Serpina6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina6
Entrez Gene ID	12401
Full Name	serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms	Cbg
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade A, member 6 Names corticosteroid-binding globulin serine (or cysteine) proteinase inhibitor, clade A, member 6 serpin A6 transcortin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 E\|12 52.98 cM
Summary	This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007618.3	NP_031644.1	corticosteroid-binding globulin precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Serpina6	NP_031644.1
Canis lupus familiaris (dog)	SERPINA6	XP_005623821.1
Homo sapiens (human)	SERPINA6	NP_001747.2
Pan troglodytes (chimpanzee)	SERPINA6	XP_510143.2
	SERPINA6	XP_002805222.1
Bos taurus (cattle)	SERPINA6	XP_005222338.1
Rattus norvegicus (Norway rat)	Serpina6	NP_001009663.1

Gene Ontology
Bibliography

Related articles in PubMed

New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.
Gulfo J, Ledda A, Gea-Sorl? S, Bonjoch L, Closa D, Grasa M, Esteve M
PloS one11(1)e0146497(2016)

Adrenal steroids in the brain: role of the intrinsic expression of corticosteroid-binding globulin (CBG) in the stress response.
Sivukhina EV, Jirikowski GF
Steroids8170-3(2014 Mar)

Corticosteroid-binding globulin contributes to the neuroendocrine phenotype of mice selected for extremes in stress reactivity.
Mattos GE, Heinzmann JM, Norkowski S, Helbling JC, Minni AM, Moisan MP, Touma C
The Journal of endocrinology219(3)217-29(2013 Dec)

Update of the human and mouse SERPIN gene superfamily.
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V
Human genomics722(2013 Oct)

Intrinsic expression of transcortin in neural cells of the mouse brain: a histochemical and molecular study.
Sivukhina E, Helbling JC, Minni AM, Sch?fer HH, Pallet V, Jirikowski GF, Moisan MP
The Journal of experimental biology216(Pt 2)245-52(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung.
Title: New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.

the same gene encodes brain and liver corticosteroid-binding globulin
Title: Adrenal steroids in the brain: role of the intrinsic expression of corticosteroid-binding globulin (CBG) in the stress response.

Data suggest fine control interaction between plasma CBG upregulation and stress-induced corticosterone (CORT) release in mouse model of psychological stress; CBG appears to function in maintaining dynamic equilibrium between CBG-bound/-unbound CORT.
Title: Corticosteroid-binding globulin contributes to the neuroendocrine phenotype of mice selected for extremes in stress reactivity.

Sequencing analysis showed that Cbg cDNA obtained from the mouse hypothalamus was homologous to Cbg cDNA obtained from the liver.
Title: Intrinsic expression of transcortin in neural cells of the mouse brain: a histochemical and molecular study.

Cbg-/- mice, unlike controls, remain insensitive to stress applied before memory retrieval. Furthermore, under stress conditions, we observed a blunted surge of corticosterone (CORT) in plasma and no free CORT rise in the hippocampus of Cbg-/-.
Title: Critical role of plasma corticosteroid-binding-globulin during stress to promote glucocorticoid delivery to the brain: impact on memory retrieval.

The following Serpina6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00478	NM_007618.3 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 6 (Serpina6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina6 ( NM_007618.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031644.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 6 (Serpina6), mRNA.

Price & Availability↑

CloneID	OMu00478
Clone ID Related Accession (Same CDS sequence)	NM_007618.3
Accession Version	NM_007618.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Mus musculus(house mouse)
Product	corticosteroid-binding globulin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC125360.4, BY090546.1, AK145842.1 and AA230586.1. On Sep 15, 2015 this sequence version replaced NM_007618.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013632.1, AK145842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGCTCG CCCTGTATAC CTGTCTCTTC TGGCTCTGCA CCAGTGGCCT CTGGACCACC 
CAGGCTGTCA CTGATGAGGA TTCAAGTTCT CACCGAGACC TGGCTCCCAC CAATGTTGAC 
TTTGCCTTCA ACTTGTACAA ACGCCTAGTG GCCCTGAATT CTGACAAGAA TACCTTAATC 
TCCCCAGTGA GCATCTCCAT GGCCCTGGCC ATGCTGTCCC TAAGCACCAG GGGCTCCACC 
CAGTATCTCG AGAACCTGGG CTTCAACATG TCAAAGATGT CTGAAGCTGA GATCCACCAG 
GGTTTCCAGT ACCTCAATTC CCTTCTCCAG CAGTCTGACA CTGGCTTGGA GATGAACATG 
GGCAATGTCA TGTTCCTCCT CCAGAACCTA AAGCTGAAAG ACTCATTCTT AGCAGACACC 
AAACACTATT ATGAGTCAGA GGCCTTGACC ATCCCTTCCA AGGACTGGAC TAAAGCCGGC 
GAACAGATCA ACAATCATGT GAAGAATAAG ACACAGGGGA AAATTGAGCA TGTGGTCTCA 
GACCTGGATA GTTCAGCCAC CCTCATCCTG ATCAACTACA TCTTCCTCAA AGGAATATGG 
AAACTTCCCT TCAGCCCAGA AAATACTAGA GAGGAGGACT TCTATGTGAA TGAGACAAGC 
ACAGTGAAGG TGCCCATGAT GGTCCAGTCA GGCAACATTA GTTACTTTCG TGATTCGGCG 
ATCCCCTGCC AGATGGTACA GATGAATTAT GTGGGAAATG GAACTACCTT CATCATTCTT 
CCAGACCAGG GCCAGATGGA CACTGTCGTC GCTGCACTTA ATCGGGACAC AATTGATAGG 
TGGGGCAAGC TTATGATTCC AAGGCAGATG AACCTGTACA TCCCCAAATT CTCCATGTCT 
GATACCTATG ACCTTCAAGA TGTGCTGGCA GATGTGGGCA TTAAGGATTT GTTCACCAAC 
CAATCTGATT TCGCAGACAC CACCAAAGAC ACTCCCTTGA CATTAACGGT ACTCCACAAG 
GCCATGCTGC AACTGGATGA AGGGAATGTG CTGCCTGCTG CCACCAATGG CCCTCCTGTA 
CACCTGCCCT CCGAATCATT CACCCTCAAG TACAACAGGC CCTTCATCTT CCTGGCCTTT 
GACAAGTACA CATGGAGCAG CCTGATGATG AGCCAAGTCA TGAATCCAGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031644.1
CDS	202..1395
Translation	MSLALYTCLFWLCTSGLWTTQAVTDEDSSSHRDLAPTNVDFAFNLYKRLVALNSDKNTLISPVSISMALAMLSLSTRGSTQYLENLGFNMSKMSEAEIHQGFQYLNSLLQQSDTGLEMNMGNVMFLLQNLKLKDSFLADTKHYYESEALTIPSKDWTKAGEQINNHVKNKTQGKIEHVVSDLDSSATLILINYIFLKGIWKLPFSPENTREEDFYVNETSTVKVPMMVQSGNISYFRDSAIPCQMVQMNYVGNGTTFIILPDQGQMDTVVAALNRDTIDRWGKLMIPRQMNLYIPKFSMSDTYDLQDVLADVGIKDLFTNQSDFADTTKDTPLTLTVLHKAMLQLDEGNVLPAATNGPPVHLPSESFTLKYNRPFIFLAFDKYTWSSLMMSQVMNPA

Target ORF information:

RefSeq Version	NM_007618.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 6 (Serpina6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007618.3

ORF Insert Sequence:

ATGTCGCTCG CCCTGTATAC CTGTCTCTTC TGGCTCTGCA CCAGTGGCCT CTGGACCACC 
CAGGCTGTCA CTGATGAGGA TTCAAGTTCT CACCGAGACC TGGCTCCCAC CAATGTTGAC 
TTTGCCTTCA ACTTGTACAA ACGCCTAGTG GCCCTGAATT CTGACAAGAA TACCTTAATC 
TCCCCAGTGA GCATCTCCAT GGCCCTGGCC ATGCTGTCCC TAAGCACCAG GGGCTCCACC 
CAGTATCTCG AGAACCTGGG CTTCAACATG TCAAAGATGT CTGAAGCTGA GATCCACCAG 
GGTTTCCAGT ACCTCAATTC CCTTCTCCAG CAGTCTGACA CTGGCTTGGA GATGAACATG 
GGCAATGTCA TGTTCCTCCT CCAGAACCTA AAGCTGAAAG ACTCATTCTT AGCAGACACC 
AAACACTATT ATGAGTCAGA GGCCTTGACC ATCCCTTCCA AGGACTGGAC TAAAGCCGGC 
GAACAGATCA ACAATCATGT GAAGAATAAG ACACAGGGGA AAATTGAGCA TGTGGTCTCA 
GACCTGGATA GTTCAGCCAC CCTCATCCTG ATCAACTACA TCTTCCTCAA AGGAATATGG 
AAACTTCCCT TCAGCCCAGA AAATACTAGA GAGGAGGACT TCTATGTGAA TGAGACAAGC 
ACAGTGAAGG TGCCCATGAT GGTCCAGTCA GGCAACATTA GTTACTTTCG TGATTCGGCG 
ATCCCCTGCC AGATGGTACA GATGAATTAT GTGGGAAATG GAACTACCTT CATCATTCTT 
CCAGACCAGG GCCAGATGGA CACTGTCGTC GCTGCACTTA ATCGGGACAC AATTGATAGG 
TGGGGCAAGC TTATGATTCC AAGGCAGATG AACCTGTACA TCCCCAAATT CTCCATGTCT 
GATACCTATG ACCTTCAAGA TGTGCTGGCA GATGTGGGCA TTAAGGATTT GTTCACCAAC 
CAATCTGATT TCGCAGACAC CACCAAAGAC ACTCCCTTGA CATTAACGGT ACTCCACAAG 
GCCATGCTGC AACTGGATGA AGGGAATGTG CTGCCTGCTG CCACCAATGG CCCTCCTGTA 
CACCTGCCCT CCGAATCATT CACCCTCAAG TACAACAGGC CCTTCATCTT CCTGGCCTTT 
GACAAGTACA CATGGAGCAG CCTGATGATG AGCCAAGTCA TGAATCCAGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.
PloS one11(1)e0146497(2016)
Gulfo J,Ledda A,Gea-Sorl? S,Bonjoch L,Closa D,Grasa M,Esteve M

Adrenal steroids in the brain: role of the intrinsic expression of corticosteroid-binding globulin (CBG) in the stress response.
Steroids8170-3(2014 Mar)
Sivukhina EV,Jirikowski GF

Corticosteroid-binding globulin contributes to the neuroendocrine phenotype of mice selected for extremes in stress reactivity.
The Journal of endocrinology219(3)217-29(2013 Dec)
Mattos GE,Heinzmann JM,Norkowski S,Helbling JC,Minni AM,Moisan MP,Touma C

Update of the human and mouse SERPIN gene superfamily.
Human genomics722(2013 Oct)
Heit C,Jackson BC,McAndrews M,Wright MW,Thompson DC,Silverman GA,Nebert DW,Vasiliou V

Intrinsic expression of transcortin in neural cells of the mouse brain: a histochemical and molecular study.
The Journal of experimental biology216(Pt 2)245-52(2013 Jan)
Sivukhina E,Helbling JC,Minni AM,Sch?fer HH,Pallet V,Jirikowski GF,Moisan MP

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Serpina6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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