BCL2 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	BCL2
Entrez Gene ID	12043
Full Name	B cell leukemia/lymphoma 2
Synonyms	AW986256,Bcl-2,C430015F12Rik,D630044D05Rik,D830018M01Rik
General protein information	Preferred Names B cell leukemia/lymphoma 2 Names apoptosis regulator Bcl-2
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 1 Map Location: 1 E2.1\|1 49.76 cM
Summary	This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009741.5	NP_033871.2	apoptosis regulator Bcl-2 isoform 1
NM_177410.3	NP_803129.2	apoptosis regulator Bcl-2 isoform 2
NM_009741.4	NP_033871.2	apoptosis regulator Bcl-2 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	BCL2	NP_000624.2
Pan troglodytes (chimpanzee)	BCL2	XP_001145537.1
Canis lupus familiaris (dog)	BCL2	NP_001002949.1
Xenopus tropicalis (tropical clawed frog)	bcl2	XP_002934442.1
Bos taurus (cattle)	BCL2	NP_001159958.1
Rattus norvegicus (Norway rat)	Bcl2	NP_058689.1
Gallus gallus (chicken)	BCL2	NP_990670.1
Mus musculus (house mouse)	Bcl2	NP_033871.2

Gene Ontology
Bibliography

Related articles in PubMed

Bcl-2 promotes regeneration of severed axons in mammalian CNS.
Chen DF, Schneider GE, Martinou JC, Tonegawa S
Nature385(6615)434-9(1997 Jan)

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice.
Nakayama K, Nakayama K, Negishi I, Kuida K, Shinkai Y, Louie MC, Fields LE, Lucas PJ, Stewart V, Alt FW
Science (New York, N.Y.)261(5128)1584-8(1993 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS-JNK-Bcl-2 signaling pathway.
Title: Acute ethanol exposure-induced autophagy-mediated cardiac injury via activation of the ROS-JNK-Bcl-2 pathway.

This study provides evidence from transgenic mouse models that Crebbp deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma.

Bcell lymphoma 2, an antiapoptotic gene, was the target of mmumiR96.
Title: Expression of mmu-miR-96 in the endometrium during early pregnancy and its regulatory effects on stromal cell apoptosis via Bcl2.

The abnormal expression of epidermal cytokeratins suggests that Ha-Ras and Bcl-2 suppress the terminal differentiation and sustain the stem cell-like features in epidermal keratinocytes
Title: Restrained Terminal Differentiation and Sustained Stemness in Neonatal Skin by Ha-Ras and Bcl-2.

an essential role for the binding of BCL2 to BIM in the survival of noncycling NK cells.
Title: Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.

The following BCL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20895	NM_177410.3 Latest version!	Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu20452	NM_009741.5 Latest version!	Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu20452	NM_009741.4	Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BCL2 ( NM_177410.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_803129.2 Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu20895
Clone ID Related Accession (Same CDS sequence)	NM_177410.3
Accession Version	NM_177410.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	apoptosis regulator Bcl-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY118935.1, AK049473.1, AC122842.3 and BC068988.1. On Sep 23, 2015 this sequence version replaced NM_177410.2. Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCGCAAG CCGGGAGAAC AGGGTATGAT AACCGGGAGA TCGTGATGAA GTACATACAT 
TATAAGCTGT CACAGAGGGG CTACGAGTGG GATGCTGGAG ATGCGGACGC GGCGCCCCTG 
GGGGCTGCCC CCACCCCTGG CATCTTCTCC TTCCAGCCTG AGAGCAACCC AATGCCCGCT 
GTGCACCGGG ACATGGCTGC CAGGACGTCT CCTCTCAGGC CCCTCGTTGC CACCGCTGGG 
CCTGCGCTCA GCCCTGTGCC ACCTGTGGTC CATCTGACCC TCCGCCGGGC TGGGGATGAC 
TTCTCTCGTC GCTACCGTCG TGACTTCGCA GAGATGTCCA GTCAGCTGCA CCTGACGCCC 
TTCACCGCGA GGGGACGCTT TGCCACGGTG GTGGAGGAAC TCTTCAGGGA TGGGGTGAAC 
TGGGGGAGGA TTGTGGCCTT CTTTGAGTTC GGTGGGGTCA TGTGTGTGGA GAGCGTCAAC 
AGGGAGATGT CACCCCTGGT GGACAACATC GCCCTGTGGA TGACTGAGTA CCTGAACCGG 
CATCTGCACA CCTGGATCCA GGATAACGGA GGCTGGGTAG GTGCATGTCT GGTTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803129.2
CDS	1411..2010
Translation	MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWVGACLVE

Target ORF information:

RefSeq Version	NM_177410.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177410.3

ORF Insert Sequence:

ATGGCGCAAG CCGGGAGAAC AGGGTATGAT AACCGGGAGA TCGTGATGAA GTACATACAT 
TATAAGCTGT CACAGAGGGG CTACGAGTGG GATGCTGGAG ATGCGGACGC GGCGCCCCTG 
GGGGCTGCCC CCACCCCTGG CATCTTCTCC TTCCAGCCTG AGAGCAACCC AATGCCCGCT 
GTGCACCGGG ACATGGCTGC CAGGACGTCT CCTCTCAGGC CCCTCGTTGC CACCGCTGGG 
CCTGCGCTCA GCCCTGTGCC ACCTGTGGTC CATCTGACCC TCCGCCGGGC TGGGGATGAC 
TTCTCTCGTC GCTACCGTCG TGACTTCGCA GAGATGTCCA GTCAGCTGCA CCTGACGCCC 
TTCACCGCGA GGGGACGCTT TGCCACGGTG GTGGAGGAAC TCTTCAGGGA TGGGGTGAAC 
TGGGGGAGGA TTGTGGCCTT CTTTGAGTTC GGTGGGGTCA TGTGTGTGGA GAGCGTCAAC 
AGGGAGATGT CACCCCTGGT GGACAACATC GCCCTGTGGA TGACTGAGTA CCTGAACCGG 
CATCTGCACA CCTGGATCCA GGATAACGGA GGCTGGGTAG GTGCATGTCT GGTTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2 ( NM_009741.5 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_033871.2 Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20452
Clone ID Related Accession (Same CDS sequence)	NM_009741.5 , NM_009741.4
Accession Version	NM_009741.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	apoptosis regulator Bcl-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC122842.3, BC095964.1 and AC162916.3. On Sep 23, 2015 this sequence version replaced NM_009741.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.111809.1, BC095964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAAG CCGGGAGAAC AGGGTATGAT AACCGGGAGA TCGTGATGAA GTACATACAT 
TATAAGCTGT CACAGAGGGG CTACGAGTGG GATGCTGGAG ATGCGGACGC GGCGCCCCTG 
GGGGCTGCCC CCACCCCTGG CATCTTCTCC TTCCAGCCTG AGAGCAACCC AATGCCCGCT 
GTGCACCGGG ACATGGCTGC CAGGACGTCT CCTCTCAGGC CCCTCGTTGC CACCGCTGGG 
CCTGCGCTCA GCCCTGTGCC ACCTGTGGTC CATCTGACCC TCCGCCGGGC TGGGGATGAC 
TTCTCTCGTC GCTACCGTCG TGACTTCGCA GAGATGTCCA GTCAGCTGCA CCTGACGCCC 
TTCACCGCGA GGGGACGCTT TGCCACGGTG GTGGAGGAAC TCTTCAGGGA TGGGGTGAAC 
TGGGGGAGGA TTGTGGCCTT CTTTGAGTTC GGTGGGGTCA TGTGTGTGGA GAGCGTCAAC 
AGGGAGATGT CACCCCTGGT GGACAACATC GCCCTGTGGA TGACTGAGTA CCTGAACCGG 
CATCTGCACA CCTGGATCCA GGATAACGGA GGCTGGGATG CCTTTGTGGA ACTATATGGC 
CCCAGCATGC GACCTCTGTT TGATTTCTCC TGGCTGTCTC TGAAGACCCT GCTCAGCCTG 
GCCCTGGTCG GGGCCTGCAT CACTCTGGGT GCATACCTGG GCCACAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033871.2
CDS	1411..2121
Translation	MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

Target ORF information:

RefSeq Version	NM_009741.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009741.5

ORF Insert Sequence:

ATGGCGCAAG CCGGGAGAAC AGGGTATGAT AACCGGGAGA TCGTGATGAA GTACATACAT 
TATAAGCTGT CACAGAGGGG CTACGAGTGG GATGCTGGAG ATGCGGACGC GGCGCCCCTG 
GGGGCTGCCC CCACCCCTGG CATCTTCTCC TTCCAGCCTG AGAGCAACCC AATGCCCGCT 
GTGCACCGGG ACATGGCTGC CAGGACGTCT CCTCTCAGGC CCCTCGTTGC CACCGCTGGG 
CCTGCGCTCA GCCCTGTGCC ACCTGTGGTC CATCTGACCC TCCGCCGGGC TGGGGATGAC 
TTCTCTCGTC GCTACCGTCG TGACTTCGCA GAGATGTCCA GTCAGCTGCA CCTGACGCCC 
TTCACCGCGA GGGGACGCTT TGCCACGGTG GTGGAGGAAC TCTTCAGGGA TGGGGTGAAC 
TGGGGGAGGA TTGTGGCCTT CTTTGAGTTC GGTGGGGTCA TGTGTGTGGA GAGCGTCAAC 
AGGGAGATGT CACCCCTGGT GGACAACATC GCCCTGTGGA TGACTGAGTA CCTGAACCGG 
CATCTGCACA CCTGGATCCA GGATAACGGA GGCTGGGATG CCTTTGTGGA ACTATATGGC 
CCCAGCATGC GACCTCTGTT TGATTTCTCC TGGCTGTCTC TGAAGACCCT GCTCAGCCTG 
GCCCTGGTCG GGGCCTGCAT CACTCTGGGT GCATACCTGG GCCACAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BCL2 ( NM_009741.4 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_033871.2 Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20452
Clone ID Related Accession (Same CDS sequence)	NM_009741.5 , NM_009741.4
Accession Version	NM_009741.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	apoptosis regulator Bcl-2 isoform 1
Comment

ATGGCGCAAG CCGGGAGAAC AGGGTATGAT AACCGGGAGA TCGTGATGAA GTACATACAT 
TATAAGCTGT CACAGAGGGG CTACGAGTGG GATGCTGGAG ATGCGGACGC GGCGCCCCTG 
GGGGCTGCCC CCACCCCTGG CATCTTCTCC TTCCAGCCTG AGAGCAACCC AATGCCCGCT 
GTGCACCGGG ACATGGCTGC CAGGACGTCT CCTCTCAGGC CCCTCGTTGC CACCGCTGGG 
CCTGCGCTCA GCCCTGTGCC ACCTGTGGTC CATCTGACCC TCCGCCGGGC TGGGGATGAC 
TTCTCTCGTC GCTACCGTCG TGACTTCGCA GAGATGTCCA GTCAGCTGCA CCTGACGCCC 
TTCACCGCGA GGGGACGCTT TGCCACGGTG GTGGAGGAAC TCTTCAGGGA TGGGGTGAAC 
TGGGGGAGGA TTGTGGCCTT CTTTGAGTTC GGTGGGGTCA TGTGTGTGGA GAGCGTCAAC 
AGGGAGATGT CACCCCTGGT GGACAACATC GCCCTGTGGA TGACTGAGTA CCTGAACCGG 
CATCTGCACA CCTGGATCCA GGATAACGGA GGCTGGGATG CCTTTGTGGA ACTATATGGC 
CCCAGCATGC GACCTCTGTT TGATTTCTCC TGGCTGTCTC TGAAGACCCT GCTCAGCCTG 
GCCCTGGTCG GGGCCTGCAT CACTCTGGGT GCATACCTGG GCCACAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033871.2
Translation	MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDADAAPLGAAPTPGIFSFQPESNPMPAVHRDMAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

Target ORF information:

RefSeq Version	NM_009741.4
Organism	Mus musculus(House mouse)
Definition	Mus musculus B cell leukemia/lymphoma 2 (Bcl2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009741.4

ORF Insert Sequence:

ATGGCGCAAG CCGGGAGAAC AGGGTATGAT AACCGGGAGA TCGTGATGAA GTACATACAT 
TATAAGCTGT CACAGAGGGG CTACGAGTGG GATGCTGGAG ATGCGGACGC GGCGCCCCTG 
GGGGCTGCCC CCACCCCTGG CATCTTCTCC TTCCAGCCTG AGAGCAACCC AATGCCCGCT 
GTGCACCGGG ACATGGCTGC CAGGACGTCT CCTCTCAGGC CCCTCGTTGC CACCGCTGGG 
CCTGCGCTCA GCCCTGTGCC ACCTGTGGTC CATCTGACCC TCCGCCGGGC TGGGGATGAC 
TTCTCTCGTC GCTACCGTCG TGACTTCGCA GAGATGTCCA GTCAGCTGCA CCTGACGCCC 
TTCACCGCGA GGGGACGCTT TGCCACGGTG GTGGAGGAAC TCTTCAGGGA TGGGGTGAAC 
TGGGGGAGGA TTGTGGCCTT CTTTGAGTTC GGTGGGGTCA TGTGTGTGGA GAGCGTCAAC 
AGGGAGATGT CACCCCTGGT GGACAACATC GCCCTGTGGA TGACTGAGTA CCTGAACCGG 
CATCTGCACA CCTGGATCCA GGATAACGGA GGCTGGGATG CCTTTGTGGA ACTATATGGC 
CCCAGCATGC GACCTCTGTT TGATTTCTCC TGGCTGTCTC TGAAGACCCT GCTCAGCCTG 
GCCCTGGTCG GGGCCTGCAT CACTCTGGGT GCATACCTGG GCCACAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bcl-2 promotes regeneration of severed axons in mammalian CNS.
Nature385(6615)434-9(1997 Jan)
Chen DF,Schneider GE,Martinou JC,Tonegawa S

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice.
Science (New York, N.Y.)261(5128)1584-8(1993 Sep)
Nakayama K,Nakayama K,Negishi I,Kuida K,Shinkai Y,Louie MC,Fields LE,Lucas PJ,Stewart V,Alt FW

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BCL2 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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