Noct cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Noct
Entrez Gene ID	12457
Full Name	nocturnin
Synonyms	AU043840,Ccr4,Ccrn4l
General protein information	Preferred Names nocturnin Names nocturnin CCR4 carbon catabolite repression 4-like CCR4 protein homolog carbon catabolite repression 4 homolog carbon catabolite repression 4-like protein circadian deadenylase NOC
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 C

mRNA and Protein(s)

mRNA	Protein	Name
XM_006500956.1	XP_006501019.1	nocturnin isoform X1
NM_009834.2	NP_033964.1	nocturnin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CCRN4L	NP_001075923.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009893	XP_319013.3
Xenopus tropicalis (tropical clawed frog)	ccrn4l	NP_001016531.1
Gallus gallus (chicken)	CCRN4L	NP_001009928.1
Canis lupus familiaris (dog)	CCRN4L	XP_005631848.1
Mus musculus (house mouse)	Ccrn4l	NP_033964.1
Drosophila melanogaster (fruit fly)	cu	NP_001097747.1
Homo sapiens (human)	CCRN4L	NP_036250.2
Pan troglodytes (chimpanzee)	CCRN4L	XP_003310517.1
	CCRN4L	XP_002804251.1
Rattus norvegicus (Norway rat)	Ccrn4l	NP_612535.1

Gene Ontology
Bibliography

Related articles in PubMed

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.
Sinturel F, Gerber A, Mauvoisin D, Wang J, Gatfield D, Stubblefield JJ, Green CB, Gachon F, Schibler U
Cell169(4)651-663.e14(2017 May)

Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin.
Kojima S, Gendreau KL, Sher-Chen EL, Gao P, Green CB
Scientific reports517059(2015 Nov)

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.
Summa KC, Jiang P, Fitzpatrick K, Voigt RM, Bowers SJ, Forsyth CB, Vitaterna MH, Keshavarzian A, Turek FW
Alcoholism, clinical and experimental research39(10)1917-29(2015 Oct)

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T
Proceedings of the National Academy of Sciences of the United States of America110(40)E3820-9(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Nocturnin (NOC) exerts strong effects on physiology through direct and indirect control of target mRNAs.
Title: Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin.

precise expression of nocturnin is critical to proper development of early mouse embryos
Title: Functional analysis of nocturnin, a circadian deadenylase, at maternal-to-zygotic transition in mice.

Loss of nocturnin enhances bone formation; the circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate.
Title: An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis.

Data suggest that nocturnin plays an important role in the trafficking of dietary lipid in the intestinal enterocytes by optimizing efficient absorption of lipids.
Title: Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes.

data suggest that Nocturnin has a novel stabilizing activity that plays an important role in the circadian response to inflammatory signals
Title: The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice.

The following Noct gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Noct cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu31590	XM_006500956.1 Latest version!	Mus musculus nocturnin (Noct), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu21189	NM_009834.2 Latest version!	Mus musculus nocturnin (Noct), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Noct ( XM_006500956.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006501019.1 Mus musculus nocturnin (Noct), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu31590
Clone ID Related Accession (Same CDS sequence)	XM_006500956.1
Accession Version	XM_006500956.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	nocturnin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTAC CAGTGAGTTC CATGGGAAAC GGCACCAGTC GACTCTACAG TGCTCTCGCC 
AAGACCGTCA ACAGCAGTGC AGCTGCTCAG CACCCGGAGT ACTTGGTGTC AACTGACCCC 
GAACATCTGG AGCCCATCGA TCCTAAGGAA CTTCTGGAGG AATGCAGGGC TGTTCTGCAC 
ACTCGGCCAC CCCGCTACCA GCGGGATTTT GTGGACCTGA GGACAGATTG CTCCAGCAGC 
CACTCTCCCA TTCGCGTCAT GCAGTGGAAC ATCCTCGCCC AAGCTCTCGG AGAAGGCAAA 
GACAACTTTG TGCAGTGCCC CGTGGAAGCG CTCAAATGGG AAGAGAGGAA GTGCCTGATC 
CTGGAGGAGA TCCTGGCTTA CCAGCCAGAC ATACTGTGCC TCCAGGAAGT GGACCACTAC 
TTTGACACCT TCCAGCCACT CCTCAGTAGA CTGGGCTACC AAGGCACGTT TTTCCCCAAG 
CCCTGGTCAC CATGTCTAGA TGTGGAACAC AACAACGGTC CAGATGGCTG TGCCTTATTT 
TTTCTCCAAA ACCGATTCAA GCTTATCAGC AGCACCAATA TTAGGCTGAC AGCCATGACC 
CTAAAAACCA ATCAGGTGGC CATCGCACAG ACCCTGGAGT GCAAGGAGTC TGGGCGACAG 
TTCTGCATTG CTGTCACCCA CTTAAAAGCC CGCACTGGCT GGGAGCGGTT CCGGTCAGCT 
CAGGGCTGTG ACCTCCTCCA GAACCTGCAG AACATCACCC AGGGAGCAAA GATCCCCCTG 
ATCGTCTGCG GGGACTTCAA CGCAGAGCCA ACCGAAGAGG TCTACAAACA CTTTGCGTCC 
TCCAGCCTCA ACCTCAACAG CGCCTACAAG CTGCTGAGTC CCGATGGACA GTCGGAGCCT 
CCCTACACAA CCTGGAAGAT CCGGACCTCA GGCGAGTGTC GCCACACGCT GGACTATATC 
TGGTACTCCA GACATGCTCT GAGTGTCACG TCCGCCCTGG ATCTACTCAC TGAAGAACAG 
ATTGGGCCCA ACCGGCTCCC ATCCTTCCAT TACCCCTCGG ACCACCTGTC CCTGGTGTGT 
GACTTCAGCT TTAACGAGGA GCCCCATGAG CTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006501019.1
CDS	31..1149
Translation	MALPVSSMGNGTSRLYSALAKTVNSSAAAQHPEYLVSTDPEHLEPIDPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHSPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLISSTNIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQIGPNRLPSFHYPSDHLSLVCDFSFNEEPHELF

Target ORF information:

RefSeq Version	XM_006500956.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus nocturnin (Noct), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006500956.1

ORF Insert Sequence:

ATGGCTTTAC CAGTGAGTTC CATGGGAAAC GGCACCAGTC GACTCTACAG TGCTCTCGCC 
AAGACCGTCA ACAGCAGTGC AGCTGCTCAG CACCCGGAGT ACTTGGTGTC AACTGACCCC 
GAACATCTGG AGCCCATCGA TCCTAAGGAA CTTCTGGAGG AATGCAGGGC TGTTCTGCAC 
ACTCGGCCAC CCCGCTACCA GCGGGATTTT GTGGACCTGA GGACAGATTG CTCCAGCAGC 
CACTCTCCCA TTCGCGTCAT GCAGTGGAAC ATCCTCGCCC AAGCTCTCGG AGAAGGCAAA 
GACAACTTTG TGCAGTGCCC CGTGGAAGCG CTCAAATGGG AAGAGAGGAA GTGCCTGATC 
CTGGAGGAGA TCCTGGCTTA CCAGCCAGAC ATACTGTGCC TCCAGGAAGT GGACCACTAC 
TTTGACACCT TCCAGCCACT CCTCAGTAGA CTGGGCTACC AAGGCACGTT TTTCCCCAAG 
CCCTGGTCAC CATGTCTAGA TGTGGAACAC AACAACGGTC CAGATGGCTG TGCCTTATTT 
TTTCTCCAAA ACCGATTCAA GCTTATCAGC AGCACCAATA TTAGGCTGAC AGCCATGACC 
CTAAAAACCA ATCAGGTGGC CATCGCACAG ACCCTGGAGT GCAAGGAGTC TGGGCGACAG 
TTCTGCATTG CTGTCACCCA CTTAAAAGCC CGCACTGGCT GGGAGCGGTT CCGGTCAGCT 
CAGGGCTGTG ACCTCCTCCA GAACCTGCAG AACATCACCC AGGGAGCAAA GATCCCCCTG 
ATCGTCTGCG GGGACTTCAA CGCAGAGCCA ACCGAAGAGG TCTACAAACA CTTTGCGTCC 
TCCAGCCTCA ACCTCAACAG CGCCTACAAG CTGCTGAGTC CCGATGGACA GTCGGAGCCT 
CCCTACACAA CCTGGAAGAT CCGGACCTCA GGCGAGTGTC GCCACACGCT GGACTATATC 
TGGTACTCCA GACATGCTCT GAGTGTCACG TCCGCCCTGG ATCTACTCAC TGAAGAACAG 
ATTGGGCCCA ACCGGCTCCC ATCCTTCCAT TACCCCTCGG ACCACCTGTC CCTGGTGTGT 
GACTTCAGCT TTAACGAGGA GCCCCATGAG CTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Noct ( NM_009834.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033964.1 Mus musculus nocturnin (Noct), mRNA.

Price & Availability↑

CloneID	OMu21189
Clone ID Related Accession (Same CDS sequence)	NM_009834.2
Accession Version	NM_009834.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-09
Organism	Mus musculus(house mouse)
Product	nocturnin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK087790.1, AK084516.1 and BB261546.1. On Nov 30, 2007 this sequence version replaced NM_009834.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK087790.1, AF183960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTATCAGA GCCCGCGGCG GCTCTGCTCG GCCCTGCTGC TCAGGGACGC CCCCGGCCTG 
CGCCGCACAC TCGTGCCCGG CCCGCGCCGA ACGCTCGCCC CGCCGGTGCT CGGATCTCGG 
CCCAAGTCCC CGCAACTGCA GGCGGCGGCG GCCTCGGGCG CCGCGAGGTC GCGTCCCCGA 
ACAGTGAGTT CCATGGGAAA CGGCACCAGT CGACTCTACA GTGCTCTCGC CAAGACCGTC 
AACAGCAGTG CAGCTGCTCA GCACCCGGAG TACTTGGTGT CAACTGACCC CGAACATCTG 
GAGCCCATCG ATCCTAAGGA ACTTCTGGAG GAATGCAGGG CTGTTCTGCA CACTCGGCCA 
CCCCGCTACC AGCGGGATTT TGTGGACCTG AGGACAGATT GCTCCAGCAG CCACTCTCCC 
ATTCGCGTCA TGCAGTGGAA CATCCTCGCC CAAGCTCTCG GAGAAGGCAA AGACAACTTT 
GTGCAGTGCC CCGTGGAAGC GCTCAAATGG GAAGAGAGGA AGTGCCTGAT CCTGGAGGAG 
ATCCTGGCTT ACCAGCCAGA CATACTGTGC CTCCAGGAAG TGGACCACTA CTTTGACACC 
TTCCAGCCAC TCCTCAGTAG ACTGGGCTAC CAAGGCACGT TTTTCCCCAA GCCCTGGTCA 
CCATGTCTAG ATGTGGAACA CAACAACGGT CCAGATGGCT GTGCCTTATT TTTTCTCCAA 
AACCGATTCA AGCTTATCAG CAGCACCAAT ATTAGGCTGA CAGCCATGAC CCTAAAAACC 
AATCAGGTGG CCATCGCACA GACCCTGGAG TGCAAGGAGT CTGGGCGACA GTTCTGCATT 
GCTGTCACCC ACTTAAAAGC CCGCACTGGC TGGGAGCGGT TCCGGTCAGC TCAGGGCTGT 
GACCTCCTCC AGAACCTGCA GAACATCACC CAGGGAGCAA AGATCCCCCT GATCGTCTGC 
GGGGACTTCA ACGCAGAGCC AACCGAAGAG GTCTACAAAC ACTTTGCGTC CTCCAGCCTC 
AACCTCAACA GCGCCTACAA GCTGCTGAGT CCCGATGGAC AGTCGGAGCC TCCCTACACA 
ACCTGGAAGA TCCGGACCTC AGGCGAGTGT CGCCACACGC TGGACTATAT CTGGTACTCC 
AGACATGCTC TGAGTGTCAC GTCCGCCCTG GATCTACTCA CTGAAGAACA GATTGGGCCC 
AACCGGCTCC CATCCTTCCA TTACCCCTCG GACCACCTGT CCCTGGTGTG TGACTTCAGC 
TTTAACGAGG AGCCCCATGA GCTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033964.1
CDS	658..1947
Translation	MYQSPRRLCSALLLRDAPGLRRTLVPGPRRTLAPPVLGSRPKSPQLQAAAASGAARSRPRTVSSMGNGTSRLYSALAKTVNSSAAAQHPEYLVSTDPEHLEPIDPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHSPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLISSTNIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQIGPNRLPSFHYPSDHLSLVCDFSFNEEPHELF

Target ORF information:

RefSeq Version	NM_009834.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus nocturnin (Noct), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009834.2

ORF Insert Sequence:

ATGTATCAGA GCCCGCGGCG GCTCTGCTCG GCCCTGCTGC TCAGGGACGC CCCCGGCCTG 
CGCCGCACAC TCGTGCCCGG CCCGCGCCGA ACGCTCGCCC CGCCGGTGCT CGGATCTCGG 
CCCAAGTCCC CGCAACTGCA GGCGGCGGCG GCCTCGGGCG CCGCGAGGTC GCGTCCCCGA 
ACAGTGAGTT CCATGGGAAA CGGCACCAGT CGACTCTACA GTGCTCTCGC CAAGACCGTC 
AACAGCAGTG CAGCTGCTCA GCACCCGGAG TACTTGGTGT CAACTGACCC CGAACATCTG 
GAGCCCATCG ATCCTAAGGA ACTTCTGGAG GAATGCAGGG CTGTTCTGCA CACTCGGCCA 
CCCCGCTACC AGCGGGATTT TGTGGACCTG AGGACAGATT GCTCCAGCAG CCACTCTCCC 
ATTCGCGTCA TGCAGTGGAA CATCCTCGCC CAAGCTCTCG GAGAAGGCAA AGACAACTTT 
GTGCAGTGCC CCGTGGAAGC GCTCAAATGG GAAGAGAGGA AGTGCCTGAT CCTGGAGGAG 
ATCCTGGCTT ACCAGCCAGA CATACTGTGC CTCCAGGAAG TGGACCACTA CTTTGACACC 
TTCCAGCCAC TCCTCAGTAG ACTGGGCTAC CAAGGCACGT TTTTCCCCAA GCCCTGGTCA 
CCATGTCTAG ATGTGGAACA CAACAACGGT CCAGATGGCT GTGCCTTATT TTTTCTCCAA 
AACCGATTCA AGCTTATCAG CAGCACCAAT ATTAGGCTGA CAGCCATGAC CCTAAAAACC 
AATCAGGTGG CCATCGCACA GACCCTGGAG TGCAAGGAGT CTGGGCGACA GTTCTGCATT 
GCTGTCACCC ACTTAAAAGC CCGCACTGGC TGGGAGCGGT TCCGGTCAGC TCAGGGCTGT 
GACCTCCTCC AGAACCTGCA GAACATCACC CAGGGAGCAA AGATCCCCCT GATCGTCTGC 
GGGGACTTCA ACGCAGAGCC AACCGAAGAG GTCTACAAAC ACTTTGCGTC CTCCAGCCTC 
AACCTCAACA GCGCCTACAA GCTGCTGAGT CCCGATGGAC AGTCGGAGCC TCCCTACACA 
ACCTGGAAGA TCCGGACCTC AGGCGAGTGT CGCCACACGC TGGACTATAT CTGGTACTCC 
AGACATGCTC TGAGTGTCAC GTCCGCCCTG GATCTACTCA CTGAAGAACA GATTGGGCCC 
AACCGGCTCC CATCCTTCCA TTACCCCTCG GACCACCTGT CCCTGGTGTG TGACTTCAGC 
TTTAACGAGG AGCCCCATGA GCTCTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles.
Cell169(4)651-663.e14(2017 May)
Sinturel F,Gerber A,Mauvoisin D,Wang J,Gatfield D,Stubblefield JJ,Green CB,Gachon F,Schibler U

Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin.
Scientific reports517059(2015 Nov)
Kojima S,Gendreau KL,Sher-Chen EL,Gao P,Green CB

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.
Alcoholism, clinical and experimental research39(10)1917-29(2015 Oct)
Summa KC,Jiang P,Fitzpatrick K,Voigt RM,Bowers SJ,Forsyth CB,Vitaterna MH,Keshavarzian A,Turek FW

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
Proceedings of the National Academy of Sciences of the United States of America110(40)E3820-9(2013 Oct)
Zhou K,Muroyama A,Underwood J,Leylek R,Ray S,Soderling SH,Lechler T

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Noct cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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