Cd5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cd5
Entrez Gene ID	12507
Full Name	CD5 antigen
Synonyms	Ly-1,Ly-12,Ly-A,Lyt-1
General protein information	Preferred Names CD5 antigen Names T-cell surface glycoprotein CD5 lymphocyte antigen 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 A\|19 7.16 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006526621.2	XP_006526684.1	T-cell surface glycoprotein CD5 isoform X1
NM_007650.3	NP_031676.3	T-cell surface glycoprotein CD5 precursor

Pathways from BioSystems

Homologies

	CD5	XP_001083880.1
Pan troglodytes (chimpanzee)	CD5	XP_001138219.1
Bos taurus (cattle)	CD5	NP_776324.1
Mus musculus (house mouse)	Cd5	NP_031676.3
Homo sapiens (human)	CD5	NP_055022.2
Rattus norvegicus (Norway rat)	Cd5	NP_062168.1
Rattus norvegicus (Norway rat)	LOC100911215	XP_006231143.1
Canis lupus familiaris (dog)	CD5	XP_005631747.1
Gallus gallus (chicken)	CD5	NP_990252.1

Gene Ontology
Bibliography

Related articles in PubMed

TLR4 supports the expansion of FasL
Wang K, Tao L, Su J, Zhang Y, Zou B, Wang Y, Zou M, Chen N, Lei L, Li X
Molecular immunology87188-199(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FasL expression in splenic CD5(+)CD1d(hi) B cells was decreased compared to the control group after TLR4 ligation.
Title: TLR4 supports the expansion of FasL

the reduction in the positive selection conferred by CD5 overexpression was unaffected by SHP-1 deficiency.
Title: CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1.

In mouse tumor models, CD5(+) but not CD5(-) B cells promoted tumor growth. The results demonstrate a critical role of CD5(+) B cells in promoting cancer.
Title: CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer.

In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity.
Title: Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cells.

CD5-CK2 signaling axis regulates positive selection by modulating activation of ERK and promoting survival independent of proximal TCR signals
Title: CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival.

The following Cd5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cd5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00540	NM_007650.3 Latest version!	Mus musculus CD5 antigen (Cd5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$286.30 $409.00
OMu55210	XM_006526621.2 Latest version!	Mus musculus CD5 antigen (Cd5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cd5 ( NM_007650.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031676.3 Mus musculus CD5 antigen (Cd5), mRNA.

Price & Availability↑

CloneID	OMu00540
Clone ID Related Accession (Same CDS sequence)	NM_007650.3
Accession Version	NM_007650.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1485bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	T-cell surface glycoprotein CD5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132247.3, AK143736.1 and AI528619.1. On Mar 2, 2007 this sequence version replaced NM_007650.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011258.1, AK143736.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGACTCCC ACGAAGTGCT GCTGGCTGCC ACATACCTGC TGGGAACGCT GGCGGCTTTC 
TGCCTCGGAC AGTCTGGAAG GGGTGGCCTA GATATCCAGG TGATGCTAAG TGGCTCCAAT 
TCCAAGTGTC AGGGTCAAGT GGAGATCCAG ATGGAAAACA AGTGGAAAAC AGTGTGCAGT 
TCCAGTTGGA GGCTGAGCCA GGACCATTCG AAAAATGCCC AGCAGGCCTC TGCAGTGTGC 
AAACAGCTGA GATGTGGTGA CCCCTTGGCC CTTGGTCCTT TCCCTTCATT GAACAGACCC 
CAGAACCAGG TCTTCTGCCA AGGATCTCCG TGGTCTATAT CCAACTGCAA CAACACAAGT 
TCACAAGACC AGTGCCTTCC GCTGAGCCTG ATCTGCCTAG AGCCCCAGAG AACGACACCT 
CCACCCACAA CCACCCCACC CACCACCGTG CCGGAGCCCA CAGCTCCTCC CAGATTGCAG 
CTGGTGCCAG GACACGAAGG CCTGAGGTGC ACAGGTGTGG TGGAATTCTA CAATGGCAGC 
TGGGGTGGCA CCATCCTCTA CAAGGCCAAG GACAGGCCCC TGGGCCTGGG GAACCTCATC 
TGTAAGTCTC TGCAGTGTGG CTCTTTCTTG ACACATCTGT CCGGGACAGA GGCAGCAGGG 
ACACCAGCTC CTGCAGAGCT GAGGGACCCC AGGCCCTTGC CAATTCGATG GGAGGCCCCG 
AACGGGAGCT GTGTCTCACT ACAGCAGTGC TTCCAGAAAA CAACGGCCCA GGAGGGCGGC 
CAGGCGCTCA CCGTCATCTG CTCTGATTTC CAGCCCAAGG TTCAGAGCCG CCTGGTCGGG 
GGCAGCAGTG TGTGTGAGGG CATCGCTGAA GTGCGCCAGA GATCACAGTG GGAGGCCCTG 
TGTGACAGTT CTGCAGCCAG GGGCCGGGGA CGGTGGGAAG AGCTATGTCG GGAGCAGCAG 
TGTGGCGACC TCATCTCCTT CCACACGGTG GATGCTGACA AAACCTCCCC CGGGTTCCTC 
TGTGCCCAGG AGAAGCTGTC TCAGTGTTAC CATCTCCAGA AAAAAAAACA CTGCAACAAG 
AGGGTATTCG TCACATGCCA AGACCCAAAC CCAGCGGGCC TGGCCCCAGG CACTGTGGCA 
AGCATCATCC TGACCCTTGT ACTCCTGGTG GTGCTGCTGG CCATGTGTGG TCCTCTGGTC 
TACAAGAAGC TGGTGAAGAA ATTTCGTCAG AAAAAGCAGC GTCAGTGGAT TGGCCCCACA 
GGAGTGAACC AGAACATGTC TTTCCATCGA AGCCACACAG CAACTGTGCG GTCCCAAGTT 
GAGAACCCAA CAGCCTCTCA TGTGGACAAT GAATACAGCC AGCCTCCCAG GAACTCTCAC 
CTGTCTGCTT ATCCAGCTCT GGAAGGAGCC CTACACCGAT CTTCTACACA ACCTGACAAC 
TCCTCTGACA GTGACTATGA CCTGCAAGTG GCTCAGAGAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031676.3
CDS	129..1613
Translation	MDSHEVLLAATYLLGTLAAFCLGQSGRGGLDIQVMLSGSNSKCQGQVEIQMENKWKTVCSSSWRLSQDHSKNAQQASAVCKQLRCGDPLALGPFPSLNRPQNQVFCQGSPWSISNCNNTSSQDQCLPLSLICLEPQRTTPPPTTTPPTTVPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSWGGTILYKAKDRPLGLGNLICKSLQCGSFLTHLSGTEAAGTPAPAELRDPRPLPIRWEAPNGSCVSLQQCFQKTTAQEGGQALTVICSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWEALCDSSAARGRGRWEELCREQQCGDLISFHTVDADKTSPGFLCAQEKLSQCYHLQKKKHCNKRVFVTCQDPNPAGLAPGTVASIILTLVLLVVLLAMCGPLVYKKLVKKFRQKKQRQWIGPTGVNQNMSFHRSHTATVRSQVENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL

Target ORF information:

RefSeq Version	NM_007650.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD5 antigen (Cd5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007650.3

ORF Insert Sequence:

ATGGACTCCC ACGAAGTGCT GCTGGCTGCC ACATACCTGC TGGGAACGCT GGCGGCTTTC 
TGCCTCGGAC AGTCTGGAAG GGGTGGCCTA GATATCCAGG TGATGCTAAG TGGCTCCAAT 
TCCAAGTGTC AGGGTCAAGT GGAGATCCAG ATGGAAAACA AGTGGAAAAC AGTGTGCAGT 
TCCAGTTGGA GGCTGAGCCA GGACCATTCG AAAAATGCCC AGCAGGCCTC TGCAGTGTGC 
AAACAGCTGA GATGTGGTGA CCCCTTGGCC CTTGGTCCTT TCCCTTCATT GAACAGACCC 
CAGAACCAGG TCTTCTGCCA AGGATCTCCG TGGTCTATAT CCAACTGCAA CAACACAAGT 
TCACAAGACC AGTGCCTTCC GCTGAGCCTG ATCTGCCTAG AGCCCCAGAG AACGACACCT 
CCACCCACAA CCACCCCACC CACCACCGTG CCGGAGCCCA CAGCTCCTCC CAGATTGCAG 
CTGGTGCCAG GACACGAAGG CCTGAGGTGC ACAGGTGTGG TGGAATTCTA CAATGGCAGC 
TGGGGTGGCA CCATCCTCTA CAAGGCCAAG GACAGGCCCC TGGGCCTGGG GAACCTCATC 
TGTAAGTCTC TGCAGTGTGG CTCTTTCTTG ACACATCTGT CCGGGACAGA GGCAGCAGGG 
ACACCAGCTC CTGCAGAGCT GAGGGACCCC AGGCCCTTGC CAATTCGATG GGAGGCCCCG 
AACGGGAGCT GTGTCTCACT ACAGCAGTGC TTCCAGAAAA CAACGGCCCA GGAGGGCGGC 
CAGGCGCTCA CCGTCATCTG CTCTGATTTC CAGCCCAAGG TTCAGAGCCG CCTGGTCGGG 
GGCAGCAGTG TGTGTGAGGG CATCGCTGAA GTGCGCCAGA GATCACAGTG GGAGGCCCTG 
TGTGACAGTT CTGCAGCCAG GGGCCGGGGA CGGTGGGAAG AGCTATGTCG GGAGCAGCAG 
TGTGGCGACC TCATCTCCTT CCACACGGTG GATGCTGACA AAACCTCCCC CGGGTTCCTC 
TGTGCCCAGG AGAAGCTGTC TCAGTGTTAC CATCTCCAGA AAAAAAAACA CTGCAACAAG 
AGGGTATTCG TCACATGCCA AGACCCAAAC CCAGCGGGCC TGGCCCCAGG CACTGTGGCA 
AGCATCATCC TGACCCTTGT ACTCCTGGTG GTGCTGCTGG CCATGTGTGG TCCTCTGGTC 
TACAAGAAGC TGGTGAAGAA ATTTCGTCAG AAAAAGCAGC GTCAGTGGAT TGGCCCCACA 
GGAGTGAACC AGAACATGTC TTTCCATCGA AGCCACACAG CAACTGTGCG GTCCCAAGTT 
GAGAACCCAA CAGCCTCTCA TGTGGACAAT GAATACAGCC AGCCTCCCAG GAACTCTCAC 
CTGTCTGCTT ATCCAGCTCT GGAAGGAGCC CTACACCGAT CTTCTACACA ACCTGACAAC 
TCCTCTGACA GTGACTATGA CCTGCAAGTG GCTCAGAGAC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cd5 ( XM_006526621.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006526684.1 Mus musculus CD5 antigen (Cd5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu55210
Clone ID Related Accession (Same CDS sequence)	XM_006526621.2
Accession Version	XM_006526621.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	T-cell surface glycoprotein CD5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006526621.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTCCC ACGAAGTGCT GCTGGCTGCC ACATACCTGC TGGGAACGCT GGCGGCTTTC 
TGCCTCGGAC AGTCTGGAAG GGGTGGCCTA GATATCCAGG TGATGCTAAG TGGCTCCAAT 
TCCAAGTGTC AGGGTCAAGT GGAGATCCAG ATGGAAAACA AGTGGAAAAC AGTGTGCAGT 
TCCAGTTGGA GGCTGAGCCA GGACCATTCG AAAAATGCCC AGCAGGCCTC TGCAGTGTGC 
AAACAGCTGA GATGTGGTGA CCCCTTGGCC CTTGGTCCTT TCCCTTCATT GAACAGACCC 
CAGAACCAGG TCTTCTGCCA AGGATCTCCG TGGTCTATAT CCAACTGCAA CAACACAAGT 
TCACAAGACC AGTGCCTTCC GCTGAGCCTG ATCTGCCTAG AGCCCCAGAG AACGACACCT 
CCACCCACAA CCACCCCACC CACCACCGTG CCGGAGCCCA CAGCTCCTCC CAGATTGCAG 
CTGGTGCCAG GACACGAAGG CCTGAGGTGC ACAGGTGTGG TGGAATTCTA CAATGGCAGC 
TGGGGTGGCA CCATCCTCTA CAAGGCCAAG GACAGGCCCT TGCCAATTCG ATGGGAGGCC 
CCGAACGGGA GCTGTGTCTC ACTACAGCAG TGCTTCCAGA AAACAACGGC CCAGGAGGGC 
GGCCAGGCGC TCACCGTCAT CTGCTCTGAT TTCCAGCCCA AGGTTCAGAG CCGCCTGGTC 
GGGGGCAGCA GTGTGTGTGA GGGCATCGCT GAAGTGCGCC AGAGATCACA GTGGGAGGCC 
CTGTGTGACA GTTCTGCAGC CAGGGGCCGG GGACGGTGGG AAGAGCTATG TCGGGAGCAG 
CAGTGTGGCG ACCTCATCTC CTTCCACACG GTGGATGCTG ACAAAACCTC CCCCGGGTTC 
CTCTGTGCCC AGGAGAAGCT GTCTCAGTGT TACCATCTCC AGAAAAAAAA ACACTGCAAC 
AAGAGGGTAT TCGTCACATG CCAAGACCCA AACCCAGCGG GCCTGGCCCC AGGCACTGTG 
GCAAGCATCA TCCTGACCCT TGTACTCCTG GTGGTGCTGC TGGCCATGTG TGGTCCTCTG 
GTCTACAAGA AGCTGGTGAA GAAATTTCGT CAGAAAAAGC AGCGTCAGTG GATTGGCCCC 
ACAGGAGTGA ACCAGAACAT GTCTTTCCAT CGAAGCCACA CAGCAACTGT GCGGTCCCAA 
GTTGAGAACC CAACAGCCTC TCATGTGGAC AATGAATACA GCCAGCCTCC CAGGAACTCT 
CACCTGTCTG CTTATCCAGC TCTGGAAGGA GCCCTACACC GATCTTCTAC ACAACCTGAC 
AACTCCTCTG ACAGTGACTA TGACCTGCAA GTGGCTCAGA GACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006526684.1
CDS	181..1548
Translation	MDSHEVLLAATYLLGTLAAFCLGQSGRGGLDIQVMLSGSNSKCQGQVEIQMENKWKTVCSSSWRLSQDHSKNAQQASAVCKQLRCGDPLALGPFPSLNRPQNQVFCQGSPWSISNCNNTSSQDQCLPLSLICLEPQRTTPPPTTTPPTTVPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSWGGTILYKAKDRPLPIRWEAPNGSCVSLQQCFQKTTAQEGGQALTVICSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWEALCDSSAARGRGRWEELCREQQCGDLISFHTVDADKTSPGFLCAQEKLSQCYHLQKKKHCNKRVFVTCQDPNPAGLAPGTVASIILTLVLLVVLLAMCGPLVYKKLVKKFRQKKQRQWIGPTGVNQNMSFHRSHTATVRSQVENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL

Target ORF information:

RefSeq Version	XM_006526621.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus CD5 antigen (Cd5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006526621.2

ORF Insert Sequence:

ATGGACTCCC ACGAAGTGCT GCTGGCTGCC ACATACCTGC TGGGAACGCT GGCGGCTTTC 
TGCCTCGGAC AGTCTGGAAG GGGTGGCCTA GATATCCAGG TGATGCTAAG TGGCTCCAAT 
TCCAAGTGTC AGGGTCAAGT GGAGATCCAG ATGGAAAACA AGTGGAAAAC AGTGTGCAGT 
TCCAGTTGGA GGCTGAGCCA GGACCATTCG AAAAATGCCC AGCAGGCCTC TGCAGTGTGC 
AAACAGCTGA GATGTGGTGA CCCCTTGGCC CTTGGTCCTT TCCCTTCATT GAACAGACCC 
CAGAACCAGG TCTTCTGCCA AGGATCTCCG TGGTCTATAT CCAACTGCAA CAACACAAGT 
TCACAAGACC AGTGCCTTCC GCTGAGCCTG ATCTGCCTAG AGCCCCAGAG AACGACACCT 
CCACCCACAA CCACCCCACC CACCACCGTG CCGGAGCCCA CAGCTCCTCC CAGATTGCAG 
CTGGTGCCAG GACACGAAGG CCTGAGGTGC ACAGGTGTGG TGGAATTCTA CAATGGCAGC 
TGGGGTGGCA CCATCCTCTA CAAGGCCAAG GACAGGCCCT TGCCAATTCG ATGGGAGGCC 
CCGAACGGGA GCTGTGTCTC ACTACAGCAG TGCTTCCAGA AAACAACGGC CCAGGAGGGC 
GGCCAGGCGC TCACCGTCAT CTGCTCTGAT TTCCAGCCCA AGGTTCAGAG CCGCCTGGTC 
GGGGGCAGCA GTGTGTGTGA GGGCATCGCT GAAGTGCGCC AGAGATCACA GTGGGAGGCC 
CTGTGTGACA GTTCTGCAGC CAGGGGCCGG GGACGGTGGG AAGAGCTATG TCGGGAGCAG 
CAGTGTGGCG ACCTCATCTC CTTCCACACG GTGGATGCTG ACAAAACCTC CCCCGGGTTC 
CTCTGTGCCC AGGAGAAGCT GTCTCAGTGT TACCATCTCC AGAAAAAAAA ACACTGCAAC 
AAGAGGGTAT TCGTCACATG CCAAGACCCA AACCCAGCGG GCCTGGCCCC AGGCACTGTG 
GCAAGCATCA TCCTGACCCT TGTACTCCTG GTGGTGCTGC TGGCCATGTG TGGTCCTCTG 
GTCTACAAGA AGCTGGTGAA GAAATTTCGT CAGAAAAAGC AGCGTCAGTG GATTGGCCCC 
ACAGGAGTGA ACCAGAACAT GTCTTTCCAT CGAAGCCACA CAGCAACTGT GCGGTCCCAA 
GTTGAGAACC CAACAGCCTC TCATGTGGAC AATGAATACA GCCAGCCTCC CAGGAACTCT 
CACCTGTCTG CTTATCCAGC TCTGGAAGGA GCCCTACACC GATCTTCTAC ACAACCTGAC 
AACTCCTCTG ACAGTGACTA TGACCTGCAA GTGGCTCAGA GACTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TLR4 supports the expansion of FasL
Molecular immunology87188-199(2017 Jul)
Wang K,Tao L,Su J,Zhang Y,Zou B,Wang Y,Zou M,Chen N,Lei L,Li X

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Cd5 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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