Prdx3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prdx3
Entrez Gene ID	11757
Full Name	peroxiredoxin 3
Synonyms	AW822249,Aop1,D0Tohi1,Ef2l,Mer5,Prx3,SP22,TDXM
General protein information	Preferred Names peroxiredoxin 3 Names thioredoxin-dependent peroxide reductase, mitochondrial AOP-1 Prx III anti-oxidant protein 1 antioxidant protein mitochondrial Trx dependent peroxide reductase mitochondrial thioredoxin dependent peroxide reductase perioredoxin-3 peroxiredoxin III
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 D3\|19 56.52 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007452.2	NP_031478.1	thioredoxin-dependent peroxide reductase, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PRDX3	NP_006784.1
	PRDX3	XP_001097456.1
Bos taurus (cattle)	PRDX3	NP_776857.1
Gallus gallus (chicken)	PRDX3	XP_004942376.1
Kluyveromyces lactis	KLLA0B01628g	XP_451603.1
Anopheles gambiae (African malaria mosquito)	TPX1	XP_310704.3
Caenorhabditis elegans (roundworm)	prdx-3	NP_497892.1
Xenopus tropicalis (tropical clawed frog)	prdx3	NP_001025608.1
Mus musculus (house mouse)	Prdx3	NP_031478.1
Pan troglodytes (chimpanzee)	PRDX3	XP_003951819.1
Canis lupus familiaris (dog)	PRDX3	NP_001243414.1
Rattus norvegicus (Norway rat)	Prdx3	NP_071985.1
Danio rerio (zebrafish)	prdx3	NP_001013478.2
Drosophila melanogaster (fruit fly)	Prx3	NP_524387.1
Saccharomyces cerevisiae (baker's yeast)	TSA2	NP_010741.1
Eremothecium gossypii	AGOS_AER312W	NP_985168.1

Gene Ontology
Bibliography

Related articles in PubMed

Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).
Olson DH, Burrill JS, Kuzmicic J, Hahn WS, Park JM, Kim DH, Bernlohr DA
Biochemical and biophysical research communications493(3)1311-1317(2017 11)

Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes.
Baek JY, Park S, Park J, Jang JY, Wang SB, Kim SR, Woo HA, Lim KM, Chang TS
The Journal of investigative dermatology137(6)1333-1342(2017 Jun)

Embryonic cholecystitis and defective gallbladder contraction in the
Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M, Kanai Y
Development (Cambridge, England)144(10)1906-1917(2017 05)

cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.
Wang R, Islam BN, Bridges A, Sharman SK, Hu M, Hou Y, Somanath PR, Venable L, Singh N, Kim S, Sridhar S, Hofmann F, Browning DD
The American journal of pathology187(2)377-389(2017 Feb)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The importance of mitochondrial Prdx3 in regulating the oxidative stress environment in adipocytes.Loss of Prdx3 leads to decreased pS473 Akt and insulin-stimulated glucose transport.
Title: Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).

Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes.
Title: Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.

This study showed that from E10.5,Prdx3 showed strong ventral lateral expression. This increased ventral immunotaining persisted until E18.5 but became relatively less striking at later stages.
Title: Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.

Prx3 plays a crucial role in mitochondrial homeostasis and thereby controls the contractile functions of skeletal muscle.
Title: Peroxiredoxin 3 has a crucial role in the contractile function of skeletal muscle by regulating mitochondrial homeostasis.

Prx3 is up-regulated in response to oxidative stress; the maintenance of Prx3 levels in hair cells is a critical factor in their susceptibility to acquired hearing loss.
Title: Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.

The following Prdx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prdx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14747	NM_007452.2 Latest version!	Mus musculus peroxiredoxin 3 (Prdx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prdx3 ( NM_007452.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031478.1 Mus musculus peroxiredoxin 3 (Prdx3), mRNA.

Price & Availability↑

CloneID	OMu14747
Clone ID Related Accession (Same CDS sequence)	NM_007452.2
Accession Version	NM_007452.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	thioredoxin-dependent peroxide reductase, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY318475.1, AK002448.1 and BB372344.1. On Dec 19, 2006 this sequence version replaced NM_007452.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M28723.1, BC005626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCGGCAG CTGCGGGAAG GTTGCTCTGG TCCTCGGTTG CTCGTCATGC AAGTGCTATT 
TCCCGGAGTA TTTCTGCCTC AACAGTTCTT AGGCCTGTTG CTTCTAGAAG AACCTGTTTG 
ACAGACATAC TGTGGTCTGC CTCTGCCCAA GGAAAGTCAG CCTTTAGCAC CAGTTCCTCT 
TTCCACACCC CTGCTGTCAC CCAGCACGCG CCCTATTTTA AAGGTACTGC TGTTGTCAAT 
GGAGAGTTCA AAGAGCTGAG TCTCGACGAC TTTAAGGGAA AATACTTGGT GCTTTTCTTC 
TACCCTTTGG ATTTCACATT TGTGTGTCCT ACAGAAATTG TTGCTTTCAG TGACAAAGCC 
AATGAATTTC ATGATGTAAA CTGTGAAGTA GTTGCAGTTT CAGTGGATTC CCACTTCAGT 
CATCTTGCCT GGATCAACAC ACCAAGAAAG AATGGTGGTT TGGGCCACAT GAACATCACA 
CTGTTGTCGG ATATAACTAA GCAGATATCC CGAGACTACG GAGTGCTGTT GGAAAGTGCT 
GGCATTGCAC TCAGAGGTCT CTTCATTATT GACCCTAATG GTGTCGTCAA GCACCTGAGT 
GTCAACGACC TTCCGGTGGG CCGCAGTGTG GAAGAAACAC TCCGTTTGGT AAAGGCGTTC 
CAGTTTGTGG AGACCCATGG AGAAGTCTGC CCAGCCAACT GGACACCAGA GTCCCCTACG 
ATCAAGCCAA GTCCAACAGC TTCCAAAGAG TACTTTGAGA AGGTCCATCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031478.1
CDS	72..845
Translation	MAAAAGRLLWSSVARHASAISRSISASTVLRPVASRRTCLTDILWSASAQGKSAFSTSSSFHTPAVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDITKQISRDYGVLLESAGIALRGLFIIDPNGVVKHLSVNDLPVGRSVEETLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ

Target ORF information:

RefSeq Version	NM_007452.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus peroxiredoxin 3 (Prdx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007452.2

ORF Insert Sequence:

ATGGCGGCAG CTGCGGGAAG GTTGCTCTGG TCCTCGGTTG CTCGTCATGC AAGTGCTATT 
TCCCGGAGTA TTTCTGCCTC AACAGTTCTT AGGCCTGTTG CTTCTAGAAG AACCTGTTTG 
ACAGACATAC TGTGGTCTGC CTCTGCCCAA GGAAAGTCAG CCTTTAGCAC CAGTTCCTCT 
TTCCACACCC CTGCTGTCAC CCAGCACGCG CCCTATTTTA AAGGTACTGC TGTTGTCAAT 
GGAGAGTTCA AAGAGCTGAG TCTCGACGAC TTTAAGGGAA AATACTTGGT GCTTTTCTTC 
TACCCTTTGG ATTTCACATT TGTGTGTCCT ACAGAAATTG TTGCTTTCAG TGACAAAGCC 
AATGAATTTC ATGATGTAAA CTGTGAAGTA GTTGCAGTTT CAGTGGATTC CCACTTCAGT 
CATCTTGCCT GGATCAACAC ACCAAGAAAG AATGGTGGTT TGGGCCACAT GAACATCACA 
CTGTTGTCGG ATATAACTAA GCAGATATCC CGAGACTACG GAGTGCTGTT GGAAAGTGCT 
GGCATTGCAC TCAGAGGTCT CTTCATTATT GACCCTAATG GTGTCGTCAA GCACCTGAGT 
GTCAACGACC TTCCGGTGGG CCGCAGTGTG GAAGAAACAC TCCGTTTGGT AAAGGCGTTC 
CAGTTTGTGG AGACCCATGG AGAAGTCTGC CCAGCCAACT GGACACCAGA GTCCCCTACG 
ATCAAGCCAA GTCCAACAGC TTCCAAAGAG TACTTTGAGA AGGTCCATCA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).
Biochemical and biophysical research communications493(3)1311-1317(2017 11)
Olson DH,Burrill JS,Kuzmicic J,Hahn WS,Park JM,Kim DH,Bernlohr DA

Protective Role of Mitochondrial Peroxiredoxin III against UVB-Induced Apoptosis of Epidermal Keratinocytes.
The Journal of investigative dermatology137(6)1333-1342(2017 Jun)
Baek JY,Park S,Park J,Jang JY,Wang SB,Kim SR,Woo HA,Lim KM,Chang TS

Embryonic cholecystitis and defective gallbladder contraction in the
Development (Cambridge, England)144(10)1906-1917(2017 05)
Higashiyama H,Ozawa A,Sumitomo H,Uemura M,Fujino K,Igarashi H,Imaimatsu K,Tsunekawa N,Hirate Y,Kurohmaru M,Saijoh Y,Kanai-Azuma M,Kanai Y

cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.
The American journal of pathology187(2)377-389(2017 Feb)
Wang R,Islam BN,Bridges A,Sharman SK,Hu M,Hou Y,Somanath PR,Venable L,Singh N,Kim S,Sridhar S,Hofmann F,Browning DD

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

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Prdx3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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