Casp6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casp6
Entrez Gene ID	12368
Full Name	caspase 6
Synonyms	CASP-6,Mch2
General protein information	Preferred Names caspase 6 Names caspase-6 apoptotic protease Mch-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 G3
Summary	This gene encodes a member of the cysteine proteases that plays important roles in regulating apoptosis and neurodegeneration. The encoded protein is involved in the transmission of pain and axonal degeneration. Genetic deletion of this gene in mice results in the delay of axon pruning and protects from axon degeneration. [provided by RefSeq, Apr 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009811.4	NP_033941.3	caspase-6 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Casp6	NP_033941.3
Bos taurus (cattle)	CASP6	NP_001030496.1
Gallus gallus (chicken)	CASP6	NP_990057.1
Xenopus tropicalis (tropical clawed frog)	casp6	NP_001011068.1
Homo sapiens (human)	CASP6	NP_001217.2
Pan troglodytes (chimpanzee)	CASP6	XP_001136602.2
	LOC698788	XP_002804209.1
Danio rerio (zebrafish)	casp6	NP_001018333.1
Canis lupus familiaris (dog)	CASP6	XP_545022.3
Rattus norvegicus (Norway rat)	Casp6	NP_001258913.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
No?l A, Zhou L, Foveau B, Sj?str?m PJ, LeBlanc AC
Cell death and differentiation(2018 Jan)

Caspase-6 is a Dispensable Enabler of Adult Mammalian Axonal Degeneration.
Woo V, Cheng C, Duraikannu A, Chandrasekhar A, Purdy K, Martinez JA, Zochodne DW
Neuroscience371242-253(2017 Dec)

Palmitoylation of caspase-6 by HIP14 regulates its activation.
Skotte NH, Sanders SS, Singaraja RR, Ehrnhoefer DE, Vaid K, Qiu X, Kannan S, Verma C, Hayden MR
Cell death and differentiation24(3)433-444(2017 Mar)

Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
Bartel A, G?hler A, Hopf V, Breitbach K
PloS one12(7)e0180203(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Caspase-6 is posttranslationally palmitoylated by the palmitoyl acyltransferase HIP14 and that the palmitoylation of Caspase-6 inhibits its activation.
Title: Palmitoylation of caspase-6 by HIP14 regulates its activation.

The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b gene, known to be detrimental in murine melioidosis. Expression of the IL-10 gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 rendered mice more susceptible against B. pseudomallei challenge
Title: Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.

Caspases and their substrates are key mediators of apoptosis.
Title: Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process.

caspase-6 could regulate breast cancer cell invasion by modulating MMP-2 and MMP-9 expression in 4T1 tumor-associated macrophages
Title: Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.

Casp6 is unlikely to be involved in colitis-associated tumors.
Title: Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.

The following Casp6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20428	NM_009811.4 Latest version!	Mus musculus caspase 6 (Casp6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp6 ( NM_009811.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033941.3 Mus musculus caspase 6 (Casp6), mRNA.

Price & Availability↑

CloneID	OMu20428
Clone ID Related Accession (Same CDS sequence)	NM_009811.4
Accession Version	NM_009811.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	caspase-6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY265671.1, AK168842.1, AV048874.1 and AC118620.10. On Apr 3, 2015 this sequence version replaced NM_009811.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146363.1, AK168842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAGAAA CCGATGGCTT CTACAAAAGT AGGGAAGTGT TCGATCCAGC CGAGCAGTAC 
AAGATGGACC ACAAGAGGAG AGGAGTTGCC CTCATCTTCA ATCACGAGAG GTTCTTTTGG 
CACCTGACCC TCCCAGAGAG GCGGGGCACC AACGCAGACA GAGACAACCT GACTCGCAGG 
TTTTCAGATC TAGGATTTGA AGTGAAATGC TTTAACGACC TCAGAGCAGA AGAACTCCTG 
CTCAAAATTC ACGAGGTGTC GACTTCAAGC CACATAGATG CCGATTGCTT CATCTGTGTC 
TTCCTGAGCC ATGGGGAAGG CAACCACGTT TACGCATACG ACGCCAAAAT TGAAATTCAG 
ACGTTGACTG GCTTGTTCAA AGGAGACAAG TGTCAGAGCC TGGTTGGAAA ACCCAAGATA 
TTTATCATCC AGGCCTGTCG GGGTAGCCAG CATGACGTAC CCGTGGTTCC CCTGGACATG 
GTGGATCACC AGACAGACAA GCTGGACAAC GTGACCCAGG TGGATGCTGC GTCCGTGTAC 
ACGCTGCCGG CAGGGGCAGA CTTCCTCATG TGCTACTCTG TCGCAGAAGG GTATTACTCT 
CACCGAGAAA CTGTGAATGG CTCCTGGTAC ATTCAGGATT TGTGTGAGAT GCTGGCGAGG 
TACGGCAGTT CCCTGGAGTT CACGGAGCTG CTCACGCTGG TGAACAGAAA GGTCTCTCAG 
CGCCGCGTGG ACTTCTGCAA AGACCCGGAT GCAATCGGCA AGAAGCAGGT GCCCTGCTTC 
GCCTCAATGC TGACCAAAAA GCTGCATTTC TGTCCCAAAC CTAGCAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033941.3
CDS	106..936
Translation	MTETDGFYKSREVFDPAEQYKMDHKRRGVALIFNHERFFWHLTLPERRGTNADRDNLTRRFSDLGFEVKCFNDLRAEELLLKIHEVSTSSHIDADCFICVFLSHGEGNHVYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPVVPLDMVDHQTDKLDNVTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLARYGSSLEFTELLTLVNRKVSQRRVDFCKDPDAIGKKQVPCFASMLTKKLHFCPKPSK

Target ORF information:

RefSeq Version	NM_009811.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 6 (Casp6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009811.4

ORF Insert Sequence:

ATGACAGAAA CCGATGGCTT CTACAAAAGT AGGGAAGTGT TCGATCCAGC CGAGCAGTAC 
AAGATGGACC ACAAGAGGAG AGGAGTTGCC CTCATCTTCA ATCACGAGAG GTTCTTTTGG 
CACCTGACCC TCCCAGAGAG GCGGGGCACC AACGCAGACA GAGACAACCT GACTCGCAGG 
TTTTCAGATC TAGGATTTGA AGTGAAATGC TTTAACGACC TCAGAGCAGA AGAACTCCTG 
CTCAAAATTC ACGAGGTGTC GACTTCAAGC CACATAGATG CCGATTGCTT CATCTGTGTC 
TTCCTGAGCC ATGGGGAAGG CAACCACGTT TACGCATACG ACGCCAAAAT TGAAATTCAG 
ACGTTGACTG GCTTGTTCAA AGGAGACAAG TGTCAGAGCC TGGTTGGAAA ACCCAAGATA 
TTTATCATCC AGGCCTGTCG GGGTAGCCAG CATGACGTAC CCGTGGTTCC CCTGGACATG 
GTGGATCACC AGACAGACAA GCTGGACAAC GTGACCCAGG TGGATGCTGC GTCCGTGTAC 
ACGCTGCCGG CAGGGGCAGA CTTCCTCATG TGCTACTCTG TCGCAGAAGG GTATTACTCT 
CACCGAGAAA CTGTGAATGG CTCCTGGTAC ATTCAGGATT TGTGTGAGAT GCTGGCGAGG 
TACGGCAGTT CCCTGGAGTT CACGGAGCTG CTCACGCTGG TGAACAGAAA GGTCTCTCAG 
CGCCGCGTGG ACTTCTGCAA AGACCCGGAT GCAATCGGCA AGAAGCAGGT GCCCTGCTTC 
GCCTCAATGC TGACCAAAAA GCTGCATTTC TGTCCCAAAC CTAGCAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Cell death and differentiation(2018 Jan)
No?l A,Zhou L,Foveau B,Sj?str?m PJ,LeBlanc AC

Caspase-6 is a Dispensable Enabler of Adult Mammalian Axonal Degeneration.
Neuroscience371242-253(2017 Dec)
Woo V,Cheng C,Duraikannu A,Chandrasekhar A,Purdy K,Martinez JA,Zochodne DW

Palmitoylation of caspase-6 by HIP14 regulates its activation.
Cell death and differentiation24(3)433-444(2017 Mar)
Skotte NH,Sanders SS,Singaraja RR,Ehrnhoefer DE,Vaid K,Qiu X,Kannan S,Verma C,Hayden MR

Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
PloS one12(7)e0180203(2017)
Bartel A,G?hler A,Hopf V,Breitbach K

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Casp6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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