Bmp8b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bmp8b
Entrez Gene ID	12164
Full Name	bone morphogenetic protein 8b
Synonyms	Op3
General protein information	Preferred Names bone morphogenetic protein 8b Names bone morphogenetic protein 8B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D2.2\|4 57.38 cM
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein may play a role in the generation of primordial germ cells, and has been shown to stimulate thermogenesis in brown adipose tissue. Male mice lacking a functional copy of this gene exhibit variable degrees of germ-cell deficiency. Homozygous knockout mice of both sexes exhibit impaired thermogenesis and reduced metabolic rate, resulting in weight gain. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007559.4	NP_031585.2	bone morphogenetic protein 8B precursor
XM_011240420.1	XP_011238722.1	bone morphogenetic protein 8B isoform X1
XM_011240420.2	XP_011238722.1	bone morphogenetic protein 8B isoform X1
NM_007559.5	NP_031585.2	bone morphogenetic protein 8B preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Bmp8b	NP_031585.2
Rattus norvegicus (Norway rat)	Bmp8b	XP_002729572.1

Gene Ontology
Bibliography

Related articles in PubMed

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.
Martins L, Seoane-Collazo P, Contreras C, Gonz?lez-Garc?a I, Mart?nez-S?nchez N, Gonz?lez F, Zalvide J, Gallego R, Di?guez C, Nogueiras R, Tena-Sempere M, L?pez M
Cell reports16(8)2231-2242(2016 Aug)

Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS
Proceedings of the National Academy of Sciences of the United States of America110(41)16492-7(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that BMP8B is a thermogenic protein that regulates energy balance in partnership with hypothalamic AMPK.
Title: BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.

The following Bmp8b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmp8b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00380	NM_007559.5 Latest version!	Mus musculus bone morphogenetic protein 8b (Bmp8b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu67212	XM_011240420.2 Latest version!	Mus musculus bone morphogenetic protein 8b (Bmp8b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu67212	XM_011240420.1	Mus musculus bone morphogenetic protein 8b (Bmp8b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu00380	NM_007559.4	Mus musculus bone morphogenetic protein 8b (Bmp8b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmp8b ( XM_011240420.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011238722.1 Mus musculus bone morphogenetic protein 8b (Bmp8b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu67212
Clone ID Related Accession (Same CDS sequence)	XM_011240420.1 , XM_011240420.2
Accession Version	XM_011240420.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	bone morphogenetic protein 8B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTACTG GGCCTGGCTC TGTGCGTGTT GGGCGGCGGT CACCTCTCGC ATCCCCCGCA 
CGTCTTTCCC CAGCGTCGAC TAGGAGTACG CGAGCCCCGC GACATGCAGC GCGAGATTCG 
GGAGGTGCTG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011238722.1
CDS	1068..2207
Translation	MATGPGSVRVGRRSPLASPARLSPASTRSTRAPRHAARDSGGAGAAQQPASAPLFMLDLYRAMTDDSGGGTPQPHLDRADLIMSFVNIVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETEDGHSIDPGLAGLLGRQAPRSRQPFMVGFFRANQSPVRAPRTARPLKKKQLNQINQLPHSNKHLGILDDGHGSHGREVCRRHELYVSFRDLGWLDSVIAPQGYSAYYCAGECIYPLNSCMNSTNHATMQALVHLMKPDIIPKVCCVPTELSAISLLYYDRNNNVILRRERNMVVQACGCH

Target ORF information:

RefSeq Version	XM_011240420.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone morphogenetic protein 8b (Bmp8b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011240420.1

ORF Insert Sequence:

ATGGCTACTG GGCCTGGCTC TGTGCGTGTT GGGCGGCGGT CACCTCTCGC ATCCCCCGCA 
CGTCTTTCCC CAGCGTCGAC TAGGAGTACG CGAGCCCCGC GACATGCAGC GCGAGATTCG 
GGAGGTGCTG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmp8b ( NM_007559.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031585.2 Mus musculus bone morphogenetic protein 8b (Bmp8b), mRNA.

Price & Availability↑

CloneID	OMu00380
Clone ID Related Accession (Same CDS sequence)	NM_007559.4 , NM_007559.5
Accession Version	NM_007559.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	bone morphogenetic protein 8B precursor
Comment

ATGGCTGCGC GTCCGGGACT CCTATGGCTA CTGGGCCTGG CTCTGTGCGT GTTGGGCGGC 
GGTCACCTCT CGCATCCCCC GCACGTCTTT CCCCAGCGTC GACTAGGAGT ACGCGAGCCC 
CGCGACATGC AGCGCGAGAT TCGGGAGGTG CTGGGGCTGC CGGGGCGGCC CCGATCCCGA 
GCACCGGTCG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031585.2
Translation	MAARPGLLWLLGLALCVLGGGHLSHPPHVFPQRRLGVREPRDMQREIREVLGLPGRPRSRAPVGAAQQPASAPLFMLDLYRAMTDDSGGGTPQPHLDRADLIMSFVNIVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETEDGHSIDPGLAGLLGRQAPRSRQPFMVGFFRANQSPVRAPRTARPLKKKQLNQINQLPHSNKHLGILDDGHGSHGREVCRRHELYVSFRDLGWLDSVIAPQGYSAYYCAGECIYPLNSCMNSTNHATMQALVHLMKPDIIPKVCCVPTELSAISLLYYDRNNNVILRRERNMVVQACGCH

Target ORF information:

RefSeq Version	NM_007559.4
Organism	Mus musculus(House mouse)
Definition	Mus musculus bone morphogenetic protein 8b (Bmp8b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007559.4

ORF Insert Sequence:

ATGGCTGCGC GTCCGGGACT CCTATGGCTA CTGGGCCTGG CTCTGTGCGT GTTGGGCGGC 
GGTCACCTCT CGCATCCCCC GCACGTCTTT CCCCAGCGTC GACTAGGAGT ACGCGAGCCC 
CGCGACATGC AGCGCGAGAT TCGGGAGGTG CTGGGGCTGC CGGGGCGGCC CCGATCCCGA 
GCACCGGTCG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmp8b ( NM_007559.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031585.2 Mus musculus bone morphogenetic protein 8b (Bmp8b), mRNA.

Price & Availability↑

CloneID	OMu00380
Clone ID Related Accession (Same CDS sequence)	NM_007559.4 , NM_007559.5
Accession Version	NM_007559.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	bone morphogenetic protein 8B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL606934.12, AK082895.1, BQ551035.1 and BQ031736.1. On Oct 20, 2015 this sequence version replaced NM_007559.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U39545.1, AK082895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCGC GTCCGGGACT CCTATGGCTA CTGGGCCTGG CTCTGTGCGT GTTGGGCGGC 
GGTCACCTCT CGCATCCCCC GCACGTCTTT CCCCAGCGTC GACTAGGAGT ACGCGAGCCC 
CGCGACATGC AGCGCGAGAT TCGGGAGGTG CTGGGGCTGC CGGGGCGGCC CCGATCCCGA 
GCACCGGTCG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031585.2
CDS	191..1390
Translation	MAARPGLLWLLGLALCVLGGGHLSHPPHVFPQRRLGVREPRDMQREIREVLGLPGRPRSRAPVGAAQQPASAPLFMLDLYRAMTDDSGGGTPQPHLDRADLIMSFVNIVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETEDGHSIDPGLAGLLGRQAPRSRQPFMVGFFRANQSPVRAPRTARPLKKKQLNQINQLPHSNKHLGILDDGHGSHGREVCRRHELYVSFRDLGWLDSVIAPQGYSAYYCAGECIYPLNSCMNSTNHATMQALVHLMKPDIIPKVCCVPTELSAISLLYYDRNNNVILRRERNMVVQACGCH

Target ORF information:

RefSeq Version	NM_007559.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone morphogenetic protein 8b (Bmp8b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007559.5

ORF Insert Sequence:

ATGGCTGCGC GTCCGGGACT CCTATGGCTA CTGGGCCTGG CTCTGTGCGT GTTGGGCGGC 
GGTCACCTCT CGCATCCCCC GCACGTCTTT CCCCAGCGTC GACTAGGAGT ACGCGAGCCC 
CGCGACATGC AGCGCGAGAT TCGGGAGGTG CTGGGGCTGC CGGGGCGGCC CCGATCCCGA 
GCACCGGTCG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmp8b ( XM_011240420.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011238722.1 Mus musculus bone morphogenetic protein 8b (Bmp8b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu67212
Clone ID Related Accession (Same CDS sequence)	XM_011240420.1 , XM_011240420.2
Accession Version	XM_011240420.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	bone morphogenetic protein 8B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011240420.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTACTG GGCCTGGCTC TGTGCGTGTT GGGCGGCGGT CACCTCTCGC ATCCCCCGCA 
CGTCTTTCCC CAGCGTCGAC TAGGAGTACG CGAGCCCCGC GACATGCAGC GCGAGATTCG 
GGAGGTGCTG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011238722.1
CDS	1067..2206
Translation	MATGPGSVRVGRRSPLASPARLSPASTRSTRAPRHAARDSGGAGAAQQPASAPLFMLDLYRAMTDDSGGGTPQPHLDRADLIMSFVNIVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETEDGHSIDPGLAGLLGRQAPRSRQPFMVGFFRANQSPVRAPRTARPLKKKQLNQINQLPHSNKHLGILDDGHGSHGREVCRRHELYVSFRDLGWLDSVIAPQGYSAYYCAGECIYPLNSCMNSTNHATMQALVHLMKPDIIPKVCCVPTELSAISLLYYDRNNNVILRRERNMVVQACGCH

Target ORF information:

RefSeq Version	XM_011240420.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone morphogenetic protein 8b (Bmp8b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011240420.2

ORF Insert Sequence:

ATGGCTACTG GGCCTGGCTC TGTGCGTGTT GGGCGGCGGT CACCTCTCGC ATCCCCCGCA 
CGTCTTTCCC CAGCGTCGAC TAGGAGTACG CGAGCCCCGC GACATGCAGC GCGAGATTCG 
GGAGGTGCTG GGGCTGCCCA GCAGCCAGCG TCTGCGCCCC TCTTTATGTT GGACCTGTAC 
CGTGCCATGA CGGATGACAG TGGCGGTGGG ACCCCGCAGC CTCACTTGGA CCGTGCTGAC 
CTGATTATGA GCTTTGTCAA CATAGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGT ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTAGGACTCC GCCTCTATGT GGAAACCGAG 
GATGGGCACA GCATAGATCC TGGCCTAGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTTGG TTTCTTCAGG GCCAACCAGA GTCCTGTGCG GGCCCCTCGA 
ACAGCAAGAC CACTGAAGAA GAAGCAGCTA AATCAAATCA ACCAGCTGCC GCACTCCAAC 
AAACACCTAG GAATCCTTGA TGATGGCCAC GGTTCTCACG GCAGAGAAGT TTGCCGCAGG 
CATGAGCTCT ATGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTCTGTCAT TGCCCCCCAG 
GGCTACTCCG CCTATTACTG TGCTGGGGAG TGCATCTACC CACTGAACTC CTGTATGAAC 
TCCACCAACC ACGCCACTAT GCAGGCCCTG GTACATCTGA TGAAGCCAGA TATCATCCCC 
AAGGTGTGCT GTGTGCCTAC TGAGCTGAGT GCCATTTCTC TGCTCTACTA TGATAGAAAC 
AATAATGTCA TCCTGCGCAG GGAGCGCAAC ATGGTAGTCC AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.
Cell reports16(8)2231-2242(2016 Aug)
Martins L,Seoane-Collazo P,Contreras C,Gonz?lez-Garc?a I,Mart?nez-S?nchez N,Gonz?lez F,Zalvide J,Gallego R,Di?guez C,Nogueiras R,Tena-Sempere M,L?pez M

Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America110(41)16492-7(2013 Oct)
Pandey RR,Tokuzawa Y,Yang Z,Hayashi E,Ichisaka T,Kajita S,Asano Y,Kunieda T,Sachidanandam R,Chuma S,Yamanaka S,Pillai RS

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Bmp8b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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