Cav3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cav3
Entrez Gene ID	12391
Full Name	caveolin 3
Synonyms	AI385751,Cav-3,M-cav
General protein information	Preferred Names caveolin 3 Names caveolin-3 M-caveolin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 E3\|6 52.26 cM
Summary	This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. The encoded protein is muscle-specific and forms homooligomers in muscle cells. The protein binds and regulates phosphofructokinase M and neuronal nitric oxide synthase. It also associates with dystrophin in muscle cells. Mutations in this gene are associated with muscular dystrophy. [provided by RefSeq, Apr 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007617.3	NP_031643.1	caveolin-3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CAV3	XP_001144093.2
Mus musculus (house mouse)	Cav3	NP_031643.1
Danio rerio (zebrafish)	cav3	NP_991301.1
	CAV3	XP_001097615.1
Bos taurus (cattle)	CAV3	NP_001040023.1
Homo sapiens (human)	CAV3	NP_203123.1
Canis lupus familiaris (dog)	CAV3	XP_541786.2
Xenopus tropicalis (tropical clawed frog)	cav3.1	NP_001096498.1
Rattus norvegicus (Norway rat)	Cav3	NP_062028.1
Gallus gallus (chicken)	CAV3	NP_989701.1

Gene Ontology
Bibliography

Related articles in PubMed

Caveolin-3 deficiency causes muscle degeneration in mice.
Hagiwara Y, Sasaoka T, Araishi K, Imamura M, Yorifuji H, Nonaka I, Ozawa E, Kikuchi T
Human molecular genetics9(20)3047-54(2000 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Cav3 P104L mutation of limb girdle muscular dystrophy-1C leads to disordered glucose metabolism in muscle cells.
Title: The Caveolin-3 P104L mutation of LGMD-1C leads to disordered glucose metabolism in muscle cells.

CAV3 protein has a physiological role in glycometabolism, growth and proliferation, independent of insulin stimulation
Title: Caveolin-3 promotes glycometabolism, growth and proliferation in muscle cells.

Cav-3 overexpressing mice have changes in ECG intervals, heart rates, and cardiac ion channel expression
Title: Electrophysiology and metabolism of caveolin-3-overexpressing mice.

Loss of CAV3 interferes with downstream insulin signaling and lipid uptake and increases susceptibility to palmitate-induced insulin resistance.
Title: Heterozygous caveolin-3 mice show increased susceptibility to palmitate-induced insulin resistance.

Data show that caveolin-3 binds to low glycosylated extracellular matrix metalloproteinase inducer (LG-EMMPRIN) in cardiac cells and in the hearts of healthy mice.
Title: Nitric Oxide Induces Cardiac Protection by Preventing Extracellular Matrix Degradation through the Complex Caveolin-3/EMMPRIN in Cardiac Myocytes.

The following Cav3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cav3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00476	NM_007617.3 Latest version!	Mus musculus caveolin 3 (Cav3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cav3 ( NM_007617.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031643.1 Mus musculus caveolin 3 (Cav3), mRNA.

Price & Availability↑

CloneID	OMu00476
Clone ID Related Accession (Same CDS sequence)	NM_007617.3
Accession Version	NM_007617.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Mus musculus(house mouse)
Product	caveolin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC153594.15, CJ057698.1, AA434625.1 and AI385751.1. On Apr 18, 2013 this sequence version replaced NM_007617.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024383.1, U36579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGACCG AAGAGCACAC GGATCTGGAA GCTCGGATCA TCAAGGACAT TCACTGCAAG 
GAGATAGACT TGGTGAACCG CGACCCCAAG AACATCAATG AGGACATTGT GAAGGTAGAT 
TTTGAAGACG TGATTGCGGA GCCCGAGGGC ACCTACAGCT TCGACGGTGT ATGGAAGGTG 
AGCTTCACCA CGTTCACCGT CTCCAAGTAC TGGTGCTACC GCCTGTTGTC TACACTGCTG 
GGTGTTCCAC TGGCCCTGCT CTGGGGATTC CTGTTCGCCT GTATCTCCTT CTGCCACATC 
TGGGCCGTGG TGCCCTGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTGT GTATCCGCAC CTTCTGCAAC CCGCTCTTCG CTGCGTTGGG CCAGGTCTGC 
AGCAACATTA AGGTGGTGCT GCGAAGGGAA GGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031643.1
CDS	308..763
Translation	MMTEEHTDLEARIIKDIHCKEIDLVNRDPKNINEDIVKVDFEDVIAEPEGTYSFDGVWKVSFTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFCHIWAVVPCIKSYLIEIQCISHIYSLCIRTFCNPLFAALGQVCSNIKVVLRREG

Target ORF information:

RefSeq Version	NM_007617.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus caveolin 3 (Cav3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007617.3

ORF Insert Sequence:

ATGATGACCG AAGAGCACAC GGATCTGGAA GCTCGGATCA TCAAGGACAT TCACTGCAAG 
GAGATAGACT TGGTGAACCG CGACCCCAAG AACATCAATG AGGACATTGT GAAGGTAGAT 
TTTGAAGACG TGATTGCGGA GCCCGAGGGC ACCTACAGCT TCGACGGTGT ATGGAAGGTG 
AGCTTCACCA CGTTCACCGT CTCCAAGTAC TGGTGCTACC GCCTGTTGTC TACACTGCTG 
GGTGTTCCAC TGGCCCTGCT CTGGGGATTC CTGTTCGCCT GTATCTCCTT CTGCCACATC 
TGGGCCGTGG TGCCCTGCAT TAAGAGCTAC CTGATCGAGA TCCAGTGCAT CAGCCACATC 
TACTCACTGT GTATCCGCAC CTTCTGCAAC CCGCTCTTCG CTGCGTTGGG CCAGGTCTGC 
AGCAACATTA AGGTGGTGCT GCGAAGGGAA GGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Caveolin-3 deficiency causes muscle degeneration in mice.
Human molecular genetics9(20)3047-54(2000 Dec)
Hagiwara Y,Sasaoka T,Araishi K,Imamura M,Yorifuji H,Nonaka I,Ozawa E,Kikuchi T

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Cav3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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