Bcl3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bcl3
Entrez Gene ID	12051
Full Name	B cell leukemia/lymphoma 3
Synonyms	AI528691,Bcl-3
General protein information	Preferred Names B cell leukemia/lymphoma 3 Names B-cell lymphoma 3 protein homolog B-cell CLL/lymphoma 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 9.95 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_033601.3	NP_291079.2	B-cell lymphoma 3 protein homolog
XM_006539487.3	XP_006539550.1	B-cell lymphoma 3 protein homolog isoform X1
XM_006539487.4	XP_006539550.1	B-cell lymphoma 3 protein homolog isoform X1

Pathways from BioSystems

Homologies

	BCL3	XP_001109319.2
Mus musculus (house mouse)	Bcl3	NP_291079.2
Homo sapiens (human)	BCL3	NP_005169.2
Pan troglodytes (chimpanzee)	BCL3	XP_003953570.1
Bos taurus (cattle)	BCL3	NP_001192922.1
Rattus norvegicus (Norway rat)	Bcl3	NP_001102892.1
Xenopus tropicalis (tropical clawed frog)	LOC100489600	XP_002941081.2

Gene Ontology
Bibliography

Related articles in PubMed

Adequate concentration of B cell leukemia/lymphoma 3 (Bcl3) is required for pluripotency and self-renewal of mouse embryonic stem cells via downregulation of Nanog transcription.
Kang S, Yun J, Kim DY, Jung SY, Kim YJ, Park JH, Ji ST, Jang WB, Ha J, Kim JH, Baek SH, Kwon SM
BMB reports(2018 Jan)

Balanced Bcl-3 expression in murine CD4
Mufazalov IA, Kuschmann J, Andruszewski D, Masri J, Gabriel LA, Adams P, Reissig S, H?velmeyer N, Waisman A
European journal of immunology47(8)1335-1341(2017 08)

Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.
Chuang Y, Hung ME, Cangelose BK, Leonard JN
Innate immunity22(8)647-657(2016 11)

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP
Cell reports17(3)684-696(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thus, we concluded that fine-tuning expression of Bcl-3 is needed for proper CD4(+) T-cell development and is required to sustain Th17-cell mediated pathology.
Title: Balanced Bcl-3 expression in murine CD4

Bcl-3 suppressed colorectal tumor formation: Bcl-3-deficient mice were relatively protected from DSS-induced epithelial damage and developed more polyps after AOM/DSS treatment, although polyp size was unaffected.
Title: The B-cell tumor promoter Bcl-3 suppresses inflammation-associated colon tumorigenesis in epithelial cells.

this study implicates the intracellular protein, BCL3, as a key mediator of the IL-10-induced immunosuppressive macrophage phenotype
Title: Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.

Bcl3 reduces the inflammatory response in pancreas/biliary tissue by blocking ubiquitination and proteasome-mediated degradation of nuclear factor-kappaB p50 homodimers.
Title: BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.

Low expression of IL-6 and TNF-alpha correlates with the presence of the nuclear regulators of NF-kappaB, IkappaBNS and BCL-3, in the uterus of mice.
Title: Low expression of IL-6 and TNF-? correlates with the presence of the nuclear regulators of NF-?B, I?BNS and BCL-3, in the uterus of mice.

The following Bcl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19018	NM_033601.3 Latest version!	Mus musculus B cell leukemia/lymphoma 3 (Bcl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu37966	XM_006539487.4 Latest version!	Mus musculus B cell leukemia/lymphoma 3 (Bcl3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu37966	XM_006539487.3	Mus musculus B cell leukemia/lymphoma 3 (Bcl3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcl3 ( XM_006539487.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006539550.1 Mus musculus B cell leukemia/lymphoma 3 (Bcl3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu37966
Clone ID Related Accession (Same CDS sequence)	XM_006539487.3 , XM_006539487.4
Accession Version	XM_006539487.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	B-cell lymphoma 3 protein homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006539487.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCGAT GCCCCGCGGG GGCCATGGAC GAGGGGCCCG TGGACCTGCG CACCCGGCCC 
AAGGGCACCC CGGGCGCCGC GCTGCCACTC CGCAAACGCC CGCTGCGCCC CGCGTCCCCA 
GAGCCCGCAA CCACGCGCAG CCCCGCTGGA CCCCTGGACG CCCTGCGCAG CGGCTGCGAC 
GTCCCGGTTG TCCCTGGGCC CCCCCACTGT GTGGCCAGGC CGGAGGCCCT TTACTACCAG 
GGACCTTTGA TGCCCATTTA CTCTACCCCG ACGATGGCCC CCCACTTTCC GCTGCTGAAC 
CTGCCTACTC ACCCCTACTC CATGATATGC CCCATGGAAC ACCCCCTTTC AGCTGATATT 
GCCATGGCCA CTCGGGTGGA TGAGGATGGA GACACGCCTC TCCACATCGC TGTGGTCCAG 
AATAACATAG CCGCTGTCTA CCGAATACTC AGCCTTTTCA AGCTTGGGAG CCGCGAAGTA 
GACGTCCATA ACAACCTGCG GCAGACCCCG CTCCACCTGG CTGTCATCAC CACATTACCA 
GACATGGTCC GGCTCTTGGT GACAGCTGGT GCCAGCCCCA TGGCCCTGGA TCGTCACGGC 
CAGACTGCAA TTCACCTGGC ATGCGAGCAC CGCAGCCCCA GCTGCCTGCA GGCCCTGCTG 
GACAGCGCAA CCTCAGGCTC CGTGGACCTG GAGGTTCGCA ATTATGAAGG GCTCACTGCC 
CTGCACGTGG CCGTGAACAC CGGGTGCCAG GAGGCTGTTC TGCTGCTCCT GGAGCGTGGC 
GCGGACATCG ATGCAGTGGA TATCAAGAGC GGCCGCTCCC CACTCATCCA CGCCGTGGAG 
AACAACAGCC TGAACATGGT GCAACTCCTG CTGCTGCACG GCGCCAACGT GAACGCTCAG 
ATGTATTCTG GCAGCTCGGC TCTGCATTCT GCGTCTGGCC GCGGGCTTCT GCCTCTGGTG 
CGCACGCTGG TGCGCAGCGG GGCTGACAGC GGCCTCAAGA ACTGTCACAA TGACACACCT 
CTCATGGTGG CGCGCAGCCG CAGGGTCATT GATATCTTAA GGGGGAAGGC CTCTCGGGCT 
GCTTCAGGGT CACAGCCTGA GCCATCCCCA GACCAAAGTG CCACCAACTC CCCCGAGAGC 
AGCAGTCGTC TCAGCTCCAA TGGAGTCCTC CGAGGCCCTG GCCGGCCCGT ACCCCCTTCC 
CCAGCTCCAG GAAGCAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006539550.1
CDS	91..1311
Translation	MPRCPAGAMDEGPVDLRTRPKGTPGAALPLRKRPLRPASPEPATTRSPAGPLDALRSGCDVPVVPGPPHCVARPEALYYQGPLMPIYSTPTMAPHFPLLNLPTHPYSMICPMEHPLSADIAMATRVDEDGDTPLHIAVVQNNIAAVYRILSLFKLGSREVDVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPMALDRHGQTAIHLACEHRSPSCLQALLDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLIHAVENNSLNMVQLLLLHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSGLKNCHNDTPLMVARSRRVIDILRGKASRAASGSQPEPSPDQSATNSPESSSRLSSNGVLRGPGRPVPPSPAPGSS

Target ORF information:

RefSeq Version	XM_006539487.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus B cell leukemia/lymphoma 3 (Bcl3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006539487.3

ORF Insert Sequence:

ATGCCCCGAT GCCCCGCGGG GGCCATGGAC GAGGGGCCCG TGGACCTGCG CACCCGGCCC 
AAGGGCACCC CGGGCGCCGC GCTGCCACTC CGCAAACGCC CGCTGCGCCC CGCGTCCCCA 
GAGCCCGCAA CCACGCGCAG CCCCGCTGGA CCCCTGGACG CCCTGCGCAG CGGCTGCGAC 
GTCCCGGTTG TCCCTGGGCC CCCCCACTGT GTGGCCAGGC CGGAGGCCCT TTACTACCAG 
GGACCTTTGA TGCCCATTTA CTCTACCCCG ACGATGGCCC CCCACTTTCC GCTGCTGAAC 
CTGCCTACTC ACCCCTACTC CATGATATGC CCCATGGAAC ACCCCCTTTC AGCTGATATT 
GCCATGGCCA CTCGGGTGGA TGAGGATGGA GACACGCCTC TCCACATCGC TGTGGTCCAG 
AATAACATAG CCGCTGTCTA CCGAATACTC AGCCTTTTCA AGCTTGGGAG CCGCGAAGTA 
GACGTCCATA ACAACCTGCG GCAGACCCCG CTCCACCTGG CTGTCATCAC CACATTACCA 
GACATGGTCC GGCTCTTGGT GACAGCTGGT GCCAGCCCCA TGGCCCTGGA TCGTCACGGC 
CAGACTGCAA TTCACCTGGC ATGCGAGCAC CGCAGCCCCA GCTGCCTGCA GGCCCTGCTG 
GACAGCGCAA CCTCAGGCTC CGTGGACCTG GAGGTTCGCA ATTATGAAGG GCTCACTGCC 
CTGCACGTGG CCGTGAACAC CGGGTGCCAG GAGGCTGTTC TGCTGCTCCT GGAGCGTGGC 
GCGGACATCG ATGCAGTGGA TATCAAGAGC GGCCGCTCCC CACTCATCCA CGCCGTGGAG 
AACAACAGCC TGAACATGGT GCAACTCCTG CTGCTGCACG GCGCCAACGT GAACGCTCAG 
ATGTATTCTG GCAGCTCGGC TCTGCATTCT GCGTCTGGCC GCGGGCTTCT GCCTCTGGTG 
CGCACGCTGG TGCGCAGCGG GGCTGACAGC GGCCTCAAGA ACTGTCACAA TGACACACCT 
CTCATGGTGG CGCGCAGCCG CAGGGTCATT GATATCTTAA GGGGGAAGGC CTCTCGGGCT 
GCTTCAGGGT CACAGCCTGA GCCATCCCCA GACCAAAGTG CCACCAACTC CCCCGAGAGC 
AGCAGTCGTC TCAGCTCCAA TGGAGTCCTC CGAGGCCCTG GCCGGCCCGT ACCCCCTTCC 
CCAGCTCCAG GAAGCAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcl3 ( NM_033601.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_291079.2 Mus musculus B cell leukemia/lymphoma 3 (Bcl3), mRNA.

Price & Availability↑

CloneID	OMu19018
Clone ID Related Accession (Same CDS sequence)	NM_033601.3
Accession Version	NM_033601.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	B-cell lymphoma 3 protein homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY749796.1, AF067774.1 and AI528691.1. On Jan 11, 2008 this sequence version replaced NM_033601.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF067774.1, AK155016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849388 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCGAT GCCCCGCGGG GGCCATGGAC GAGGGGCCCG TGGACCTGCG CACCCGGCCC 
AAGGGCACCC CGGGCGCCGC GCTGCCACTC CGCAAACGCC CGCTGCGCCC CGCGTCCCCA 
GAGCCCGCAA CCACGCGCAG CCCCGCTGGA CCCCTGGACG CCCTGCGCAG CGGCTGCGAC 
GTCCCGGTTG TCCCTGGGCC CCCCCACTGT GTGGCCAGGC CGGAGGCCCT TTACTACCAG 
GGACCTTTGA TGCCCATTTA CTCTACCCCG ACGATGGCCC CCCACTTTCC GCTGCTGAAC 
CTGCCTACTC ACCCCTACTC CATGATATGC CCCATGGAAC ACCCCCTTTC AGCTGATATT 
GCCATGGCCA CTCGGGTGGA TGAGGATGGA GACACGCCTC TCCACATCGC TGTGGTCCAG 
AATAACATAG CCGCTGTCTA CCGAATACTC AGCCTTTTCA AGCTTGGGAG CCGCGAAGTA 
GACGTCCATA ACAACCTGCG GCAGACCCCG CTCCACCTGG CTGTCATCAC CACATTACCA 
GACATGGTCC GGCTCTTGGT GACAGCTGGT GCCAGCCCCA TGGCCCTGGA TCGTCACGGC 
CAGACTGCAA TTCACCTGGC ATGCGAGCAC CGCAGCCCCA GCTGCCTGCA GGCCCTGCTG 
GACAGCGCAA CCTCAGGCTC CGTGGACCTG GAGGTTCGCA ATTATGAAGG GCTCACTGCC 
CTGCACGTGG CCGTGAACAC CGGGTGCCAG GAGGCTGTTC TGCTGCTCCT GGAGCGTGGC 
GCGGACATCG ATGCAGTGGA TATCAAGAGC GGCCGCTCCC CACTCATCCA CGCCGTGGAG 
AACAACAGCC TGAACATGGT GCAACTCCTG CTGCTGCACG GCGCCAACGT GAACGCTCAG 
ATGTATTCTG GCAGCTCGGC TCTGCATTCT GCGTCTGGCC GCGGGCTTCT GCCTCTGGTG 
CGCACGCTGG TGCGCAGCGG GGCTGACAGC GGCCTCAAGA ACTGTCACAA TGACACACCT 
CTCATGGTGG CGCGCAGCCG CAGGGTCATT GATATCTTAA GGGGGAAGGC CTCTCGGGCT 
GCTTCAGGGT CACAGCCTGA GCCATCCCCA GACCAAAGTG CCACCAACTC CCCCGAGAGC 
AGCAGTCGTC TCAGCTCCAA TGGCCTCCAG TCCTCGCCAA GCTCCTCACC CTCGCTGTCT 
CCCCCGAAAG ATGCTCCTGG CTTCCCCGCG ACTCCCCAAA ACTTTTTCCT TCCCACAACA 
TCTACACCTG CCTTCCTGCC CTTCCCAGGA GTCCTCCGAG GCCCTGGCCG GCCCGTACCC 
CCTTCCCCAG CTCCAGGAAG CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_291079.2
CDS	79..1425
Translation	MPRCPAGAMDEGPVDLRTRPKGTPGAALPLRKRPLRPASPEPATTRSPAGPLDALRSGCDVPVVPGPPHCVARPEALYYQGPLMPIYSTPTMAPHFPLLNLPTHPYSMICPMEHPLSADIAMATRVDEDGDTPLHIAVVQNNIAAVYRILSLFKLGSREVDVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPMALDRHGQTAIHLACEHRSPSCLQALLDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLIHAVENNSLNMVQLLLLHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSGLKNCHNDTPLMVARSRRVIDILRGKASRAASGSQPEPSPDQSATNSPESSSRLSSNGLQSSPSSSPSLSPPKDAPGFPATPQNFFLPTTSTPAFLPFPGVLRGPGRPVPPSPAPGSS

Target ORF information:

RefSeq Version	NM_033601.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus B cell leukemia/lymphoma 3 (Bcl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033601.3

ORF Insert Sequence:

ATGCCCCGAT GCCCCGCGGG GGCCATGGAC GAGGGGCCCG TGGACCTGCG CACCCGGCCC 
AAGGGCACCC CGGGCGCCGC GCTGCCACTC CGCAAACGCC CGCTGCGCCC CGCGTCCCCA 
GAGCCCGCAA CCACGCGCAG CCCCGCTGGA CCCCTGGACG CCCTGCGCAG CGGCTGCGAC 
GTCCCGGTTG TCCCTGGGCC CCCCCACTGT GTGGCCAGGC CGGAGGCCCT TTACTACCAG 
GGACCTTTGA TGCCCATTTA CTCTACCCCG ACGATGGCCC CCCACTTTCC GCTGCTGAAC 
CTGCCTACTC ACCCCTACTC CATGATATGC CCCATGGAAC ACCCCCTTTC AGCTGATATT 
GCCATGGCCA CTCGGGTGGA TGAGGATGGA GACACGCCTC TCCACATCGC TGTGGTCCAG 
AATAACATAG CCGCTGTCTA CCGAATACTC AGCCTTTTCA AGCTTGGGAG CCGCGAAGTA 
GACGTCCATA ACAACCTGCG GCAGACCCCG CTCCACCTGG CTGTCATCAC CACATTACCA 
GACATGGTCC GGCTCTTGGT GACAGCTGGT GCCAGCCCCA TGGCCCTGGA TCGTCACGGC 
CAGACTGCAA TTCACCTGGC ATGCGAGCAC CGCAGCCCCA GCTGCCTGCA GGCCCTGCTG 
GACAGCGCAA CCTCAGGCTC CGTGGACCTG GAGGTTCGCA ATTATGAAGG GCTCACTGCC 
CTGCACGTGG CCGTGAACAC CGGGTGCCAG GAGGCTGTTC TGCTGCTCCT GGAGCGTGGC 
GCGGACATCG ATGCAGTGGA TATCAAGAGC GGCCGCTCCC CACTCATCCA CGCCGTGGAG 
AACAACAGCC TGAACATGGT GCAACTCCTG CTGCTGCACG GCGCCAACGT GAACGCTCAG 
ATGTATTCTG GCAGCTCGGC TCTGCATTCT GCGTCTGGCC GCGGGCTTCT GCCTCTGGTG 
CGCACGCTGG TGCGCAGCGG GGCTGACAGC GGCCTCAAGA ACTGTCACAA TGACACACCT 
CTCATGGTGG CGCGCAGCCG CAGGGTCATT GATATCTTAA GGGGGAAGGC CTCTCGGGCT 
GCTTCAGGGT CACAGCCTGA GCCATCCCCA GACCAAAGTG CCACCAACTC CCCCGAGAGC 
AGCAGTCGTC TCAGCTCCAA TGGCCTCCAG TCCTCGCCAA GCTCCTCACC CTCGCTGTCT 
CCCCCGAAAG ATGCTCCTGG CTTCCCCGCG ACTCCCCAAA ACTTTTTCCT TCCCACAACA 
TCTACACCTG CCTTCCTGCC CTTCCCAGGA GTCCTCCGAG GCCCTGGCCG GCCCGTACCC 
CCTTCCCCAG CTCCAGGAAG CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcl3 ( XM_006539487.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006539550.1 Mus musculus B cell leukemia/lymphoma 3 (Bcl3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu37966
Clone ID Related Accession (Same CDS sequence)	XM_006539487.3 , XM_006539487.4
Accession Version	XM_006539487.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	B-cell lymphoma 3 protein homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006539487.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCGAT GCCCCGCGGG GGCCATGGAC GAGGGGCCCG TGGACCTGCG CACCCGGCCC 
AAGGGCACCC CGGGCGCCGC GCTGCCACTC CGCAAACGCC CGCTGCGCCC CGCGTCCCCA 
GAGCCCGCAA CCACGCGCAG CCCCGCTGGA CCCCTGGACG CCCTGCGCAG CGGCTGCGAC 
GTCCCGGTTG TCCCTGGGCC CCCCCACTGT GTGGCCAGGC CGGAGGCCCT TTACTACCAG 
GGACCTTTGA TGCCCATTTA CTCTACCCCG ACGATGGCCC CCCACTTTCC GCTGCTGAAC 
CTGCCTACTC ACCCCTACTC CATGATATGC CCCATGGAAC ACCCCCTTTC AGCTGATATT 
GCCATGGCCA CTCGGGTGGA TGAGGATGGA GACACGCCTC TCCACATCGC TGTGGTCCAG 
AATAACATAG CCGCTGTCTA CCGAATACTC AGCCTTTTCA AGCTTGGGAG CCGCGAAGTA 
GACGTCCATA ACAACCTGCG GCAGACCCCG CTCCACCTGG CTGTCATCAC CACATTACCA 
GACATGGTCC GGCTCTTGGT GACAGCTGGT GCCAGCCCCA TGGCCCTGGA TCGTCACGGC 
CAGACTGCAA TTCACCTGGC ATGCGAGCAC CGCAGCCCCA GCTGCCTGCA GGCCCTGCTG 
GACAGCGCAA CCTCAGGCTC CGTGGACCTG GAGGTTCGCA ATTATGAAGG GCTCACTGCC 
CTGCACGTGG CCGTGAACAC CGGGTGCCAG GAGGCTGTTC TGCTGCTCCT GGAGCGTGGC 
GCGGACATCG ATGCAGTGGA TATCAAGAGC GGCCGCTCCC CACTCATCCA CGCCGTGGAG 
AACAACAGCC TGAACATGGT GCAACTCCTG CTGCTGCACG GCGCCAACGT GAACGCTCAG 
ATGTATTCTG GCAGCTCGGC TCTGCATTCT GCGTCTGGCC GCGGGCTTCT GCCTCTGGTG 
CGCACGCTGG TGCGCAGCGG GGCTGACAGC GGCCTCAAGA ACTGTCACAA TGACACACCT 
CTCATGGTGG CGCGCAGCCG CAGGGTCATT GATATCTTAA GGGGGAAGGC CTCTCGGGCT 
GCTTCAGGGT CACAGCCTGA GCCATCCCCA GACCAAAGTG CCACCAACTC CCCCGAGAGC 
AGCAGTCGTC TCAGCTCCAA TGGAGTCCTC CGAGGCCCTG GCCGGCCCGT ACCCCCTTCC 
CCAGCTCCAG GAAGCAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006539550.1
CDS	148..1368
Translation	MPRCPAGAMDEGPVDLRTRPKGTPGAALPLRKRPLRPASPEPATTRSPAGPLDALRSGCDVPVVPGPPHCVARPEALYYQGPLMPIYSTPTMAPHFPLLNLPTHPYSMICPMEHPLSADIAMATRVDEDGDTPLHIAVVQNNIAAVYRILSLFKLGSREVDVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPMALDRHGQTAIHLACEHRSPSCLQALLDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLIHAVENNSLNMVQLLLLHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSGLKNCHNDTPLMVARSRRVIDILRGKASRAASGSQPEPSPDQSATNSPESSSRLSSNGVLRGPGRPVPPSPAPGSS

Target ORF information:

RefSeq Version	XM_006539487.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus B cell leukemia/lymphoma 3 (Bcl3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006539487.4

ORF Insert Sequence:

ATGCCCCGAT GCCCCGCGGG GGCCATGGAC GAGGGGCCCG TGGACCTGCG CACCCGGCCC 
AAGGGCACCC CGGGCGCCGC GCTGCCACTC CGCAAACGCC CGCTGCGCCC CGCGTCCCCA 
GAGCCCGCAA CCACGCGCAG CCCCGCTGGA CCCCTGGACG CCCTGCGCAG CGGCTGCGAC 
GTCCCGGTTG TCCCTGGGCC CCCCCACTGT GTGGCCAGGC CGGAGGCCCT TTACTACCAG 
GGACCTTTGA TGCCCATTTA CTCTACCCCG ACGATGGCCC CCCACTTTCC GCTGCTGAAC 
CTGCCTACTC ACCCCTACTC CATGATATGC CCCATGGAAC ACCCCCTTTC AGCTGATATT 
GCCATGGCCA CTCGGGTGGA TGAGGATGGA GACACGCCTC TCCACATCGC TGTGGTCCAG 
AATAACATAG CCGCTGTCTA CCGAATACTC AGCCTTTTCA AGCTTGGGAG CCGCGAAGTA 
GACGTCCATA ACAACCTGCG GCAGACCCCG CTCCACCTGG CTGTCATCAC CACATTACCA 
GACATGGTCC GGCTCTTGGT GACAGCTGGT GCCAGCCCCA TGGCCCTGGA TCGTCACGGC 
CAGACTGCAA TTCACCTGGC ATGCGAGCAC CGCAGCCCCA GCTGCCTGCA GGCCCTGCTG 
GACAGCGCAA CCTCAGGCTC CGTGGACCTG GAGGTTCGCA ATTATGAAGG GCTCACTGCC 
CTGCACGTGG CCGTGAACAC CGGGTGCCAG GAGGCTGTTC TGCTGCTCCT GGAGCGTGGC 
GCGGACATCG ATGCAGTGGA TATCAAGAGC GGCCGCTCCC CACTCATCCA CGCCGTGGAG 
AACAACAGCC TGAACATGGT GCAACTCCTG CTGCTGCACG GCGCCAACGT GAACGCTCAG 
ATGTATTCTG GCAGCTCGGC TCTGCATTCT GCGTCTGGCC GCGGGCTTCT GCCTCTGGTG 
CGCACGCTGG TGCGCAGCGG GGCTGACAGC GGCCTCAAGA ACTGTCACAA TGACACACCT 
CTCATGGTGG CGCGCAGCCG CAGGGTCATT GATATCTTAA GGGGGAAGGC CTCTCGGGCT 
GCTTCAGGGT CACAGCCTGA GCCATCCCCA GACCAAAGTG CCACCAACTC CCCCGAGAGC 
AGCAGTCGTC TCAGCTCCAA TGGAGTCCTC CGAGGCCCTG GCCGGCCCGT ACCCCCTTCC 
CCAGCTCCAG GAAGCAGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Adequate concentration of B cell leukemia/lymphoma 3 (Bcl3) is required for pluripotency and self-renewal of mouse embryonic stem cells via downregulation of Nanog transcription.
BMB reports(2018 Jan)
Kang S,Yun J,Kim DY,Jung SY,Kim YJ,Park JH,Ji ST,Jang WB,Ha J,Kim JH,Baek SH,Kwon SM

Balanced Bcl-3 expression in murine CD4
European journal of immunology47(8)1335-1341(2017 08)
Mufazalov IA,Kuschmann J,Andruszewski D,Masri J,Gabriel LA,Adams P,Reissig S,H?velmeyer N,Waisman A

Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli.
Innate immunity22(8)647-657(2016 11)
Chuang Y,Hung ME,Cangelose BK,Leonard JN

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Cell reports17(3)684-696(2016 10)
Van den Bossche J,Baardman J,Otto NA,van der Velden S,Neele AE,van den Berg SM,Luque-Martin R,Chen HJ,Boshuizen MC,Ahmed M,Hoeksema MA,de Vos AF,de Winther MP

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Bcl3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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