Casp9 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casp9
Entrez Gene ID	12371
Full Name	caspase 9
Synonyms	AI115399,APAF-3,AW493809,CASP-9,Caspase-9,ICE-LAP6,Mch6
General protein information	Preferred Names caspase 9 Names caspase-9 ICE-like apoptotic protease 6 apoptotic protease Mch-6 apoptotic protease-activating factor 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 E1
Summary	This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, the initiator caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001277932.1	NP_001264861.1	caspase-9 isoform 2
NM_001355176.1	NP_001342105.1	caspase-9 isoform 3 precursor
XM_017319928.1	XP_017175417.1	caspase-9 isoform X1
NM_015733.5	NP_056548.2	caspase-9 isoform 1 precursor

Pathways from BioSystems

Homologies

	CASP9	XP_001082859.1
Mus musculus (house mouse)	Casp9	NP_056548.2
Rattus norvegicus (Norway rat)	Casp9	NP_113820.1
Canis lupus familiaris (dog)	CASP9	NP_001026803.1
Bos taurus (cattle)	CASP9	NP_001192433.1
Danio rerio (zebrafish)	casp9	NP_001007405.2
Homo sapiens (human)	CASP9	NP_001220.2
Pan troglodytes (chimpanzee)	CASP9	XP_513049.2
Gallus gallus (chicken)	CASP9	XP_424580.4

Gene Ontology
Bibliography

Related articles in PubMed

Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells.
Diaconu I, Ballard B, Zhang M, Chen Y, West J, Dotti G, Savoldo B
Molecular therapy : the journal of the American Society of Gene Therapy25(3)580-592(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

inducible caspase-9 (iC9) safety switch can eliminate CD19.CAR-Ts in a dose-dependent manner, allowing either a selective containment of CD19.CAR-T expansion in case of CRS or complete deletion on demand granting normal B cell reconstitution.
Title: Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells.

Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 and caspase-3/7, in a dose-dependent fashion.
Title: Cepharanthine induces apoptosis through the mitochondria/caspase pathway in murine dendritic cells.

Bcl-2-caspase-9 apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related proteins.
Title: Activation of Bcl-2-Caspase-9 Apoptosis Pathway in the Testis of Asthmatic Mice.

Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.
Title: An epistatic effect of apaf-1 and caspase-9 on chlamydial infection.

The study demonstrates sublethal caspase-activation has an important role in cardiomyocyte differentiation and may have significant implications for promoting cardiac regeneration after myocardial injury involving exogenous or endogenous cell sources.
Title: Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells.

The following Casp9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17124	NM_001277932.1 Latest version!	Mus musculus caspase 9 (Casp9), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu23279	NM_015733.5 Latest version!	Mus musculus caspase 9 (Casp9), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$272.30 $389.00
OMu80823	NM_001355176.1 Latest version!	Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu80823	XM_017319928.1 Latest version!	Mus musculus caspase 9 (Casp9), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp9 ( NM_001277932.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264861.1 Mus musculus caspase 9 (Casp9), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17124
Clone ID Related Accession (Same CDS sequence)	NM_001277932.1
Accession Version	NM_001277932.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	caspase-9 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL928577.21. Transcript Variant: This variant (2) lacks an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB019601.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGCAGGCAGG ATCTGGGTCT CGGCGGGATC AGGCCAGGCA GCTGGTCACA 
GACCTTGAGA CCCGAGGGAG GCAGGCCCTT CCTCTCTTCA TCTCCTGCTT AGAGGACACA 
GGCCAAGGCA CCCTGGCTTC ACTCTTGCAA AGCGGTCGGC AAGCAGCCAA GCAGGATCCA 
GAGGCTGTTA AACCCCTAGA CCACCTGGTG CCTGTGGTCC TGGGACCAAT GGGACTCACA 
GCAAAGGAGC AGAGAGTAGT GAAGCTGGAC CCGTCACAGC CTGCCGTGGG AAACCTCACC 
CCAGTGGTGC TGGGGCCAGA AGAGCTCTGG CCTGCTCGGC TCAAGCCAGA GGTTCTCAGA 
CCAGAAACAC CCAGGCCCGT GGACATTGGT TCTGGCGGAG CTCATGATGT CTGTGTTCCA 
GGGAAGATCA GGGGACATGC AGATATGGCA TACACCCTGG ATTCGGATCC CTGTGGCCAC 
TGCCTCATCA TCAACAATGT GAACTTCTGC CCTTCCTCGG GGCTCGGCAC ACGCACGGGC 
TCCAACTTGG ACCGTGACAA ACTTGAGCAC CGATTCCGCT GGCTGCGCTT CATGGTGGAG 
GTGAAGAACG ACCTGACTGC CAAGAAAATG GTCACGGCTT TGATGGAGAT GGCACACCGG 
AACCACCGTG CCCTGGACTG CTTTGTGGTG GTCATCCTCT CTCATGGCTG CCAGGCCAGC 
CACCTCCAGT TCCCGGGTGC TGTCTATGGG ACAGATGGAT GCTCCGTGTC CATTGAGAAA 
ATTGTGAATA TCTTCAACGG GAGCGGCTGC CCCAGCCTGG GAGGGAAGCC CAAGCTCTTC 
TTCATCCAGG CCTGCGGTGG TGAGCAGAAA GACCATGGCT TTGAGGTGGC CTGCACTTCC 
TCTCAAGGCA GGACCTTGGA CAGTGACTCT GAGCCAGATG CTGTCCCCTA TCAGGAAGGC 
CCAAGGCCCT TGGACCAGCT GGATGCTGTG TCAAGTTTGC CTACCCCCAG TGACATCCTT 
GTGTCCTACT CCACCTTCCC AGGTTGCCAA TGCTGTTTCT GCGAAAGGGA CTTACAAGCA 
GATTCCTGGC TGTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264861.1
CDS	244..1461
Translation	MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGCQCCFCERDLQADSWLF

Target ORF information:

RefSeq Version	NM_001277932.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 9 (Casp9), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277932.1

ORF Insert Sequence:

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGCAGGCAGG ATCTGGGTCT CGGCGGGATC AGGCCAGGCA GCTGGTCACA 
GACCTTGAGA CCCGAGGGAG GCAGGCCCTT CCTCTCTTCA TCTCCTGCTT AGAGGACACA 
GGCCAAGGCA CCCTGGCTTC ACTCTTGCAA AGCGGTCGGC AAGCAGCCAA GCAGGATCCA 
GAGGCTGTTA AACCCCTAGA CCACCTGGTG CCTGTGGTCC TGGGACCAAT GGGACTCACA 
GCAAAGGAGC AGAGAGTAGT GAAGCTGGAC CCGTCACAGC CTGCCGTGGG AAACCTCACC 
CCAGTGGTGC TGGGGCCAGA AGAGCTCTGG CCTGCTCGGC TCAAGCCAGA GGTTCTCAGA 
CCAGAAACAC CCAGGCCCGT GGACATTGGT TCTGGCGGAG CTCATGATGT CTGTGTTCCA 
GGGAAGATCA GGGGACATGC AGATATGGCA TACACCCTGG ATTCGGATCC CTGTGGCCAC 
TGCCTCATCA TCAACAATGT GAACTTCTGC CCTTCCTCGG GGCTCGGCAC ACGCACGGGC 
TCCAACTTGG ACCGTGACAA ACTTGAGCAC CGATTCCGCT GGCTGCGCTT CATGGTGGAG 
GTGAAGAACG ACCTGACTGC CAAGAAAATG GTCACGGCTT TGATGGAGAT GGCACACCGG 
AACCACCGTG CCCTGGACTG CTTTGTGGTG GTCATCCTCT CTCATGGCTG CCAGGCCAGC 
CACCTCCAGT TCCCGGGTGC TGTCTATGGG ACAGATGGAT GCTCCGTGTC CATTGAGAAA 
ATTGTGAATA TCTTCAACGG GAGCGGCTGC CCCAGCCTGG GAGGGAAGCC CAAGCTCTTC 
TTCATCCAGG CCTGCGGTGG TGAGCAGAAA GACCATGGCT TTGAGGTGGC CTGCACTTCC 
TCTCAAGGCA GGACCTTGGA CAGTGACTCT GAGCCAGATG CTGTCCCCTA TCAGGAAGGC 
CCAAGGCCCT TGGACCAGCT GGATGCTGTG TCAAGTTTGC CTACCCCCAG TGACATCCTT 
GTGTCCTACT CCACCTTCCC AGGTTGCCAA TGCTGTTTCT GCGAAAGGGA CTTACAAGCA 
GATTCCTGGC TGTTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp9 ( NM_015733.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_056548.2 Mus musculus caspase 9 (Casp9), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23279
Clone ID Related Accession (Same CDS sequence)	NM_015733.5
Accession Version	NM_015733.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	caspase-9 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC056447.1, BC056372.1 and BY549141.1. On May 1, 2013 this sequence version replaced NM_015733.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056447.1, SRR1660815.270057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGCAGGCAGG ATCTGGGTCT CGGCGGGATC AGGCCAGGCA GCTGGTCACA 
GACCTTGAGA CCCGAGGGAG GCAGGCCCTT CCTCTCTTCA TCTCCTGCTT AGAGGACACA 
GGCCAAGGCA CCCTGGCTTC ACTCTTGCAA AGCGGTCGGC AAGCAGCCAA GCAGGATCCA 
GAGGCTGTTA AACCCCTAGA CCACCTGGTG CCTGTGGTCC TGGGACCAAT GGGACTCACA 
GCAAAGGAGC AGAGAGTAGT GAAGCTGGAC CCGTCACAGC CTGCCGTGGG AAACCTCACC 
CCAGTGGTGC TGGGGCCAGA AGAGCTCTGG CCTGCTCGGC TCAAGCCAGA GGTTCTCAGA 
CCAGAAACAC CCAGGCCCGT GGACATTGGT TCTGGCGGAG CTCATGATGT CTGTGTTCCA 
GGGAAGATCA GGGGACATGC AGATATGGCA TACACCCTGG ATTCGGATCC CTGTGGCCAC 
TGCCTCATCA TCAACAATGT GAACTTCTGC CCTTCCTCGG GGCTCGGCAC ACGCACGGGC 
TCCAACTTGG ACCGTGACAA ACTTGAGCAC CGATTCCGCT GGCTGCGCTT CATGGTGGAG 
GTGAAGAACG ACCTGACTGC CAAGAAAATG GTCACGGCTT TGATGGAGAT GGCACACCGG 
AACCACCGTG CCCTGGACTG CTTTGTGGTG GTCATCCTCT CTCATGGCTG CCAGGCCAGC 
CACCTCCAGT TCCCGGGTGC TGTCTATGGG ACAGATGGAT GCTCCGTGTC CATTGAGAAA 
ATTGTGAATA TCTTCAACGG GAGCGGCTGC CCCAGCCTGG GAGGGAAGCC CAAGCTCTTC 
TTCATCCAGG CCTGCGGTGG TGAGCAGAAA GACCATGGCT TTGAGGTGGC CTGCACTTCC 
TCTCAAGGCA GGACCTTGGA CAGTGACTCT GAGCCAGATG CTGTCCCCTA TCAGGAAGGC 
CCAAGGCCCT TGGACCAGCT GGATGCTGTG TCAAGTTTGC CTACCCCCAG TGACATCCTT 
GTGTCCTACT CCACCTTCCC AGGTTTTGTC TCCTGGAGGG ACAAGAAAAG TGGCTCCTGG 
TACATCGAGA CCTTGGATGG CATTCTGGAG CAGTGGGCTC GCTCTGAAGA CCTGCAGTCC 
CTCCTTCTCA GGGTTGCCAA TGCTGTTTCT GCGAAAGGGA CTTACAAGCA GATTCCTGGC 
TGTTTTAACT TCCTCCGGAA AAAGCTGTTT TTTAAAACTT CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056548.2
CDS	244..1608
Translation	MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLFFKTS

Target ORF information:

RefSeq Version	NM_015733.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 9 (Casp9), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015733.5

ORF Insert Sequence:

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGCAGGCAGG ATCTGGGTCT CGGCGGGATC AGGCCAGGCA GCTGGTCACA 
GACCTTGAGA CCCGAGGGAG GCAGGCCCTT CCTCTCTTCA TCTCCTGCTT AGAGGACACA 
GGCCAAGGCA CCCTGGCTTC ACTCTTGCAA AGCGGTCGGC AAGCAGCCAA GCAGGATCCA 
GAGGCTGTTA AACCCCTAGA CCACCTGGTG CCTGTGGTCC TGGGACCAAT GGGACTCACA 
GCAAAGGAGC AGAGAGTAGT GAAGCTGGAC CCGTCACAGC CTGCCGTGGG AAACCTCACC 
CCAGTGGTGC TGGGGCCAGA AGAGCTCTGG CCTGCTCGGC TCAAGCCAGA GGTTCTCAGA 
CCAGAAACAC CCAGGCCCGT GGACATTGGT TCTGGCGGAG CTCATGATGT CTGTGTTCCA 
GGGAAGATCA GGGGACATGC AGATATGGCA TACACCCTGG ATTCGGATCC CTGTGGCCAC 
TGCCTCATCA TCAACAATGT GAACTTCTGC CCTTCCTCGG GGCTCGGCAC ACGCACGGGC 
TCCAACTTGG ACCGTGACAA ACTTGAGCAC CGATTCCGCT GGCTGCGCTT CATGGTGGAG 
GTGAAGAACG ACCTGACTGC CAAGAAAATG GTCACGGCTT TGATGGAGAT GGCACACCGG 
AACCACCGTG CCCTGGACTG CTTTGTGGTG GTCATCCTCT CTCATGGCTG CCAGGCCAGC 
CACCTCCAGT TCCCGGGTGC TGTCTATGGG ACAGATGGAT GCTCCGTGTC CATTGAGAAA 
ATTGTGAATA TCTTCAACGG GAGCGGCTGC CCCAGCCTGG GAGGGAAGCC CAAGCTCTTC 
TTCATCCAGG CCTGCGGTGG TGAGCAGAAA GACCATGGCT TTGAGGTGGC CTGCACTTCC 
TCTCAAGGCA GGACCTTGGA CAGTGACTCT GAGCCAGATG CTGTCCCCTA TCAGGAAGGC 
CCAAGGCCCT TGGACCAGCT GGATGCTGTG TCAAGTTTGC CTACCCCCAG TGACATCCTT 
GTGTCCTACT CCACCTTCCC AGGTTTTGTC TCCTGGAGGG ACAAGAAAAG TGGCTCCTGG 
TACATCGAGA CCTTGGATGG CATTCTGGAG CAGTGGGCTC GCTCTGAAGA CCTGCAGTCC 
CTCCTTCTCA GGGTTGCCAA TGCTGTTTCT GCGAAAGGGA CTTACAAGCA GATTCCTGGC 
TGTTTTAACT TCCTCCGGAA AAAGCTGTTT TTTAAAACTT CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp9 ( NM_001355176.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001342105.1 Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu80823
Clone ID Related Accession (Same CDS sequence)	NM_001355176.1 , XM_017319928.1
Accession Version	NM_001355176.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	caspase-9 isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC056447.1, BB610740.1, BC056372.1 and BY549141.1. On Sep 20, 2017 this sequence version replaced XM_017319928.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) is one amino acid shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.225143.1, SRR7652917.1287260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGGCAGGATC TGGGTCTCGG CGGGATCAGG CCAGGCAGCT GGTCACAGAC 
CTTGAGACCC GAGGGAGGCA GGCCCTTCCT CTCTTCATCT CCTGCTTAGA GGACACAGGC 
CAAGGCACCC TGGCTTCACT CTTGCAAAGC GGTCGGCAAG CAGCCAAGCA GGATCCAGAG 
GCTGTTAAAC CCCTAGACCA CCTGGTGCCT GTGGTCCTGG GACCAATGGG ACTCACAGCA 
AAGGAGCAGA GAGTAGTGAA GCTGGACCCG TCACAGCCTG CCGTGGGAAA CCTCACCCCA 
GTGGTGCTGG GGCCAGAAGA GCTCTGGCCT GCTCGGCTCA AGCCAGAGGT TCTCAGACCA 
GAAACACCCA GGCCCGTGGA CATTGGTTCT GGCGGAGCTC ATGATGTCTG TGTTCCAGGG 
AAGATCAGGG GACATGCAGA TATGGCATAC ACCCTGGATT CGGATCCCTG TGGCCACTGC 
CTCATCATCA ACAATGTGAA CTTCTGCCCT TCCTCGGGGC TCGGCACACG CACGGGCTCC 
AACTTGGACC GTGACAAACT TGAGCACCGA TTCCGCTGGC TGCGCTTCAT GGTGGAGGTG 
AAGAACGACC TGACTGCCAA GAAAATGGTC ACGGCTTTGA TGGAGATGGC ACACCGGAAC 
CACCGTGCCC TGGACTGCTT TGTGGTGGTC ATCCTCTCTC ATGGCTGCCA GGCCAGCCAC 
CTCCAGTTCC CGGGTGCTGT CTATGGGACA GATGGATGCT CCGTGTCCAT TGAGAAAATT 
GTGAATATCT TCAACGGGAG CGGCTGCCCC AGCCTGGGAG GGAAGCCCAA GCTCTTCTTC 
ATCCAGGCCT GCGGTGGTGA GCAGAAAGAC CATGGCTTTG AGGTGGCCTG CACTTCCTCT 
CAAGGCAGGA CCTTGGACAG TGACTCTGAG CCAGATGCTG TCCCCTATCA GGAAGGCCCA 
AGGCCCTTGG ACCAGCTGGA TGCTGTGTCA AGTTTGCCTA CCCCCAGTGA CATCCTTGTG 
TCCTACTCCA CCTTCCCAGG TTTTGTCTCC TGGAGGGACA AGAAAAGTGG CTCCTGGTAC 
ATCGAGACCT TGGATGGCAT TCTGGAGCAG TGGGCTCGCT CTGAAGACCT GCAGTCCCTC 
CTTCTCAGGG TTGCCAATGC TGTTTCTGCG AAAGGGACTT ACAAGCAGAT TCCTGGCTGT 
TTTAACTTCC TCCGGAAAAA GCTGTTTTTT AAAACTTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001342105.1
CDS	244..1605
Translation	MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLFFKTS

Target ORF information:

RefSeq Version	NM_001355176.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355176.1

ORF Insert Sequence:

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGGCAGGATC TGGGTCTCGG CGGGATCAGG CCAGGCAGCT GGTCACAGAC 
CTTGAGACCC GAGGGAGGCA GGCCCTTCCT CTCTTCATCT CCTGCTTAGA GGACACAGGC 
CAAGGCACCC TGGCTTCACT CTTGCAAAGC GGTCGGCAAG CAGCCAAGCA GGATCCAGAG 
GCTGTTAAAC CCCTAGACCA CCTGGTGCCT GTGGTCCTGG GACCAATGGG ACTCACAGCA 
AAGGAGCAGA GAGTAGTGAA GCTGGACCCG TCACAGCCTG CCGTGGGAAA CCTCACCCCA 
GTGGTGCTGG GGCCAGAAGA GCTCTGGCCT GCTCGGCTCA AGCCAGAGGT TCTCAGACCA 
GAAACACCCA GGCCCGTGGA CATTGGTTCT GGCGGAGCTC ATGATGTCTG TGTTCCAGGG 
AAGATCAGGG GACATGCAGA TATGGCATAC ACCCTGGATT CGGATCCCTG TGGCCACTGC 
CTCATCATCA ACAATGTGAA CTTCTGCCCT TCCTCGGGGC TCGGCACACG CACGGGCTCC 
AACTTGGACC GTGACAAACT TGAGCACCGA TTCCGCTGGC TGCGCTTCAT GGTGGAGGTG 
AAGAACGACC TGACTGCCAA GAAAATGGTC ACGGCTTTGA TGGAGATGGC ACACCGGAAC 
CACCGTGCCC TGGACTGCTT TGTGGTGGTC ATCCTCTCTC ATGGCTGCCA GGCCAGCCAC 
CTCCAGTTCC CGGGTGCTGT CTATGGGACA GATGGATGCT CCGTGTCCAT TGAGAAAATT 
GTGAATATCT TCAACGGGAG CGGCTGCCCC AGCCTGGGAG GGAAGCCCAA GCTCTTCTTC 
ATCCAGGCCT GCGGTGGTGA GCAGAAAGAC CATGGCTTTG AGGTGGCCTG CACTTCCTCT 
CAAGGCAGGA CCTTGGACAG TGACTCTGAG CCAGATGCTG TCCCCTATCA GGAAGGCCCA 
AGGCCCTTGG ACCAGCTGGA TGCTGTGTCA AGTTTGCCTA CCCCCAGTGA CATCCTTGTG 
TCCTACTCCA CCTTCCCAGG TTTTGTCTCC TGGAGGGACA AGAAAAGTGG CTCCTGGTAC 
ATCGAGACCT TGGATGGCAT TCTGGAGCAG TGGGCTCGCT CTGAAGACCT GCAGTCCCTC 
CTTCTCAGGG TTGCCAATGC TGTTTCTGCG AAAGGGACTT ACAAGCAGAT TCCTGGCTGT 
TTTAACTTCC TCCGGAAAAA GCTGTTTTTT AAAACTTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp9 ( XM_017319928.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017175417.1 Mus musculus caspase 9 (Casp9), transcript variant X1, mRNA.

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CloneID	OMu80823
Clone ID Related Accession (Same CDS sequence)	NM_001355176.1 , XM_017319928.1
Accession Version	XM_017319928.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	caspase-9 isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGGCAGGATC TGGGTCTCGG CGGGATCAGG CCAGGCAGCT GGTCACAGAC 
CTTGAGACCC GAGGGAGGCA GGCCCTTCCT CTCTTCATCT CCTGCTTAGA GGACACAGGC 
CAAGGCACCC TGGCTTCACT CTTGCAAAGC GGTCGGCAAG CAGCCAAGCA GGATCCAGAG 
GCTGTTAAAC CCCTAGACCA CCTGGTGCCT GTGGTCCTGG GACCAATGGG ACTCACAGCA 
AAGGAGCAGA GAGTAGTGAA GCTGGACCCG TCACAGCCTG CCGTGGGAAA CCTCACCCCA 
GTGGTGCTGG GGCCAGAAGA GCTCTGGCCT GCTCGGCTCA AGCCAGAGGT TCTCAGACCA 
GAAACACCCA GGCCCGTGGA CATTGGTTCT GGCGGAGCTC ATGATGTCTG TGTTCCAGGG 
AAGATCAGGG GACATGCAGA TATGGCATAC ACCCTGGATT CGGATCCCTG TGGCCACTGC 
CTCATCATCA ACAATGTGAA CTTCTGCCCT TCCTCGGGGC TCGGCACACG CACGGGCTCC 
AACTTGGACC GTGACAAACT TGAGCACCGA TTCCGCTGGC TGCGCTTCAT GGTGGAGGTG 
AAGAACGACC TGACTGCCAA GAAAATGGTC ACGGCTTTGA TGGAGATGGC ACACCGGAAC 
CACCGTGCCC TGGACTGCTT TGTGGTGGTC ATCCTCTCTC ATGGCTGCCA GGCCAGCCAC 
CTCCAGTTCC CGGGTGCTGT CTATGGGACA GATGGATGCT CCGTGTCCAT TGAGAAAATT 
GTGAATATCT TCAACGGGAG CGGCTGCCCC AGCCTGGGAG GGAAGCCCAA GCTCTTCTTC 
ATCCAGGCCT GCGGTGGTGA GCAGAAAGAC CATGGCTTTG AGGTGGCCTG CACTTCCTCT 
CAAGGCAGGA CCTTGGACAG TGACTCTGAG CCAGATGCTG TCCCCTATCA GGAAGGCCCA 
AGGCCCTTGG ACCAGCTGGA TGCTGTGTCA AGTTTGCCTA CCCCCAGTGA CATCCTTGTG 
TCCTACTCCA CCTTCCCAGG TTTTGTCTCC TGGAGGGACA AGAAAAGTGG CTCCTGGTAC 
ATCGAGACCT TGGATGGCAT TCTGGAGCAG TGGGCTCGCT CTGAAGACCT GCAGTCCCTC 
CTTCTCAGGG TTGCCAATGC TGTTTCTGCG AAAGGGACTT ACAAGCAGAT TCCTGGCTGT 
TTTAACTTCC TCCGGAAAAA GCTGTTTTTT AAAACTTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175417.1
CDS	170..1531
Translation	MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLFFKTS

Target ORF information:

RefSeq Version	XM_017319928.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus caspase 9 (Casp9), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319928.1

ORF Insert Sequence:

ATGGACGAGG CGGACCGGCA GCTCCTGCGG CGATGCAGGG TGCGCCTAGT GAGCGAGCTG 
CAAGTCGCGG AGCTCTGGGA CGCTCTGCTG AGTCGAGAGC TCTTCACGCG CGACATGATC 
GAGGATATTC AGGCAGGATC TGGGTCTCGG CGGGATCAGG CCAGGCAGCT GGTCACAGAC 
CTTGAGACCC GAGGGAGGCA GGCCCTTCCT CTCTTCATCT CCTGCTTAGA GGACACAGGC 
CAAGGCACCC TGGCTTCACT CTTGCAAAGC GGTCGGCAAG CAGCCAAGCA GGATCCAGAG 
GCTGTTAAAC CCCTAGACCA CCTGGTGCCT GTGGTCCTGG GACCAATGGG ACTCACAGCA 
AAGGAGCAGA GAGTAGTGAA GCTGGACCCG TCACAGCCTG CCGTGGGAAA CCTCACCCCA 
GTGGTGCTGG GGCCAGAAGA GCTCTGGCCT GCTCGGCTCA AGCCAGAGGT TCTCAGACCA 
GAAACACCCA GGCCCGTGGA CATTGGTTCT GGCGGAGCTC ATGATGTCTG TGTTCCAGGG 
AAGATCAGGG GACATGCAGA TATGGCATAC ACCCTGGATT CGGATCCCTG TGGCCACTGC 
CTCATCATCA ACAATGTGAA CTTCTGCCCT TCCTCGGGGC TCGGCACACG CACGGGCTCC 
AACTTGGACC GTGACAAACT TGAGCACCGA TTCCGCTGGC TGCGCTTCAT GGTGGAGGTG 
AAGAACGACC TGACTGCCAA GAAAATGGTC ACGGCTTTGA TGGAGATGGC ACACCGGAAC 
CACCGTGCCC TGGACTGCTT TGTGGTGGTC ATCCTCTCTC ATGGCTGCCA GGCCAGCCAC 
CTCCAGTTCC CGGGTGCTGT CTATGGGACA GATGGATGCT CCGTGTCCAT TGAGAAAATT 
GTGAATATCT TCAACGGGAG CGGCTGCCCC AGCCTGGGAG GGAAGCCCAA GCTCTTCTTC 
ATCCAGGCCT GCGGTGGTGA GCAGAAAGAC CATGGCTTTG AGGTGGCCTG CACTTCCTCT 
CAAGGCAGGA CCTTGGACAG TGACTCTGAG CCAGATGCTG TCCCCTATCA GGAAGGCCCA 
AGGCCCTTGG ACCAGCTGGA TGCTGTGTCA AGTTTGCCTA CCCCCAGTGA CATCCTTGTG 
TCCTACTCCA CCTTCCCAGG TTTTGTCTCC TGGAGGGACA AGAAAAGTGG CTCCTGGTAC 
ATCGAGACCT TGGATGGCAT TCTGGAGCAG TGGGCTCGCT CTGAAGACCT GCAGTCCCTC 
CTTCTCAGGG TTGCCAATGC TGTTTCTGCG AAAGGGACTT ACAAGCAGAT TCCTGGCTGT 
TTTAACTTCC TCCGGAAAAA GCTGTTTTTT AAAACTTCAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inducible Caspase-9 Selectively Modulates the Toxicities of CD19-Specific Chimeric Antigen Receptor-Modified T Cells.
Molecular therapy : the journal of the American Society of Gene Therapy25(3)580-592(2017 Mar)
Diaconu I,Ballard B,Zhang M,Chen Y,West J,Dotti G,Savoldo B

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Casp9 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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