Atox1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atox1
Entrez Gene ID	11927
Full Name	antioxidant 1 copper chaperone
Synonyms	AI256639,Atx1
General protein information	Preferred Names antioxidant 1 copper chaperone Names copper transport protein ATOX1 ATX1 (antioxidant protein 1) homolog 1 metal transport protein ATX1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B1.3\|11 33.07 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009720.3	NP_033850.1	copper transport protein ATOX1
NM_009720.2	NP_033850.1	copper transport protein ATOX1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	ATOX1	NP_001003119.1
Bos taurus (cattle)	ATOX1	NP_001124230.1
	LOC712464	XP_001101466.2
Danio rerio (zebrafish)	atox1	NP_001243562.1
Homo sapiens (human)	ATOX1	NP_004036.1
Mus musculus (house mouse)	Atox1	NP_033850.1
Xenopus tropicalis (tropical clawed frog)	atox1	NP_001039238.1
Pan troglodytes (chimpanzee)	ATOX1	XP_001169183.1
Rattus norvegicus (Norway rat)	Atox1	NP_445811.1
Gallus gallus (chicken)	ATOX1	NP_001264641.1

Gene Ontology
Bibliography

Related articles in PubMed

Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos.
Celauro E, Mukaj A, Fierro-Gonz?lez JC, Wittung-Stafshede P
Biochemical and biophysical research communications491(1)147-153(2017 09)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.
Das A, Sudhahar V, Chen GF, Kim HW, Youn SW, Finney L, Vogt S, Yang J, Kweon J, Surenkhuu B, Ushio-Fukai M, Fukai T
Scientific reports633783(2016 Sep)

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.
Chen GF, Sudhahar V, Youn SW, Das A, Cho J, Kamiya T, Urao N, McKinney RD, Surenkhuu B, Hamakubo T, Iwanari H, Li S, Christman JW, Shantikumar S, Angelini GD, Emanueli C, Ushio-Fukai M, Fukai T
Scientific reports514780(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ATOX1 appeared ubiquitously expressed throughout the cells until compaction; in subsequent embryo stages, ATOX1 relocalized to cytoplasmic perinuclear domains in the inner cell mass. Silencing of Oct4 did not affect Atox1 expression, but silencing of Atox1 at the 2-cell stage strongly diminished Oct4 expression in 16-cell embryos.
Title: Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos.

Cu chaperone function of Atox1 mediated through Cu transporter ATP7A is required for VEGF-induced angiogenesis via activation of Cu enzyme lysyl oxidase.
Title: Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.

Atox1 is involved in neointimal formation after vascular injury through promoting vascular smooth muscle cell migration and inflammatory cell recruitment in injured vessels
Title: Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.

Atox1 functions to prevent Ang II-induced endothelial dysfunction and hypercontraction in resistant vessels, as well as hypertension.
Title: Role of copper transport protein antioxidant 1 in angiotensin II-induced hypertension: a key regulator of extracellular superoxide dismutase.

the importance of Atox1, not only as a metallochaperone for delivering Cu to cuproenzymes, but also as a key player in maintaining the proper distribution and organization of Cu at the cellular level
Title: Copper redistribution in Atox1-deficient mouse fibroblast cells.

The following Atox1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atox1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17911	NM_009720.3 Latest version!	Mus musculus antioxidant 1 copper chaperone (Atox1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu17911	NM_009720.2	Mus musculus antioxidant 1 copper chaperone (Atox1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atox1 ( NM_009720.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033850.1 Mus musculus antioxidant 1 copper chaperone (Atox1), mRNA.

Price & Availability↑

CloneID	OMu17911
Clone ID Related Accession (Same CDS sequence)	NM_009720.3 , NM_009720.2
Accession Version	NM_009720.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Mus musculus(house mouse)
Product	copper transport protein ATOX1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ747750.1 and BP773958.1. On Feb 13, 2018 this sequence version replaced NM_009720.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF551157.1, BQ747750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGAAGC ACGAGTTCTC CGTGGACATG ACCTGTGAGG GCTGTGCTGA AGCCGTCTCC 
AGAGTCCTCA ACAAGCTGGG AGGAGTGGAG TTCAACATTG ACCTGCCCAA CAAGAAGGTC 
TGCATCGACT CTGAGCACAG CTCAGACACC CTGCTGGCAA CCCTCAACAA AACAGGAAAG 
GCTGTTTCCT ACCTTGGCCC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033850.1
CDS	116..322
Translation	MPKHEFSVDMTCEGCAEAVSRVLNKLGGVEFNIDLPNKKVCIDSEHSSDTLLATLNKTGKAVSYLGPK

Target ORF information:

RefSeq Version	NM_009720.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus antioxidant 1 copper chaperone (Atox1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009720.3

ORF Insert Sequence:

ATGCCGAAGC ACGAGTTCTC CGTGGACATG ACCTGTGAGG GCTGTGCTGA AGCCGTCTCC 
AGAGTCCTCA ACAAGCTGGG AGGAGTGGAG TTCAACATTG ACCTGCCCAA CAAGAAGGTC 
TGCATCGACT CTGAGCACAG CTCAGACACC CTGCTGGCAA CCCTCAACAA AACAGGAAAG 
GCTGTTTCCT ACCTTGGCCC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Atox1 ( NM_009720.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033850.1 Mus musculus antioxidant 1 copper chaperone (Atox1), mRNA.

Price & Availability↑

CloneID	OMu17911
Clone ID Related Accession (Same CDS sequence)	NM_009720.3 , NM_009720.2
Accession Version	NM_009720.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 207bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Mus musculus(house mouse)
Product	copper transport protein ATOX1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC027632.1. On Jun 19, 2003 this sequence version replaced NM_009720.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027632.1, AL022926.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCGAAGC ACGAGTTCTC CGTGGACATG ACCTGTGAGG GCTGTGCTGA AGCCGTCTCC 
AGAGTCCTCA ACAAGCTGGG AGGAGTGGAG TTCAACATTG ACCTGCCCAA CAAGAAGGTC 
TGCATCGACT CTGAGCACAG CTCAGACACC CTGCTGGCAA CCCTCAACAA AACAGGAAAG 
GCTGTTTCCT ACCTTGGCCC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033850.1
CDS	46..252
Translation	MPKHEFSVDMTCEGCAEAVSRVLNKLGGVEFNIDLPNKKVCIDSEHSSDTLLATLNKTGKAVSYLGPK

Target ORF information:

RefSeq Version	NM_009720.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus antioxidant 1 copper chaperone (Atox1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009720.2

ORF Insert Sequence:

ATGCCGAAGC ACGAGTTCTC CGTGGACATG ACCTGTGAGG GCTGTGCTGA AGCCGTCTCC 
AGAGTCCTCA ACAAGCTGGG AGGAGTGGAG TTCAACATTG ACCTGCCCAA CAAGAAGGTC 
TGCATCGACT CTGAGCACAG CTCAGACACC CTGCTGGCAA CCCTCAACAA AACAGGAAAG 
GCTGTTTCCT ACCTTGGCCC CAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos.
Biochemical and biophysical research communications491(1)147-153(2017 09)
Celauro E,Mukaj A,Fierro-Gonz?lez JC,Wittung-Stafshede P

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.
Scientific reports633783(2016 Sep)
Das A,Sudhahar V,Chen GF,Kim HW,Youn SW,Finney L,Vogt S,Yang J,Kweon J,Surenkhuu B,Ushio-Fukai M,Fukai T

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.
Scientific reports514780(2015 Oct)
Chen GF,Sudhahar V,Youn SW,Das A,Cho J,Kamiya T,Urao N,McKinney RD,Surenkhuu B,Hamakubo T,Iwanari H,Li S,Christman JW,Shantikumar S,Angelini GD,Emanueli C,Ushio-Fukai M,Fukai T

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Atox1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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