C2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	C2
Entrez Gene ID	12263
Full Name	complement component 2 (within H-2S)
General protein information	Preferred Names complement component 2 (within H-2S) Names complement C2 MHC complement component C2 classical-complement pathway C3/C5 convertase complement component C2 complement factor C2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 18.41 cM
Summary	This gene encodes component C2 of the classical pathway of the complement system. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the complement system. Mice lacking the encoded protein are found to be more susceptible to bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013484.2	NP_038512.2	complement C2 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C2	XP_003311224.1
Bos taurus (cattle)	C2	NP_001029664.1
Danio rerio (zebrafish)	LOC563828	XP_001921532.4
Canis lupus familiaris (dog)	C2	XP_860410.2
Mus musculus (house mouse)	C2	NP_038512.2
Homo sapiens (human)	C2	NP_000054.2
Xenopus tropicalis (tropical clawed frog)	c2	XP_002943019.2
Rattus norvegicus (Norway rat)	C2	NP_757376.2
Gallus gallus (chicken)	C2	XP_417722.4

Gene Ontology
Bibliography

Related articles in PubMed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.
Ramos TN, Darley MM, Weckbach S, Stahel PF, Tomlinson S, Barnum SR
The Journal of biological chemistry287(29)24734-8(2012 Jul)

Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2.
Tong HH, Li YX, Stahl GL, Thurman JM
Infection and immunity78(3)976-83(2010 Mar)

Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans.
Held K, Thiel S, Loos M, Petry F
Molecular immunology45(15)3934-41(2008 Sep)

Orientation and molecular map position of the complement genes in the mouse MHC.
M?ller U, Stephan D, Philippsen P, Steinmetz M
The EMBO journal6(2)369-73(1987 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that activation of C5 in experimental cerebral malaria likely occurs via coagulation enzymes of the extrinsic protease pathway.
Title: The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.

Bacterial titers of both Streptococcus pneumoniae serotype 6A and 14 in the middle ear lavage fluid samples from Bf/C2(-/)(-), Bf(-)(/)(-), and C1qa(-/)(-) mice were significantly higher than in samples from wild-type mice.
Title: Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2.

The more pronounced lack of complement activation in Bf/C2-/- mice leads to uncontrolled infection due to an opsonophagocytic defect
Title: Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans.

The following C2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09462	NM_013484.2 Latest version!	Mus musculus complement component 2 (within H-2S) (C2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$447.30 $639.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C2 ( NM_013484.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038512.2 Mus musculus complement component 2 (within H-2S) (C2), mRNA.

Price & Availability↑

CloneID	OMu09462
Clone ID Related Accession (Same CDS sequence)	NM_013484.2
Accession Version	NM_013484.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	complement C2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK146812.1 and BY688722.1. On Oct 6, 2007 this sequence version replaced NM_013484.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146812.1, BC011086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCTC TGCTGGCTCT CTTCTACCTG CTGCAGCTGG GCCCAGGCCT GGCTGCTCTC 
TTCTGCAACC AGAATGTCAA TATCACCGGT GGTAATTTCA CCCTCAGCCA TGGCTGGGCC 
CCTGGGAGCC TCCTCATCTA CTCCTGCCCC CTGGGCAGGT ACCCGTCCCC AGCCTGGAGG 
AAATGTCAGA GCAACGGACA GTGGCTGACA CCAAGGTCTA GCTCACATCA CACCCTGCGA 
TCCTCTCGGA TGGTTAAAGC AGTCTGCAAA CCGGTTCGAT GCCTAGCTCC TTCATCCTTT 
GAAAATGGCA TCTATTTCCC TCGGCTGGTG TCCTACCCTG TGGGTAGCAA CGTGAGCTTT 
GAGTGTGAGC AAGACTTCAC CTTGCGGGGC TCACCTGTGC GGTACTGTCG CCCCAACGGC 
CTGTGGGATG GAGAGACGGC TGTGTGTGAC AATGGGGCTA GCCACTGCCC CAACCCTGGC 
ATCTCAGTGG GCACAGCTCG GACAGGCTTG AACTTTGACC TTGGGGACAA GGTCAGGTAC 
CGCTGCTCCT CCTCAAATAT GGTATTGACT GGCTCTGCAG AGCGGGAGTG TCAGAGCAAT 
GGAGTGTGGA GTGGGTCGGA ACCCATTTGC CGACAGCCTT ACTCTTACGA CTTCCCTGAG 
GATGTAGCAT CTGCCCTAGA CACCTCCCTC ACCAACCTGC TTGGAGCCAC CAATCCCACC 
CAGAACCTTC TGACAAAAAG TTTGGGCCGT AAGATCATAA TCCAGCGCTC GGGTCACCTG 
AACCTCTATT TGCTGCTTGA TGCTTCTCAG AGTGTGACAG AAAAAGACTT TGACATCTTC 
AAGAAGAGTG CCGAACTCAT GGTGGAGAGG ATCTTCAGCT TTGAGGTAAA TGTCAGCGTA 
GCTATCATCA CCTTTGCCTC TCAGCCCAAA ACCATCATGT CGATCCTGAG TGAGAGATCC 
CAGGATGTGA CGGAGGTGAT CACCAGTCTG GACTCTGCCA GCTACAAAGA TCACGAAAAT 
GCCACTGGCA CTAACACTTA TGAGGTTCTC ATCCGCGTTT ACTCCATGAT GCAAAGCCAG 
ATGGATCGCC TGGGCATGGA GACCTCTGCC TGGAAGGAAA TCCGTCACAC CATCATCCTT 
CTGACTGACG GAAAGTCCAA CATGGGTGAC TCTCCCAAGA AAGCAGTCAC CAGAATCAGA 
GAGCTCCTGA GCATCGAACA GAACAGAGAT GACTACCTGG ACATCTATGC TATTGGGGTG 
GGCAAGCTGG ATGTGGACTG GAAAGAACTG AATGAGCTGG GTTCCAAGAA GGATGGCGAG 
AGGCATGCCT TCATCTTGCA GGATGCAAAG GCCTTGCAAC AGATCTTTGA GCACATGTTG 
GATGTCTCTA AGCTCACAGA TACCATCTGT GGGGTGGGGA ACATGTCCGC CAATGCCTCT 
GACCAGGAGA GGACACCTTG GCAAGTCACC TTTAAGCCCA AGAGCAAGGA AACTTGCCAG 
GGATCACTCA TCTCTGATCA GTGGGTGCTG ACAGCAGCTC ACTGCTTCCA TGACATTCAG 
ATGGAGGACC ACCACCTGTG GAGGGTCAAT GTAGGTGATC CCACCTCTCA GCATGGCAAA 
GAATTTCTTG TGGAGGACGT GATAATTGCC CCAGGGTTTA ATGTCCATGC AAAGCGGAAG 
CAGGGCATCT CAGAGTTCTA TGCTGATGAC ATTGCCTTGC TGAAGCTATC TCGGAAAGTG 
AAAATGTCCA CCCATGCCAG ACCCATCTGC CTTCCTTGCA CTGTGGGAGC CAACATGGCT 
CTGCGGAGAT CCCCAGGTAG TACCTGTAAA GATCATGAGA CAGAACTTCT GTCACAGCAG 
AAAGTTCCTG CACATTTTGT AGCTTTGAAT GGGAACAGAC TCAACATCAA CCTCAGGACA 
GGACCTGAGT GGACAAGGTG TATCCAGGCT GTCTCCCAAA ACAAAAACAT CTTCCCCAGC 
TTGACAAACG TTAGCGAGGT GGTGACAGAC CAGTTCCTAT GCAGTGGGAT GGAGGAGGAA 
GATGACAATC CTTGCAAAGG AGAATCTGGG GGAGCCGTTT TCCTTGGACG GAGATACAGG 
TTCTTCCAGG TGGGCCTGGT GAGTTGGGGT CTTTTTGACC CTTGTCATGG TTCCTCCAAC 
AAAAACTTGC GCAAGAAACC TCCACGTGGT GTTCTGCCAA GGGACTTCCA CATTAGTCTT 
TTCCGCCTGC AGCCCTGGCT GAGGCAGCAC CTGGATGGTG TCCTGGACTT TCTGCCACTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038512.2
CDS	106..2388
Translation	MAPLLALFYLLQLGPGLAALFCNQNVNITGGNFTLSHGWAPGSLLIYSCPLGRYPSPAWRKCQSNGQWLTPRSSSHHTLRSSRMVKAVCKPVRCLAPSSFENGIYFPRLVSYPVGSNVSFECEQDFTLRGSPVRYCRPNGLWDGETAVCDNGASHCPNPGISVGTARTGLNFDLGDKVRYRCSSSNMVLTGSAERECQSNGVWSGSEPICRQPYSYDFPEDVASALDTSLTNLLGATNPTQNLLTKSLGRKIIIQRSGHLNLYLLLDASQSVTEKDFDIFKKSAELMVERIFSFEVNVSVAIITFASQPKTIMSILSERSQDVTEVITSLDSASYKDHENATGTNTYEVLIRVYSMMQSQMDRLGMETSAWKEIRHTIILLTDGKSNMGDSPKKAVTRIRELLSIEQNRDDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAKALQQIFEHMLDVSKLTDTICGVGNMSANASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAAHCFHDIQMEDHHLWRVNVGDPTSQHGKEFLVEDVIIAPGFNVHAKRKQGISEFYADDIALLKLSRKVKMSTHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAHFVALNGNRLNINLRTGPEWTRCIQAVSQNKNIFPSLTNVSEVVTDQFLCSGMEEEDDNPCKGESGGAVFLGRRYRFFQVGLVSWGLFDPCHGSSNKNLRKKPPRGVLPRDFHISLFRLQPWLRQHLDGVLDFLPL

Target ORF information:

RefSeq Version	NM_013484.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus complement component 2 (within H-2S) (C2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013484.2

ORF Insert Sequence:

ATGGCCCCTC TGCTGGCTCT CTTCTACCTG CTGCAGCTGG GCCCAGGCCT GGCTGCTCTC 
TTCTGCAACC AGAATGTCAA TATCACCGGT GGTAATTTCA CCCTCAGCCA TGGCTGGGCC 
CCTGGGAGCC TCCTCATCTA CTCCTGCCCC CTGGGCAGGT ACCCGTCCCC AGCCTGGAGG 
AAATGTCAGA GCAACGGACA GTGGCTGACA CCAAGGTCTA GCTCACATCA CACCCTGCGA 
TCCTCTCGGA TGGTTAAAGC AGTCTGCAAA CCGGTTCGAT GCCTAGCTCC TTCATCCTTT 
GAAAATGGCA TCTATTTCCC TCGGCTGGTG TCCTACCCTG TGGGTAGCAA CGTGAGCTTT 
GAGTGTGAGC AAGACTTCAC CTTGCGGGGC TCACCTGTGC GGTACTGTCG CCCCAACGGC 
CTGTGGGATG GAGAGACGGC TGTGTGTGAC AATGGGGCTA GCCACTGCCC CAACCCTGGC 
ATCTCAGTGG GCACAGCTCG GACAGGCTTG AACTTTGACC TTGGGGACAA GGTCAGGTAC 
CGCTGCTCCT CCTCAAATAT GGTATTGACT GGCTCTGCAG AGCGGGAGTG TCAGAGCAAT 
GGAGTGTGGA GTGGGTCGGA ACCCATTTGC CGACAGCCTT ACTCTTACGA CTTCCCTGAG 
GATGTAGCAT CTGCCCTAGA CACCTCCCTC ACCAACCTGC TTGGAGCCAC CAATCCCACC 
CAGAACCTTC TGACAAAAAG TTTGGGCCGT AAGATCATAA TCCAGCGCTC GGGTCACCTG 
AACCTCTATT TGCTGCTTGA TGCTTCTCAG AGTGTGACAG AAAAAGACTT TGACATCTTC 
AAGAAGAGTG CCGAACTCAT GGTGGAGAGG ATCTTCAGCT TTGAGGTAAA TGTCAGCGTA 
GCTATCATCA CCTTTGCCTC TCAGCCCAAA ACCATCATGT CGATCCTGAG TGAGAGATCC 
CAGGATGTGA CGGAGGTGAT CACCAGTCTG GACTCTGCCA GCTACAAAGA TCACGAAAAT 
GCCACTGGCA CTAACACTTA TGAGGTTCTC ATCCGCGTTT ACTCCATGAT GCAAAGCCAG 
ATGGATCGCC TGGGCATGGA GACCTCTGCC TGGAAGGAAA TCCGTCACAC CATCATCCTT 
CTGACTGACG GAAAGTCCAA CATGGGTGAC TCTCCCAAGA AAGCAGTCAC CAGAATCAGA 
GAGCTCCTGA GCATCGAACA GAACAGAGAT GACTACCTGG ACATCTATGC TATTGGGGTG 
GGCAAGCTGG ATGTGGACTG GAAAGAACTG AATGAGCTGG GTTCCAAGAA GGATGGCGAG 
AGGCATGCCT TCATCTTGCA GGATGCAAAG GCCTTGCAAC AGATCTTTGA GCACATGTTG 
GATGTCTCTA AGCTCACAGA TACCATCTGT GGGGTGGGGA ACATGTCCGC CAATGCCTCT 
GACCAGGAGA GGACACCTTG GCAAGTCACC TTTAAGCCCA AGAGCAAGGA AACTTGCCAG 
GGATCACTCA TCTCTGATCA GTGGGTGCTG ACAGCAGCTC ACTGCTTCCA TGACATTCAG 
ATGGAGGACC ACCACCTGTG GAGGGTCAAT GTAGGTGATC CCACCTCTCA GCATGGCAAA 
GAATTTCTTG TGGAGGACGT GATAATTGCC CCAGGGTTTA ATGTCCATGC AAAGCGGAAG 
CAGGGCATCT CAGAGTTCTA TGCTGATGAC ATTGCCTTGC TGAAGCTATC TCGGAAAGTG 
AAAATGTCCA CCCATGCCAG ACCCATCTGC CTTCCTTGCA CTGTGGGAGC CAACATGGCT 
CTGCGGAGAT CCCCAGGTAG TACCTGTAAA GATCATGAGA CAGAACTTCT GTCACAGCAG 
AAAGTTCCTG CACATTTTGT AGCTTTGAAT GGGAACAGAC TCAACATCAA CCTCAGGACA 
GGACCTGAGT GGACAAGGTG TATCCAGGCT GTCTCCCAAA ACAAAAACAT CTTCCCCAGC 
TTGACAAACG TTAGCGAGGT GGTGACAGAC CAGTTCCTAT GCAGTGGGAT GGAGGAGGAA 
GATGACAATC CTTGCAAAGG AGAATCTGGG GGAGCCGTTT TCCTTGGACG GAGATACAGG 
TTCTTCCAGG TGGGCCTGGT GAGTTGGGGT CTTTTTGACC CTTGTCATGG TTCCTCCAAC 
AAAAACTTGC GCAAGAAACC TCCACGTGGT GTTCTGCCAA GGGACTTCCA CATTAGTCTT 
TTCCGCCTGC AGCCCTGGCT GAGGCAGCAC CTGGATGGTG TCCTGGACTT TCTGCCACTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.
The Journal of biological chemistry287(29)24734-8(2012 Jul)
Ramos TN,Darley MM,Weckbach S,Stahel PF,Tomlinson S,Barnum SR

Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2.
Infection and immunity78(3)976-83(2010 Mar)
Tong HH,Li YX,Stahl GL,Thurman JM

Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans.
Molecular immunology45(15)3934-41(2008 Sep)
Held K,Thiel S,Loos M,Petry F

Orientation and molecular map position of the complement genes in the mouse MHC.
The EMBO journal6(2)369-73(1987 Feb)
M?ller U,Stephan D,Philippsen P,Steinmetz M

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C2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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