Ank cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ank
Entrez Gene ID	11732
Full Name	progressive ankylosis
Synonyms	Ankh,D15Ertd221e,ank,mKIAA1581
General protein information	Preferred Names progressive ankylosis Names progressive ankylosis protein fn54 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 B1\|15 10.23 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_020332.4	NP_065065.3	progressive ankylosis protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANKH	NP_473368.1
Canis lupus familiaris (dog)	ANKH	XP_005619485.1
	ANKH	XP_002804357.1
Mus musculus (house mouse)	Ank	NP_065065.3
Pan troglodytes (chimpanzee)	ANKH	XP_003310678.1
Bos taurus (cattle)	ANKH	NP_001103263.1
Rattus norvegicus (Norway rat)	Ankh	NP_446166.1
Gallus gallus (chicken)	ANKH	NP_001012580.1
Xenopus tropicalis (tropical clawed frog)	ankh	XP_002933168.1
Danio rerio (zebrafish)	ankhb	NP_919351.1

Gene Ontology
Bibliography

Related articles in PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P
Bone107131-142(2018 Feb)

Osteopontin regulates dentin and alveolar bone development and mineralization.
Foster BL, Ao M, Salmon CR, Chavez MB, Kolli TN, Tran AB, Chu EY, Kantovitz KR, Yadav M, Narisawa S, Mill?n JL, Nociti FH Jr, Somerman MJ
Bone(2017 Dec)

Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.
Ao M, Chavez MB, Chu EY, Hemstreet KC, Yin Y, Yadav MC, Mill?n JL, Fisher LW, Goldberg HA, Somerman MJ, Foster BL
Bone105134-147(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our study provides evidence that ANK plays a critical role in the adipogenic/osteogenic fate decision of adult mesenchymal precursor cells
Title: The role of the progressive ankylosis protein (ANK) in adipogenic/osteogenic fate decision of precursor cells.

regulates the transport of inorganic pyrophosphate, and Ank knock-out mice feature a rapidly forming and thick cementum and increased cementum regeneration
Title: Modulation of phosphate/pyrophosphate metabolism to regenerate the periodontium: a novel in vivo approach.

Phe377del mutation in ANK causes impaired osteoblastogenesis and osteoclastogenesis resulting in hypomineralization and a high bone mass phenotype.
Title: A Phe377del mutation in ANK leads to impaired osteoblastogenesis and osteoclastogenesis in a mouse model for craniometaphyseal dysplasia (CMD).

Loss of Ank alters cementoblast gene expression and cervical cementum extracellular matrix composition.
Title: The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition.

the relationship between the type of temporomandibular disorders (TMD) and ANKH polymorphisms
Title: Increased risk of temporomandibular joint closed lock: a case-control study of ANKH polymorphisms.

The following Ank gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ank cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11989	NM_020332.4 Latest version!	Mus musculus progressive ankylosis (Ank), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ank ( NM_020332.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_065065.3 Mus musculus progressive ankylosis (Ank), mRNA.

Price & Availability↑

CloneID	OMu11989
Clone ID Related Accession (Same CDS sequence)	NM_020332.4
Accession Version	NM_020332.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	progressive ankylosis protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK083135.1, BC054379.1 and AW049351.1. On Oct 6, 2007 this sequence version replaced NM_020332.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ832285.1, AK083135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAT TCCCGGCGCT CACGCACTAC TGGCCCCTGA TCCGGTTCCT GGTGCCCCTC 
GGCATCACCA ACATAGCCAT CGACTTCGGG GAGCAGGCCT TGAACCGGGG CATCGCTGCA 
GTCAAGGAGG ATGCAGTAGA AATGCTGGCC AGCTACGGGC TGGCGTATTC TTTGATGAAG 
TTCTTCACGG GGCCCATGAG TGACTTCAAA AATGTGGGCC TGGTGTTCGT GAACAGCAAG 
AGAGACAGGG CCAAAGCCGT CCTCTGCATG GTGGTGGCCG GTGCCATCGC TGCCGTCTTC 
CACACCCTGA TAGCCTACAG TGACTTAGGG TACTACATCA TCAACAAGCT GCATCATGTG 
GATGAGTCTG TGGGGAGCAA AACACGAAGG GCCTTCCTGT ATCTCGCTGC CTTCCCTTTT 
ATGGATGCCA TGGCGTGGAC TCATGCTGGC ATTCTCTTAA AACACAAATA CAGTTTCCTG 
GTGGGATGTG CCTCAATCTC AGATGTCATA GCTCAGGTTG TTTTCGTAGC CATTTTGCTT 
CACAGTCACC TGGAATGCCG AGAACCGCTG CTCATCCCCA TCCTGTCTCT GTACATGGGT 
GCGCTTGTGC GCTGCACCAC ACTGTGCCTG GGCTACTACA GGAACATCCA CGACATCATC 
CCCGACAGGA GCGGCCCAGA GCTGGGGGGT GATGCAACCA TAAGAAAGAT GCTGAGCTTC 
TGGTGGCCCC TGGCTCTGAT CCTGGCCACG CAGCGAATCA GTCGGCCCAT TGTCAACCTC 
TTCGTGTCCC GGGACCTTGG TGGCAGCTCT GCTGCTACAG AGGCAGTGGC CATTCTGACA 
GCCACCTACC CCGTGGGTCA TATGCCATAT GGCTGGTTGA CAGAAATCCG GGCTGTCTAC 
CCTGCTTTTG ACAAGAATAA CCCCAGCAAT AAACTGGCGA ACACAAGCAA CACGGTCACC 
TCAGCCCACA TCAAGAAGTT CACCTTTGTC TGCATGGCGC TGTCGCTGAC GCTCTGTTTT 
GTCATGTTCT GGACCCCCAA CGTCTCTGAG AAGATTCTGA TAGATATCAT TGGAGTGGAC 
TTTGCCTTTG CAGAACTCTG TGTCATTCCT CTGCGTATCT TCTCCTTCTT CCCAGTGCCA 
GTGACTGTGA GAGCTCATCT CACTGGATGG CTGATGACAC TGAAGAAAAC CTTTGTGCTG 
GCGCCCAGCT CCGTGCTGCG CATCATCGTC CTCATCACCA GCCTTGTGGT CCTGCCGTAC 
CTGGGGGTGC ACGGAGCCAC ACTAGGTGTG GGCTCCCTTC TAGCAGGGTT TGTGGGAGAA 
TCTACCATGG TTGCCCTTGC AGCATGCTAT GTCTATCGAA AACAGAAAAA GAAGATGGAG 
AATGAGTCAG CCACCGAGGG AGAAGACTCG GCCATGACCG ACATGCCTCC AACAGAGGAG 
GTCACAGACA TCGTAGAGAT GAGAGAAGAA AATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065065.3
CDS	328..1806
Translation	MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRAKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLANTSNTVTSAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVIPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLVVLPYLGVHGATLGVGSLLAGFVGESTMVALAACYVYRKQKKKMENESATEGEDSAMTDMPPTEEVTDIVEMREENE

Target ORF information:

RefSeq Version	NM_020332.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus progressive ankylosis (Ank), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020332.4

ORF Insert Sequence:

ATGGTGAAAT TCCCGGCGCT CACGCACTAC TGGCCCCTGA TCCGGTTCCT GGTGCCCCTC 
GGCATCACCA ACATAGCCAT CGACTTCGGG GAGCAGGCCT TGAACCGGGG CATCGCTGCA 
GTCAAGGAGG ATGCAGTAGA AATGCTGGCC AGCTACGGGC TGGCGTATTC TTTGATGAAG 
TTCTTCACGG GGCCCATGAG TGACTTCAAA AATGTGGGCC TGGTGTTCGT GAACAGCAAG 
AGAGACAGGG CCAAAGCCGT CCTCTGCATG GTGGTGGCCG GTGCCATCGC TGCCGTCTTC 
CACACCCTGA TAGCCTACAG TGACTTAGGG TACTACATCA TCAACAAGCT GCATCATGTG 
GATGAGTCTG TGGGGAGCAA AACACGAAGG GCCTTCCTGT ATCTCGCTGC CTTCCCTTTT 
ATGGATGCCA TGGCGTGGAC TCATGCTGGC ATTCTCTTAA AACACAAATA CAGTTTCCTG 
GTGGGATGTG CCTCAATCTC AGATGTCATA GCTCAGGTTG TTTTCGTAGC CATTTTGCTT 
CACAGTCACC TGGAATGCCG AGAACCGCTG CTCATCCCCA TCCTGTCTCT GTACATGGGT 
GCGCTTGTGC GCTGCACCAC ACTGTGCCTG GGCTACTACA GGAACATCCA CGACATCATC 
CCCGACAGGA GCGGCCCAGA GCTGGGGGGT GATGCAACCA TAAGAAAGAT GCTGAGCTTC 
TGGTGGCCCC TGGCTCTGAT CCTGGCCACG CAGCGAATCA GTCGGCCCAT TGTCAACCTC 
TTCGTGTCCC GGGACCTTGG TGGCAGCTCT GCTGCTACAG AGGCAGTGGC CATTCTGACA 
GCCACCTACC CCGTGGGTCA TATGCCATAT GGCTGGTTGA CAGAAATCCG GGCTGTCTAC 
CCTGCTTTTG ACAAGAATAA CCCCAGCAAT AAACTGGCGA ACACAAGCAA CACGGTCACC 
TCAGCCCACA TCAAGAAGTT CACCTTTGTC TGCATGGCGC TGTCGCTGAC GCTCTGTTTT 
GTCATGTTCT GGACCCCCAA CGTCTCTGAG AAGATTCTGA TAGATATCAT TGGAGTGGAC 
TTTGCCTTTG CAGAACTCTG TGTCATTCCT CTGCGTATCT TCTCCTTCTT CCCAGTGCCA 
GTGACTGTGA GAGCTCATCT CACTGGATGG CTGATGACAC TGAAGAAAAC CTTTGTGCTG 
GCGCCCAGCT CCGTGCTGCG CATCATCGTC CTCATCACCA GCCTTGTGGT CCTGCCGTAC 
CTGGGGGTGC ACGGAGCCAC ACTAGGTGTG GGCTCCCTTC TAGCAGGGTT TGTGGGAGAA 
TCTACCATGG TTGCCCTTGC AGCATGCTAT GTCTATCGAA AACAGAAAAA GAAGATGGAG 
AATGAGTCAG CCACCGAGGG AGAAGACTCG GCCATGACCG ACATGCCTCC AACAGAGGAG 
GTCACAGACA TCGTAGAGAT GAGAGAAGAA AATGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Bone107131-142(2018 Feb)
Rauch F,Geng Y,Lamplugh L,Hekmatnejad B,Gaumond MH,Penney J,Yamanaka Y,Moffatt P

Osteopontin regulates dentin and alveolar bone development and mineralization.
Bone(2017 Dec)
Foster BL,Ao M,Salmon CR,Chavez MB,Kolli TN,Tran AB,Chu EY,Kantovitz KR,Yadav M,Narisawa S,Mill?n JL,Nociti FH Jr,Somerman MJ

Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.
Bone105134-147(2017 Dec)
Ao M,Chavez MB,Chu EY,Hemstreet KC,Yin Y,Yadav MC,Mill?n JL,Fisher LW,Goldberg HA,Somerman MJ,Foster BL

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Ank cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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