Atp6v1b2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atp6v1b2
Entrez Gene ID	11966
Full Name	ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms	AI194269,AI790362,Atp6b2,HO57,R74844
General protein information	Preferred Names ATPase, H+ transporting, lysosomal V1 subunit B2 Names V-type proton ATPase subunit B, brain isoform ATPase, H+ transporting, V1 subunit B ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa ATPase, H+ transporting, lysosomal 56/58kD, V1 subunit B V-ATPase subunit B 2 endomembrane proton pump 58 kDa subunit lysosomal 56/58kDa vacuolar proton pump subunit B 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 B3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_007509.3	NP_031535.2	V-type proton ATPase subunit B, brain isoform

Pathways from BioSystems

Homologies

Homo sapiens (human)	ATP6V1B2	NP_001684.2
Pan troglodytes (chimpanzee)	ATP6V1B2	XP_519638.2
Saccharomyces cerevisiae (baker's yeast)	VMA2	NP_009685.3
Arabidopsis thaliana (thale cress)	AT1G20260	NP_173451.5
Oryza sativa (rice)	Os06g0568200	NP_001057902.1
Rattus norvegicus (Norway rat)	Atp6v1b2	NP_476561.1
Caenorhabditis elegans (roundworm)	spe-5	NP_491518.1
Magnaporthe oryzae (rice blast fungus)	MGG_03244	XP_003716730.1
Xenopus tropicalis (tropical clawed frog)	atp6v1b2	NP_001072182.1
	ATP6V1B2	XP_001100869.1
Canis lupus familiaris (dog)	ATP6V1B2	XP_543263.2
Bos taurus (cattle)	ATP6V1B2	NP_788844.2
Mus musculus (house mouse)	Atp6v1b2	NP_031535.2
Arabidopsis thaliana (thale cress)	AT1G76030	NP_177729.1
Gallus gallus (chicken)	ATP6V1B2	XP_424534.3
Drosophila melanogaster (fruit fly)	Vha55	NP_001163597.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002884	XP_312029.3
Schizosaccharomyces pombe (fission yeast)	vma2	NP_594623.1
Neurospora crassa	NCU08515	XP_963165.1
Danio rerio (zebrafish)	atp6v1b2	NP_878299.1
Kluyveromyces lactis	KLLA0D09152g	XP_453470.1
Eremothecium gossypii	AGOS_ADL380W	NP_983716.1

Gene Ontology
Bibliography

Related articles in PubMed

Widespread and dynamic translational control of red blood cell development.
Alvarez-Dominguez JR, Zhang X, Hu W
Blood129(5)619-629(2017 02)

Identification of Modifier Genes in a Mouse Model of Gaucher Disease.
Klein AD, Ferreira NS, Ben-Dor S, Duan J, Hardy J, Cox TM, Merrill AH Jr, Futerman AH
Cell reports16(10)2546-2553(2016 09)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.
Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R
Journal of cell science128(23)4293-305(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ATP6V1B2 is a molecular target of SIRT1 in fat cells.
Title: SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes.

Disruption of vacuolar H+-ATPase a3-B2 subunit interaction inhibited osteoclast bone resorption.
Title: Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.

the activity of apical B2-containing V-ATPase holoenzymes in A intercalated cells is sufficient to maintain baseline acid-base homeostasis
Title: Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.

Redistribution of Atp6v1b2 occurs from intracellular compartments into the apical membrane of epididymal clear cells from Atp6v1b1(-/-) mice.
Title: Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.

expressed in most, if not all, proton-secreting cells in the epithelium lining the nephron and the collecting ducts, and it is also present in proton-secreting clear cells of the epididymis
Title: Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.

The following Atp6v1b2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atp6v1b2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00297	NM_007509.3 Latest version!	Mus musculus ATPase, H+ transporting, lysosomal V1 subunit B2 (Atp6v1b2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atp6v1b2 ( NM_007509.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031535.2 Mus musculus ATPase, H+ transporting, lysosomal V1 subunit B2 (Atp6v1b2), mRNA.

Price & Availability↑

CloneID	OMu00297
Clone ID Related Accession (Same CDS sequence)	NM_007509.3
Accession Version	NM_007509.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Mus musculus(house mouse)
Product	V-type proton ATPase subunit B, brain isoform
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK151200.1, BC046302.1 and AK197153.1. On Apr 25, 2009 this sequence version replaced NM_007509.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151200.1, AK170110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTTGC GAGCGATGCG GGGAATCGTG AACGGGGCCG CACCCGAACT GCCCGTGCCC 
ACCGGTGGGC CGATGGCCGG AGCTCGGGAG CAGGCGCTGG CGGTGAGCCG GAACTACCTA 
TCCCAGCCTC GTCTCACCTA CAAGACTGTC TCTGGGGTGA ATGGTCCACT AGTGATCCTA 
GATCATGTGA AGTTTCCCAG ATACGCTGAG ATTGTCCACT TGACATTACC AGATGGCACA 
AAGAGAAGTG GGCAAGTCCT AGAAGTTAGT GGCTCCAAAG CAGTGGTTCA GGTATTTGAA 
GGGACATCTG GTATAGACGC CAAGAAAACA TCCTGTGAGT TTACTGGAGA TATTCTCCGA 
ACACCAGTGT CTGAGGATAT GCTTGGTCGA GTATTCAACG GATCAGGAAA ACCCATTGAC 
CGAGGCCCTG TGGTGCTGGC TGAAGACTTC CTTGACATCA TGGGTCAGCC AATCAACCCT 
CAGTGTCGGA TCTATCCAGA AGAGATGATT CAGACGGGCA TTTCCGCCAT CGATGGCATG 
AACAGTATTG CTAGGGGACA GAAAATCCCC ATCTTTTCTG CTGCTGGATT ACCACACAAC 
GAGATTGCAG CTCAGATCTG TCGCCAGGCT GGTTTGGTAA AGAAATCCAA AGATGTAGTG 
GACTATAGTG AAGAAAATTT TGCCATTGTG TTTGCTGCTA TGGGAGTAAA CATGGAAACA 
GCCCGGTTCT TTAAATCTGA CTTTGAAGAA AATGGCTCAA TGGACAATGT CTGCCTTTTT 
TTGAATCTGG CTAATGACCC AACCATTGAG CGGATCATCA CTCCTCGCCT GGCTCTGACC 
ACGGCCGAGT TTCTGGCATA TCAGTGTGAG AAGCACGTGC TGGTGATCCT GACGGACATG 
AGCTCCTACG CTGAAGCGCT GCGAGAGGTT TCAGCTGCCA GGGAAGAGGT CCCTGGTCGG 
CGAGGCTTCC CAGGCTACAT GTATACCGAC TTAGCCACAA TCTATGAACG TGCCGGTCGA 
GTGGAAGGTA GAAACGGCTC TATTACCCAA ATCCCTATTC TCACCATGCC CAATGACGAT 
ATCACTCATC CCATCCCTGA CTTGACTGGG TACATTACTG AGGGCCAGAT CTATGTGGAC 
AGACAGCTGC ACAACAGACA GATTTACCCT CCTATTAATG TGCTGCCCTC ACTCTCTCGG 
TTAATGAAGT CAGCTATCGG AGAAGGAATG ACCAGAAAGG ATCACGCTGA TGTGTCTAAC 
CAGTTGTATG CGTGCTATGC CATCGGTAAG GACGTGCAAG CCATGAAAGC CGTGGTGGGA 
GAGGAAGCCC TGACCTCAGA TGATCTCCTT TACCTGGAAT TTCTGCAGAA GTTTGAGAAG 
AACTTCATTA CTCAGGGTCC CTATGAAAAC CGAACTGTTT ATGAGACTTT GGACATTGGC 
TGGCAGTTGC TTCGAATCTT CCCCAAAGAA ATGCTGAAGA GAATCCCTCA GAGCACCCTG 
AGCGAATTTT ACCCTCGAGA CTCTGCAAAA CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031535.2
CDS	58..1593
Translation	MALRAMRGIVNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH

Target ORF information:

RefSeq Version	NM_007509.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATPase, H+ transporting, lysosomal V1 subunit B2 (Atp6v1b2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007509.3

ORF Insert Sequence:

ATGGCGTTGC GAGCGATGCG GGGAATCGTG AACGGGGCCG CACCCGAACT GCCCGTGCCC 
ACCGGTGGGC CGATGGCCGG AGCTCGGGAG CAGGCGCTGG CGGTGAGCCG GAACTACCTA 
TCCCAGCCTC GTCTCACCTA CAAGACTGTC TCTGGGGTGA ATGGTCCACT AGTGATCCTA 
GATCATGTGA AGTTTCCCAG ATACGCTGAG ATTGTCCACT TGACATTACC AGATGGCACA 
AAGAGAAGTG GGCAAGTCCT AGAAGTTAGT GGCTCCAAAG CAGTGGTTCA GGTATTTGAA 
GGGACATCTG GTATAGACGC CAAGAAAACA TCCTGTGAGT TTACTGGAGA TATTCTCCGA 
ACACCAGTGT CTGAGGATAT GCTTGGTCGA GTATTCAACG GATCAGGAAA ACCCATTGAC 
CGAGGCCCTG TGGTGCTGGC TGAAGACTTC CTTGACATCA TGGGTCAGCC AATCAACCCT 
CAGTGTCGGA TCTATCCAGA AGAGATGATT CAGACGGGCA TTTCCGCCAT CGATGGCATG 
AACAGTATTG CTAGGGGACA GAAAATCCCC ATCTTTTCTG CTGCTGGATT ACCACACAAC 
GAGATTGCAG CTCAGATCTG TCGCCAGGCT GGTTTGGTAA AGAAATCCAA AGATGTAGTG 
GACTATAGTG AAGAAAATTT TGCCATTGTG TTTGCTGCTA TGGGAGTAAA CATGGAAACA 
GCCCGGTTCT TTAAATCTGA CTTTGAAGAA AATGGCTCAA TGGACAATGT CTGCCTTTTT 
TTGAATCTGG CTAATGACCC AACCATTGAG CGGATCATCA CTCCTCGCCT GGCTCTGACC 
ACGGCCGAGT TTCTGGCATA TCAGTGTGAG AAGCACGTGC TGGTGATCCT GACGGACATG 
AGCTCCTACG CTGAAGCGCT GCGAGAGGTT TCAGCTGCCA GGGAAGAGGT CCCTGGTCGG 
CGAGGCTTCC CAGGCTACAT GTATACCGAC TTAGCCACAA TCTATGAACG TGCCGGTCGA 
GTGGAAGGTA GAAACGGCTC TATTACCCAA ATCCCTATTC TCACCATGCC CAATGACGAT 
ATCACTCATC CCATCCCTGA CTTGACTGGG TACATTACTG AGGGCCAGAT CTATGTGGAC 
AGACAGCTGC ACAACAGACA GATTTACCCT CCTATTAATG TGCTGCCCTC ACTCTCTCGG 
TTAATGAAGT CAGCTATCGG AGAAGGAATG ACCAGAAAGG ATCACGCTGA TGTGTCTAAC 
CAGTTGTATG CGTGCTATGC CATCGGTAAG GACGTGCAAG CCATGAAAGC CGTGGTGGGA 
GAGGAAGCCC TGACCTCAGA TGATCTCCTT TACCTGGAAT TTCTGCAGAA GTTTGAGAAG 
AACTTCATTA CTCAGGGTCC CTATGAAAAC CGAACTGTTT ATGAGACTTT GGACATTGGC 
TGGCAGTTGC TTCGAATCTT CCCCAAAGAA ATGCTGAAGA GAATCCCTCA GAGCACCCTG 
AGCGAATTTT ACCCTCGAGA CTCTGCAAAA CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread and dynamic translational control of red blood cell development.
Blood129(5)619-629(2017 02)
Alvarez-Dominguez JR,Zhang X,Hu W

Identification of Modifier Genes in a Mouse Model of Gaucher Disease.
Cell reports16(10)2546-2553(2016 09)
Klein AD,Ferreira NS,Ben-Dor S,Duan J,Hardy J,Cox TM,Merrill AH Jr,Futerman AH

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.
Journal of cell science128(23)4293-305(2015 Dec)
Elias BC,Das A,Parekh DV,Mernaugh G,Adams R,Yang Z,Brakebusch C,Pozzi A,Marciano DK,Carroll TJ,Zent R

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Atp6v1b2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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