Bmp8a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bmp8a
Entrez Gene ID	12163
Full Name	bone morphogenetic protein 8a
Synonyms	Bmp7r1,OP-2,OP2
General protein information	Preferred Names bone morphogenetic protein 8a Names bone morphogenetic protein 8A osteogenic protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D2.2\|4 57.42 cM
Summary	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. Mice lacking a functional copy of this gene exhibit degeneration of germ cells and the epididymal epithelium. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256019.1	NP_001242948.1	bone morphogenetic protein 8A isoform 1 precursor
NM_007558.3	NP_031584.1	bone morphogenetic protein 8A isoform 2 preproprotein

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Bmp8a	NP_001102902.1
	LOC718677	XP_001111685.1
Homo sapiens (human)	BMP8A	NP_861525.2
Mus musculus (house mouse)	Bmp8a	NP_001242948.1

Gene Ontology
Bibliography

Related articles in PubMed

Forkhead box a2 (FOXA2) is essential for uterine function and fertility.
Kelleher AM, Peng W, Pru JK, Pru CA, DeMayo FJ, Spencer TE
Proceedings of the National Academy of Sciences of the United States of America114(6)E1018-E1026(2017 Feb)

Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.
Chung D, Gao F, Jegga AG, Das SK
Molecular and cellular endocrinology40048-60(2015 Jan)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Stromal Fgf10 and Bmp8a serve as potential paracrine factors for estrogen-dependent regulation of epithelial proliferation in the uterus.
Title: Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.

BMP-8 might be an essential player in bone metabolism, especially in response to glucocorticoids
Title: The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.

The following Bmp8a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmp8a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05842	NM_001256019.1 Latest version!	Mus musculus bone morphogenetic protein 8a (Bmp8a), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu00377	NM_007558.3 Latest version!	Mus musculus bone morphogenetic protein 8a (Bmp8a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmp8a ( NM_001256019.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001242948.1 Mus musculus bone morphogenetic protein 8a (Bmp8a), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05842
Clone ID Related Accession (Same CDS sequence)	NM_001256019.1
Accession Version	NM_001256019.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	bone morphogenetic protein 8A isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052168.1 and AK157978.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052168.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGCTATGC GTCCCGGGCC ACTCTGGCTA TTGGGCCTTG CTCTGTGCGC GCTGGGAGGC 
GGCCACGGTC CGCGTCCCCC GCACACCTGT CCCCAGCGTC GCCTGGGAGC GCGCGAGCGC 
CGCGACATGC AGCGTGAAAT CCTGGCGGTG CTCGGGCTAC CGGGACGGCC CCGACCCCGT 
GCACAACCCG CCGCTGCCCG GCAGCCAGCG TCCGCGCCCC TCTTCATGTT GGACCTATAC 
CACGCCATGA CCGATGACGA CGACGGCGGG CCACCACAGG CTCACTTAGG CCGTGCCGAC 
CTGGTCATGA GCTTCGTCAA CATGGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGC ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTGGGACTCC GCCTCTATGT GGAAACCGCG 
GATGGGCACA GCATGGATCC TGGCCTGGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTAAC CTTCTTCAGG GCCAGCCAGA GTCCTGTGCG GGCCCCTCGG 
GCAGCGAGAC CACTGAAGAG GAGGCAGCCA AAGAAAACGA ACGAGCTTCC GCACCCCAAC 
AAACTCCCAG GGATCTTTGA TGATGGCCAC GGTTCCCGCG GCAGAGAGGT TTGCCGCAGG 
CATGAGCTCT ACGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTGGGTCAT CGCCCCCCAG 
GGCTACTCTG CCTATTACTG TGAGGGGGAG TGTGCTTTCC CACTGGACTC CTGTATGAAC 
GCCACCAACC ATGCCATCTT GCAGTCTCTG GTCAGTACCA CAGTAGCCTG CTGCGACAGG 
TGGAGCGGGG TGCACCTGAT GAAGCCAGAT GTTGTCCCCA AGGCATGCTG TGCACCCACC 
AAACTGAGTG CCACCTCTGT GCTGTACTAT GACAGCAGCA ACAATGTCAT CCTGCGTAAA 
CACCGTAACA TGGTGGTCAA GGCCTGTGGC TGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001242948.1
CDS	545..1783
Translation	MAMRPGPLWLLGLALCALGGGHGPRPPHTCPQRRLGARERRDMQREILAVLGLPGRPRPRAQPAAARQPASAPLFMLDLYHAMTDDDDGGPPQAHLGRADLVMSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETADGHSMDPGLAGLLGRQAPRSRQPFMVTFFRASQSPVRAPRAARPLKRRQPKKTNELPHPNKLPGIFDDGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFPLDSCMNATNHAILQSLVSTTVACCDRWSGVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH

Target ORF information:

RefSeq Version	NM_001256019.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone morphogenetic protein 8a (Bmp8a), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256019.1

ORF Insert Sequence:

ATGGCTATGC GTCCCGGGCC ACTCTGGCTA TTGGGCCTTG CTCTGTGCGC GCTGGGAGGC 
GGCCACGGTC CGCGTCCCCC GCACACCTGT CCCCAGCGTC GCCTGGGAGC GCGCGAGCGC 
CGCGACATGC AGCGTGAAAT CCTGGCGGTG CTCGGGCTAC CGGGACGGCC CCGACCCCGT 
GCACAACCCG CCGCTGCCCG GCAGCCAGCG TCCGCGCCCC TCTTCATGTT GGACCTATAC 
CACGCCATGA CCGATGACGA CGACGGCGGG CCACCACAGG CTCACTTAGG CCGTGCCGAC 
CTGGTCATGA GCTTCGTCAA CATGGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGC ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTGGGACTCC GCCTCTATGT GGAAACCGCG 
GATGGGCACA GCATGGATCC TGGCCTGGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTAAC CTTCTTCAGG GCCAGCCAGA GTCCTGTGCG GGCCCCTCGG 
GCAGCGAGAC CACTGAAGAG GAGGCAGCCA AAGAAAACGA ACGAGCTTCC GCACCCCAAC 
AAACTCCCAG GGATCTTTGA TGATGGCCAC GGTTCCCGCG GCAGAGAGGT TTGCCGCAGG 
CATGAGCTCT ACGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTGGGTCAT CGCCCCCCAG 
GGCTACTCTG CCTATTACTG TGAGGGGGAG TGTGCTTTCC CACTGGACTC CTGTATGAAC 
GCCACCAACC ATGCCATCTT GCAGTCTCTG GTCAGTACCA CAGTAGCCTG CTGCGACAGG 
TGGAGCGGGG TGCACCTGAT GAAGCCAGAT GTTGTCCCCA AGGCATGCTG TGCACCCACC 
AAACTGAGTG CCACCTCTGT GCTGTACTAT GACAGCAGCA ACAATGTCAT CCTGCGTAAA 
CACCGTAACA TGGTGGTCAA GGCCTGTGGC TGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bmp8a ( NM_007558.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031584.1 Mus musculus bone morphogenetic protein 8a (Bmp8a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu00377
Clone ID Related Accession (Same CDS sequence)	NM_007558.3
Accession Version	NM_007558.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	bone morphogenetic protein 8A isoform 2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC052168.1 and AK157978.1. On Dec 22, 2011 this sequence version replaced NM_007558.2. Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M97017.1, AK157978.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGCTATGC GTCCCGGGCC ACTCTGGCTA TTGGGCCTTG CTCTGTGCGC GCTGGGAGGC 
GGCCACGGTC CGCGTCCCCC GCACACCTGT CCCCAGCGTC GCCTGGGAGC GCGCGAGCGC 
CGCGACATGC AGCGTGAAAT CCTGGCGGTG CTCGGGCTAC CGGGACGGCC CCGACCCCGT 
GCACAACCCG CCGCTGCCCG GCAGCCAGCG TCCGCGCCCC TCTTCATGTT GGACCTATAC 
CACGCCATGA CCGATGACGA CGACGGCGGG CCACCACAGG CTCACTTAGG CCGTGCCGAC 
CTGGTCATGA GCTTCGTCAA CATGGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGC ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTGGGACTCC GCCTCTATGT GGAAACCGCG 
GATGGGCACA GCATGGATCC TGGCCTGGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTAAC CTTCTTCAGG GCCAGCCAGA GTCCTGTGCG GGCCCCTCGG 
GCAGCGAGAC CACTGAAGAG GAGGCAGCCA AAGAAAACGA ACGAGCTTCC GCACCCCAAC 
AAACTCCCAG GGATCTTTGA TGATGGCCAC GGTTCCCGCG GCAGAGAGGT TTGCCGCAGG 
CATGAGCTCT ACGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTGGGTCAT CGCCCCCCAG 
GGCTACTCTG CCTATTACTG TGAGGGGGAG TGTGCTTTCC CACTGGACTC CTGTATGAAC 
GCCACCAACC ATGCCATCTT GCAGTCTCTG GTGCACCTGA TGAAGCCAGA TGTTGTCCCC 
AAGGCATGCT GTGCACCCAC CAAACTGAGT GCCACCTCTG TGCTGTACTA TGACAGCAGC 
AACAATGTCA TCCTGCGTAA ACACCGTAAC ATGGTGGTCA AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031584.1
CDS	545..1744
Translation	MAMRPGPLWLLGLALCALGGGHGPRPPHTCPQRRLGARERRDMQREILAVLGLPGRPRPRAQPAAARQPASAPLFMLDLYHAMTDDDDGGPPQAHLGRADLVMSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETADGHSMDPGLAGLLGRQAPRSRQPFMVTFFRASQSPVRAPRAARPLKRRQPKKTNELPHPNKLPGIFDDGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFPLDSCMNATNHAILQSLVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH

Target ORF information:

RefSeq Version	NM_007558.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus bone morphogenetic protein 8a (Bmp8a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007558.3

ORF Insert Sequence:

ATGGCTATGC GTCCCGGGCC ACTCTGGCTA TTGGGCCTTG CTCTGTGCGC GCTGGGAGGC 
GGCCACGGTC CGCGTCCCCC GCACACCTGT CCCCAGCGTC GCCTGGGAGC GCGCGAGCGC 
CGCGACATGC AGCGTGAAAT CCTGGCGGTG CTCGGGCTAC CGGGACGGCC CCGACCCCGT 
GCACAACCCG CCGCTGCCCG GCAGCCAGCG TCCGCGCCCC TCTTCATGTT GGACCTATAC 
CACGCCATGA CCGATGACGA CGACGGCGGG CCACCACAGG CTCACTTAGG CCGTGCCGAC 
CTGGTCATGA GCTTCGTCAA CATGGTGGAA CGCGACCGTA CCCTGGGCTA CCAGGAGCCA 
CACTGGAAGG AATTCCACTT TGACCTAACC CAGATCCCTG CTGGGGAGGC TGTCACAGCT 
GCTGAGTTCC GGATCTACAA AGAACCCAGC ACCCACCCGC TCAACACAAC CCTCCACATC 
AGCATGTTCG AAGTGGTCCA AGAGCACTCC AACAGGGAGT CTGACTTGTT CTTTTTGGAT 
CTTCAGACGC TCCGATCTGG GGACGAGGGC TGGCTGGTGC TGGACATCAC AGCAGCCAGT 
GACCGATGGC TGCTGAACCA TCACAAGGAC CTGGGACTCC GCCTCTATGT GGAAACCGCG 
GATGGGCACA GCATGGATCC TGGCCTGGCT GGTCTGCTTG GACGACAAGC ACCACGCTCC 
AGACAGCCTT TCATGGTAAC CTTCTTCAGG GCCAGCCAGA GTCCTGTGCG GGCCCCTCGG 
GCAGCGAGAC CACTGAAGAG GAGGCAGCCA AAGAAAACGA ACGAGCTTCC GCACCCCAAC 
AAACTCCCAG GGATCTTTGA TGATGGCCAC GGTTCCCGCG GCAGAGAGGT TTGCCGCAGG 
CATGAGCTCT ACGTCAGCTT CCGTGACCTT GGCTGGCTGG ACTGGGTCAT CGCCCCCCAG 
GGCTACTCTG CCTATTACTG TGAGGGGGAG TGTGCTTTCC CACTGGACTC CTGTATGAAC 
GCCACCAACC ATGCCATCTT GCAGTCTCTG GTGCACCTGA TGAAGCCAGA TGTTGTCCCC 
AAGGCATGCT GTGCACCCAC CAAACTGAGT GCCACCTCTG TGCTGTACTA TGACAGCAGC 
AACAATGTCA TCCTGCGTAA ACACCGTAAC ATGGTGGTCA AGGCCTGTGG CTGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Forkhead box a2 (FOXA2) is essential for uterine function and fertility.
Proceedings of the National Academy of Sciences of the United States of America114(6)E1018-E1026(2017 Feb)
Kelleher AM,Peng W,Pru JK,Pru CA,DeMayo FJ,Spencer TE

Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.
Molecular and cellular endocrinology40048-60(2015 Jan)
Chung D,Gao F,Jegga AG,Das SK

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Bmp8a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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