Cct8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cct8
Entrez Gene ID	12469
Full Name	chaperonin containing Tcp1, subunit 8 (theta)
Synonyms	AI132397,Cctq,Tcpq
General protein information	Preferred Names chaperonin containing Tcp1, subunit 8 (theta) Names T-complex protein 1 subunit theta CCT-theta TCP-1-theta chaperonin subunit 8 (theta)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 C3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_009840.3	NP_033970.3	T-complex protein 1 subunit theta

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010588	XP_314553.3
Saccharomyces cerevisiae (baker's yeast)	CCT8	NP_012526.1
Arabidopsis thaliana (thale cress)	AT3G03960	NP_566219.1
Gallus gallus (chicken)	CCT8	NP_001004389.1
Drosophila melanogaster (fruit fly)	CG8258	NP_610418.1
Magnaporthe oryzae (rice blast fungus)	MGG_00135	XP_003718996.1
Homo sapiens (human)	CCT8	NP_006576.2
	CCT8	XP_001101969.1
Rattus norvegicus (Norway rat)	Cct8	NP_001099367.2
Caenorhabditis elegans (roundworm)	cct-8	NP_500035.3
Kluyveromyces lactis	KLLA0D09350g	XP_453479.1
Eremothecium gossypii	AGOS_ACR045W	NP_983448.2
Xenopus tropicalis (tropical clawed frog)	cct8	NP_001007875.1
Pan troglodytes (chimpanzee)	CCT8	XP_531416.2
Danio rerio (zebrafish)	cct8	NP_957356.1
Oryza sativa (rice)	Os03g0804800	NP_001051623.1
Canis lupus familiaris (dog)	CCT8	XP_535576.3
Bos taurus (cattle)	CCT8	NP_001028781.1
Mus musculus (house mouse)	Cct8	NP_033970.3
Schizosaccharomyces pombe (fission yeast)	cct8	NP_595406.1
Neurospora crassa	NCU07567	XP_958612.1

Gene Ontology
Bibliography

Related articles in PubMed

DYX1C1 is required for axonemal dynein assembly and ciliary motility.
Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, K?hler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K, , Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H
Nature genetics45(9)995-1003(2013 Sep)

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT
Proceedings of the National Academy of Sciences of the United States of America110(24)9932-7(2013 Jun)

The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction.
Dun MD, Smith ND, Baker MA, Lin M, Aitken RJ, Nixon B
The Journal of biological chemistry286(42)36875-87(2011 Oct)

The protein profile of mouse mature cumulus-oocyte complex.
Meng Y, Liu XH, Ma X, Shen Y, Fan L, Leng J, Liu JY, Sha JH
Biochimica et biophysica acta1774(11)1477-90(2007 Nov)

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

transcription of the Cctq gene is regulated by TCFs under the control of the Ras/MAPK pathway, probably independently of serum response factor.
Title: Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and Net in the absence of serum response factor.

The following Cct8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cct8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20879	NM_009840.3 Latest version!	Mus musculus chaperonin containing Tcp1, subunit 8 (theta) (Cct8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cct8 ( NM_009840.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033970.3 Mus musculus chaperonin containing Tcp1, subunit 8 (theta) (Cct8), mRNA.

Price & Availability↑

CloneID	OMu20879
Clone ID Related Accession (Same CDS sequence)	NM_009840.3
Accession Version	NM_009840.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	T-complex protein 1 subunit theta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147038.1, AK075880.1, AK075711.1 and AV335786.1. On Mar 8, 2007 this sequence version replaced NM_009840.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147038.1, AK075880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCTTC ACGTCCCCAA GGCCCCGGGC TTTGCCCAGA TGCTCAAGGA TGGAGCCAAA 
CATTTCTCGG GATTAGAAGA GGCTGTGTAT AGAAATATAC AGGCCTGCAA GGAGCTTGCT 
CAGACTACTC GCACAGCGTA CGGACCAAAT GGAATGAATA AAATGGTCAT CAATCGCCTG 
GAGAAGTTGT TTGTGACAAA CGATGCAGCG ACTATTTTAA GAGAGCTAGA AGTGCAGCAT 
CCTGCTGCAA AGATGATAGT GATGGCCTCT CATATGCAAG AACAAGAGGT TGGTGATGGC 
ACAAACTTCG TTCTGGTGTT CGCTGGGGCT CTTCTGGAAC TAGCTGAAGA ACTTCTGAGG 
ATTGGCCTGT CAGTATCAGA GGTAATATCG GGGTATGAAA TAGCTTGCAA AAAAGCTCAT 
GAGATCCTTC CTGAGTTGGT ATGTTGTTCT GCCAAAAACC TTCGAGATGT TGATGAAGTG 
TCCTCTCTGC TTCGAACCTC CATCATGAGT AAGCAGTACG GCAGCGAGAC GTTTTTGGCC 
AAGCTTATTG CTCAGGCTTG TGTTTCTATC TTTCCTGATT CTGGCAATTT CAATGTTGAT 
AACATCAGAG TATGTAAGAT TCTGGGCTCT GGTATTTATT CATCCTCAGT ATTACATGGC 
ATGGTTTTTA AGAAGGAAAC TGAAGGTGAT GTGACATCTG TCAAAGATGC AAAGATAGCT 
GTGTACTCTT GTCCGTTTGA TGGCATGATA ACAGAGACAA AGGGGACCGT GCTGATTAAG 
ACTGCCGAGG AGCTAATGAA CTTCAGTAAG GGAGAGGAGA ACCTCATGGA TGCTCAGGTG 
AAGGCCATTG CAGGCACTGG TGCAAATGTC ATAGTAACAG GCGGCAAAGT GGCGGACATA 
GCTCTTCATT ATGCTAACAA GTACAATATC ATGTTGGTGA GACTGAACTC AAAGTGGGAT 
CTCAGACGAC TCTGTAAAAC AGTTGGTGCC ACAGCTCTTC CAAAATTGAC TCCTCCCGTC 
CAAGAAGAAA TGGGACATTG TGACAGTGTT TACCTCTCAG AAGTTGGAGA TACACAAGTG 
GTTGTTTTTA AGCATGAAAA AGAAGATGGT GCCATTTCTA CTATAGTTCT TCGAGGTTCT 
ACAGACAATC TGATGGATGA CATAGAAAGG GCAGTAGATG ATGGAGTTAA TACTTTCAAA 
GTTCTCACAA GGGATAAGCG TCTTGTACCT GGAGGTGGAG CTACCGAAAT TGAATTGGCT 
AAACAAATCA CATCATATGG AGAGACGTGT CCTGGGCTTG AACAGTATGC TATTAAGAAG 
TTTGCTGAAG CGTTTGAAGC GATTCCACGG GCACTGGCAG AAAATTCTGG CGTGAAGGCC 
AATGAAGTTA TCTCTAAACT TTATTCCGTA CACCAAGAAG GAAACAAAAA TGTGGGGTTG 
GATATCGAGG CTGAAGTCCC TGCTGTAAAG GATATGTTAG AAGCCAGTAT TTTAGATACT 
TACTTGGGAA AATACTGGGC TATTAAACTG GCCACTAATG CTGCAGTCAC TGTACTAAGA 
GTGGATCAGA TCATCATGGC AAAACCAGCT GGTGGGCCCA AACCTCCAAG TGGGAAGAAG 
GACTGGGATG ACGACCAGAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033970.3
CDS	82..1728
Translation	MALHVPKAPGFAQMLKDGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINRLEKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRIGLSVSEVISGYEIACKKAHEILPELVCCSAKNLRDVDEVSSLLRTSIMSKQYGSETFLAKLIAQACVSIFPDSGNFNVDNIRVCKILGSGIYSSSVLHGMVFKKETEGDVTSVKDAKIAVYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIAGTGANVIVTGGKVADIALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPKLTPPVQEEMGHCDSVYLSEVGDTQVVVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYSVHQEGNKNVGLDIEAEVPAVKDMLEASILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKKDWDDDQND

Target ORF information:

RefSeq Version	NM_009840.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chaperonin containing Tcp1, subunit 8 (theta) (Cct8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009840.3

ORF Insert Sequence:

ATGGCGCTTC ACGTCCCCAA GGCCCCGGGC TTTGCCCAGA TGCTCAAGGA TGGAGCCAAA 
CATTTCTCGG GATTAGAAGA GGCTGTGTAT AGAAATATAC AGGCCTGCAA GGAGCTTGCT 
CAGACTACTC GCACAGCGTA CGGACCAAAT GGAATGAATA AAATGGTCAT CAATCGCCTG 
GAGAAGTTGT TTGTGACAAA CGATGCAGCG ACTATTTTAA GAGAGCTAGA AGTGCAGCAT 
CCTGCTGCAA AGATGATAGT GATGGCCTCT CATATGCAAG AACAAGAGGT TGGTGATGGC 
ACAAACTTCG TTCTGGTGTT CGCTGGGGCT CTTCTGGAAC TAGCTGAAGA ACTTCTGAGG 
ATTGGCCTGT CAGTATCAGA GGTAATATCG GGGTATGAAA TAGCTTGCAA AAAAGCTCAT 
GAGATCCTTC CTGAGTTGGT ATGTTGTTCT GCCAAAAACC TTCGAGATGT TGATGAAGTG 
TCCTCTCTGC TTCGAACCTC CATCATGAGT AAGCAGTACG GCAGCGAGAC GTTTTTGGCC 
AAGCTTATTG CTCAGGCTTG TGTTTCTATC TTTCCTGATT CTGGCAATTT CAATGTTGAT 
AACATCAGAG TATGTAAGAT TCTGGGCTCT GGTATTTATT CATCCTCAGT ATTACATGGC 
ATGGTTTTTA AGAAGGAAAC TGAAGGTGAT GTGACATCTG TCAAAGATGC AAAGATAGCT 
GTGTACTCTT GTCCGTTTGA TGGCATGATA ACAGAGACAA AGGGGACCGT GCTGATTAAG 
ACTGCCGAGG AGCTAATGAA CTTCAGTAAG GGAGAGGAGA ACCTCATGGA TGCTCAGGTG 
AAGGCCATTG CAGGCACTGG TGCAAATGTC ATAGTAACAG GCGGCAAAGT GGCGGACATA 
GCTCTTCATT ATGCTAACAA GTACAATATC ATGTTGGTGA GACTGAACTC AAAGTGGGAT 
CTCAGACGAC TCTGTAAAAC AGTTGGTGCC ACAGCTCTTC CAAAATTGAC TCCTCCCGTC 
CAAGAAGAAA TGGGACATTG TGACAGTGTT TACCTCTCAG AAGTTGGAGA TACACAAGTG 
GTTGTTTTTA AGCATGAAAA AGAAGATGGT GCCATTTCTA CTATAGTTCT TCGAGGTTCT 
ACAGACAATC TGATGGATGA CATAGAAAGG GCAGTAGATG ATGGAGTTAA TACTTTCAAA 
GTTCTCACAA GGGATAAGCG TCTTGTACCT GGAGGTGGAG CTACCGAAAT TGAATTGGCT 
AAACAAATCA CATCATATGG AGAGACGTGT CCTGGGCTTG AACAGTATGC TATTAAGAAG 
TTTGCTGAAG CGTTTGAAGC GATTCCACGG GCACTGGCAG AAAATTCTGG CGTGAAGGCC 
AATGAAGTTA TCTCTAAACT TTATTCCGTA CACCAAGAAG GAAACAAAAA TGTGGGGTTG 
GATATCGAGG CTGAAGTCCC TGCTGTAAAG GATATGTTAG AAGCCAGTAT TTTAGATACT 
TACTTGGGAA AATACTGGGC TATTAAACTG GCCACTAATG CTGCAGTCAC TGTACTAAGA 
GTGGATCAGA TCATCATGGC AAAACCAGCT GGTGGGCCCA AACCTCCAAG TGGGAAGAAG 
GACTGGGATG ACGACCAGAA TGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DYX1C1 is required for axonemal dynein assembly and ciliary motility.
Nature genetics45(9)995-1003(2013 Sep)
Tarkar A,Loges NT,Slagle CE,Francis R,Dougherty GW,Tamayo JV,Shook B,Cantino M,Schwartz D,Jahnke C,Olbrich H,Werner C,Raidt J,Pennekamp P,Abouhamed M,Hjeij R,K?hler G,Griese M,Li Y,Lemke K,Klena N,Liu X,Gabriel G,Tobita K,Jaspers M,Morgan LC,Shapiro AJ,Letteboer SJ,Mans DA,Carson JL,Leigh MW,Wolf WE,Chen S,Lucas JS,Onoufriadis A,Plagnol V,Schmidts M,Boldt K,,Roepman R,Zariwala MA,Lo CW,Mitchison HM,Knowles MR,Burdine RD,Loturco JJ,Omran H

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Proceedings of the National Academy of Sciences of the United States of America110(24)9932-7(2013 Jun)
Slater LH,Hett EC,Clatworthy AE,Mark KG,Hung DT

The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction.
The Journal of biological chemistry286(42)36875-87(2011 Oct)
Dun MD,Smith ND,Baker MA,Lin M,Aitken RJ,Nixon B

The protein profile of mouse mature cumulus-oocyte complex.
Biochimica et biophysica acta1774(11)1477-90(2007 Nov)
Meng Y,Liu XH,Ma X,Shen Y,Fan L,Leng J,Liu JY,Sha JH

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)
Okazaki N,F-Kikuno R,Ohara R,Inamoto S,Koseki H,Hiraoka S,Saga Y,Seino S,Nishimura M,Kaisho T,Hoshino K,Kitamura H,Nagase T,Ohara O,Koga H

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Cct8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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