AMBP cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	AMBP
Entrez Gene ID	11699
Full Name	alpha 1 microglobulin/bikunin
Synonyms	AI194774,ASPI,HI-30,Intin4,Itil,UTI
General protein information	Preferred Names alpha 1 microglobulin/bikunin Names protein AMBP Urinary Trypsin Inhibitor ulinastatin
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 4 Map Location: 4 B3\|4 33.96 cM
Summary	This gene encodes a fusion protein that undergoes proteolytic processing to generate two mature proteins: alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein of the lipocalin superfamily of proteins that bind to hydrophobic molecules, whereas bikunin belongs to the superfamily of Kunitz-type protease inhibitors. The transgenic mice specifically lacking bikunin, but not A1m, exhibit female infertility and an increased sensitivity to lung metastasis. [provided by RefSeq, Oct 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_007443.4	NP_031469.1	protein AMBP preproprotein
NM_007443.3	NP_031469.1	protein AMBP precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	AMBP	NP_001624.1
Rattus norvegicus (Norway rat)	Ambp	NP_037033.1
Canis lupus familiaris (dog)	AMBP	XP_538807.3
Bos taurus (cattle)	AMBP	NP_776414.1
Danio rerio (zebrafish)	ambp	NP_957412.2
Pan troglodytes (chimpanzee)	AMBP	XP_001155186.2
Gallus gallus (chicken)	AMBP	NP_001264627.1
	AMBP	XP_002800088.1
Mus musculus (house mouse)	Ambp	NP_031469.1
Xenopus tropicalis (tropical clawed frog)	ambp	NP_989345.1

Gene Ontology
Bibliography

Related articles in PubMed

Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice.
Dwyer CA, Scudder SL, Lin Y, Dozier LE, Phan D, Allen NJ, Patrick GN, Esko JD
Scientific reports746576(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In this review, the use of genetically targeted mice selectively lacking UTI provides evidence of a therapeutic option for experimental endotoxin-related inflammatory disorders such as acute lung injury and acute liver injury.
Title: Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders.

Report impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice.
Title: Impaired liver regeneration with humoral and genetic disturbances in urinary trypsin inhibitor-deficient mice.

UTI protects against severe liver injury and subsequent coagulatory disturbance which was mediated, at least partly, through the suppression of TNF-alpha production along with its antiprotease activity.
Title: Urinary trypsin inhibitor protects against liver injury and coagulation pathway dysregulation induced by lipopolysaccharide/D-galactosamine in mice.

UTI reduces NF-kappaB activation and downregulates the expression of its related mediators, followed by the inhibition of neutrophil aggregation and infiltration in hepatic ischemia reperfusion injury
Title: Urinary trypsin inhibitor attenuates hepatic ischemia-reperfusion injury by reducing nuclear factor-kappa B activation.

increased sensitivity of Bik-/- mice to lung metastasis in vivo is due to a lack of circulating proteins of the inter-alpha inhibitor family, especially bikunin
Title: Enhanced spontaneous metastasis in bikunin-deficient mice.

The following AMBP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AMBP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00185	NM_007443.4 Latest version!	Mus musculus alpha 1 microglobulin/bikunin precursor (Ambp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OMu00185	NM_007443.3	Mus musculus alpha 1 microglobulin/bikunin (Ambp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AMBP ( NM_007443.4 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_031469.1 Mus musculus alpha 1 microglobulin/bikunin precursor (Ambp), mRNA.

Price & Availability↑

CloneID	OMu00185
Clone ID Related Accession (Same CDS sequence)	NM_007443.4 , NM_007443.3
Accession Version	NM_007443.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Mus musculus(house mouse)
Product	protein AMBP preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL691496.13, AK004907.1 and BU758284.1. On Oct 9, 2015 this sequence version replaced NM_007443.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021660.1, D28812.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGGTC TCAGGACCCT GTTCCTGCTG CTGACTGCCT GCCTCGCTTC GAGGGCTGAC 
CCTGCGTCAA CACTGCCAGA TATCCAGGTT CAGGAGAACT TCAGTGAGTC CCGGATCTAT 
GGAAAATGGT ACAACCTGGC GGTGGGATCC ACCTGCCCGT GGCTGAGCCG CATTAAGGAC 
AAGATGAGCG TGAGCACGCT GGTGCTGCAG GAGGGGGCGA CAGAAACAGA GATCAGCATG 
ACCAGTACTC GATGGCGGAG AGGTGTCTGT GAGGAGATCA CTGGGGCGTA CCAGAAGACG 
GACATCGATG GAAAGTTCCT CTACCACAAA TCCAAATGGA ACATAACCTT GGAATCCTAT 
GTGGTCCACA CCAACTATGA CGAATATGCC ATTTTCCTTA CCAAGAAGTC CAGCCACCAC 
CACGGGCTCA CCATCACTGC CAAGCTCTAT GGTCGGGAGC CACAGCTGAG GGACAGCCTT 
CTGCAGGAGT TCAAGGATGT GGCCCTGAAT GTGGGCATCT CTGAGAACTC CATCATTTTT 
ATGCCTGACA GAGGGGAATG TGTCCCTGGG GATCGGGAGG TGGAGCCCAC ATCAATTGCC 
AGAGCCCGGC GGGCAGTGCT GCCCCAAGAG AGTGAGGGGT CAGGGACTGA GCCACTAATA 
ACTGGGACCC TCAAGAAAGA AGACTCCTGC CAGCTCAATT ACTCAGAAGG CCCCTGCCTA 
GGGATGCAAG AGAGGTATTA CTACAACGGC GCTTCCATGG CCTGCGAGAC CTTTCAATAT 
GGGGGTTGCC TAGGCAACGG CAACAACTTC ATCTCTGAGA AGGACTGTCT GCAGACATGT 
CGGACCATAG CGGCCTGCAA TCTCCCCATA GTCCAAGGCC CCTGCCGAGC CTTCATAAAG 
CTCTGGGCAT TTGATGCAGC ACAAGGGAAG TGCATCCAAT TCCACTACGG GGGCTGCAAA 
GGCAACGGCA ACAAATTCTA CTCTGAGAAG GAATGCAAAG AGTACTGTGG AGTCCCTGGT 
GATGGGTACG AGGAACTAAT ACGCAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031469.1
CDS	118..1167
Translation	MQGLRTLFLLLTACLASRADPASTLPDIQVQENFSESRIYGKWYNLAVGSTCPWLSRIKDKMSVSTLVLQEGATETEISMTSTRWRRGVCEEITGAYQKTDIDGKFLYHKSKWNITLESYVVHTNYDEYAIFLTKKSSHHHGLTITAKLYGREPQLRDSLLQEFKDVALNVGISENSIIFMPDRGECVPGDREVEPTSIARARRAVLPQESEGSGTEPLITGTLKKEDSCQLNYSEGPCLGMQERYYYNGASMACETFQYGGCLGNGNNFISEKDCLQTCRTIAACNLPIVQGPCRAFIKLWAFDAAQGKCIQFHYGGCKGNGNKFYSEKECKEYCGVPGDGYEELIRS

Target ORF information:

RefSeq Version	NM_007443.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus alpha 1 microglobulin/bikunin precursor (Ambp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007443.4

ORF Insert Sequence:

ATGCAGGGTC TCAGGACCCT GTTCCTGCTG CTGACTGCCT GCCTCGCTTC GAGGGCTGAC 
CCTGCGTCAA CACTGCCAGA TATCCAGGTT CAGGAGAACT TCAGTGAGTC CCGGATCTAT 
GGAAAATGGT ACAACCTGGC GGTGGGATCC ACCTGCCCGT GGCTGAGCCG CATTAAGGAC 
AAGATGAGCG TGAGCACGCT GGTGCTGCAG GAGGGGGCGA CAGAAACAGA GATCAGCATG 
ACCAGTACTC GATGGCGGAG AGGTGTCTGT GAGGAGATCA CTGGGGCGTA CCAGAAGACG 
GACATCGATG GAAAGTTCCT CTACCACAAA TCCAAATGGA ACATAACCTT GGAATCCTAT 
GTGGTCCACA CCAACTATGA CGAATATGCC ATTTTCCTTA CCAAGAAGTC CAGCCACCAC 
CACGGGCTCA CCATCACTGC CAAGCTCTAT GGTCGGGAGC CACAGCTGAG GGACAGCCTT 
CTGCAGGAGT TCAAGGATGT GGCCCTGAAT GTGGGCATCT CTGAGAACTC CATCATTTTT 
ATGCCTGACA GAGGGGAATG TGTCCCTGGG GATCGGGAGG TGGAGCCCAC ATCAATTGCC 
AGAGCCCGGC GGGCAGTGCT GCCCCAAGAG AGTGAGGGGT CAGGGACTGA GCCACTAATA 
ACTGGGACCC TCAAGAAAGA AGACTCCTGC CAGCTCAATT ACTCAGAAGG CCCCTGCCTA 
GGGATGCAAG AGAGGTATTA CTACAACGGC GCTTCCATGG CCTGCGAGAC CTTTCAATAT 
GGGGGTTGCC TAGGCAACGG CAACAACTTC ATCTCTGAGA AGGACTGTCT GCAGACATGT 
CGGACCATAG CGGCCTGCAA TCTCCCCATA GTCCAAGGCC CCTGCCGAGC CTTCATAAAG 
CTCTGGGCAT TTGATGCAGC ACAAGGGAAG TGCATCCAAT TCCACTACGG GGGCTGCAAA 
GGCAACGGCA ACAAATTCTA CTCTGAGAAG GAATGCAAAG AGTACTGTGG AGTCCCTGGT 
GATGGGTACG AGGAACTAAT ACGCAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AMBP ( NM_007443.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_031469.1 Mus musculus alpha 1 microglobulin/bikunin (Ambp), mRNA.

Price & Availability↑

CloneID	OMu00185
Clone ID Related Accession (Same CDS sequence)	NM_007443.4 , NM_007443.3
Accession Version	NM_007443.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	protein AMBP precursor
Comment

ATGCAGGGTC TCAGGACCCT GTTCCTGCTG CTGACTGCCT GCCTCGCTTC GAGGGCTGAC 
CCTGCGTCAA CACTGCCAGA TATCCAGGTT CAGGAGAACT TCAGTGAGTC CCGGATCTAT 
GGAAAATGGT ACAACCTGGC GGTGGGATCC ACCTGCCCGT GGCTGAGCCG CATTAAGGAC 
AAGATGAGCG TGAGCACGCT GGTGCTGCAG GAGGGGGCGA CAGAAACAGA GATCAGCATG 
ACCAGTACTC GATGGCGGAG AGGTGTCTGT GAGGAGATCA CTGGGGCGTA CCAGAAGACG 
GACATCGATG GAAAGTTCCT CTACCACAAA TCCAAATGGA ACATAACCTT GGAATCCTAT 
GTGGTCCACA CCAACTATGA CGAATATGCC ATTTTCCTTA CCAAGAAGTC CAGCCACCAC 
CACGGGCTCA CCATCACTGC CAAGCTCTAT GGTCGGGAGC CACAGCTGAG GGACAGCCTT 
CTGCAGGAGT TCAAGGATGT GGCCCTGAAT GTGGGCATCT CTGAGAACTC CATCATTTTT 
ATGCCTGACA GAGGGGAATG TGTCCCTGGG GATCGGGAGG TGGAGCCCAC ATCAATTGCC 
AGAGCCCGGC GGGCAGTGCT GCCCCAAGAG AGTGAGGGGT CAGGGACTGA GCCACTAATA 
ACTGGGACCC TCAAGAAAGA AGACTCCTGC CAGCTCAATT ACTCAGAAGG CCCCTGCCTA 
GGGATGCAAG AGAGGTATTA CTACAACGGC GCTTCCATGG CCTGCGAGAC CTTTCAATAT 
GGGGGTTGCC TAGGCAACGG CAACAACTTC ATCTCTGAGA AGGACTGTCT GCAGACATGT 
CGGACCATAG CGGCCTGCAA TCTCCCCATA GTCCAAGGCC CCTGCCGAGC CTTCATAAAG 
CTCTGGGCAT TTGATGCAGC ACAAGGGAAG TGCATCCAAT TCCACTACGG GGGCTGCAAA 
GGCAACGGCA ACAAATTCTA CTCTGAGAAG GAATGCAAAG AGTACTGTGG AGTCCCTGGT 
GATGGGTACG AGGAACTAAT ACGCAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031469.1
Translation	MQGLRTLFLLLTACLASRADPASTLPDIQVQENFSESRIYGKWYNLAVGSTCPWLSRIKDKMSVSTLVLQEGATETEISMTSTRWRRGVCEEITGAYQKTDIDGKFLYHKSKWNITLESYVVHTNYDEYAIFLTKKSSHHHGLTITAKLYGREPQLRDSLLQEFKDVALNVGISENSIIFMPDRGECVPGDREVEPTSIARARRAVLPQESEGSGTEPLITGTLKKEDSCQLNYSEGPCLGMQERYYYNGASMACETFQYGGCLGNGNNFISEKDCLQTCRTIAACNLPIVQGPCRAFIKLWAFDAAQGKCIQFHYGGCKGNGNKFYSEKECKEYCGVPGDGYEELIRS

Target ORF information:

RefSeq Version	NM_007443.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus alpha 1 microglobulin/bikunin (Ambp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007443.3

ORF Insert Sequence:

ATGCAGGGTC TCAGGACCCT GTTCCTGCTG CTGACTGCCT GCCTCGCTTC GAGGGCTGAC 
CCTGCGTCAA CACTGCCAGA TATCCAGGTT CAGGAGAACT TCAGTGAGTC CCGGATCTAT 
GGAAAATGGT ACAACCTGGC GGTGGGATCC ACCTGCCCGT GGCTGAGCCG CATTAAGGAC 
AAGATGAGCG TGAGCACGCT GGTGCTGCAG GAGGGGGCGA CAGAAACAGA GATCAGCATG 
ACCAGTACTC GATGGCGGAG AGGTGTCTGT GAGGAGATCA CTGGGGCGTA CCAGAAGACG 
GACATCGATG GAAAGTTCCT CTACCACAAA TCCAAATGGA ACATAACCTT GGAATCCTAT 
GTGGTCCACA CCAACTATGA CGAATATGCC ATTTTCCTTA CCAAGAAGTC CAGCCACCAC 
CACGGGCTCA CCATCACTGC CAAGCTCTAT GGTCGGGAGC CACAGCTGAG GGACAGCCTT 
CTGCAGGAGT TCAAGGATGT GGCCCTGAAT GTGGGCATCT CTGAGAACTC CATCATTTTT 
ATGCCTGACA GAGGGGAATG TGTCCCTGGG GATCGGGAGG TGGAGCCCAC ATCAATTGCC 
AGAGCCCGGC GGGCAGTGCT GCCCCAAGAG AGTGAGGGGT CAGGGACTGA GCCACTAATA 
ACTGGGACCC TCAAGAAAGA AGACTCCTGC CAGCTCAATT ACTCAGAAGG CCCCTGCCTA 
GGGATGCAAG AGAGGTATTA CTACAACGGC GCTTCCATGG CCTGCGAGAC CTTTCAATAT 
GGGGGTTGCC TAGGCAACGG CAACAACTTC ATCTCTGAGA AGGACTGTCT GCAGACATGT 
CGGACCATAG CGGCCTGCAA TCTCCCCATA GTCCAAGGCC CCTGCCGAGC CTTCATAAAG 
CTCTGGGCAT TTGATGCAGC ACAAGGGAAG TGCATCCAAT TCCACTACGG GGGCTGCAAA 
GGCAACGGCA ACAAATTCTA CTCTGAGAAG GAATGCAAAG AGTACTGTGG AGTCCCTGGT 
GATGGGTACG AGGAACTAAT ACGCAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice.
Scientific reports746576(2017 Apr)
Dwyer CA,Scudder SL,Lin Y,Dozier LE,Phan D,Allen NJ,Patrick GN,Esko JD

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AMBP cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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