Tspo cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tspo
Entrez Gene ID	12257
Full Name	translocator protein
Synonyms	Bzrp,IBP,PBR,Tspo1
General protein information	Preferred Names translocator protein Names translocator protein PKBS benzodiazepine receptor, peripheral isoquinoline-binding protein mitochondrial benzodiazepine receptor peripheral-type benzodiazepine receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 E1\|15 39.4 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009775.4	NP_033905.3	translocator protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TSPO	XP_001171840.1
	TSPO	XP_001108482.1
Mus musculus (house mouse)	Tspo	NP_033905.3
Danio rerio (zebrafish)	tspo	NP_001006032.1
Drosophila melanogaster (fruit fly)	CG2789	NP_608531.1
Xenopus tropicalis (tropical clawed frog)	tspo	NP_001120003.1
Rattus norvegicus (Norway rat)	Tspo	NP_036647.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000426	XP_003436990.1
Gallus gallus (chicken)	TSPO	NP_001264986.1
Homo sapiens (human)	TSPO	NP_001243460.1
Canis lupus familiaris (dog)	TSPO	XP_005625831.1
Bos taurus (cattle)	TSPO	NP_786970.1

Gene Ontology
Bibliography

Related articles in PubMed

CRISPR/CAS9-mediated Tspo gene mutations lead to reduced mitochondrial membrane potential and STEROID FORMation in MA-10 mouse tumor Leydig cells.
Fan J, Wang K, Zirkin B, Papadopoulos V
Endocrinology(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TSPO expression increases ( approximately 9-fold) in rodent-derived macrophages and microglia upon pro-inflammatory stimulation.
Title: Pro-inflammatory activation of primary microglia and macrophages increases 18?kDa translocator protein expression in rodents but not humans.

A potential modulatory role of TSPO is in response to immune system deficit.
Title: Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice.

Results showed that TSPO and other mitophagy related proteins, such as VDAC1, Pink1 and Beclin1 were significantly decreased by LH challenge. Moreover, KIFC2, relevant to the mitochondrial transport and Snap25, relevant to neurotransmitter vesicle release, were also obviously down-regulated in the LH mice, which further rendered supportive evidence for the existing mitochondrial dysfunction in LH mice.
Title: Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice.

The expression of TSPO was found to be increased in the peri-hematomal brain region after intracerebral hemorrhage.
Title: Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?

This study confirms TSPO deficiency does not affect viability and bronchial alveolar immune homeostasis.
Title: Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.

The following Tspo gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tspo cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16666	NM_009775.4 Latest version!	Mus musculus translocator protein (Tspo), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tspo ( NM_009775.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033905.3 Mus musculus translocator protein (Tspo), mRNA.

Price & Availability↑

CloneID	OMu16666
Clone ID Related Accession (Same CDS sequence)	NM_009775.4
Accession Version	NM_009775.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-28
Organism	Mus musculus(house mouse)
Product	translocator protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA472650.1, AK153273.1 and AI841615.1. On Dec 21, 2007 this sequence version replaced NM_009775.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AA472650.1, BQ938533.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGAAT CCTGGGTGCC TGCCGTGGGC CTCACTCTGG TGCCCAGCCT GGGGGGCTTC 
ATGGGAGCCT ACTTTGTACG TGGCGAGGGC CTCCGGTGGT ATGCTAGCTT GCAGAAACCC 
TCTTGGCATC CGCCTCGCTG GACACTGGCT CCCATCTGGG GCACACTGTA TTCAGCCATG 
GGGTATGGCT CCTACATAGT CTGGAAAGAG CTGGGAGGTT TCACAGAGGA CGCTATGGTT 
CCCTTGGGTC TCTACACTGG TCAGCTGGCT CTGAACTGGG CGTGGCCCCC CATCTTCTTT 
GGTGCCCGGC AGATGGGCTG GGCCTTGGCC GATCTTCTGC TTGTCAGTGG GGTGGCGACT 
GCCACAACCC TGGCTTGGCA CCGAGTGAGC CCGCCGGCTG CCCGCTTGCT GTACCCTTAC 
CTGGCCTGGC TGGCTTTTGC CACCGTGCTC AACTACTATG TATGGCGTGA TAACTCTGGC 
CGGCGAGGGG GCTCCCGGCT CCCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033905.3
CDS	102..611
Translation	MPESWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIVWKELGGFTEDAMVPLGLYTGQLALNWAWPPIFFGARQMGWALADLLLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATVLNYYVWRDNSGRRGGSRLPE

Target ORF information:

RefSeq Version	NM_009775.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus translocator protein (Tspo), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009775.4

ORF Insert Sequence:

ATGCCTGAAT CCTGGGTGCC TGCCGTGGGC CTCACTCTGG TGCCCAGCCT GGGGGGCTTC 
ATGGGAGCCT ACTTTGTACG TGGCGAGGGC CTCCGGTGGT ATGCTAGCTT GCAGAAACCC 
TCTTGGCATC CGCCTCGCTG GACACTGGCT CCCATCTGGG GCACACTGTA TTCAGCCATG 
GGGTATGGCT CCTACATAGT CTGGAAAGAG CTGGGAGGTT TCACAGAGGA CGCTATGGTT 
CCCTTGGGTC TCTACACTGG TCAGCTGGCT CTGAACTGGG CGTGGCCCCC CATCTTCTTT 
GGTGCCCGGC AGATGGGCTG GGCCTTGGCC GATCTTCTGC TTGTCAGTGG GGTGGCGACT 
GCCACAACCC TGGCTTGGCA CCGAGTGAGC CCGCCGGCTG CCCGCTTGCT GTACCCTTAC 
CTGGCCTGGC TGGCTTTTGC CACCGTGCTC AACTACTATG TATGGCGTGA TAACTCTGGC 
CGGCGAGGGG GCTCCCGGCT CCCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRISPR/CAS9-mediated Tspo gene mutations lead to reduced mitochondrial membrane potential and STEROID FORMation in MA-10 mouse tumor Leydig cells.
Endocrinology(2017 Dec)
Fan J,Wang K,Zirkin B,Papadopoulos V