Ang cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ang
Entrez Gene ID	11727
Full Name	angiogenin, ribonuclease, RNase A family, 5
Synonyms	AI385586,Ang1,Rnase5,Rnase5a
General protein information	Preferred Names angiogenin, ribonuclease, RNase A family, 5 Names angiogenin RNase 5 angiogenin, ribonuclease A family, member 1 angiogenin-1 ribonuclease 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 C1\|14 26.37 cM
Summary	This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001161731.2	NP_001155203.1	angiogenin precursor
NM_007447.3	NP_031473.1	angiogenin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANG	NP_001136.1
Pan troglodytes (chimpanzee)	ANG	NP_001009159.1
Rattus norvegicus (Norway rat)	Ang	NP_001006993.1
Rattus norvegicus (Norway rat)	Ang2	NP_001012359.1
Mus musculus (house mouse)	Ang	NP_001155203.1

Gene Ontology
Bibliography

Related articles in PubMed

Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.
Yu W, Goncalves KA, Li S, Kishikawa H, Sun G, Yang H, Vanli N, Wu Y, Jiang Y, Hu MG, Friedel RH, Hu GF
Cell171(4)849-864.e25(2017 Nov)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells.
Goncalves KA, Silberstein L, Li S, Severe N, Hu MG, Yang H, Scadden DT, Hu GF
Cell166(4)894-906(2016 Aug)

The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression.
Dyer KD, Rosenberg HF
Nucleic acids research33(3)1077-86(2005)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ANG plays a non-cell-autonomous role in regulation of hematopoiesis by simultaneously preserving hematopoietic stem/progenitor cells stemness and promoting myeloid-restricted progenitor cell proliferation.
Title: Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells.

angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth
Title: Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway.

Our data provide new insights into the paracrine activities of angiogenin in the nervous system, and further highlight the critical role of non-neuronal cells in the pathogenesis of Amyotrophic lateral sclerosis
Title: Motoneurons secrete angiogenin to induce RNA cleavage in astroglia.

Murine angiogenin mRNA and protein are upregulated in motoneurons in response to hypoxia, and that Hypoxia-Inducible Factor 1 is sufficient and required to upregulate angiogenin expression during hypoxia.
Title: Angiogenin protects motoneurons against hypoxic injury.

All three types of the ANG inhibitor suppress rRNA transcription of the prostate luminal epithelial cells and inhibit AKT-induced PIN, indicating an essential role of ANG in AKT-mediated cell proliferation and survival.
Title: Angiogenin-stimulated rRNA transcription is essential for initiation and survival of AKT-induced prostate intraepithelial neoplasia.

The following Ang gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ang cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00192	NM_007447.3 Latest version!	Mus musculus angiogenin, ribonuclease, RNase A family, 5 (Ang), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu00192	NM_001161731.2 Latest version!	Mus musculus angiogenin, ribonuclease, RNase A family, 5 (Ang), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ang ( NM_001161731.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001155203.1 Mus musculus angiogenin, ribonuclease, RNase A family, 5 (Ang), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu00192
Clone ID Related Accession (Same CDS sequence)	NM_001161731.2 , NM_007447.3
Accession Version	NM_001161731.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	angiogenin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC163664.3, BF721354.1 and AW122635.1. On Jun 20, 2009 this sequence version replaced NM_001161731.1. Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK171251.1, AI121741.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGATAA GCCCAGGCCC GTTGTTCTTG ATCTTCGTGC TGGGTCTGGT TGTGATCCCT 
CCCACTCTGG CTCAGGATGA CTCCAGGTAC ACAAAATTCC TGACTCAGCA CCATGACGCC 
AAGCCAAAGG GCCGGGACGA CAGATACTGT GAACGTATGA TGAAGAGAAG AAGCCTAACC 
TCACCCTGCA AAGATGTCAA CACCTTTATC CATGGCAACA AGAGCAACAT CAAGGCCATC 
TGTGGAGCGA ATGGAAGCCC TTACAGAGAA AACTTAAGAA TGAGCAAGTC TCCCTTCCAG 
GTCACCACTT GCAAGCACAC AGGAGGGTCT CCCCGACCTC CATGCCAGTA CCGAGCCTCT 
GCAGGGTTCA GACATGTTGT TATTGCCTGT GAGAATGGTT TGCCTGTCCA CTTCGATGAG 
TCGTTTTTCA GTCTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155203.1
CDS	196..633
Translation	MAISPGPLFLIFVLGLVVIPPTLAQDDSRYTKFLTQHHDAKPKGRDDRYCERMMKRRSLTSPCKDVNTFIHGNKSNIKAICGANGSPYRENLRMSKSPFQVTTCKHTGGSPRPPCQYRASAGFRHVVIACENGLPVHFDESFFSL

Target ORF information:

RefSeq Version	NM_001161731.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus angiogenin, ribonuclease, RNase A family, 5 (Ang), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161731.2

ORF Insert Sequence:

ATGGCGATAA GCCCAGGCCC GTTGTTCTTG ATCTTCGTGC TGGGTCTGGT TGTGATCCCT 
CCCACTCTGG CTCAGGATGA CTCCAGGTAC ACAAAATTCC TGACTCAGCA CCATGACGCC 
AAGCCAAAGG GCCGGGACGA CAGATACTGT GAACGTATGA TGAAGAGAAG AAGCCTAACC 
TCACCCTGCA AAGATGTCAA CACCTTTATC CATGGCAACA AGAGCAACAT CAAGGCCATC 
TGTGGAGCGA ATGGAAGCCC TTACAGAGAA AACTTAAGAA TGAGCAAGTC TCCCTTCCAG 
GTCACCACTT GCAAGCACAC AGGAGGGTCT CCCCGACCTC CATGCCAGTA CCGAGCCTCT 
GCAGGGTTCA GACATGTTGT TATTGCCTGT GAGAATGGTT TGCCTGTCCA CTTCGATGAG 
TCGTTTTTCA GTCTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ang ( NM_007447.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031473.1 Mus musculus angiogenin, ribonuclease, RNase A family, 5 (Ang), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu00192
Clone ID Related Accession (Same CDS sequence)	NM_001161731.2 , NM_007447.3
Accession Version	NM_007447.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	angiogenin precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK159966.1 and AW122635.1. On Jun 20, 2009 this sequence version replaced NM_007447.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK159966.1, BC055355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGATAA GCCCAGGCCC GTTGTTCTTG ATCTTCGTGC TGGGTCTGGT TGTGATCCCT 
CCCACTCTGG CTCAGGATGA CTCCAGGTAC ACAAAATTCC TGACTCAGCA CCATGACGCC 
AAGCCAAAGG GCCGGGACGA CAGATACTGT GAACGTATGA TGAAGAGAAG AAGCCTAACC 
TCACCCTGCA AAGATGTCAA CACCTTTATC CATGGCAACA AGAGCAACAT CAAGGCCATC 
TGTGGAGCGA ATGGAAGCCC TTACAGAGAA AACTTAAGAA TGAGCAAGTC TCCCTTCCAG 
GTCACCACTT GCAAGCACAC AGGAGGGTCT CCCCGACCTC CATGCCAGTA CCGAGCCTCT 
GCAGGGTTCA GACATGTTGT TATTGCCTGT GAGAATGGTT TGCCTGTCCA CTTCGATGAG 
TCGTTTTTCA GTCTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031473.1
CDS	493..930
Translation	MAISPGPLFLIFVLGLVVIPPTLAQDDSRYTKFLTQHHDAKPKGRDDRYCERMMKRRSLTSPCKDVNTFIHGNKSNIKAICGANGSPYRENLRMSKSPFQVTTCKHTGGSPRPPCQYRASAGFRHVVIACENGLPVHFDESFFSL

Target ORF information:

RefSeq Version	NM_007447.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus angiogenin, ribonuclease, RNase A family, 5 (Ang), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007447.3

ORF Insert Sequence:

ATGGCGATAA GCCCAGGCCC GTTGTTCTTG ATCTTCGTGC TGGGTCTGGT TGTGATCCCT 
CCCACTCTGG CTCAGGATGA CTCCAGGTAC ACAAAATTCC TGACTCAGCA CCATGACGCC 
AAGCCAAAGG GCCGGGACGA CAGATACTGT GAACGTATGA TGAAGAGAAG AAGCCTAACC 
TCACCCTGCA AAGATGTCAA CACCTTTATC CATGGCAACA AGAGCAACAT CAAGGCCATC 
TGTGGAGCGA ATGGAAGCCC TTACAGAGAA AACTTAAGAA TGAGCAAGTC TCCCTTCCAG 
GTCACCACTT GCAAGCACAC AGGAGGGTCT CCCCGACCTC CATGCCAGTA CCGAGCCTCT 
GCAGGGTTCA GACATGTTGT TATTGCCTGT GAGAATGGTT TGCCTGTCCA CTTCGATGAG 
TCGTTTTTCA GTCTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.
Cell171(4)849-864.e25(2017 Nov)
Yu W,Goncalves KA,Li S,Kishikawa H,Sun G,Yang H,Vanli N,Wu Y,Jiang Y,Hu MG,Friedel RH,Hu GF

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells.
Cell166(4)894-906(2016 Aug)
Goncalves KA,Silberstein L,Li S,Severe N,Hu MG,Yang H,Scadden DT,Hu GF

The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression.
Nucleic acids research33(3)1077-86(2005)
Dyer KD,Rosenberg HF

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Ang cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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