Cav2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cav2
Entrez Gene ID	12390
Full Name	caveolin 2
Synonyms	AI447843
General protein information	Preferred Names caveolin 2 Names caveolin-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 A2
Summary	This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_016900.4	NP_058596.1	caveolin-2 isoform 1
NM_001277756.1	NP_001264685.1	caveolin-2 isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CAV2	NP_001007809.1
Rattus norvegicus (Norway rat)	Cav2	NP_571989.2
Gallus gallus (chicken)	CAV2	NP_001007087.1
Xenopus tropicalis (tropical clawed frog)	cav2	NP_001015763.1
Homo sapiens (human)	CAV2	NP_001224.1
	CAV2	NP_001162090.1
Mus musculus (house mouse)	Cav2	NP_058596.1
Danio rerio (zebrafish)	cav2	NP_001002150.1
Canis lupus familiaris (dog)	CAV2	NP_001010997.2
Pan troglodytes (chimpanzee)	CAV2	NP_001129298.1

Gene Ontology
Bibliography

Related articles in PubMed

Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels.
Otis JP, Shen MC, Quinlivan V, Anderson JL, Farber SA
Disease models & mechanisms10(3)283-295(2017 03)

Attenuated rapid onset vasodilation with greater force production in skeletal muscle of caveolin-2-/- mice.
Fernando CA, Liu Y, Sowa G, Segal SS
American journal of physiology. Heart and circulatory physiology311(2)H415-25(2016 Aug)

Bone marrow-derived macrophages exclusively expressed caveolin-2: The role of inflammatory activators and hypoxia.
Maceckova M, Martiskova H, Koudelka A, Kubala L, Lojek A, Pekarova M
Immunobiology220(11)1266-74(2015 Nov)

Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
Wang H, Shun MC, Dickson AK, Engelman AN
PloS one10(9)e0137797(2015)

Identification of a splice variant of mouse caveolin-2 mRNA encoding an isoform lacking the C-terminal domain.
Kogo H, Ishiguro K, Kuwaki S, Fujimoto T
Archives of biochemistry and biophysics401(1)108-14(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

While structural and functional properties of resistance networks are well maintained in the gluteus muscle of Cav2(-/-) mice, diminished rapid onset vasodilation with greater force production reveals novel physiological roles for Cav2 in skeletal muscle.
Title: Attenuated rapid onset vasodilation with greater force production in skeletal muscle of caveolin-2-/- mice.

We concluded that caveolin-2 is most probably involved in regulation of pro-inflammatory responses of BMDMs, triggered via activation of ERK1/2.
Title: Bone marrow-derived macrophages exclusively expressed caveolin-2: The role of inflammatory activators and hypoxia.

Cav-2 expressed in tumor microenvironment may potentially become a novel target for cancer therapy
Title: Host deficiency in caveolin-2 inhibits lung carcinoma tumor growth by impairing tumor angiogenesis.

In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta compared to empty vector.
Title: N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells.

The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 expression levels and is not because of changing targeting of caveolin 1 protein to plasma membrane lipid raft/caveolar domains.
Title: Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-? in endothelial cells.

The following Cav2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cav2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16968	NM_001277756.1 Latest version!	Mus musculus caveolin 2 (Cav2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu10673	NM_016900.4 Latest version!	Mus musculus caveolin 2 (Cav2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cav2 ( NM_001277756.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264685.1 Mus musculus caveolin 2 (Cav2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu16968
Clone ID Related Accession (Same CDS sequence)	NM_001277756.1
Accession Version	NM_001277756.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	caveolin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023173.3 and AA475015.1. Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter at the C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB049605.1, AA475015.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTGG AGACCGAGAA GGCCGATGTG CAGCTCTTCA TGGCCGATGA CGCCTACAGC 
CACCACAGTG GCGTTGACTA CGCAGATCCT GAGAAGTATG TTGACTCGAG TCACGACCGG 
GATCCTCACC AGCTCAACTC TCATCTCAAG CTAGGCTTCG AGGATCTGAT TGCAGAGCCT 
GAGACTACAC ACTCCTTTGA CAAAGTGTGG ATCTGCAGCC ATGCTCTCTT TGAAATCAGC 
AAATATGTGA TGTACAAGTT CCTGACCGTA TTTCTGGCCA TCCCCTTGGC CTTCATTGCG 
GGTATCCTGT TTGCTACCCT CAGCTGTCTG CACATCTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264685.1
CDS	177..518
Translation	MGLETEKADVQLFMADDAYSHHSGVDYADPEKYVDSSHDRDPHQLNSHLKLGFEDLIAEPETTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGILFATLSCLHIW

Target ORF information:

RefSeq Version	NM_001277756.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caveolin 2 (Cav2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277756.1

ORF Insert Sequence:

ATGGGGCTGG AGACCGAGAA GGCCGATGTG CAGCTCTTCA TGGCCGATGA CGCCTACAGC 
CACCACAGTG GCGTTGACTA CGCAGATCCT GAGAAGTATG TTGACTCGAG TCACGACCGG 
GATCCTCACC AGCTCAACTC TCATCTCAAG CTAGGCTTCG AGGATCTGAT TGCAGAGCCT 
GAGACTACAC ACTCCTTTGA CAAAGTGTGG ATCTGCAGCC ATGCTCTCTT TGAAATCAGC 
AAATATGTGA TGTACAAGTT CCTGACCGTA TTTCTGGCCA TCCCCTTGGC CTTCATTGCG 
GGTATCCTGT TTGCTACCCT CAGCTGTCTG CACATCTGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cav2 ( NM_016900.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058596.1 Mus musculus caveolin 2 (Cav2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10673
Clone ID Related Accession (Same CDS sequence)	NM_016900.4
Accession Version	NM_016900.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	caveolin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CJ157462.1, AK151397.1, AK009913.1, AK158419.1 and AC023173.3. On Apr 18, 2013 this sequence version replaced NM_016900.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK009913.1, BC023095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGCTGG AGACCGAGAA GGCCGATGTG CAGCTCTTCA TGGCCGATGA CGCCTACAGC 
CACCACAGTG GCGTTGACTA CGCAGATCCT GAGAAGTATG TTGACTCGAG TCACGACCGG 
GATCCTCACC AGCTCAACTC TCATCTCAAG CTAGGCTTCG AGGATCTGAT TGCAGAGCCT 
GAGACTACAC ACTCCTTTGA CAAAGTGTGG ATCTGCAGCC ATGCTCTCTT TGAAATCAGC 
AAATATGTGA TGTACAAGTT CCTGACCGTA TTTCTGGCCA TCCCCTTGGC CTTCATTGCG 
GGTATCCTGT TTGCTACCCT CAGCTGTCTG CACATCTGGA TCCTGATGCC TTTTGTGAAG 
ACCTGCCTAA TGGTCTTGCC TTCCGTGCAG ACAATATGGA AGAGTGTGAC AGACGTTGTC 
ATTGGCCCAT TGTGTACAAG TGTGGGCCGC AGCTTCTCAT CGGTCAGCAT GCAACTGAGC 
CACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058596.1
CDS	177..665
Translation	MGLETEKADVQLFMADDAYSHHSGVDYADPEKYVDSSHDRDPHQLNSHLKLGFEDLIAEPETTHSFDKVWICSHALFEISKYVMYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVVIGPLCTSVGRSFSSVSMQLSHD

Target ORF information:

RefSeq Version	NM_016900.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus caveolin 2 (Cav2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016900.4

ORF Insert Sequence:

ATGGGGCTGG AGACCGAGAA GGCCGATGTG CAGCTCTTCA TGGCCGATGA CGCCTACAGC 
CACCACAGTG GCGTTGACTA CGCAGATCCT GAGAAGTATG TTGACTCGAG TCACGACCGG 
GATCCTCACC AGCTCAACTC TCATCTCAAG CTAGGCTTCG AGGATCTGAT TGCAGAGCCT 
GAGACTACAC ACTCCTTTGA CAAAGTGTGG ATCTGCAGCC ATGCTCTCTT TGAAATCAGC 
AAATATGTGA TGTACAAGTT CCTGACCGTA TTTCTGGCCA TCCCCTTGGC CTTCATTGCG 
GGTATCCTGT TTGCTACCCT CAGCTGTCTG CACATCTGGA TCCTGATGCC TTTTGTGAAG 
ACCTGCCTAA TGGTCTTGCC TTCCGTGCAG ACAATATGGA AGAGTGTGAC AGACGTTGTC 
ATTGGCCCAT TGTGTACAAG TGTGGGCCGC AGCTTCTCAT CGGTCAGCAT GCAACTGAGC 
CACGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels.
Disease models & mechanisms10(3)283-295(2017 03)
Otis JP,Shen MC,Quinlivan V,Anderson JL,Farber SA

Attenuated rapid onset vasodilation with greater force production in skeletal muscle of caveolin-2-/- mice.
American journal of physiology. Heart and circulatory physiology311(2)H415-25(2016 Aug)
Fernando CA,Liu Y,Sowa G,Segal SS

Bone marrow-derived macrophages exclusively expressed caveolin-2: The role of inflammatory activators and hypoxia.
Immunobiology220(11)1266-74(2015 Nov)
Maceckova M,Martiskova H,Koudelka A,Kubala L,Lojek A,Pekarova M

Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
PloS one10(9)e0137797(2015)
Wang H,Shun MC,Dickson AK,Engelman AN

Identification of a splice variant of mouse caveolin-2 mRNA encoding an isoform lacking the C-terminal domain.
Archives of biochemistry and biophysics401(1)108-14(2002 May)
Kogo H,Ishiguro K,Kuwaki S,Fujimoto T

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Cav2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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