Ccs cDNA ORF clone, Mus musculus(house mouse)

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim BE, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC
Human molecular genetics26(23)4617-4628(2017 Dec)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

Effects of Cu,Zn-superoxide dismutase on cell proliferation and neuroblast differentiation in the mouse dentate gyrus.
Yoo DY, Shin BN, Kim IH, Kim W, Kim DW, Yoo KY, Choi JH, Lee CH, Yoon YS, Choi SY, Won MH, Hwang IK
Neurochemical research37(2)261-7(2012 Feb)

Erythrocyte copper chaperone for superoxide dismutase is increased following marginal copper deficiency in adult and postweanling mice.
Lassi KC, Prohaska JR
The Journal of nutrition142(2)292-7(2012 Feb)

Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis.
Miyayama T, Ishizuka Y, Iijima T, Hiraoka D, Ogra Y
Metallomics : integrated biometal science3(7)693-701(2011 Jul)

results suggest that a SOD1 supplement to healthy mice may not be necessary to modulate cell proliferation and neuroblast differentiation in the dentate gyrus
Title: Effects of Cu,Zn-superoxide dismutase on cell proliferation and neuroblast differentiation in the mouse dentate gyrus.

Small interfering RNA (siRNA) targeting CCS was introduced into metallothionein-knockout mouse fibroblasts (MT-KO cells) and their wild type cells (MT-WT cells) to reveal the interactive role of CCS with other Cu-regulating proteins.
Title: Roles of copper chaperone for superoxide dismutase 1 and metallothionein in copper homeostasis.

effects of copper chaperone for SOD1 on mitochondrial dysfunction are SOD1 mutation dependent and correlate with SOD1 redox susceptibility
Title: Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo.

Study finds that as expected, CCS over-expression promotes oxidation of a wild-type SOD1 disulfide; however, in the diseased G93A/CCS mouse, there was no increased oxidation of the mutant SOD1 disulfide.
Title: Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS.

These results establish that CCS/G93A SOD1 mice manifest an isolated complex IV deficiency which may underlie a substantial part of mutant SOD1-induced mitochondrial cytopathy.
Title: Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein.