C1qbp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	C1qbp
Entrez Gene ID	12261
Full Name	complement component 1, q subcomponent binding protein
Synonyms	AA407365,AA986492,D11Wsu182e,HABP1,P32,gC1qBP
General protein information	Preferred Names complement component 1, q subcomponent binding protein Names complement component 1 Q subcomponent-binding protein, mitochondrial GC1q-R protein glycoprotein gC1qBP
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B4\|11 43.21 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007573.2	NP_031599.2	complement component 1 Q subcomponent-binding protein, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	C1QBP	NP_001203.1
Canis lupus familiaris (dog)	C1QBP	XP_546568.2
Mus musculus (house mouse)	C1qbp	NP_031599.2
	LOC711817	XP_001100940.1
Bos taurus (cattle)	C1QBP	NP_001029699.1
Rattus norvegicus (Norway rat)	C1qbp	NP_062132.2
Drosophila melanogaster (fruit fly)	P32	NP_611243.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003987	XP_318437.3
Caenorhabditis elegans (roundworm)	cri-3	NP_497701.1
Gallus gallus (chicken)	C1QBP	XP_415748.4
Xenopus tropicalis (tropical clawed frog)	c1qbp	XP_002936868.2
Pan troglodytes (chimpanzee)	C1QBP	XP_003952998.1
Danio rerio (zebrafish)	c1qbp	NP_001017858.2

Gene Ontology
Bibliography

Related articles in PubMed

Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration.
Yagi M, Uchiumi T, Sagata N, Setoyama D, Amamoto R, Matsushima Y, Kang D
Scientific reports7(1)15131(2017 Nov)

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).
Neumann A, Papareddy P, Westman J, Hyldegaard O, Sn?ll J, Norrby-Teglund A, Herwald H
Journal of innate immunity(2017 Oct)

p32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure.
Liu Y, Leslie PL, Jin A, Itahana K, Graves LM, Zhang Y
Scientific reports7(1)5754(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hepatitis C virus core protein ligates gC1qR to induce A20 expression in macrophages via P38, JNK and NF-kappaB signaling pathways, which leads to a low-grade chronic inflammation during HCV infection.
Title: HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-?B signaling pathways.

application of p33 significantly improved survival in mice receiving an otherwise lethal dose of histones.
Title: Treatment with p33 curtails morbidity and mortality in a histone-induced murine shock model.

Authors propose that p32 is required for functional mitoribosome formation to synthesize proteins within mitochondria.
Title: p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.

we have identified a mitochondrial protein p32 as a novel interactor of parkin in the brain
Title: p32 regulates mitochondrial morphology and dynamics through parkin.

C1qbp could directly bind to CypD. Therefore C1qbp appears to act as an endogenous inhibitor of the MPT pore, most likely through binding to CypD, and thus protects cells against oxidative stress.
Title: Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death.

The following C1qbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C1qbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20649	NM_007573.2 Latest version!	Mus musculus complement component 1, q subcomponent binding protein (C1qbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C1qbp ( NM_007573.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031599.2 Mus musculus complement component 1, q subcomponent binding protein (C1qbp), mRNA.

Price & Availability↑

CloneID	OMu20649
Clone ID Related Accession (Same CDS sequence)	NM_007573.2
Accession Version	NM_007573.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	complement component 1 Q subcomponent-binding protein, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY275303.1, AK010601.1 and CF381952.1. On Aug 12, 2006 this sequence version replaced NM_007573.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038075.1, AK169764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTCCCTC TGCTGCGTTG CGTGCCCCGC GCCCTCGGCG CCGCCGCCTC CGGCCTCCGA 
ACCGCCATCC CGGCCCAGCC GCTTCGGCAT CTCCTGCAGC CCGCGCCCCG GCCATGCCTC 
CGGCCCTTCG GTTTGCTCAG CGTACGGGCC GGCTCGGCTC GGCGCTCTGG CCTCCTGCAG 
CCCCCGGTTC CCTGCGCGTG CGGCTGTGGC GCTCTGCACA CGGAAGGAGA CAAGGCCTTC 
GTTGAATTCT TGACTGATGA AATTAAGGAA GAAAAGAAGA TCCAGAAACA CAAGTCCCTT 
CCCAAGATGT CTGGAGATTG GGAGCTGGAG GTGAACGGCA CGGAGGCTAA ATTATTGCGC 
AAAGTTGCCG GAGAAAAGAT CACGGTCACT TTCAACATCA ACAACAGCAT CCCTCCAACA 
TTTGATGGTG AGGAGGAGCC CTCACAGGGG CAGAAGGCTG AAGAACAGGA GCCAGAACTG 
ACATCAACTC CCAACTTTGT GGTTGAAGTT ACCAAGACTG ATGGCAAGAA GACCCTTGTA 
CTGGACTGTC ACTATCCTGA GGATGAGATT GGACACGAAG ATGAGGCCGA GAGTGATATT 
TTCTCTATCA AGGAAGTTAG CTTTCAGGCC ACTGGTGACT CTGAGTGGAG GGATACAAAC 
TATACACTCA ACACAGATTC CCTGGACTGG GCCTTGTATG ACCACCTAAT GGATTTCCTT 
GCGGACCGAG GGGTGGATAA CACTTTTGCG GATGAGTTGG TGGAGCTCAG CACAGCCCTG 
GAGCACCAGG AATATATCAC CTTTCTTGAG GACCTCAAAA GCTTTGTCAA GAACCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031599.2
CDS	77..916
Translation	MLPLLRCVPRALGAAASGLRTAIPAQPLRHLLQPAPRPCLRPFGLLSVRAGSARRSGLLQPPVPCACGCGALHTEGDKAFVEFLTDEIKEEKKIQKHKSLPKMSGDWELEVNGTEAKLLRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKAEEQEPELTSTPNFVVEVTKTDGKKTLVLDCHYPEDEIGHEDEAESDIFSIKEVSFQATGDSEWRDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKNQ

Target ORF information:

RefSeq Version	NM_007573.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus complement component 1, q subcomponent binding protein (C1qbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007573.2

ORF Insert Sequence:

ATGCTCCCTC TGCTGCGTTG CGTGCCCCGC GCCCTCGGCG CCGCCGCCTC CGGCCTCCGA 
ACCGCCATCC CGGCCCAGCC GCTTCGGCAT CTCCTGCAGC CCGCGCCCCG GCCATGCCTC 
CGGCCCTTCG GTTTGCTCAG CGTACGGGCC GGCTCGGCTC GGCGCTCTGG CCTCCTGCAG 
CCCCCGGTTC CCTGCGCGTG CGGCTGTGGC GCTCTGCACA CGGAAGGAGA CAAGGCCTTC 
GTTGAATTCT TGACTGATGA AATTAAGGAA GAAAAGAAGA TCCAGAAACA CAAGTCCCTT 
CCCAAGATGT CTGGAGATTG GGAGCTGGAG GTGAACGGCA CGGAGGCTAA ATTATTGCGC 
AAAGTTGCCG GAGAAAAGAT CACGGTCACT TTCAACATCA ACAACAGCAT CCCTCCAACA 
TTTGATGGTG AGGAGGAGCC CTCACAGGGG CAGAAGGCTG AAGAACAGGA GCCAGAACTG 
ACATCAACTC CCAACTTTGT GGTTGAAGTT ACCAAGACTG ATGGCAAGAA GACCCTTGTA 
CTGGACTGTC ACTATCCTGA GGATGAGATT GGACACGAAG ATGAGGCCGA GAGTGATATT 
TTCTCTATCA AGGAAGTTAG CTTTCAGGCC ACTGGTGACT CTGAGTGGAG GGATACAAAC 
TATACACTCA ACACAGATTC CCTGGACTGG GCCTTGTATG ACCACCTAAT GGATTTCCTT 
GCGGACCGAG GGGTGGATAA CACTTTTGCG GATGAGTTGG TGGAGCTCAG CACAGCCCTG 
GAGCACCAGG AATATATCAC CTTTCTTGAG GACCTCAAAA GCTTTGTCAA GAACCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration.
Scientific reports7(1)15131(2017 Nov)
Yagi M,Uchiumi T,Sagata N,Setoyama D,Amamoto R,Matsushima Y,Kang D

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).
Journal of innate immunity(2017 Oct)
Neumann A,Papareddy P,Westman J,Hyldegaard O,Sn?ll J,Norrby-Teglund A,Herwald H

p32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure.
Scientific reports7(1)5754(2017 Jul)
Liu Y,Leslie PL,Jin A,Itahana K,Graves LM,Zhang Y

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C1qbp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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