Casp8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casp8
Entrez Gene ID	12370
Full Name	caspase 8
Synonyms	CASP-8,FLICE,MACH,Mch5
General protein information	Preferred Names caspase 8 Names caspase-8 Fas-linked ICE-like protease
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C1.3\|1 29.19 cM
Summary	This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006495634.4	XP_006495697.1	caspase-8 isoform X1
XM_006495634.3	XP_006495697.1	caspase-8 isoform X1
NM_001277926.1	NP_001264855.1	caspase-8 isoform 2
NM_009812.2	NP_033942.1	caspase-8 isoform 1
NM_001080126.1	NP_001073595.1	caspase-8 isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Casp8	NP_071613.1
Xenopus tropicalis (tropical clawed frog)	casp8	XP_002936586.2
Homo sapiens (human)	CASP8	NP_001073594.1
Bos taurus (cattle)	CASP8	NP_001039435.1
Danio rerio (zebrafish)	casp8	NP_571585.2
Danio rerio (zebrafish)	casp8l1	NP_001092089.1
Pan troglodytes (chimpanzee)	CASP8	XP_001172193.1
Canis lupus familiaris (dog)	CASP8	NP_001041494.1
Gallus gallus (chicken)	CASP8	NP_989923.1
	CASP8	XP_001091080.2
Mus musculus (house mouse)	Casp8	NP_001264855.1

Gene Ontology
Bibliography

Related articles in PubMed

Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis.
Kumar S, Colussi PA
Trends in biochemical sciences24(1)1-4(1999 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.
Title: A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Data indicate that NLRC4 activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 release, and implicate Caspase-8 in NLRC4 inflammasome responses in vivo by generation of doubly deficient in Caspase-1 and Caspase-8.
Title: NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.

Statistically significant increases in the expression of Fas and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1, Traf3, Tnsf12, Tnfrsf1A and Ripk1.
Title: Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.

Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3)-mediated necroptosis.
Title: The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure.

we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection
Title: Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.

The following Casp8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18354	NM_001277926.1 Latest version!	Mus musculus caspase 8 (Casp8), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu18790	NM_009812.2 Latest version!	Mus musculus caspase 8 (Casp8), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu18790	NM_001080126.1 Latest version!	Mus musculus caspase 8 (Casp8), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu18354	XM_006495634.4 Latest version!	Mus musculus caspase 8 (Casp8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu18354	XM_006495634.3	Mus musculus caspase 8 (Casp8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp8 ( NM_001277926.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264855.1 Mus musculus caspase 8 (Casp8), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu18354
Clone ID Related Accession (Same CDS sequence)	XM_006495634.4 , XM_006495634.3 , NM_001277926.1
Accession Version	NM_001277926.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	caspase-8 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC112968.11, BY203369.1, AK153340.1 and AK146758.1. Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and longer N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGTGTGC TTTTGGAACT ACTGAGTGAC TGGTTACAGC TCTTCTACCT CTTGATAAGA 
ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264855.1
CDS	277..1779
Translation	MCVLLELLSDWLQLFYLLIRMDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP

Target ORF information:

RefSeq Version	NM_001277926.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 8 (Casp8), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277926.1

ORF Insert Sequence:

ATGTGTGTGC TTTTGGAACT ACTGAGTGAC TGGTTACAGC TCTTCTACCT CTTGATAAGA 
ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp8 ( XM_006495634.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006495697.1 Mus musculus caspase 8 (Casp8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu18354
Clone ID Related Accession (Same CDS sequence)	XM_006495634.4 , XM_006495634.3 , NM_001277926.1
Accession Version	XM_006495634.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	caspase-8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006495634.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTGTGC TTTTGGAACT ACTGAGTGAC TGGTTACAGC TCTTCTACCT CTTGATAAGA 
ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006495697.1
CDS	596..2098
Translation	MCVLLELLSDWLQLFYLLIRMDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP

Target ORF information:

RefSeq Version	XM_006495634.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 8 (Casp8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006495634.3

ORF Insert Sequence:

ATGTGTGTGC TTTTGGAACT ACTGAGTGAC TGGTTACAGC TCTTCTACCT CTTGATAAGA 
ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp8 ( NM_009812.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033942.1 Mus musculus caspase 8 (Casp8), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18790
Clone ID Related Accession (Same CDS sequence)	NM_009812.2 , NM_001080126.1
Accession Version	NM_009812.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Mus musculus(house mouse)
Product	caspase-8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK146758.1. On Jul 23, 2006 this sequence version replaced NM_009812.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146758.1, AK168812.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033942.1
CDS	394..1836
Translation	MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP

Target ORF information:

RefSeq Version	NM_009812.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 8 (Casp8), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009812.2

ORF Insert Sequence:

ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp8 ( NM_001080126.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001073595.1 Mus musculus caspase 8 (Casp8), transcript variant 2, mRNA.

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CloneID	OMu18790
Clone ID Related Accession (Same CDS sequence)	NM_009812.2 , NM_001080126.1
Accession Version	NM_001080126.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	caspase-8 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC112968.11, AK153340.1 and AK146758.1. Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 both encode isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK153340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073595.1
CDS	221..1663
Translation	MDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP

Target ORF information:

RefSeq Version	NM_001080126.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 8 (Casp8), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080126.1

ORF Insert Sequence:

ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp8 ( XM_006495634.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006495697.1 Mus musculus caspase 8 (Casp8), transcript variant X1, mRNA.

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CloneID	OMu18354
Clone ID Related Accession (Same CDS sequence)	XM_006495634.4 , XM_006495634.3 , NM_001277926.1
Accession Version	XM_006495634.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1503bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	caspase-8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006495634.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTGTGC TTTTGGAACT ACTGAGTGAC TGGTTACAGC TCTTCTACCT CTTGATAAGA 
ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006495697.1
CDS	591..2093
Translation	MCVLLELLSDWLQLFYLLIRMDFQSCLYAIAEELGSEDLAALKFLCLDYIPHKKQETIEDAQKLFLRLREKGMLEEGNLSFLKELLFHISRWDLLVNFLDCNREEMVRELRDPDNAQISPYRVMLFKLSEEVSELELRSFKFLLNNEIPKCKLEDDLSLLEIFVEMEKRTMLAENNLETLKSICDQVNKSLLGKIEDYERSSTERRMSLEGREELPPSVLDEMSLKMAELCDSPREQDSESRTSDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEIVSYDDCTANEIHEILEGYQSADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGVPDEAGFEQQNHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDDILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFFPP

Target ORF information:

RefSeq Version	XM_006495634.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 8 (Casp8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006495634.4

ORF Insert Sequence:

ATGTGTGTGC TTTTGGAACT ACTGAGTGAC TGGTTACAGC TCTTCTACCT CTTGATAAGA 
ATGGATTTCC AGAGTTGTCT TTATGCTATT GCTGAAGAAC TGGGCAGTGA AGACCTGGCT 
GCCCTCAAGT TCCTGTGCTT GGACTACATC CCACACAAGA AGCAGGAGAC CATCGAGGAT 
GCCCAGAAGC TATTTCTGAG GCTGCGGGAA AAGGGGATGT TGGAGGAAGG CAATCTGTCT 
TTCCTGAAAG AGCTGCTTTT CCACATCAGT CGGTGGGACC TGCTGGTCAA CTTCCTAGAC 
TGCAACCGAG AGGAGATGGT GAGAGAGCTG CGGGATCCAG ACAATGCCCA GATTTCTCCC 
TACAGGGTCA TGCTCTTTAA GCTCTCAGAA GAAGTGAGCG AGTTGGAATT GAGATCTTTT 
AAGTTCCTTT TGAACAATGA GATCCCCAAA TGTAAGCTGG AAGATGACTT GAGCCTGCTT 
GAAATTTTTG TAGAAATGGA GAAGAGGACC ATGCTGGCAG AAAATAACTT GGAAACCCTA 
AAATCAATCT GTGACCAGGT CAACAAGAGC CTGCTGGGGA AGATCGAGGA TTATGAAAGA 
TCAAGCACAG AGAGAAGAAT GAGCCTTGAA GGAAGGGAAG AGTTGCCACC TTCAGTTTTG 
GATGAGATGA GCCTCAAAAT GGCGGAACTG TGTGACTCGC CAAGAGAACA AGACAGTGAG 
TCACGGACTT CAGACAAAGT TTACCAAATG AAGAACAAAC CTCGGGGATA CTGTCTGATC 
ATCAACAATC ATGATTTCAG CAAGGCCCGG GAAGACATAA CCCAACTCCG AAAAATGAAG 
GACAGAAAAG GAACAGACTG TGATAAAGAG GCTCTGAGTA AGACCTTTAA GGAGCTTCAT 
TTTGAGATAG TATCTTACGA CGACTGCACT GCAAATGAAA TCCACGAGAT TCTAGAAGGC 
TACCAAAGCG CAGACCACAA GAACAAAGAC TGCTTCATCT GCTGTATCCT ATCCCACGGT 
GACAAGGGTG TCGTCTATGG AACGGATGGG AAGGAGGCCT CCATCTATGA CCTGACATCT 
TACTTCACTG GTTCAAAGTG CCCTTCCCTG TCTGGGAAAC CCAAGATCTT TTTCATTCAG 
GCTTGCCAAG GAAGTAACTT CCAGAAAGGA GTGCCTGATG AGGCAGGCTT CGAGCAACAG 
AACCACACTT TAGAAGTGGA TTCATCATCT CACAAGAACT ATATTCCGGA TGAGGCAGAC 
TTTCTGCTGG GAATGGCTAC GGTGAAGAAC TGCGTTTCCT ACCGAGATCC TGTGAATGGA 
ACCTGGTATA TTCAGTCACT TTGCCAGAGC CTGAGGGAAA GATGTCCTCA AGGAGATGAC 
ATTCTTAGCA TCCTGACTGG CGTGAACTAT GACGTGAGCA ATAAAGACGA CAGGAGGAAC 
AAGGGAAAGC AGATGCCACA GCCCACCTTC ACACTACGGA AGAAGCTCTT CTTCCCTCCC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis.
Trends in biochemical sciences24(1)1-4(1999 Jan)
Kumar S,Colussi PA

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Casp8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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