Rnd2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rnd2
Entrez Gene ID	11858
Full Name	Rho family GTPase 2
Synonyms	Arhn,Rohn
General protein information	Preferred Names Rho family GTPase 2 Names rho-related GTP-binding protein RhoN aplysia ras-related homolog N (RhoN) ras homolog N (RhoN) ras homolog gene family, member N rho-related GTP-binding protein Rho7 rho7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_009708.1	NP_033838.1	rho-related GTP-binding protein RhoN precursor
NM_009708.2	NP_033838.1	rho-related GTP-binding protein RhoN precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RND2	XP_003639309.1
Bos taurus (cattle)	RND2	NP_001179195.1
Mus musculus (house mouse)	Rnd2	NP_033838.1
Homo sapiens (human)	RND2	NP_005431.1
Pan troglodytes (chimpanzee)	RND2	XP_511530.3
Rattus norvegicus (Norway rat)	Rnd2	NP_001010953.1
Danio rerio (zebrafish)	rnd2	NP_001038829.1
	RND2	XP_001113043.1
Gallus gallus (chicken)	RND2	NP_001239052.1

Gene Ontology
Bibliography

Related articles in PubMed

Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome.
Flore G, Cioffi S, Bilio M, Illingworth E
Cerebral cortex (New York, N.Y. : 1991)27(3)2210-2225(2017 Mar)

Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex.
Gladwyn-Ng IE, Li SS, Qu Z, Davis JM, Ngo L, Haas M, Singer J, Heng JI
Neural development109(2015 Mar)

An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.
Azzarelli R, Pacary E, Garg R, Garcez P, van den Berg D, Riou P, Ridley AJ, Friedel RH, Parsons M, Guillemot F
Nature communications53405(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RP58 represses transcription of Rnd2 via binding to a 3'-regulatory enhancer in a sequence-specific fashion. Using reporter assays, we found that RP58 repression of Rnd2 is competed by proneural basic helix-loop-helix transcriptional activators.
Title: The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development.

Data demonstrate that COUP-TFI modulates late-born neuron migration and favours proper differentiation of callosal projection neurons by finely regulating Rnd2 expression levels.
Title: COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.

Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity.
Title: Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1.

results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration
Title: Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.

The following Rnd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rnd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu04691	NM_009708.2 Latest version!	Mus musculus Rho family GTPase 2 (Rnd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OMu04691	NM_009708.1	Mus musculus Rho family GTPase 2 (Rnd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rnd2 ( NM_009708.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033838.1 Mus musculus Rho family GTPase 2 (Rnd2), mRNA.

Price & Availability↑

CloneID	OMu04691
Clone ID Related Accession (Same CDS sequence)	NM_009708.1 , NM_009708.2
Accession Version	NM_009708.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-07-22
Organism	Mus musculus(house mouse)
Product	rho-related GTP-binding protein RhoN precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB017787.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107022.2, BC139330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGGGC AGAGTGGCCG CTGCAAGATC GTAGTGGTGG GGGACGCGGA GTGCGGCAAG 
ACAGCGTTGC TGCAGGTGTT CGCCAAGGAC GCCTACCCCG GGAGTTATGT CCCCACGGTG 
TTTGAGAACT ACACTGCCAG CTTCGAGATC GACAAGCGCC GCATTGAGCT CAACATGTGG 
GATACTTCAG GTTCCTCTTA CTATGACAAT GTCCGGCCTC TGGCCTACCC GGATTCTGAT 
GCTGTGCTTA TCTGCTTTGA CATTAGCCGG CCAGAAACAC TGGACAGTGT CCTCAAGAAG 
TGGCAAGGAG AGACTCAGGA GTTTTGCCCC AATGCCAAGG TGGTGCTGGT TGGCTGTAAG 
CTGGACATGC GGACTGACCT GGCCACACTG AGGGAGCTAT CCAAGCAGAG ACTCATCCCT 
GTCACACATG AGCAGGGTAC TGTGCTGGCC AAGCAAGTGG GAGCTGTGTC CTACGTTGAA 
TGTTCCTCCC GATCTTCTGA GCGCAGTGTC CGGGATGTCT TCCATGTGGC CACAGTGGCT 
TCTCTCGGCC GTGGCCATAG GCAGCTACGT CGTACTGACT CTCGCCGGGG ACTGCAGCGA 
TCCACTCAAC TGTCGGGACG GCCAGACCGG GGAAATGAGG GCGAGATGCA TAAGGATCGA 
GCCAAGAGCT GTAACCTCAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033838.1
CDS	1..684
Translation	MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDVFHVATVASLGRGHRQLRRTDSRRGLQRSTQLSGRPDRGNEGEMHKDRAKSCNLM

Target ORF information:

RefSeq Version	NM_009708.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rho family GTPase 2 (Rnd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009708.1

ORF Insert Sequence:

ATGGAGGGGC AGAGTGGCCG CTGCAAGATC GTAGTGGTGG GGGACGCGGA GTGCGGCAAG 
ACAGCGTTGC TGCAGGTGTT CGCCAAGGAC GCCTACCCCG GGAGTTATGT CCCCACGGTG 
TTTGAGAACT ACACTGCCAG CTTCGAGATC GACAAGCGCC GCATTGAGCT CAACATGTGG 
GATACTTCAG GTTCCTCTTA CTATGACAAT GTCCGGCCTC TGGCCTACCC GGATTCTGAT 
GCTGTGCTTA TCTGCTTTGA CATTAGCCGG CCAGAAACAC TGGACAGTGT CCTCAAGAAG 
TGGCAAGGAG AGACTCAGGA GTTTTGCCCC AATGCCAAGG TGGTGCTGGT TGGCTGTAAG 
CTGGACATGC GGACTGACCT GGCCACACTG AGGGAGCTAT CCAAGCAGAG ACTCATCCCT 
GTCACACATG AGCAGGGTAC TGTGCTGGCC AAGCAAGTGG GAGCTGTGTC CTACGTTGAA 
TGTTCCTCCC GATCTTCTGA GCGCAGTGTC CGGGATGTCT TCCATGTGGC CACAGTGGCT 
TCTCTCGGCC GTGGCCATAG GCAGCTACGT CGTACTGACT CTCGCCGGGG ACTGCAGCGA 
TCCACTCAAC TGTCGGGACG GCCAGACCGG GGAAATGAGG GCGAGATGCA TAAGGATCGA 
GCCAAGAGCT GTAACCTCAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnd2 ( NM_009708.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033838.1 Mus musculus Rho family GTPase 2 (Rnd2), mRNA.

Price & Availability↑

CloneID	OMu04691
Clone ID Related Accession (Same CDS sequence)	NM_009708.1 , NM_009708.2
Accession Version	NM_009708.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 684bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	rho-related GTP-binding protein RhoN precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY275340.1, BC139331.1 and CD775326.1. On Feb 13, 2018 this sequence version replaced NM_009708.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI410046.1, BI905297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGGGC AGAGTGGCCG CTGCAAGATC GTAGTGGTGG GGGACGCGGA GTGCGGCAAG 
ACAGCGTTGC TGCAGGTGTT CGCCAAGGAC GCCTACCCCG GGAGTTATGT CCCCACGGTG 
TTTGAGAACT ACACTGCCAG CTTCGAGATC GACAAGCGCC GCATTGAGCT CAACATGTGG 
GATACTTCAG GTTCCTCTTA CTATGACAAT GTCCGGCCTC TGGCCTACCC GGATTCTGAT 
GCTGTGCTTA TCTGCTTTGA CATTAGCCGG CCAGAAACAC TGGACAGTGT CCTCAAGAAG 
TGGCAAGGAG AGACTCAGGA GTTTTGCCCC AATGCCAAGG TGGTGCTGGT TGGCTGTAAG 
CTGGACATGC GGACTGACCT GGCCACACTG AGGGAGCTAT CCAAGCAGAG ACTCATCCCT 
GTCACACATG AGCAGGGTAC TGTGCTGGCC AAGCAAGTGG GAGCTGTGTC CTACGTTGAA 
TGTTCCTCCC GATCTTCTGA GCGCAGTGTC CGGGATGTCT TCCATGTGGC CACAGTGGCT 
TCTCTCGGCC GTGGCCATAG GCAGCTACGT CGTACTGACT CTCGCCGGGG ACTGCAGCGA 
TCCACTCAAC TGTCGGGACG GCCAGACCGG GGAAATGAGG GCGAGATGCA TAAGGATCGA 
GCCAAGAGCT GTAACCTCAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033838.1
CDS	164..847
Translation	MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMWDTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCPNAKVVLVGCKLDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDVFHVATVASLGRGHRQLRRTDSRRGLQRSTQLSGRPDRGNEGEMHKDRAKSCNLM

Target ORF information:

RefSeq Version	NM_009708.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rho family GTPase 2 (Rnd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009708.2

ORF Insert Sequence:

ATGGAGGGGC AGAGTGGCCG CTGCAAGATC GTAGTGGTGG GGGACGCGGA GTGCGGCAAG 
ACAGCGTTGC TGCAGGTGTT CGCCAAGGAC GCCTACCCCG GGAGTTATGT CCCCACGGTG 
TTTGAGAACT ACACTGCCAG CTTCGAGATC GACAAGCGCC GCATTGAGCT CAACATGTGG 
GATACTTCAG GTTCCTCTTA CTATGACAAT GTCCGGCCTC TGGCCTACCC GGATTCTGAT 
GCTGTGCTTA TCTGCTTTGA CATTAGCCGG CCAGAAACAC TGGACAGTGT CCTCAAGAAG 
TGGCAAGGAG AGACTCAGGA GTTTTGCCCC AATGCCAAGG TGGTGCTGGT TGGCTGTAAG 
CTGGACATGC GGACTGACCT GGCCACACTG AGGGAGCTAT CCAAGCAGAG ACTCATCCCT 
GTCACACATG AGCAGGGTAC TGTGCTGGCC AAGCAAGTGG GAGCTGTGTC CTACGTTGAA 
TGTTCCTCCC GATCTTCTGA GCGCAGTGTC CGGGATGTCT TCCATGTGGC CACAGTGGCT 
TCTCTCGGCC GTGGCCATAG GCAGCTACGT CGTACTGACT CTCGCCGGGG ACTGCAGCGA 
TCCACTCAAC TGTCGGGACG GCCAGACCGG GGAAATGAGG GCGAGATGCA TAAGGATCGA 
GCCAAGAGCT GTAACCTCAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome.
Cerebral cortex (New York, N.Y. : 1991)27(3)2210-2225(2017 Mar)
Flore G,Cioffi S,Bilio M,Illingworth E

Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex.
Neural development109(2015 Mar)
Gladwyn-Ng IE,Li SS,Qu Z,Davis JM,Ngo L,Haas M,Singer J,Heng JI

An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.
Nature communications53405(2014 Feb)
Azzarelli R,Pacary E,Garg R,Garcez P,van den Berg D,Riou P,Ridley AJ,Friedel RH,Parsons M,Guillemot F

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Rnd2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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