Ar cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ar
Entrez Gene ID	11835
Full Name	androgen receptor
Synonyms	AW320017,Tfm
General protein information	Preferred Names androgen receptor Names androgen receptor dihydrotestosterone receptor nuclear receptor subfamily 3 group C member 4 testicular feminization
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X C3\|X 42.82 cM
Summary	This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013476.4	NP_038504.1	androgen receptor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AR	NP_001231056.1
Homo sapiens (human)	AR	NP_000035.2
Canis lupus familiaris (dog)	AR	NP_001003053.1
Rattus norvegicus (Norway rat)	Ar	NP_036634.1
Mus musculus (house mouse)	Ar	NP_038504.1
	AR	NP_001028083.1
Gallus gallus (chicken)	AR	NP_001035179.1
Xenopus tropicalis (tropical clawed frog)	ar	XP_002941888.2

Gene Ontology
Bibliography

Related articles in PubMed

The androgen receptor in health and disease.
Matsumoto T, Sakari M, Okada M, Yokoyama A, Takahashi S, Kouzmenko A, Kato S
Annual review of physiology75201-24(2013)

Molecular cloning of androgen receptors from divergent species with a polymerase chain reaction technique: complete cDNA sequence of the mouse androgen receptor and isolation of androgen receptor cDNA probes from dog, guinea pig and clawed frog.
He WW, Fischer LM, Sun S, Bilhartz DL, Zhu XP, Young CY, Kelley DB, Tindall DJ
Biochemical and biophysical research communications171(2)697-704(1990 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data provide evidence for a role of androgens via the AR in neurons to positively regulate fast-twitch hind-limb muscle mass and physical activity in male mice.
Title: Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice.

Bisphenol A inhibits Sertoli cell proliferation by interfering with androgen receptor signaling pathway.
Title: Anti-androgenic mechanisms of Bisphenol A involve androgen receptor signaling pathway.

experimental manipulation of the prenatal androgen level, by blocking the androgen receptor with flutamide or activating the androgen receptor with dihydrotestosterone (DHT), leads to changes in the length of the fingers of all paws in males and females.
Title: Prenatal androgen-receptor activity has organizational morphological effects in mice.

Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice
Title: 5?-reductase 1 mRNA levels are positively correlated with TRAMP mouse prostate most severe lesion scores.

CDK2 phosphorylates polyQ-AR specifically at Ser(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
Title: Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.

The following Ar gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ar cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23223	NM_013476.4 Latest version!	Mus musculus androgen receptor (Ar), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ar ( NM_013476.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038504.1 Mus musculus androgen receptor (Ar), mRNA.

Price & Availability↑

CloneID	OMu23223
Clone ID Related Accession (Same CDS sequence)	NM_013476.4
Accession Version	NM_013476.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2700bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	androgen receptor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL844866.17, AK133647.1, M37890.1 and AL683800.9. On May 7, 2015 this sequence version replaced NM_013476.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.53046.1, SRR1660815.156156.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGAGGTGC AGTTAGGGCT GGGAAGGGTC TACCCACGGC CCCCATCCAA GACCTATCGA 
GGAGCGTTCC AGAATCTGTT CCAGAGCGTG CGCGAAGCGA TCCAGAACCC GGGCCCCAGG 
CACCCTGAGG CCGCTAACAT AGCACCTCCC GGCGCCTGTT TACAGCAGAG GCAGGAGACT 
AGCCCCCGGC GGCGGCGGCG GCAGCAGCAC ACTGAGGATG GTTCTCCTCA AGCCCACATC 
AGAGGCCCCA CAGGCTACCT GGCCCTGGAG GAGGAACAGC AGCCTTCACA GCAGCAGGCA 
GCCTCCGAGG GCCACCCTGA GAGCAGCTGC CTCCCCGAGC CTGGGGCGGC CACCGCTCCT 
GGCAAGGGGC TGCCGCAGCA GCCACCAGCT CCTCCAGATC AGGATGACTC AGCTGCCCCA 
TCCACGTTGT CCCTGCTGGG CCCCACTTTC CCAGGCTTAA GCAGCTGCTC CGCCGACATT 
AAAGACATTT TGAACGAGGC CGGCACCATG CAACTTCTTC AGCAGCAGCA ACAACAGCAG 
CAGCACCAAC AGCAGCACCA ACAGCACCAA CAGCAGCAGG AGGTAATCTC CGAAGGCAGC 
AGCGCAAGAG CCAGGGAGGC CACGGGGGCT CCCTCTTCCT CCAAGGATAG TTACCTAGGG 
GGCAATTCAA CCATATCTGA CAGTGCCAAG GAGTTGTGTA AAGCAGTGTC TGTGTCCATG 
GGATTGGGTG TGGAAGCATT GGAACATCTG AGTCCAGGGG AACAGCTTCG GGGAGACTGC 
ATGTACGCGT CGCTCCTGGG AGGTCCACCC GCGGTGCGTC CCACTCCTTG TGCGCCGCTG 
CCCGAATGCA AAGGTCTTCC CCTGGACGAA GGCCCAGGCA AAAGCACTGA AGAGACTGCT 
GAGTATTCCT CTTTCAAGGG AGGTTACGCC AAAGGATTGG AAGGTGAGAG CTTGGGGTGC 
TCTGGCAGCA GTGAAGCAGG TAGCTCTGGG ACACTTGAGA TCCCGTCCTC TCTGTCTCTG 
TATAAATCTG GAGCACTAGA CGAGGCAGCA GCATACCAGA ATCGCGACTA CTACAACTTT 
CCGCTGGCTC TGTCCGGGCC GCCGCACCCC CCGCCCCCTA CCCATCCACA CGCCCGTATC 
AAGCTGGAGA ACCCATTGGA CTACGGCAGC GCCTGGGCTG CGGCGGCAGC GCAATGCCGC 
TATGGGGACT TGGGTAGTCT ACATGGAGGG AGTGTAGCCG GGCCCAGCAC TGGATCGCCC 
CCAGCCACCA CCTCTTCTTC CTGGCATACT CTCTTCACAG CTGAAGAAGG CCAATTATAT 
GGGCCAGGAG GCGGGGGCGG CAGCAGCAGC CCAAGCGATG CCGGGCCTGT AGCCCCCTAT 
GGCTACACTC GGCCCCCTCA GGGGCTGACA AGCCAGGAGA GTGACTACTC TGCCTCCGAA 
GTGTGGTATC CTGGTGGAGT TGTGAACAGA GTACCCTATC CCAGTCCCAA TTGTGTCAAA 
AGTGAAATGG GACCTTGGAT GGAGAACTAC TCCGGACCTT ATGGGGACAT GCGTTTGGAC 
AGTACCAGGG ACCATGTTTT ACCCATCGAC TATTACTTTC CACCCCAGAA GACCTGCCTG 
ATCTGTGGAG ATGAAGCTTC TGGCTGTCAC TACGGAGCTC TCACTTGTGG CAGCTGCAAG 
GTCTTCTTCA AAAGAGCCGC TGAAGGGAAA CAGAAGTATC TATGTGCCAG CAGAAACGAT 
TGTACCATTG ATAAATTTCG GAGGAAAAAT TGCCCATCTT GTCGTCTCCG GAAATGTTAT 
GAAGCAGGGA TGACTCTGGG AGCTCGTAAG CTGAAGAAAC TTGGAAATCT AAAACTACAG 
GAGGAAGGAG AAAACTCCAA TGCTGGCAGC CCCACTGAGG ACCCATCCCA GAAGATGACT 
GTATCACACA TTGAAGGCTA TGAATGTCAG CCTATCTTTC TTAACGTCCT GGAAGCCATT 
GAGCCAGGAG TGGTGTGTGC CGGACATGAC AACAACCAAC CAGATTCCTT TGCTGCCTTG 
TTATCTAGCC TCAATGAGCT TGGAGAGAGG CAGCTTGTGC ATGTGGTCAA GTGGGCCAAG 
GCCTTGCCTG GCTTCCGCAA CTTGCATGTG GATGACCAGA TGGCGGTCAT TCAGTATTCC 
TGGATGGGAC TGATGGTATT TGCCATGGGT TGGCGGTCCT TCACTAATGT CAACTCCAGG 
ATGCTCTACT TTGCACCTGA CTTGGTTTTC AATGAGTACC GCATGCACAA GTCTCGGATG 
TACAGCCAGT GTGTGAGGAT GAGGCACCTG TCTCAAGAGT TTGGATGGCT CCAAATAACC 
CCCCAGGAAT TCCTGTGCAT GAAAGCACTG CTGCTCTTCA GCATTATTCC AGTGGATGGG 
CTGAAAAATC AAAAATTCTT TGATGAACTT CGAATGAACT ACATCAAGGA ACTCGATCGC 
ATCATTGCAT GCAAAAGAAA GAATCCCACA TCCTGCTCAA GGCGCTTCTA CCAGCTCACC 
AAGCTCCTGG ATTCTGTGCA GCCTATTGCA AGAGAGCTGC ATCAGTTCAC TTTTGACCTG 
CTAATCAAGT CCCATATGGT GAGCGTGGAC TTTCCTGAAA TGATGGCAGA GATCATCTCT 
GTGCAAGTGC CCAAGATCCT TTCTGGGAAA GTCAAGCCCA TCTATTTCCA CACACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038504.1
CDS	1026..3725
Translation	MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

Target ORF information:

RefSeq Version	NM_013476.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus androgen receptor (Ar), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013476.4

ORF Insert Sequence:

ATGGAGGTGC AGTTAGGGCT GGGAAGGGTC TACCCACGGC CCCCATCCAA GACCTATCGA 
GGAGCGTTCC AGAATCTGTT CCAGAGCGTG CGCGAAGCGA TCCAGAACCC GGGCCCCAGG 
CACCCTGAGG CCGCTAACAT AGCACCTCCC GGCGCCTGTT TACAGCAGAG GCAGGAGACT 
AGCCCCCGGC GGCGGCGGCG GCAGCAGCAC ACTGAGGATG GTTCTCCTCA AGCCCACATC 
AGAGGCCCCA CAGGCTACCT GGCCCTGGAG GAGGAACAGC AGCCTTCACA GCAGCAGGCA 
GCCTCCGAGG GCCACCCTGA GAGCAGCTGC CTCCCCGAGC CTGGGGCGGC CACCGCTCCT 
GGCAAGGGGC TGCCGCAGCA GCCACCAGCT CCTCCAGATC AGGATGACTC AGCTGCCCCA 
TCCACGTTGT CCCTGCTGGG CCCCACTTTC CCAGGCTTAA GCAGCTGCTC CGCCGACATT 
AAAGACATTT TGAACGAGGC CGGCACCATG CAACTTCTTC AGCAGCAGCA ACAACAGCAG 
CAGCACCAAC AGCAGCACCA ACAGCACCAA CAGCAGCAGG AGGTAATCTC CGAAGGCAGC 
AGCGCAAGAG CCAGGGAGGC CACGGGGGCT CCCTCTTCCT CCAAGGATAG TTACCTAGGG 
GGCAATTCAA CCATATCTGA CAGTGCCAAG GAGTTGTGTA AAGCAGTGTC TGTGTCCATG 
GGATTGGGTG TGGAAGCATT GGAACATCTG AGTCCAGGGG AACAGCTTCG GGGAGACTGC 
ATGTACGCGT CGCTCCTGGG AGGTCCACCC GCGGTGCGTC CCACTCCTTG TGCGCCGCTG 
CCCGAATGCA AAGGTCTTCC CCTGGACGAA GGCCCAGGCA AAAGCACTGA AGAGACTGCT 
GAGTATTCCT CTTTCAAGGG AGGTTACGCC AAAGGATTGG AAGGTGAGAG CTTGGGGTGC 
TCTGGCAGCA GTGAAGCAGG TAGCTCTGGG ACACTTGAGA TCCCGTCCTC TCTGTCTCTG 
TATAAATCTG GAGCACTAGA CGAGGCAGCA GCATACCAGA ATCGCGACTA CTACAACTTT 
CCGCTGGCTC TGTCCGGGCC GCCGCACCCC CCGCCCCCTA CCCATCCACA CGCCCGTATC 
AAGCTGGAGA ACCCATTGGA CTACGGCAGC GCCTGGGCTG CGGCGGCAGC GCAATGCCGC 
TATGGGGACT TGGGTAGTCT ACATGGAGGG AGTGTAGCCG GGCCCAGCAC TGGATCGCCC 
CCAGCCACCA CCTCTTCTTC CTGGCATACT CTCTTCACAG CTGAAGAAGG CCAATTATAT 
GGGCCAGGAG GCGGGGGCGG CAGCAGCAGC CCAAGCGATG CCGGGCCTGT AGCCCCCTAT 
GGCTACACTC GGCCCCCTCA GGGGCTGACA AGCCAGGAGA GTGACTACTC TGCCTCCGAA 
GTGTGGTATC CTGGTGGAGT TGTGAACAGA GTACCCTATC CCAGTCCCAA TTGTGTCAAA 
AGTGAAATGG GACCTTGGAT GGAGAACTAC TCCGGACCTT ATGGGGACAT GCGTTTGGAC 
AGTACCAGGG ACCATGTTTT ACCCATCGAC TATTACTTTC CACCCCAGAA GACCTGCCTG 
ATCTGTGGAG ATGAAGCTTC TGGCTGTCAC TACGGAGCTC TCACTTGTGG CAGCTGCAAG 
GTCTTCTTCA AAAGAGCCGC TGAAGGGAAA CAGAAGTATC TATGTGCCAG CAGAAACGAT 
TGTACCATTG ATAAATTTCG GAGGAAAAAT TGCCCATCTT GTCGTCTCCG GAAATGTTAT 
GAAGCAGGGA TGACTCTGGG AGCTCGTAAG CTGAAGAAAC TTGGAAATCT AAAACTACAG 
GAGGAAGGAG AAAACTCCAA TGCTGGCAGC CCCACTGAGG ACCCATCCCA GAAGATGACT 
GTATCACACA TTGAAGGCTA TGAATGTCAG CCTATCTTTC TTAACGTCCT GGAAGCCATT 
GAGCCAGGAG TGGTGTGTGC CGGACATGAC AACAACCAAC CAGATTCCTT TGCTGCCTTG 
TTATCTAGCC TCAATGAGCT TGGAGAGAGG CAGCTTGTGC ATGTGGTCAA GTGGGCCAAG 
GCCTTGCCTG GCTTCCGCAA CTTGCATGTG GATGACCAGA TGGCGGTCAT TCAGTATTCC 
TGGATGGGAC TGATGGTATT TGCCATGGGT TGGCGGTCCT TCACTAATGT CAACTCCAGG 
ATGCTCTACT TTGCACCTGA CTTGGTTTTC AATGAGTACC GCATGCACAA GTCTCGGATG 
TACAGCCAGT GTGTGAGGAT GAGGCACCTG TCTCAAGAGT TTGGATGGCT CCAAATAACC 
CCCCAGGAAT TCCTGTGCAT GAAAGCACTG CTGCTCTTCA GCATTATTCC AGTGGATGGG 
CTGAAAAATC AAAAATTCTT TGATGAACTT CGAATGAACT ACATCAAGGA ACTCGATCGC 
ATCATTGCAT GCAAAAGAAA GAATCCCACA TCCTGCTCAA GGCGCTTCTA CCAGCTCACC 
AAGCTCCTGG ATTCTGTGCA GCCTATTGCA AGAGAGCTGC ATCAGTTCAC TTTTGACCTG 
CTAATCAAGT CCCATATGGT GAGCGTGGAC TTTCCTGAAA TGATGGCAGA GATCATCTCT 
GTGCAAGTGC CCAAGATCCT TTCTGGGAAA GTCAAGCCCA TCTATTTCCA CACACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The androgen receptor in health and disease.
Annual review of physiology75201-24(2013)
Matsumoto T,Sakari M,Okada M,Yokoyama A,Takahashi S,Kouzmenko A,Kato S

Molecular cloning of androgen receptors from divergent species with a polymerase chain reaction technique: complete cDNA sequence of the mouse androgen receptor and isolation of androgen receptor cDNA probes from dog, guinea pig and clawed frog.
Biochemical and biophysical research communications171(2)697-704(1990 Sep)
He WW,Fischer LM,Sun S,Bilhartz DL,Zhu XP,Young CY,Kelley DB,Tindall DJ

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Ar cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報