Casp12 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casp12
Entrez Gene ID	12364
Full Name	caspase 12
General protein information	Preferred Names caspase 12 Names caspase-12 CASP-12
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 A1\|9 2.46 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006509840.2	XP_006509903.1	caspase-12 isoform X1
NM_009808.4	NP_033938.3	caspase-12

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CASP12	XP_522166.2
	CASP12	NP_001035896.1
Mus musculus (house mouse)	Casp12	NP_033938.3
Canis lupus familiaris (dog)	CASP12	NP_001070704.1
Rattus norvegicus (Norway rat)	Casp12	NP_569106.1

Gene Ontology
Bibliography

Related articles in PubMed

IKK? controls ATG16L1 degradation to prevent ER stress during inflammation.
Diamanti MA, Gupta J, Bennecke M, De Oliveira T, Ramakrishnan M, Braczynski AK, Richter B, Beli P, Hu Y, Saleh M, Mittelbronn M, Dikic I, Greten FR
The Journal of experimental medicine214(2)423-437(2017 Feb)

Does caspase-12 suppress inflammasome activation?
Vande Walle L, Jim?nez Fern?ndez D, Demon D, Van Laethem N, Van Hauwermeiren F, Van Gorp H, Van Opdenbosch N, Kayagaki N, Lamkanfi M
Nature534(7605)E1-4(2016 06)

Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Skeldon AM, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, Caprio S, Mehal WZ, Saleh M
Journal of immunology (Baltimore, Md. : 1950)196(1)437-47(2016 Jan)

Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.
Hidvegi T, Stolz DB, Alcorn JF, Yousem SA, Wang J, Leme AS, Houghton AM, Hale P, Ewing M, Cai H, Garchar EA, Pastore N, Annunziata P, Kaminski N, Pilewski J, Shapiro SD, Pak SC, Silverman GA, Brunetti-Pierri N, Perlmutter DH
The Journal of biological chemistry290(50)29742-57(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mice ablated for caspase-12 develop spontaneous obesity and insulin resistance.
Title: Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.

We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration.
Title: Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration.

Bnip3L and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
Title: Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12.

Caspase-12 plays a pivotal role in CCl4-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via caspase-9 activation.
Title: Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice.

Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin-deficient mdx mouse, the model for Duchenne muscular dystrophy.
Title: Caspase-12 ablation preserves muscle function in the mdx mouse.

The following Casp12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04888	NM_009808.4 Latest version!	Mus musculus caspase 12 (Casp12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu41872	XM_006509840.2 Latest version!	Mus musculus caspase 12 (Casp12), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp12 ( NM_009808.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033938.3 Mus musculus caspase 12 (Casp12), mRNA.

Price & Availability↑

CloneID	OMu04888
Clone ID Related Accession (Same CDS sequence)	NM_009808.4
Accession Version	NM_009808.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	caspase-12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK077256.1 and AC104914.9. On Oct 6, 2007 this sequence version replaced NM_009808.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030309.1, BC028979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA GGAGGACACA TGAAAGAGAT CCAATCTACA AGATCAAAGG TTTGGCCAAG 
GACATGCTGG ATGGGGTTTT TGATGACCTG GTGGAGAAGA ATGTTTTAAA TGGAGATGAG 
TTACTCAAAA TAGGGGAAAG TGCGAGTTTC ATCCTGAACA AGGCTGAGAA TCTGGTTGAG 
AACTTCTTAG AGAAAACAGA CATGGCAGGA AAAATATTTG CTGGCCACAT TGCCAATTCC 
CAGGAACAGC TGAGTTTACA ATTTTCTAAT GATGAGGATG ATGGACCTCA GAAGATATGT 
ACACCTTCTT CTCCATCAGA ATCCAAGAGA AAAGTAGAGG ATGATGAAAT GGAGGTAAAT 
GCTGGATTGG CCCATGAATC ACATCTAATG CTGACAGCTC CTCATGGACT CCAGAGCTCA 
GAAGTCCAAG ATACACTGAA GCTTTGTCCA CGTGATCAGT TTTGTAAGAT AAAGACAGAA 
AGGGCAAAAG AGATATATCC AGTGATGGAG AAGGAGGGAC GAACACGTCT GGCTCTCATC 
ATCTGCAACA AAAAGTTTGA CTACCTTTTT GATAGAGATA ATGCTGATAC TGACATTTTG 
AACATGCAAG AACTACTTGA AAATCTTGGA TACTCTGTGG TGTTAAAGGA AAACCTTACA 
GCTCAGGAAA TGGAGACAGA GTTAATGCAG TTTGCTGGCC GTCCAGAGCA CCAGTCCTCA 
GACAGCACAT TCCTGGTGTT TATGTCCCAT GGCATCCTGG AAGGAATCTG TGGGGTGAAG 
CACCGAAACA AAAAGCCAGA TGTTCTTCAT GATGACACTA TCTTCAAAAT TTTCAACAAC 
TCTAACTGTC GGAGTCTGAG AAACAAACCC AAGATTCTCA TCATGCAGGC CTGCAGAGGC 
AGATATAATG GAACTATTTG GGTATCCACA AACAAAGGGA TAGCCACTGC TGATACAGAT 
GAGGAACGTG TGTTGAGCTG TAAATGGAAT AATAGTATAA CAAAGGCCCA TGTGGAGACA 
GATTTCATTG CTTTCAAATC TTCTACCCCA CATAATATTT CTTGGAAGGT AGGCAAGACT 
GGTTCCCTCT TCATTTCCAA ACTCATTGAC TGCTTCAAAA AGTACTGTTG GTGTTATCAT 
TTGGAGGAAA TTTTTCGAAA GGTTCAACAC TCATTTGAGG TCCCAGGTGA ACTGACCCAG 
ATGCCCACTA TTGAGAGAGT ATCCATGACA CGCTATTTCT ACCTTTTTCC CGGGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033938.3
CDS	44..1303
Translation	MAARRTHERDPIYKIKGLAKDMLDGVFDDLVEKNVLNGDELLKIGESASFILNKAENLVENFLEKTDMAGKIFAGHIANSQEQLSLQFSNDEDDGPQKICTPSSPSESKRKVEDDEMEVNAGLAHESHLMLTAPHGLQSSEVQDTLKLCPRDQFCKIKTERAKEIYPVMEKEGRTRLALIICNKKFDYLFDRDNADTDILNMQELLENLGYSVVLKENLTAQEMETELMQFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFKIFNNSNCRSLRNKPKILIMQACRGRYNGTIWVSTNKGIATADTDEERVLSCKWNNSITKAHVETDFIAFKSSTPHNISWKVGKTGSLFISKLIDCFKKYCWCYHLEEIFRKVQHSFEVPGELTQMPTIERVSMTRYFYLFPGN

Target ORF information:

RefSeq Version	NM_009808.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 12 (Casp12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009808.4

ORF Insert Sequence:

ATGGCGGCCA GGAGGACACA TGAAAGAGAT CCAATCTACA AGATCAAAGG TTTGGCCAAG 
GACATGCTGG ATGGGGTTTT TGATGACCTG GTGGAGAAGA ATGTTTTAAA TGGAGATGAG 
TTACTCAAAA TAGGGGAAAG TGCGAGTTTC ATCCTGAACA AGGCTGAGAA TCTGGTTGAG 
AACTTCTTAG AGAAAACAGA CATGGCAGGA AAAATATTTG CTGGCCACAT TGCCAATTCC 
CAGGAACAGC TGAGTTTACA ATTTTCTAAT GATGAGGATG ATGGACCTCA GAAGATATGT 
ACACCTTCTT CTCCATCAGA ATCCAAGAGA AAAGTAGAGG ATGATGAAAT GGAGGTAAAT 
GCTGGATTGG CCCATGAATC ACATCTAATG CTGACAGCTC CTCATGGACT CCAGAGCTCA 
GAAGTCCAAG ATACACTGAA GCTTTGTCCA CGTGATCAGT TTTGTAAGAT AAAGACAGAA 
AGGGCAAAAG AGATATATCC AGTGATGGAG AAGGAGGGAC GAACACGTCT GGCTCTCATC 
ATCTGCAACA AAAAGTTTGA CTACCTTTTT GATAGAGATA ATGCTGATAC TGACATTTTG 
AACATGCAAG AACTACTTGA AAATCTTGGA TACTCTGTGG TGTTAAAGGA AAACCTTACA 
GCTCAGGAAA TGGAGACAGA GTTAATGCAG TTTGCTGGCC GTCCAGAGCA CCAGTCCTCA 
GACAGCACAT TCCTGGTGTT TATGTCCCAT GGCATCCTGG AAGGAATCTG TGGGGTGAAG 
CACCGAAACA AAAAGCCAGA TGTTCTTCAT GATGACACTA TCTTCAAAAT TTTCAACAAC 
TCTAACTGTC GGAGTCTGAG AAACAAACCC AAGATTCTCA TCATGCAGGC CTGCAGAGGC 
AGATATAATG GAACTATTTG GGTATCCACA AACAAAGGGA TAGCCACTGC TGATACAGAT 
GAGGAACGTG TGTTGAGCTG TAAATGGAAT AATAGTATAA CAAAGGCCCA TGTGGAGACA 
GATTTCATTG CTTTCAAATC TTCTACCCCA CATAATATTT CTTGGAAGGT AGGCAAGACT 
GGTTCCCTCT TCATTTCCAA ACTCATTGAC TGCTTCAAAA AGTACTGTTG GTGTTATCAT 
TTGGAGGAAA TTTTTCGAAA GGTTCAACAC TCATTTGAGG TCCCAGGTGA ACTGACCCAG 
ATGCCCACTA TTGAGAGAGT ATCCATGACA CGCTATTTCT ACCTTTTTCC CGGGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Casp12 ( XM_006509840.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006509903.1 Mus musculus caspase 12 (Casp12), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu41872
Clone ID Related Accession (Same CDS sequence)	XM_006509840.2
Accession Version	XM_006509840.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	caspase-12 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006509840.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCCA GGAGGACACA TGAAAGAGAT CCAATCTACA AGATCAAAGA ATTTTCTAAT 
GATGAGGATG ATGGACCTCA GAAGATATGT ACACCTTCTT CTCCATCAGA ATCCAAGAGA 
AAAGTAGAGG ATGATGAAAT GGAGGTAAAT GCTGGATTGG CCCATGAATC ACATCTAATG 
CTGACAGCTC CTCATGGACT CCAGAGCTCA GAAGTCCAAG ATACACTGAA GCTTTGTCCA 
CGTGATCAGT TTTGTAAGAT AAAGACAGAA AGGGCAAAAG AGATATATCC AGTGATGGAG 
AAGGAGGGAC GAACACGTCT GGCTCTCATC ATCTGCAACA AAAAGTTTGA CTACCTTTTT 
GATAGAGATA ATGCTGATAC TGACATTTTG AACATGCAAG AACTACTTGA AAATCTTGGA 
TACTCTGTGG TGTTAAAGGA AAACCTTACA GCTCAGGAAA TGGAGACAGA GTTAATGCAG 
TTTGCTGGCC GTCCAGAGCA CCAGTCCTCA GACAGCACAT TCCTGGTGTT TATGTCCCAT 
GGCATCCTGG AAGGAATCTG TGGGGTGAAG CACCGAAACA AAAAGCCAGA TGTTCTTCAT 
GATGACACTA TCTTCAAAAT TTTCAACAAC TCTAACTGTC GGAGTCTGAG AAACAAACCC 
AAGATTCTCA TCATGCAGGC CTGCAGAGGC AGATATAATG GAACTATTTG GGTATCCACA 
AACAAAGGGA TAGCCACTGC TGATACAGAT GAGGAACGTG TGTTGAGCTG TAAATGGAAT 
AATAGTATAA CAAAGGCCCA TGTGGAGACA GATTTCATTG CTTTCAAATC TTCTACCCCA 
CATAATATTT CTTGGAAGGT AGGCAAGACT GGTTCCCTCT TCATTTCCAA ACTCATTGAC 
TGCTTCAAAA AGTACTGTTG GTGTTATCAT TTGGAGGAAA TTTTTCGAAA GGTTCAACAC 
TCATTTGAGG TCCCAGGTGA ACTGACCCAG ATGCCCACTA TTGAGAGAGT ATCCATGACA 
CGCTATTTCT ACCTTTTTCC CGGGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006509903.1
CDS	78..1127
Translation	MAARRTHERDPIYKIKEFSNDEDDGPQKICTPSSPSESKRKVEDDEMEVNAGLAHESHLMLTAPHGLQSSEVQDTLKLCPRDQFCKIKTERAKEIYPVMEKEGRTRLALIICNKKFDYLFDRDNADTDILNMQELLENLGYSVVLKENLTAQEMETELMQFAGRPEHQSSDSTFLVFMSHGILEGICGVKHRNKKPDVLHDDTIFKIFNNSNCRSLRNKPKILIMQACRGRYNGTIWVSTNKGIATADTDEERVLSCKWNNSITKAHVETDFIAFKSSTPHNISWKVGKTGSLFISKLIDCFKKYCWCYHLEEIFRKVQHSFEVPGELTQMPTIERVSMTRYFYLFPGN

Target ORF information:

RefSeq Version	XM_006509840.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus caspase 12 (Casp12), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006509840.2

ORF Insert Sequence:

ATGGCGGCCA GGAGGACACA TGAAAGAGAT CCAATCTACA AGATCAAAGA ATTTTCTAAT 
GATGAGGATG ATGGACCTCA GAAGATATGT ACACCTTCTT CTCCATCAGA ATCCAAGAGA 
AAAGTAGAGG ATGATGAAAT GGAGGTAAAT GCTGGATTGG CCCATGAATC ACATCTAATG 
CTGACAGCTC CTCATGGACT CCAGAGCTCA GAAGTCCAAG ATACACTGAA GCTTTGTCCA 
CGTGATCAGT TTTGTAAGAT AAAGACAGAA AGGGCAAAAG AGATATATCC AGTGATGGAG 
AAGGAGGGAC GAACACGTCT GGCTCTCATC ATCTGCAACA AAAAGTTTGA CTACCTTTTT 
GATAGAGATA ATGCTGATAC TGACATTTTG AACATGCAAG AACTACTTGA AAATCTTGGA 
TACTCTGTGG TGTTAAAGGA AAACCTTACA GCTCAGGAAA TGGAGACAGA GTTAATGCAG 
TTTGCTGGCC GTCCAGAGCA CCAGTCCTCA GACAGCACAT TCCTGGTGTT TATGTCCCAT 
GGCATCCTGG AAGGAATCTG TGGGGTGAAG CACCGAAACA AAAAGCCAGA TGTTCTTCAT 
GATGACACTA TCTTCAAAAT TTTCAACAAC TCTAACTGTC GGAGTCTGAG AAACAAACCC 
AAGATTCTCA TCATGCAGGC CTGCAGAGGC AGATATAATG GAACTATTTG GGTATCCACA 
AACAAAGGGA TAGCCACTGC TGATACAGAT GAGGAACGTG TGTTGAGCTG TAAATGGAAT 
AATAGTATAA CAAAGGCCCA TGTGGAGACA GATTTCATTG CTTTCAAATC TTCTACCCCA 
CATAATATTT CTTGGAAGGT AGGCAAGACT GGTTCCCTCT TCATTTCCAA ACTCATTGAC 
TGCTTCAAAA AGTACTGTTG GTGTTATCAT TTGGAGGAAA TTTTTCGAAA GGTTCAACAC 
TCATTTGAGG TCCCAGGTGA ACTGACCCAG ATGCCCACTA TTGAGAGAGT ATCCATGACA 
CGCTATTTCT ACCTTTTTCC CGGGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IKK? controls ATG16L1 degradation to prevent ER stress during inflammation.
The Journal of experimental medicine214(2)423-437(2017 Feb)
Diamanti MA,Gupta J,Bennecke M,De Oliveira T,Ramakrishnan M,Braczynski AK,Richter B,Beli P,Hu Y,Saleh M,Mittelbronn M,Dikic I,Greten FR

Does caspase-12 suppress inflammasome activation?
Nature534(7605)E1-4(2016 06)
Vande Walle L,Jim?nez Fern?ndez D,Demon D,Van Laethem N,Van Hauwermeiren F,Van Gorp H,Van Opdenbosch N,Kayagaki N,Lamkanfi M

Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Journal of immunology (Baltimore, Md. : 1950)196(1)437-47(2016 Jan)
Skeldon AM,Morizot A,Douglas T,Santoro N,Kursawe R,Kozlitina J,Caprio S,Mehal WZ,Saleh M

Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.
The Journal of biological chemistry290(50)29742-57(2015 Dec)
Hidvegi T,Stolz DB,Alcorn JF,Yousem SA,Wang J,Leme AS,Houghton AM,Hale P,Ewing M,Cai H,Garchar EA,Pastore N,Annunziata P,Kaminski N,Pilewski J,Shapiro SD,Pak SC,Silverman GA,Brunetti-Pierri N,Perlmutter DH

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Casp12 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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