541.1, BC157978.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTTCTG CTCTGCTCCT CGCCCTCGGG CTGCTTGCCC AGAGCCTTGG CCTGTCCTGG 
GCAGTCCCTG AGCCCAAACC CAGCACCCTG TACCCCTGGC GCCGGGCATC AGCCCCAGGC 
CGTGTGCGGA GAGCCTGGGT CATCCCACCC ATTAGTGTGT CTGAGAACCA CAAACGCCTC 
CCCTACCCAC TTGTGCAGAT CAAGTCTGAC AAACAGCAGC TAGGCAGTGT CATCTACAGC 
ATCCAGGGTC CCGGAGTGGA TGAGGAGCCC CGAAATGTCT TCTCCATCGA CAAGTTCACC 
GGGAGGGTGT ACCTCAATGC CACGCTGGAC CGCGAGAAGA CGGACCGCTT CAGGCTAAGG 
GCCTTTGCCT TGGACTTGGG TGGCTCTACC CTGGAGGACC CCACGGACCT GGAGATCGTT 
GTGGTGGATC AAAATGACAA CCGGCCAGCC TTCCTACAGG ATGTGTTCAG AGGCCGCATC 
CTGGAGGGTG CCATCCCAGG CACCTTCGTC ACCAGGGCTG AGGCCACAGA TGCCGACGAC 
CCAGAGACAG ACAATGCAGC CCTCAGGTTC TCCATCCTGG AGCAGGGCAG CCCTGAGTTC 
TTCAGCATCG ACGAGCACAC GGGAGAGATC CGCACGGTGC AAGTGGGGCT GGACCGTGAG 
GTGGTGGCTG TGTATAATCT GACCTTGCAA GTGGCAGACA TGTCGGGAGA CGGACTCACT 
GCCACAGCCT CGGCCATCAT CTCCATAGAT GACATCAACG ACAATGCCCC CGAGTTCACC 
AAGGATGAGT TCTTTATGGA GGCTGCAGAG GCTGTCAGTG GAGTGGACGT GGGACGGCTC 
GAGGTGGAAG ACAAGGACCT GCCTGGTTCC CCCAACTGGG TGGCCAGGTT CACCATCCTT 
GAAGGTGATC CTGATGGGCA GTTCAAGATC TACACAGACC CTAAGACCAA TGAAGGTGTG 
CTGTCCGTGG TCAAGCCCCT GGACTATGAG AGCCGTGAGC AGTATGAGCT CAGAGTGTCT 
GTACAAAACG AGGCCCCGCT GCAGGCAGCT GCCCCTCGGG CTCGGCGGGG CCAGACCAGG 
GTCAGCGTGT GGGTTCAGGA CACCAACGAA GCTCCAGTGT TTCCAGAGAA CCCACTGAGG 
ACGAGCATAG CTGAAGGAGC CCCCCCAGGC ACCTCTGTGG CCACCTTCTC TGCCAGAGAC 
CCTGACACAG AACAGCTGCA GAGAATCAGC TACTCCAAAG ACTACGACCC AGAAGACTGG 
CTGCAAGTGG ACGGGGCCAC AGGCAGGATC CAGACCCAGC GAGTGCTGAG CCCTGCTTCA 
CCCTTTTTGA AGGACGGCTG GTACAGAGCC ATCATCCTAG CCCTGGACAA TGCCATTCCT 
CCTAGCACAG CCACAGGCAC CCTGTCCATC GAGATCCTAG AAGTCAACGA CCATGCCCCT 
GCACTGGCTC TTCCTCCATC TGGCAGCCTG TGCAGTGAAC CAGACCAGGG CCCTGGCCTC 
CTCTTGGGTG CCACGGATGA GGACCTGCCC CCACACGGGG CCCCTTTCCA CTTCCAGCTG 
AACCCCAGAG TACCAGATCT GGGCCGGAAC TGGAGCGTCA GCCAGATTAA CGTGAGCCAT 
GCACGCTTGC GGCTCCGACA TCAGGTCTCC GAGGGCCTGC ATCGCCTGAG CCTGCTACTC 
CAGGACTCTG GGGAGCCACC CCAGCAGCGA GAGCAAACGC TGAACGTCAC CGTGTGTCGC 
TGTGGGTCGG ATGGCACTTG CCTGCCCGGG GCTGCCGCGC TTCGAGGAGG AGGTGTAGGC 
GTCAGCTTGG GGGCACTGGT CATTGTGCTG GCCAGCACCG TGGTCTTACT AGTTCTCATC 
CTGCTTGCCG CGCTCCGCAC ACGGTTCCGG GGGCATTCCC GGGGCAAGAG TCTGTTGCAT 
GGCCTACAAG AGGACCTTCG GGACAACATC CTTAACTATG ATGAGCAAGG AGGCGGGGAG 
GAGGACCAGG ATGCGTACGA CATAAACCAG CTGCGCCACC CAGTGGAGCC GAGGGCCACA 
AGTCGCTCTT TGGGCAGGCC ACCCCTGCGC AGGGATGCCC CCTTCAGCTA TGTGCCACAG 
CCACATCGAG TGCTTCCCAC CAGCCCATCT GACATTGCCA ACTTCATCAG TGATGGCTTG 
GAGGCTGCGG ACAGCGACCC CAGCGTGCCT CCCTACGACA CAGCTCTCAT CTATGACTAC 
GAGGGAGATG GCTCTGTGGC AGGGACGCTG AGCTCCATTC TGTCCAGCCT GGGAGATGAA 
GACCAGGACT ATGACTACCT CCGGGACTGG GGACCCCGCT TTGCTCGGCT GGCGGACATG 
TATGGACATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031688.2
CDS	115..2469
Translation	MGSALLLALGLLAQSLGLSWAVPEPKPSTLYPWRRASAPGRVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRNVFSIDKFTGRVYLNATLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQDVFRGRILEGAIPGTFVTRAEATDADDPETDNAALRFSILEQGSPEFFSIDEHTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIISIDDINDNAPEFTKDEFFMEAAEAVSGVDVGRLEVEDKDLPGSPNWVARFTILEGDPDGQFKIYTDPKTNEGVLSVVKPLDYESREQYELRVSVQNEAPLQAAAPRARRGQTRVSVWVQDTNEAPVFPENPLRTSIAEGAPPGTSVATFSARDPDTEQLQRISYSKDYDPEDWLQVDGATGRIQTQRVLSPASPFLKDGWYRAIILALDNAIPPSTATGTLSIEILEVNDHAPALALPPSGSLCSEPDQGPGLLLGATDEDLPPHGAPFHFQLNPRVPDLGRNWSVSQINVSHARLRLRHQVSEGLHRLSLLLQDSGEPPQQREQTLNVTVCRCGSDGTCLPGAAALRGGGVGVSLGALVIVLASTVVLLVLILLAALRTRFRGHSRGKSLLHGLQEDLRDNILNYDEQGGGEEDQDAYDINQLRHPVEPRATSRSLGRPPLRRDAPFSYVPQPHRVLPTSPSDIANFISDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSLGDEDQDYDYLRDWGPRFARLADMYGHQ

Target ORF information:

RefSeq Version	NM_007662.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cadherin 15 (Cdh15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007662.2

ORF Insert Sequence:

ATGGGTTCTG CTCTGCTCCT CGCCCTCGGG CTGCTTGCCC AGAGCCTTGG CCTGTCCTGG 
GCAGTCCCTG AGCCCAAACC CAGCACCCTG TACCCCTGGC GCCGGGCATC AGCCCCAGGC 
CGTGTGCGGA GAGCCTGGGT CATCCCACCC ATTAGTGTGT CTGAGAACCA CAAACGCCTC 
CCCTACCCAC TTGTGCAGAT CAAGTCTGAC AAACAGCAGC TAGGCAGTGT CATCTACAGC 
ATCCAGGGTC CCGGAGTGGA TGAGGAGCCC CGAAATGTCT TCTCCATCGA CAAGTTCACC 
GGGAGGGTGT ACCTCAATGC CACGCTGGAC CGCGAGAAGA CGGACCGCTT CAGGCTAAGG 
GCCTTTGCCT TGGACTTGGG TGGCTCTACC CTGGAGGACC CCACGGACCT GGAGATCGTT 
GTGGTGGATC AAAATGACAA CCGGCCAGCC TTCCTACAGG ATGTGTTCAG AGGCCGCATC 
CTGGAGGGTG CCATCCCAGG CACCTTCGTC ACCAGGGCTG AGGCCACAGA TGCCGACGAC 
CCAGAGACAG ACAATGCAGC CCTCAGGTTC TCCATCCTGG AGCAGGGCAG CCCTGAGTTC 
TTCAGCATCG ACGAGCACAC GGGAGAGATC CGCACGGTGC AAGTGGGGCT GGACCGTGAG 
GTGGTGGCTG TGTATAATCT GACCTTGCAA GTGGCAGACA TGTCGGGAGA CGGACTCACT 
GCCACAGCCT CGGCCATCAT CTCCATAGAT GACATCAACG ACAATGCCCC CGAGTTCACC 
AAGGATGAGT TCTTTATGGA GGCTGCAGAG GCTGTCAGTG GAGTGGACGT GGGACGGCTC 
GAGGTGGAAG ACAAGGACCT GCCTGGTTCC CCCAACTGGG TGGCCAGGTT CACCATCCTT 
GAAGGTGATC CTGATGGGCA GTTCAAGATC TACACAGACC CTAAGACCAA TGAAGGTGTG 
CTGTCCGTGG TCAAGCCCCT GGACTATGAG AGCCGTGAGC AGTATGAGCT CAGAGTGTCT 
GTACAAAACG AGGCCCCGCT GCAGGCAGCT GCCCCTCGGG CTCGGCGGGG CCAGACCAGG 
GTCAGCGTGT GGGTTCAGGA CACCAACGAA GCTCCAGTGT TTCCAGAGAA CCCACTGAGG 
ACGAGCATAG CTGAAGGAGC CCCCCCAGGC ACCTCTGTGG CCACCTTCTC TGCCAGAGAC 
CCTGACACAG AACAGCTGCA GAGAATCAGC TACTCCAAAG ACTACGACCC AGAAGACTGG 
CTGCAAGTGG ACGGGGCCAC AGGCAGGATC CAGACCCAGC GAGTGCTGAG CCCTGCTTCA 
CCCTTTTTGA AGGACGGCTG GTACAGAGCC ATCATCCTAG CCCTGGACAA TGCCATTCCT 
CCTAGCACAG CCACAGGCAC CCTGTCCATC GAGATCCTAG AAGTCAACGA CCATGCCCCT 
GCACTGGCTC TTCCTCCATC TGGCAGCCTG TGCAGTGAAC CAGACCAGGG CCCTGGCCTC 
CTCTTGGGTG CCACGGATGA GGACCTGCCC CCACACGGGG CCCCTTTCCA CTTCCAGCTG 
AACCCCAGAG TACCAGATCT GGGCCGGAAC TGGAGCGTCA GCCAGATTAA CGTGAGCCAT 
GCACGCTTGC GGCTCCGACA TCAGGTCTCC GAGGGCCTGC ATCGCCTGAG CCTGCTACTC 
CAGGACTCTG GGGAGCCACC CCAGCAGCGA GAGCAAACGC TGAACGTCAC CGTGTGTCGC 
TGTGGGTCGG ATGGCACTTG CCTGCCCGGG GCTGCCGCGC TTCGAGGAGG AGGTGTAGGC 
GTCAGCTTGG GGGCACTGGT CATTGTGCTG GCCAGCACCG TGGTCTTACT AGTTCTCATC 
CTGCTTGCCG CGCTCCGCAC ACGGTTCCGG GGGCATTCCC GGGGCAAGAG TCTGTTGCAT 
GGCCTACAAG AGGACCTTCG GGACAACATC CTTAACTATG ATGAGCAAGG AGGCGGGGAG 
GAGGACCAGG ATGCGTACGA CATAAACCAG CTGCGCCACC CAGTGGAGCC GAGGGCCACA 
AGTCGCTCTT TGGGCAGGCC ACCCCTGCGC AGGGATGCCC CCTTCAGCTA TGTGCCACAG 
CCACATCGAG TGCTTCCCAC CAGCCCATCT GACATTGCCA ACTTCATCAG TGATGGCTTG 
GAGGCTGCGG ACAGCGACCC CAGCGTGCCT CCCTACGACA CAGCTCTCAT CTATGACTAC 
GAGGGAGATG GCTCTGTGGC AGGGACGCTG AGCTCCATTC TGTCCAGCCT GGGAGATGAA 
GACCAGGACT ATGACTACCT CCGGGACTGG GGACCCCGCT TTGCTCGGCT GGCGGACATG 
TATGGACATC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.
Proceedings of the National Academy of Sciences of the United States of America114(30)7765-7774(2017 Jul)
Lib?-Philippot B,Michel V,Boutet de Monvel J,Le Gal S,Dupont T,Avan P,M?tin C,Michalski N,Petit C

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.
EMBO reports18(5)841-857(2017 May)
Lu J,Xu Q,Ji M,Guo X,Xu X,Fargo DC,Li X

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Cdh15 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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