Scarb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scarb2
Entrez Gene ID	12492
Full Name	scavenger receptor class B, member 2
Synonyms	9330185J12Rik,Cd36l2,LGP85,LIMP II,LIMP-2,MLGP85
General protein information	Preferred Names scavenger receptor class B, member 2 Names lysosome membrane protein 2 85 kDa lysosomal membrane sialoglycoprotein CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 lysosome membrane protein II
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E2
Summary	This gene encodes a CD36-like type III transmembrane glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007644.4	NP_031670.1	lysosome membrane protein 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SCARB2	NP_001095623.1
Drosophila melanogaster (fruit fly)	emp	NP_726504.2
Canis lupus familiaris (dog)	SCARB2	XP_005639134.1
Gallus gallus (chicken)	SCARB2	XP_420593.1
Danio rerio (zebrafish)	LOC100536792	XP_003198729.1
Anopheles gambiae (African malaria mosquito)	SCRB9	XP_314345.2
Pan troglodytes (chimpanzee)	SCARB2	XP_517214.2
Rattus norvegicus (Norway rat)	Scarb2	NP_446453.1
Danio rerio (zebrafish)	scarb2	NP_775366.1
Danio rerio (zebrafish)	LOC564077	XP_003200850.2
Xenopus tropicalis (tropical clawed frog)	scarb2	NP_001016557.1
Mus musculus (house mouse)	Scarb2	NP_031670.1
Homo sapiens (human)	SCARB2	NP_005497.1
	SCARB2	XP_001096458.1

Gene Ontology
Bibliography

Related articles in PubMed

CD36 Deficiency Suppresses Epileptic Seizures.
Zheng F, Yang Y, Lu S, Yang Q, Li Y, Xu X, Zhang Y, Liu F, Tian X, Wang X
Neuroscience367110-120(2017 Dec)

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers MD
Nature communications8(1)1908(2017 Dec)

Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.
Baranova IN, Souza ACP, Bocharov AV, Vishnyakova TG, Hu X, Vaisman BL, Amar MJ, Chen Z, Remaley AT, Patterson AP, Yuen PST, Star RA, Eggerman TL
PloS one12(4)e0175824(2017)

Progranulin Recruits HSP70 to ?-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
Jian J, Tian QY, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell KDR, Sun Y, Overkleeft HS, Chan GL, Liu CJ
EBioMedicine13212-224(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings identify SR-BII as a functional SAA receptor that mediates SAA uptake and contributes to its proinflammatory signaling via the MAPK-mediated signaling pathways.
Title: Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.

AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo
Title: Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.

Heterologous expression of the luminal domain of LIMP-2 in wild-type cells.
Title: Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.

In LIMP-2-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein accumulation.
Title: LIMP-2 expression is critical for ?-glucocerebrosidase activity and ?-synuclein clearance.

absence of Limp-2 reduces inflammation in experimental crescentic glomerulonephritis with decreased macrophage and T-cell infiltration in the kidney.
Title: Absence of the lysosomal protein Limp-2 attenuates renal injury in crescentic glomerulonephritis.

The following Scarb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scarb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00529	NM_007644.4 Latest version!	Mus musculus scavenger receptor class B, member 2 (Scarb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scarb2 ( NM_007644.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031670.1 Mus musculus scavenger receptor class B, member 2 (Scarb2), mRNA.

Price & Availability↑

CloneID	OMu00529
Clone ID Related Accession (Same CDS sequence)	NM_007644.4
Accession Version	NM_007644.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Mus musculus(house mouse)
Product	lysosome membrane protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD349164.1, AK083038.1, CV558446.1, BB851354.1, AK034388.1 and BE852231.1. On Aug 20, 2015 this sequence version replaced NM_007644.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144235.1, AK083038.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END##

ATGGGCAGAT GCTGCTTCTA CACGGCGGGG ACGCTGTCTC TGCTGCTGCT GGTGACCAGC 
GTCACGCTGC TAGTGGCTCG AGTCTTTCAG AAGGCGGTAG ACCAGACGAT CGAGAAGAAT 
ATGGTATTAC AAAATGGCAC CAAGGTCTTT AATTCCTGGG AGAAGCCCCC TCTACCTGTG 
TACATCCAGT TTTATTTCTT CAATGTCACC AATCCTGAGG AGATCCTCCA AGGAGAAATC 
CCCCTACTAG AAGAAGTGGG GCCATACACC TACAGGGAGC TCCGGAACAA GGCAAATATT 
CAGTTTGGAG AAAATGGAAC AACTATATCT GCTGTCACCA ATAAGGCATA TGTTTTTGAA 
CGAAACCAAT CTGTTGGAGA TCCTAACGTT GACTTGATTA GAACAATAAA TATTCCTCTG 
TTGACTGTCG TGGATCTGGC CCAGCTGACC CTGCTCAGGG AGCTTATCGA AGCCATGCTG 
AAAGCCTATC AGCAGAAGTT GTTTGTGATT CACACCGTGC ACGAACTGCT CTGGGGCTAC 
AAAGATGAGA TCTTGTCCCT CGTCCATATT TTCAAACCTG ACGTCTCCCC GAATTTCGGC 
CTGTTCTATG AGAGAAATGG AACGAATGAC GGGGAGTACG TGTTTCTGAC TGGAGAGGAC 
AATTACCTTA ACTTTTCAAA AATCGTGGAG TGGAATGGAA AAACGTCGCT GGACTGGTGG 
ACCACAGACA CATGCAATAT GATTAACGGG ACAGACGGAG ACTCTTTTCA TCCGCTGATA 
AGCAAGGATG AGGTCCTGTA CCTCTTCCCG TCAGACTTGT GCAGGTCAGT ACATATCACT 
TTCAGCAGCT TTGAGAACGT AGAAGGACTG CCTGCTTTTC GGTATAAGGT GCCTGCAGAA 
ATACTAGCCA ACACCTCCGA AAACGCTGGC TTCTGTATAC CCGAGGGAAA CTGCATGGAC 
TCAGGGGTGT TGAACATCAG CATCTGCAAG AATGGTGCAC CCATTATCAT GTCTTTCCCA 
CACTTTTACC AAGCCGACGA GAAGTTCGTT TCTGCCATAA AAGGCATGCA TCCCAACAAG 
GAAGAGCATG AGTCGTTTGT GGACATTAAT CCCTTGACTG GAATTATTTT GAGAGGGGCC 
AAGAGATTCC AGATCAACAC TTACGTTAGG AAACTGGATG ACTTTGTTGA AACGGGAGAC 
ATCAGGACTA TGGTTTTCCC AGTGATGTAT CTCAATGAGA GTGTCCTCAT TGACAAAGAG 
ACCGCAAATC AACTGAAGTC TGTGATTAAC ACGACTTTGG TTGTCACCAA CATACCCTAC 
ATCATTATGG CACTGGGTGT GTTCTTTGGC TTGGTTTTCA CGTGGCTGGC GTGTCGAGGA 
CAGGGGTCTA TGGATGAGGG AACTGCAGAT GAAAGAGCAC CCCTCATACG AACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031670.1
CDS	350..1786
Translation	MGRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEILQGEIPLLEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPLLTVVDLAQLTLLRELIEAMLKAYQQKLFVIHTVHELLWGYKDEILSLVHIFKPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILANTSENAGFCIPEGNCMDSGVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINPLTGIILRGAKRFQINTYVRKLDDFVETGDIRTMVFPVMYLNESVLIDKETANQLKSVINTTLVVTNIPYIIMALGVFFGLVFTWLACRGQGSMDEGTADERAPLIRT

Target ORF information:

RefSeq Version	NM_007644.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus scavenger receptor class B, member 2 (Scarb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007644.4

ORF Insert Sequence:

ATGGGCAGAT GCTGCTTCTA CACGGCGGGG ACGCTGTCTC TGCTGCTGCT GGTGACCAGC 
GTCACGCTGC TAGTGGCTCG AGTCTTTCAG AAGGCGGTAG ACCAGACGAT CGAGAAGAAT 
ATGGTATTAC AAAATGGCAC CAAGGTCTTT AATTCCTGGG AGAAGCCCCC TCTACCTGTG 
TACATCCAGT TTTATTTCTT CAATGTCACC AATCCTGAGG AGATCCTCCA AGGAGAAATC 
CCCCTACTAG AAGAAGTGGG GCCATACACC TACAGGGAGC TCCGGAACAA GGCAAATATT 
CAGTTTGGAG AAAATGGAAC AACTATATCT GCTGTCACCA ATAAGGCATA TGTTTTTGAA 
CGAAACCAAT CTGTTGGAGA TCCTAACGTT GACTTGATTA GAACAATAAA TATTCCTCTG 
TTGACTGTCG TGGATCTGGC CCAGCTGACC CTGCTCAGGG AGCTTATCGA AGCCATGCTG 
AAAGCCTATC AGCAGAAGTT GTTTGTGATT CACACCGTGC ACGAACTGCT CTGGGGCTAC 
AAAGATGAGA TCTTGTCCCT CGTCCATATT TTCAAACCTG ACGTCTCCCC GAATTTCGGC 
CTGTTCTATG AGAGAAATGG AACGAATGAC GGGGAGTACG TGTTTCTGAC TGGAGAGGAC 
AATTACCTTA ACTTTTCAAA AATCGTGGAG TGGAATGGAA AAACGTCGCT GGACTGGTGG 
ACCACAGACA CATGCAATAT GATTAACGGG ACAGACGGAG ACTCTTTTCA TCCGCTGATA 
AGCAAGGATG AGGTCCTGTA CCTCTTCCCG TCAGACTTGT GCAGGTCAGT ACATATCACT 
TTCAGCAGCT TTGAGAACGT AGAAGGACTG CCTGCTTTTC GGTATAAGGT GCCTGCAGAA 
ATACTAGCCA ACACCTCCGA AAACGCTGGC TTCTGTATAC CCGAGGGAAA CTGCATGGAC 
TCAGGGGTGT TGAACATCAG CATCTGCAAG AATGGTGCAC CCATTATCAT GTCTTTCCCA 
CACTTTTACC AAGCCGACGA GAAGTTCGTT TCTGCCATAA AAGGCATGCA TCCCAACAAG 
GAAGAGCATG AGTCGTTTGT GGACATTAAT CCCTTGACTG GAATTATTTT GAGAGGGGCC 
AAGAGATTCC AGATCAACAC TTACGTTAGG AAACTGGATG ACTTTGTTGA AACGGGAGAC 
ATCAGGACTA TGGTTTTCCC AGTGATGTAT CTCAATGAGA GTGTCCTCAT TGACAAAGAG 
ACCGCAAATC AACTGAAGTC TGTGATTAAC ACGACTTTGG TTGTCACCAA CATACCCTAC 
ATCATTATGG CACTGGGTGT GTTCTTTGGC TTGGTTTTCA CGTGGCTGGC GTGTCGAGGA 
CAGGGGTCTA TGGATGAGGG AACTGCAGAT GAAAGAGCAC CCCTCATACG AACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD36 Deficiency Suppresses Epileptic Seizures.
Neuroscience367110-120(2017 Dec)
Zheng F,Yang Y,Lu S,Yang Q,Li Y,Xu X,Zhang Y,Liu F,Tian X,Wang X

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Nature communications8(1)1908(2017 Dec)
Conrad KS,Cheng TW,Ysselstein D,Heybrock S,Hoth LR,Chrunyk BA,Am Ende CW,Krainc D,Schwake M,Saftig P,Liu S,Qiu X,Ehlers MD

Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo.
PloS one12(4)e0175824(2017)
Baranova IN,Souza ACP,Bocharov AV,Vishnyakova TG,Hu X,Vaisman BL,Amar MJ,Chen Z,Remaley AT,Patterson AP,Yuen PST,Star RA,Eggerman TL

Progranulin Recruits HSP70 to ?-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
EBioMedicine13212-224(2016 Nov)
Jian J,Tian QY,Hettinghouse A,Zhao S,Liu H,Wei J,Grunig G,Zhang W,Setchell KDR,Sun Y,Overkleeft HS,Chan GL,Liu CJ

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Scarb2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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