Gene Symbol | Casp9 |
Entrez Gene ID | 12371 |
Full Name | caspase 9 |
Synonyms | AI115399,APAF-3,AW493809,CASP-9,Caspase-9,ICE-LAP6,Mch6 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome | |
Summary | This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, the initiator caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]. |