Zfp36l2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Zfp36l2
Entrez Gene ID	12193
Full Name	zinc finger protein 36, C3H type-like 2
Synonyms	Brf2,ERF2,Tis11d
General protein information	Preferred Names zinc finger protein 36, C3H type-like 2 Names mRNA decay activator protein ZFP36L2 TPA-induced sequence 11d ZFP36-like 2 butyrate response factor 2 zinc finger protein 36, C3H1 type-like 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 E4

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001806.2	NP_001001806.1	mRNA decay activator protein ZFP36L2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Zfp36l2	NP_001001806.1
Homo sapiens (human)	ZFP36L2	NP_008818.3
Canis lupus familiaris (dog)	ZFP36L2	XP_003639394.1
Xenopus tropicalis (tropical clawed frog)	zfp36l2	NP_001096423.1
	LOC716319	XP_001106984.2
Pan troglodytes (chimpanzee)	ZFP36L2	XP_515435.2
Bos taurus (cattle)	ZFP36L2	NP_001178120.1
Rattus norvegicus (Norway rat)	Zfp36l2	NP_001031703.1
Rattus norvegicus (Norway rat)	LOC100911319	XP_003750309.1
Danio rerio (zebrafish)	zfp36l2	NP_996938.1

Gene Ontology
Bibliography

Related articles in PubMed

Impact of RNA structure on ZFP36L2 interaction with luteinizing hormone receptor mRNA.
Ball CB, Solem AC, Meganck RM, Laederach A, Ramos SBV
RNA (New York, N.Y.)23(8)1209-1223(2017 08)

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.
Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE, Turner M
Nature immunology18(6)683-693(2017 Jun)

The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic ?-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.
Vogel KU, Bell LS, Galloway A, Ahlfors H, Turner M
Journal of immunology (Baltimore, Md. : 1950)197(7)2673-2685(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study tested for the first time a role of ZFP36L2 in the decay of LHR mRNA, when transcription was inhibited; results of our cell-based assay support the conclusion that LHR mRNA expression is controlled post-transcriptionally by ZFP36L2.
Title: Impact of RNA structure on ZFP36L2 interaction with luteinizing hormone receptor mRNA.

The Zfp36l2 therefore act as posttranscriptional safeguards against chromosomal instability and replication stress by integrating pre-TCR and IL-7 signaling with DNA damage and cell cycle control.
Title: The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic ?-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.

ZFP36L1 and ZFP36L2 suppress an evolutionarily conserved posttranscriptional regulon consisting of messenger RNAs whose protein products cooperatively promote transition into the S phase of the cell cycle.
Title: RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

In mature peripheral neurons, ZFP36L2 mediates post-transcriptional mechanisms by promoting axonal integrity.
Title: An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.

lack of the physiological down regulation of luteinizing hormone receptor mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest
Title: The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.

The following Zfp36l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Zfp36l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10402	NM_001001806.2 Latest version!	Mus musculus zinc finger protein 36, C3H type-like 2 (Zfp36l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$286.30 $409.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Zfp36l2 ( NM_001001806.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001001806.1 Mus musculus zinc finger protein 36, C3H type-like 2 (Zfp36l2), mRNA.

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CloneID	OMu10402
Clone ID Related Accession (Same CDS sequence)	NM_001001806.2
Accession Version	NM_001001806.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1455bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	mRNA decay activator protein ZFP36L2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB656287.1 and AC132455.3. On or before May 4, 2006 this sequence version replaced XM_984899.1, NM_001001806.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK170763.1, AK159513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGACCA CACTTCTGTC ACCCTTCTAC GATATCGACT TCTTGTGCAA GACGGAGAAA 
TCCCTGGCAA ACCTCAATCT GAACAACATG CTGGACAAGA AGGCGGTAGG GACGCCCGTG 
GCTGCTGCCC CCAGCTCGAG CTTCACTCCG GGCTTCCTGC GACGCCACTC CGCCAGCAAC 
CTCCACGCGC TTGCCCACCC TGTGCCCAGT CCGGGCAGCT GCTCGCCGAA GTTCCCGGGC 
GCCCCTAACG GCGGCGGCAG CAGCTGTGGC CCCGCAGGCG GAGGCGGTCT GGCCTCCTAC 
GGCCAGCTCA AGGAGCCTTC GGGGGGCAGC GGCACGGCGC TGGTCACCAA GGAGAGCAAA 
TTTCGGGACC GCTCGTTCAG CGAGAACGGG GAGCGCAGCC AGCACCTCCT GCACCTGCAG 
CAGCAGCAGA AGGGGGGCAG CGGCTCCCAG ATCAACTCCA CGCGCTACAA GACGGAGCTG 
TGCCGGCCCT TCGAGGAGAG CGGCACGTGC AAGTACGGCG AGAAGTGCCA GTTCGCGCAC 
GGCTTCCACG AGCTGCGCAG CCTCACCCGG CACCCCAAGT ACAAGACAGA GCTGTGCCGC 
ACCTTCCACA CCATCGGCTT CTGCCCCTAC GGCCCGCGCT GCCACTTCAT CCACAACGCG 
GACGAGCGGC GGCCCGCGCC GTCGGGGGGC GGCGGCGCCT CCGGGGACCT GCGAGCGTTT 
GGCGCACGCG ACGCGCTACA CCTAGGCTTC GCCCGCGAGC CGCGGCCCAA GCTGCATCAC 
AGCCTCAGTT TCTCCGGCTT CCCGTCGGGC CACCACCAGC CGCCGGGGGG CCTGGAGTCG 
CCGCTGCTGC TCGACAGCCC CACATCGCGC ACGCCGCCGC CGCCCTCCTC CTCGGCCTCG 
TCCTGTTCCT CCTCGGCTTC TTCCTGCTCT TCCGCCTCGG CGGCCTCCAC GCCCTCGGGC 
GCCCCGACGT GCTGCGCCAC GGCGGCGGCG GCCGCGCTGC TCTACGGCCC CGGGGGCGCG 
GAGGACCTGC TGAGCCCCGG AGCGCCGTGC GCCTCCTGCT CGTCCTCCGG CGCTAACAAC 
GCCTTCGCTT TCGGCCCGGA GCTGAGCAGC CTCATCACGC CGCTCGCCAT CCAGACCCAC 
AACTTCGCCG CCGCGGCCGC CGCCGCCTAC TACCGCAACC AGCAGCAGGG CCTGACCGGT 
CCCGCGCCAC CCCCGGCACA GCCCCCCGCG GCCCCCGCGC CGCCCTCCCC GCCCTTCGGC 
TTCCAGCTGC CGCGCCGTCT GTCCGAGTCG CCCGTGTTCG ACGCGCCCCC CAGCCCCCCG 
GACTCGCTCT CGGACCGCGA CAGCTACCTG AGCGGCTCGC TGAGCTCCGG CAGCCTCAGC 
GGCTCCGAGT CCCCCAGCCT GGACCCTGGC CGTCGCCTAC CCATCTTCAG CCGCCTCTCC 
ATCTCCGACG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001806.1
CDS	254..1708
Translation	MSTTLLSPFYDIDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSSFTPGFLRRHSASNLHALAHPVPSPGSCSPKFPGAPNGGGSSCGPAGGGGLASYGQLKEPSGGSGTALVTKESKFRDRSFSENGERSQHLLHLQQQQKGGSGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGGGASGDLRAFGARDALHLGFAREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSSSASSCSSSASSCSSASAASTPSGAPTCCATAAAAALLYGPGGAEDLLSPGAPCASCSSSGANNAFAFGPELSSLITPLAIQTHNFAAAAAAAYYRNQQQGLTGPAPPPAQPPAAPAPPSPPFGFQLPRRLSESPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD

Target ORF information:

RefSeq Version	NM_001001806.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus zinc finger protein 36, C3H type-like 2 (Zfp36l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001806.2

ORF Insert Sequence:

ATGTCGACCA CACTTCTGTC ACCCTTCTAC GATATCGACT TCTTGTGCAA GACGGAGAAA 
TCCCTGGCAA ACCTCAATCT GAACAACATG CTGGACAAGA AGGCGGTAGG GACGCCCGTG 
GCTGCTGCCC CCAGCTCGAG CTTCACTCCG GGCTTCCTGC GACGCCACTC CGCCAGCAAC 
CTCCACGCGC TTGCCCACCC TGTGCCCAGT CCGGGCAGCT GCTCGCCGAA GTTCCCGGGC 
GCCCCTAACG GCGGCGGCAG CAGCTGTGGC CCCGCAGGCG GAGGCGGTCT GGCCTCCTAC 
GGCCAGCTCA AGGAGCCTTC GGGGGGCAGC GGCACGGCGC TGGTCACCAA GGAGAGCAAA 
TTTCGGGACC GCTCGTTCAG CGAGAACGGG GAGCGCAGCC AGCACCTCCT GCACCTGCAG 
CAGCAGCAGA AGGGGGGCAG CGGCTCCCAG ATCAACTCCA CGCGCTACAA GACGGAGCTG 
TGCCGGCCCT TCGAGGAGAG CGGCACGTGC AAGTACGGCG AGAAGTGCCA GTTCGCGCAC 
GGCTTCCACG AGCTGCGCAG CCTCACCCGG CACCCCAAGT ACAAGACAGA GCTGTGCCGC 
ACCTTCCACA CCATCGGCTT CTGCCCCTAC GGCCCGCGCT GCCACTTCAT CCACAACGCG 
GACGAGCGGC GGCCCGCGCC GTCGGGGGGC GGCGGCGCCT CCGGGGACCT GCGAGCGTTT 
GGCGCACGCG ACGCGCTACA CCTAGGCTTC GCCCGCGAGC CGCGGCCCAA GCTGCATCAC 
AGCCTCAGTT TCTCCGGCTT CCCGTCGGGC CACCACCAGC CGCCGGGGGG CCTGGAGTCG 
CCGCTGCTGC TCGACAGCCC CACATCGCGC ACGCCGCCGC CGCCCTCCTC CTCGGCCTCG 
TCCTGTTCCT CCTCGGCTTC TTCCTGCTCT TCCGCCTCGG CGGCCTCCAC GCCCTCGGGC 
GCCCCGACGT GCTGCGCCAC GGCGGCGGCG GCCGCGCTGC TCTACGGCCC CGGGGGCGCG 
GAGGACCTGC TGAGCCCCGG AGCGCCGTGC GCCTCCTGCT CGTCCTCCGG CGCTAACAAC 
GCCTTCGCTT TCGGCCCGGA GCTGAGCAGC CTCATCACGC CGCTCGCCAT CCAGACCCAC 
AACTTCGCCG CCGCGGCCGC CGCCGCCTAC TACCGCAACC AGCAGCAGGG CCTGACCGGT 
CCCGCGCCAC CCCCGGCACA GCCCCCCGCG GCCCCCGCGC CGCCCTCCCC GCCCTTCGGC 
TTCCAGCTGC CGCGCCGTCT GTCCGAGTCG CCCGTGTTCG ACGCGCCCCC CAGCCCCCCG 
GACTCGCTCT CGGACCGCGA CAGCTACCTG AGCGGCTCGC TGAGCTCCGG CAGCCTCAGC 
GGCTCCGAGT CCCCCAGCCT GGACCCTGGC CGTCGCCTAC CCATCTTCAG CCGCCTCTCC 
ATCTCCGACG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impact of RNA structure on ZFP36L2 interaction with luteinizing hormone receptor mRNA.
RNA (New York, N.Y.)23(8)1209-1223(2017 08)
Ball CB,Solem AC,Meganck RM,Laederach A,Ramos SBV

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.
Nature immunology18(6)683-693(2017 Jun)
Newman R,Ahlfors H,Saveliev A,Galloway A,Hodson DJ,Williams R,Besra GS,Cook CN,Cunningham AF,Bell SE,Turner M

The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic ?-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.
Journal of immunology (Baltimore, Md. : 1950)197(7)2673-2685(2016 Oct)
Vogel KU,Bell LS,Galloway A,Ahlfors H,Turner M

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Zfp36l2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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