Cd8b1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd8b1
Entrez Gene ID	12526
Full Name	CD8 antigen, beta chain 1
Synonyms	Cd8b,Ly-3,Ly-C,Lyt-3
General protein information	Preferred Names CD8 antigen, beta chain 1 Names T-cell surface glycoprotein CD8 beta chain T-cell membrane glycoprotein Ly-3 T-cell surface glycoprotein Lyt-3 lymphocyte antigen 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 C1\|6 32.14 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009858.2	NP_033988.1	T-cell surface glycoprotein CD8 beta chain precursor
NM_009858.3	NP_033988.1	T-cell surface glycoprotein CD8 beta chain precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cd8b1	NP_033988.1
Bos taurus (cattle)	CD8B	NP_001098814.1
Homo sapiens (human)	CD8B	NP_004922.1
Canis lupus familiaris (dog)	CD8B	XP_865047.1
Rattus norvegicus (Norway rat)	Cd8b	NP_113727.1
Pan troglodytes (chimpanzee)	CD8B	XP_001139428.1

Gene Ontology
Bibliography

Related articles in PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H, Stuart JM, Gu W
BMC immunology17(1)25(2016 08)

The thymic cortical epithelium determines the TCR repertoire of IL-17-producing ??T cells.
Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu-Takanashi R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H
EMBO reports16(5)638-53(2015 May)

A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8??+ dendritic cells.
Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W
Journal of leukocyte biology97(4)635-44(2015 Apr)

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR
Nature communications55624(2014 Nov)

Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice.
Matundan H, Mott KR, Ghiasi H
Journal of virology88(14)8016-27(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.
Title: A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8??+ dendritic cells.

Lck-CD8 interaction is required for initial CD8 recruitment.
Title: Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.

CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
Title: cAMP responsive element modulator (CREM) ? mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.

We propose that ADP-ribosylation of CD8-beta can regulate the coreceptor function of CD8 in the presence of elevated levels of extracellular NAD(+) .
Title: CD8-? ADP-ribosylation affects CD8(+) T-cell function.

Data indicate that CD8low cells survive long term in vivo.
Title: Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.

The following Cd8b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd8b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20267	NM_009858.3 Latest version!	Mus musculus CD8 antigen, beta chain 1 (Cd8b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu20267	NM_009858.2	Mus musculus CD8 antigen, beta chain 1 (Cd8b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd8b1 ( NM_009858.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033988.1 Mus musculus CD8 antigen, beta chain 1 (Cd8b1), mRNA.

Price & Availability↑

CloneID	OMu20267
Clone ID Related Accession (Same CDS sequence)	NM_009858.2 , NM_009858.3
Accession Version	NM_009858.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Mus musculus(house mouse)
Product	T-cell surface glycoprotein CD8 beta chain precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC160090.4. On Nov 17, 2006 this sequence version replaced NM_009858.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154055.1, AK087944.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCCAT GGCTCTGGCT GGTCTTCAGT ATGAAGCTGG CAGCTCTCTG GAGCAGCTCT 
GCCCTCATTC AGACCCCTTC GTCCCTGCTG GTTCAAACCA ACCATACGGC AAAGATGTCC 
TGTGAGGTTA AAAGCATCTC TAAGTTAACA AGCATCTACT GGCTGCGGGA GCGCCAGGAC 
CCCAAGGACA AGTACTTTGA GTTCCTGGCC TCCTGGAGTT CTTCCAAAGG AGTTTTGTAT 
GGTGAAAGTG TGGACAAGAA AAGAAATATA ATTCTTGAGT CTTCAGACTC AAGACGGCCC 
TTTCTCAGTA TCATGAATGT GAAGCCAGAG GACAGTGACT TCTACTTCTG CGCGACGGTT 
GGGAGCCCCA AGATGGTCTT TGGGACAGGG ACGAAGCTGA CTGTGGTTGA TGTCCTTCCT 
ACAACTGCCC CAACCAAGAA GACTACCCTG AAGATGAAGA AGAAGAAGCA ATGCCCGTTC 
CCCCACCCAG AGACCCAGAA GGGCCTGACA TGCAGCCTTA CCACCCTCAG CCTGCTGGTA 
GTCTGCATCC TGCTTCTGCT GGCATTCCTC GGAGTGGCCG TCTACTTTTA CTGTGTGCGG 
AGGAGAGCCC GAATTCACTT CATGAAACAG TTTCACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033988.1
CDS	46..687
Translation	MQPWLWLVFSMKLAALWSSSALIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDPKDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRPFLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVVDVLPTTAPTKKTTLKMKKKKQCPFPHPETQKGLTCSLTTLSLLVVCILLLLAFLGVAVYFYCVRRRARIHFMKQFHK

Target ORF information:

RefSeq Version	NM_009858.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD8 antigen, beta chain 1 (Cd8b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009858.2

ORF Insert Sequence:

ATGCAGCCAT GGCTCTGGCT GGTCTTCAGT ATGAAGCTGG CAGCTCTCTG GAGCAGCTCT 
GCCCTCATTC AGACCCCTTC GTCCCTGCTG GTTCAAACCA ACCATACGGC AAAGATGTCC 
TGTGAGGTTA AAAGCATCTC TAAGTTAACA AGCATCTACT GGCTGCGGGA GCGCCAGGAC 
CCCAAGGACA AGTACTTTGA GTTCCTGGCC TCCTGGAGTT CTTCCAAAGG AGTTTTGTAT 
GGTGAAAGTG TGGACAAGAA AAGAAATATA ATTCTTGAGT CTTCAGACTC AAGACGGCCC 
TTTCTCAGTA TCATGAATGT GAAGCCAGAG GACAGTGACT TCTACTTCTG CGCGACGGTT 
GGGAGCCCCA AGATGGTCTT TGGGACAGGG ACGAAGCTGA CTGTGGTTGA TGTCCTTCCT 
ACAACTGCCC CAACCAAGAA GACTACCCTG AAGATGAAGA AGAAGAAGCA ATGCCCGTTC 
CCCCACCCAG AGACCCAGAA GGGCCTGACA TGCAGCCTTA CCACCCTCAG CCTGCTGGTA 
GTCTGCATCC TGCTTCTGCT GGCATTCCTC GGAGTGGCCG TCTACTTTTA CTGTGTGCGG 
AGGAGAGCCC GAATTCACTT CATGAAACAG TTTCACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd8b1 ( NM_009858.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033988.1 Mus musculus CD8 antigen, beta chain 1 (Cd8b1), mRNA.

Price & Availability↑

CloneID	OMu20267
Clone ID Related Accession (Same CDS sequence)	NM_009858.2 , NM_009858.3
Accession Version	NM_009858.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	T-cell surface glycoprotein CD8 beta chain precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY084951.1, AK169581.1, AK162993.1 and BF023006.1. On Feb 16, 2018 this sequence version replaced NM_009858.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK154055.1, AK087944.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCCAT GGCTCTGGCT GGTCTTCAGT ATGAAGCTGG CAGCTCTCTG GAGCAGCTCT 
GCCCTCATTC AGACCCCTTC GTCCCTGCTG GTTCAAACCA ACCATACGGC AAAGATGTCC 
TGTGAGGTTA AAAGCATCTC TAAGTTAACA AGCATCTACT GGCTGCGGGA GCGCCAGGAC 
CCCAAGGACA AGTACTTTGA GTTCCTGGCC TCCTGGAGTT CTTCCAAAGG AGTTTTGTAT 
GGTGAAAGTG TGGACAAGAA AAGAAATATA ATTCTTGAGT CTTCAGACTC AAGACGGCCC 
TTTCTCAGTA TCATGAATGT GAAGCCAGAG GACAGTGACT TCTACTTCTG CGCGACGGTT 
GGGAGCCCCA AGATGGTCTT TGGGACAGGG ACGAAGCTGA CTGTGGTTGA TGTCCTTCCT 
ACAACTGCCC CAACCAAGAA GACTACCCTG AAGATGAAGA AGAAGAAGCA ATGCCCGTTC 
CCCCACCCAG AGACCCAGAA GGGCCTGACA TGCAGCCTTA CCACCCTCAG CCTGCTGGTA 
GTCTGCATCC TGCTTCTGCT GGCATTCCTC GGAGTGGCCG TCTACTTTTA CTGTGTGCGG 
AGGAGAGCCC GAATTCACTT CATGAAACAG TTTCACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033988.1
CDS	70..711
Translation	MQPWLWLVFSMKLAALWSSSALIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDPKDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRPFLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVVDVLPTTAPTKKTTLKMKKKKQCPFPHPETQKGLTCSLTTLSLLVVCILLLLAFLGVAVYFYCVRRRARIHFMKQFHK

Target ORF information:

RefSeq Version	NM_009858.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD8 antigen, beta chain 1 (Cd8b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009858.3

ORF Insert Sequence:

ATGCAGCCAT GGCTCTGGCT GGTCTTCAGT ATGAAGCTGG CAGCTCTCTG GAGCAGCTCT 
GCCCTCATTC AGACCCCTTC GTCCCTGCTG GTTCAAACCA ACCATACGGC AAAGATGTCC 
TGTGAGGTTA AAAGCATCTC TAAGTTAACA AGCATCTACT GGCTGCGGGA GCGCCAGGAC 
CCCAAGGACA AGTACTTTGA GTTCCTGGCC TCCTGGAGTT CTTCCAAAGG AGTTTTGTAT 
GGTGAAAGTG TGGACAAGAA AAGAAATATA ATTCTTGAGT CTTCAGACTC AAGACGGCCC 
TTTCTCAGTA TCATGAATGT GAAGCCAGAG GACAGTGACT TCTACTTCTG CGCGACGGTT 
GGGAGCCCCA AGATGGTCTT TGGGACAGGG ACGAAGCTGA CTGTGGTTGA TGTCCTTCCT 
ACAACTGCCC CAACCAAGAA GACTACCCTG AAGATGAAGA AGAAGAAGCA ATGCCCGTTC 
CCCCACCCAG AGACCCAGAA GGGCCTGACA TGCAGCCTTA CCACCCTCAG CCTGCTGGTA 
GTCTGCATCC TGCTTCTGCT GGCATTCCTC GGAGTGGCCG TCTACTTTTA CTGTGTGCGG 
AGGAGAGCCC GAATTCACTT CATGAAACAG TTTCACAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.
BMC immunology17(1)25(2016 08)
Liu X,Jiao Y,Cao Y,Deng N,Ma Y,Hasty KA,Kang A,Chen H,Stuart JM,Gu W

The thymic cortical epithelium determines the TCR repertoire of IL-17-producing ??T cells.
EMBO reports16(5)638-53(2015 May)
Nitta T,Muro R,Shimizu Y,Nitta S,Oda H,Ohte Y,Goto M,Yanobu-Takanashi R,Narita T,Takayanagi H,Yasuda H,Okamura T,Murata S,Suzuki H

A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8??+ dendritic cells.
Journal of leukocyte biology97(4)635-44(2015 Apr)
Sakaguchi S,Hombauer M,Hassan H,Tanaka H,Yasmin N,Naoe Y,Bilic I,Moser MA,Hainberger D,Mayer H,Seiser C,Bergthaler A,Taniuchi I,Ellmeier W

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.
Nature communications55624(2014 Nov)
Casas J,Brzostek J,Zarnitsyna VI,Hong JS,Wei Q,Hoerter JA,Fu G,Ampudia J,Zamoyska R,Zhu C,Gascoigne NR

Role of CD8+ T cells and lymphoid dendritic cells in protection from ocular herpes simplex virus 1 challenge in immunized mice.
Journal of virology88(14)8016-27(2014 Jul)
Matundan H,Mott KR,Ghiasi H

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Cd8b1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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