Alk cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Alk
Entrez Gene ID	11682
Full Name	anaplastic lymphoma kinase
Synonyms	CD246,Tcrz
General protein information	Preferred Names anaplastic lymphoma kinase Names ALK tyrosine kinase receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 E1.3\|17 43.77 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007439.2	NP_031465.2	ALK tyrosine kinase receptor precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ALK	XP_003309006.2
Rattus norvegicus (Norway rat)	Alk	NP_001162572.1
Homo sapiens (human)	ALK	NP_004295.2
Danio rerio (zebrafish)	alk	XP_691964.5
Gallus gallus (chicken)	ALK	XP_004940244.1
Canis lupus familiaris (dog)	ALK	XP_540136.3
Mus musculus (house mouse)	Alk	NP_031465.2
Bos taurus (cattle)	LOC536642	XP_002691538.2
Xenopus tropicalis (tropical clawed frog)	LOC100495071	XP_002938468.2

Gene Ontology
Bibliography

Related articles in PubMed

Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.
Lopez-Delisle L, Pierre-Eug?ne C, Louis-Brennetot C, Surdez D, Raynal V, Baulande S, Boeva V, Grosset?te-Lalami S, Combaret V, Peuchmaur M, Delattre O, Janoueix-Lerosey I
Oncogene(2018 Jan)

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ALK inhibitor alectinib inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.
Title: The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase associated with alcohol dependence in humans and behavioral responses to ethanol in mice.
Title: Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area.

Alk -/- mice initially consume more ethanol and have increased basal and ethanol-stimulated GABA release in the central nucleus of the amygdala when compared to Alk +/+ mice. After chronic ethanol exposure, Alk +/+ mice escalate their ethanol consumption, whereas Alk -/- mice do not. Basal GABA release in Alk -/- mice is not enhanced by chronic intermittent ethanol-two bottle choice drinking as it is in Alk +/+ mice.
Title: Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice.

ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.
Title: ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.

An oral anaplastic lymphoma kinase (ALK) inhibitor.
Title: Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).

The following Alk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00178	NM_007439.2 Latest version!	Mus musculus anaplastic lymphoma kinase (Alk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$958.30 $1369.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Alk ( NM_007439.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031465.2 Mus musculus anaplastic lymphoma kinase (Alk), mRNA.

Price & Availability↑

CloneID	OMu00178
Clone ID Related Accession (Same CDS sequence)	NM_007439.2
Accession Version	NM_007439.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4866bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	ALK tyrosine kinase receptor precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK051358.1, D83002.1, AC154458.2 and BE652096.1. On Jul 14, 2006 this sequence version replaced NM_007439.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END##

ATGGGAGCTG CTGGGTTCCT GTGGCTGCTG CCTCCACTGC TTTTGGCAGC AGCCTCGTAC 
TCCGGAGCTG CAACCGATCA GCGCGCGGGT TCCCCAGCCT CAGGGCCTCC TCTGCAGCCC 
CGGGAGCCGC TCAGTTATTC GCGCCTGCAG AGGAAGAGTC TGGCAGTGGA CTTCGTTGTA 
CCCTCGCTCT TCCGCGTCTA TGCCCGAGAC CTGCTGCTAC CGCAGCCACG GTCCCCCTCG 
GAGCCCGAGG CTGGCGGGCT GGAGGCGCGG GGATCACTGG CCCTGGATTG TGAGCCTCTG 
CTCAGGCTGC TGGGGCCACT GCCTGGAATC TCCTGGGCAG ATGGAGCCAG TTCTCCTAGT 
CCCGAGGCGG GTCCGACGCT GTCCAGGGTG CTGAAGGGAG GCTCGGTGCG CAAGCTCAGG 
CGTGCCAAAC AGCTGGTGCT GGAGCTGGGC GAGGAGACGA TTCTTGAAGG CTGTATTGGT 
CCCCCAGAGG AGGTAGCGGC TGTGGGGATA CTCCAGTTCA ACCTCAGCGA GCTGTTCAGC 
TGGTGGATTC TCCACGGCGA AGGGAGGCTG AGGATCCGCC TGATGCCTGA GAAGAAGGCA 
TCGGAAGTGG GCAGGGAGGG AAGGCTATCC AGTGCGATCC GAGCCTCCCA GCCCCGCCTT 
CTCTTCCAGA TCTTCGGGAC GGGACACAGC TCCATGGAGT CACCCTCAGA AACGCCTTCT 
CCTCCTGGTA CCTTCATGTG GAATCTGACC TGGACGATGA AAGACTCCTT CCCTTTCCTT 
TCCCACCGCA GTCGATATGG TCTGGAGTGC AGCTTTGACT TCCCCTGTGA GCTGGAATAT 
TCTCCTCCCC TGCACAACCA CGGGAATCAG AGCTGGTCCT GGCGCCATGT GCCCTCCGAG 
GAGGCCTCGA GGATGAACTT GCTGGATGGG CCAGAGGCAG AGCATTCTCA AGAGATGCCC 
AGAGGCTCCT TCCTCCTCCT GAACACCTCT GCAGATTCCA AGCATACCAT TCTGAGCCCA 
TGGATGAGGA GCAGTAGTGA TCACTGCACA CTGGCTGTCT CCGTGCACAG ACATCTACAG 
CCTTCGGGGA GATATGTTGC CCAGCTCCTA CCCCACAACG AAGCTGGAAG AGAGATTCTT 
TTGGTGCCCA CCCCAGGGAA GCATGGCTGG ACAGTGCTGC AGGGGAGAGT CGGGCGCCCA 
GCAAACCCAT TTCGAGTGGC TCTGGAATAC ATCTCCAGTG GCAACCGGAG CTTGTCGGCG 
GTGGATTTCT TTGCCCTGAA GAACTGCAGT GAAGGGACAT CCCCAGGCTC CAAGATGGCA 
TTGCAGAGTT CCTTCACTTG TTGGAATGGG ACCGTCCTCC AGCTCGGGCA AGCCTGTGAT 
TTCCACCAGG ACTGTGCCCA AGGAGAAGAT GAGGGCCAGC TGTGCAGTAA ACTTCCTGCT 
GGATTTTACT GTAACTTTGA AAATGGCTTC TGTGGCTGGA CCCAAAGTCC ACTCTCACCC 
CATATGCCCC GGTGGCAAGT GAGGACCCTA AGAGATGCCC ATTCCCAGGG CCACCAAGGC 
CGTGCCCTGT TGCTCAGCAC CACTGACATC CTCGCTTCTG AAGGTGCAAC AGTGACCAGT 
GCCACCTTCC CTGCACCAAT GAAAAATTCT CCTTGTGAGC TCCGCATGTC CTGGCTCATC 
CGCGGGGTTT TGAGAGGAAA CGTATCTCTG GTGCTGGTGG AGAACAAAAC CGGAAAGGAG 
CAAAGCCGGA CTGTCTGGCA TGTCGCCACT GACGAAGGCT TAAGCCTGTG GCAGCATACA 
GTGCTGTCCC TCCTCGATGT GACTGACAGG TTCTGGCTGC AGATAGTCAC ATGGTGGGGT 
CCAGGATCCA GGGCAACCGT GGGATTTGAC AACATTTCCA TCAGCCTCGA CTGCTACCTT 
ACCATCAGTG GAGAGGAGAA AATGTCCCTG AATTCAGTAC CCAAATCTAG AAATCTGTTT 
GAGAAAAACC CAAACAAGGA GTCAAAATCC TGGGCAAACA TATCAGGACC AACTCCCATC 
TTCGACCCTA CAGTTCACTG GCTGTTCACC ACGTGTGGGG CCAGTGGACC TCATGGCCCC 
ACCCAGGCAC AGTGCAACAA CGCCTACCAG AATTCCAACT TGAGCGTGGT GGTGGGAAGT 
GAAGGGCCCT TGAAGGGAGT CCAGATTTGG AAAGTGCCAG CTACTGACAC CTACAGTATC 
TCGGGCTACG GAGCAGCTGG CGGGAAAGGT GGGAAAAACA CCATGATGCG GTCCCATGGC 
GTGTCTGTCC TGGGCATCTT CAATCTGGAG AAAGGTGACA CACTCTACAT CCTTGTCGGT 
CAGCAAGGGG AGGATGCCTG TCCCAGGGCA AACCAACTAA TCCAGAAAGT CTGTGTGGGT 
GAGAACAATG TCATAGAAGA AGAGATCCGA GTGAACAGAA GCGTGCACGA GTGGGCAGGA 
GGAGGAGGAG GTGGGGGTGG AGCCACCTAC GTGTTTAAGA TGAAAGATGG CGTGCCTGTA 
CCCCTGATCA TTGCAGCTGG TGGTGGTGGC AGGGCCTATG GGGCCAAGAC AGAAACGTTC 
CACCCAGAGA GACTGGAGAG TAACTCCTCG GTTCTAGGGC TGAACGGCAA TTCCGGAGCC 
GCAGGTGGTG GAGGCGGCTG GAATGATAAC ACTTCCTTGC TCTGGGCCGG AAAGTCTTTG 
CTGGAGGGTG CCGCCGGAGG ACATTCCTGC CCCCAGGCCA TGAAGAAGTG GGGGTGGGAG 
ACAAGAGGGG GTTTCGGAGG GGGTGGAGGG GGGTGCTCCT CAGGTGGAGG AGGCGGAGGA 
TATATAGGTG GCAACGCAGC ATCAAACAAT GACCCCGAAA TGGATGGGGA AGATGGGGTT 
TCCTTCATCA GTCCATTGGG TATCCTGTAC ACCCCGGCCT TAAAAGTGAT GGAGGGCCAC 
GGGGAAGTGA ATATCAAGCA TTATCTAAAC TGCAGTCACT GCGAGGTAGA CGAATGTCAC 
ATGGACCCCG AGAGCCACAA AGTCATCTGC TTCTGTGATC ATGGGACCGT GCTGGCTGAT 
GATGGTGTCT CCTGCATTGT GTCACCCACC CCGGAGCCCC ACCTGCCGCT CTCATTGATC 
CTCTCCGTCG TGACCTCTGC CCTGGTGGCT GCCCTTGTTC TGGCATTCTC CGGCATCATG 
ATTGTGTACC GTCGGAAGCA CCAGGAGTTG CAGGCTATGC AGATGGAACT GCAGAGCCCC 
GAGTATAAGC TGAGCAAGCT ACGGACCTCG ACCATCATGA CCGACTACAA CCCCAACTAC 
TGCTTCGCTG GCAAGACTTC CTCCATCAGT GACCTGAAAG AAGTGCCACG GAAAAACATC 
ACACTCATCC GGGGCCTAGG CCATGGCGCA TTTGGGGAGG TGTATGAAGG CCAGGTGTCT 
GGAATGCCCA ATGACCCAAG CCCTCTACAA GTGGCTGTAA AGACGCTGCC AGAAGTGTGT 
TCAGAACAAG ATGAGCTGGA CTTTCTCATG GAAGCTCTGA TCATCAGCAA ATTCAACCAC 
CAGAATATTG TTCGCTGCAT CGGGGTGAGT CTACAAGCCC TGCCCCGCTT CATCCTGCTG 
GAACTCATGG CTGGCGGAGA CCTCAAGTCC TTCCTCAGGG AGACACGCCC TCGCCCGAAC 
CAACCCACCT CCCTGGCCAT GCTGGACCTT CTGCATGTGG CTCGGGACAT TGCCTGTGGC 
TGTCAGTACC TAGAGGAGAA TCACTTTATC CACCGGGATA TTGCTGCTAG AAACTGTCTG 
TTGACCTGCC CAGGAGCTGG AAGAATAGCA AAGATTGGAG ACTTTGGGAT GGCCCGAGAT 
ATCTACAGGG CCAGCTACTA CCGAAAGGGA GGCTGCGCCA TGCTGCCGGT CAAGTGGATG 
CCCCCTGAAG CCTTCATGGA AGGGATATTT ACCTCTAAAA CAGACACATG GTCTTTTGGA 
GTGTTGCTAT GGGAAATATT TTCTCTTGGA TATATGCCGT ACCCCAGCAA GAGCAACCAG 
GAAGTTCTGG AGTTTGTCAC CAGCGGAGGA CGGATGGACC CGCCTAAGAA CTGCCCCGGG 
CCTGTATACC GGATAATGAC GCAGTGCTGG CAGCATCAGC CTGAAGACAG ACCCAACTTC 
GCCATCATTT TGGAGAGGAT CGAATACTGC ACCCAGGACC CCGATGTGAT CAACACAGCT 
CTGCCCATCG AATACGGTCC AGTAGTAGAA GAGGAGGAGA AAGTGCCCAT GCGCCCCAAA 
GACCCCGAGG GGATGCCACC TTTGCTGGTG TCTCCCCAGC CTGCGAAGCA CGAGGAGGCG 
TCCGCAGCTC CCCAGCCCGC AGCCCTGACG GCACCAGGCC CATCGGTGAA GAAGCCCCCG 
GGTGCGGGTG CGGGCGCGGG CGCGGGTGCG GGTGCCGGCC CGGTGCCCCG AGGTGCGGCC 
GATCGGGGCC ACGTGAACAT GGCTTTCTCT CAGCCCAACC CTCCCCCGGA GCTGCACAAA 
GGCCCGGGAT CCAGAAACAA GCCGACCAGC CTGTGGAACC CCACCTACGG CTCGTGGTTC 
ACCGAGAAGC CTGCCAAAAA GACCCATCCT CCGCCAGGCG CCGAGCCGCA GGCGCGGGCA 
GGAGCGGCCG AGGGTGGCTG GACCGGGCCG GGCGCGGGGC CCCGCAGAGC CGAGGCAGCG 
CTGCTGCTAG AGCCATCGGC GCTGAGCGCC ACCATGAAGG AGGTGCCGCT GTTCAGGCTG 
CGCCACTTCC CCTGCGGCAA TGTCAACTAT GGTTACCAGC AACAGGGTCT CCCCTTGGAA 
GCCACAGCCG CGCCAGGGGA CACCATGCTG AAAAGCAAGA ATAAGGTCAC CCAGCCGGGG 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031465.2
CDS	599..5464
Translation	MGAAGFLWLLPPLLLAAASYSGAATDQRAGSPASGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPQPRSPSEPEAGGLEARGSLALDCEPLLRLLGPLPGISWADGASSPSPEAGPTLSRVLKGGSVRKLRRAKQLVLELGEETILEGCIGPPEEVAAVGILQFNLSELFSWWILHGEGRLRIRLMPEKKASEVGREGRLSSAIRASQPRLLFQIFGTGHSSMESPSETPSPPGTFMWNLTWTMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHNHGNQSWSWRHVPSEEASRMNLLDGPEAEHSQEMPRGSFLLLNTSADSKHTILSPWMRSSSDHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPTPGKHGWTVLQGRVGRPANPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDEGQLCSKLPAGFYCNFENGFCGWTQSPLSPHMPRWQVRTLRDAHSQGHQGRALLLSTTDILASEGATVTSATFPAPMKNSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQSRTVWHVATDEGLSLWQHTVLSLLDVTDRFWLQIVTWWGPGSRATVGFDNISISLDCYLTISGEEKMSLNSVPKSRNLFEKNPNKESKSWANISGPTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVVVGSEGPLKGVQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKGDTLYILVGQQGEDACPRANQLIQKVCVGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTETFHPERLESNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLLEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLADDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQPAKHEEASAAPQPAALTAPGPSVKKPPGAGAGAGAGAGAGPVPRGAADRGHVNMAFSQPNPPPELHKGPGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAEPQARAGAAEGGWTGPGAGPRRAEAALLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATAAPGDTMLKSKNKVTQPGP

Target ORF information:

RefSeq Version	NM_007439.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus anaplastic lymphoma kinase (Alk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007439.2

ORF Insert Sequence:

ATGGGAGCTG CTGGGTTCCT GTGGCTGCTG CCTCCACTGC TTTTGGCAGC AGCCTCGTAC 
TCCGGAGCTG CAACCGATCA GCGCGCGGGT TCCCCAGCCT CAGGGCCTCC TCTGCAGCCC 
CGGGAGCCGC TCAGTTATTC GCGCCTGCAG AGGAAGAGTC TGGCAGTGGA CTTCGTTGTA 
CCCTCGCTCT TCCGCGTCTA TGCCCGAGAC CTGCTGCTAC CGCAGCCACG GTCCCCCTCG 
GAGCCCGAGG CTGGCGGGCT GGAGGCGCGG GGATCACTGG CCCTGGATTG TGAGCCTCTG 
CTCAGGCTGC TGGGGCCACT GCCTGGAATC TCCTGGGCAG ATGGAGCCAG TTCTCCTAGT 
CCCGAGGCGG GTCCGACGCT GTCCAGGGTG CTGAAGGGAG GCTCGGTGCG CAAGCTCAGG 
CGTGCCAAAC AGCTGGTGCT GGAGCTGGGC GAGGAGACGA TTCTTGAAGG CTGTATTGGT 
CCCCCAGAGG AGGTAGCGGC TGTGGGGATA CTCCAGTTCA ACCTCAGCGA GCTGTTCAGC 
TGGTGGATTC TCCACGGCGA AGGGAGGCTG AGGATCCGCC TGATGCCTGA GAAGAAGGCA 
TCGGAAGTGG GCAGGGAGGG AAGGCTATCC AGTGCGATCC GAGCCTCCCA GCCCCGCCTT 
CTCTTCCAGA TCTTCGGGAC GGGACACAGC TCCATGGAGT CACCCTCAGA AACGCCTTCT 
CCTCCTGGTA CCTTCATGTG GAATCTGACC TGGACGATGA AAGACTCCTT CCCTTTCCTT 
TCCCACCGCA GTCGATATGG TCTGGAGTGC AGCTTTGACT TCCCCTGTGA GCTGGAATAT 
TCTCCTCCCC TGCACAACCA CGGGAATCAG AGCTGGTCCT GGCGCCATGT GCCCTCCGAG 
GAGGCCTCGA GGATGAACTT GCTGGATGGG CCAGAGGCAG AGCATTCTCA AGAGATGCCC 
AGAGGCTCCT TCCTCCTCCT GAACACCTCT GCAGATTCCA AGCATACCAT TCTGAGCCCA 
TGGATGAGGA GCAGTAGTGA TCACTGCACA CTGGCTGTCT CCGTGCACAG ACATCTACAG 
CCTTCGGGGA GATATGTTGC CCAGCTCCTA CCCCACAACG AAGCTGGAAG AGAGATTCTT 
TTGGTGCCCA CCCCAGGGAA GCATGGCTGG ACAGTGCTGC AGGGGAGAGT CGGGCGCCCA 
GCAAACCCAT TTCGAGTGGC TCTGGAATAC ATCTCCAGTG GCAACCGGAG CTTGTCGGCG 
GTGGATTTCT TTGCCCTGAA GAACTGCAGT GAAGGGACAT CCCCAGGCTC CAAGATGGCA 
TTGCAGAGTT CCTTCACTTG TTGGAATGGG ACCGTCCTCC AGCTCGGGCA AGCCTGTGAT 
TTCCACCAGG ACTGTGCCCA AGGAGAAGAT GAGGGCCAGC TGTGCAGTAA ACTTCCTGCT 
GGATTTTACT GTAACTTTGA AAATGGCTTC TGTGGCTGGA CCCAAAGTCC ACTCTCACCC 
CATATGCCCC GGTGGCAAGT GAGGACCCTA AGAGATGCCC ATTCCCAGGG CCACCAAGGC 
CGTGCCCTGT TGCTCAGCAC CACTGACATC CTCGCTTCTG AAGGTGCAAC AGTGACCAGT 
GCCACCTTCC CTGCACCAAT GAAAAATTCT CCTTGTGAGC TCCGCATGTC CTGGCTCATC 
CGCGGGGTTT TGAGAGGAAA CGTATCTCTG GTGCTGGTGG AGAACAAAAC CGGAAAGGAG 
CAAAGCCGGA CTGTCTGGCA TGTCGCCACT GACGAAGGCT TAAGCCTGTG GCAGCATACA 
GTGCTGTCCC TCCTCGATGT GACTGACAGG TTCTGGCTGC AGATAGTCAC ATGGTGGGGT 
CCAGGATCCA GGGCAACCGT GGGATTTGAC AACATTTCCA TCAGCCTCGA CTGCTACCTT 
ACCATCAGTG GAGAGGAGAA AATGTCCCTG AATTCAGTAC CCAAATCTAG AAATCTGTTT 
GAGAAAAACC CAAACAAGGA GTCAAAATCC TGGGCAAACA TATCAGGACC AACTCCCATC 
TTCGACCCTA CAGTTCACTG GCTGTTCACC ACGTGTGGGG CCAGTGGACC TCATGGCCCC 
ACCCAGGCAC AGTGCAACAA CGCCTACCAG AATTCCAACT TGAGCGTGGT GGTGGGAAGT 
GAAGGGCCCT TGAAGGGAGT CCAGATTTGG AAAGTGCCAG CTACTGACAC CTACAGTATC 
TCGGGCTACG GAGCAGCTGG CGGGAAAGGT GGGAAAAACA CCATGATGCG GTCCCATGGC 
GTGTCTGTCC TGGGCATCTT CAATCTGGAG AAAGGTGACA CACTCTACAT CCTTGTCGGT 
CAGCAAGGGG AGGATGCCTG TCCCAGGGCA AACCAACTAA TCCAGAAAGT CTGTGTGGGT 
GAGAACAATG TCATAGAAGA AGAGATCCGA GTGAACAGAA GCGTGCACGA GTGGGCAGGA 
GGAGGAGGAG GTGGGGGTGG AGCCACCTAC GTGTTTAAGA TGAAAGATGG CGTGCCTGTA 
CCCCTGATCA TTGCAGCTGG TGGTGGTGGC AGGGCCTATG GGGCCAAGAC AGAAACGTTC 
CACCCAGAGA GACTGGAGAG TAACTCCTCG GTTCTAGGGC TGAACGGCAA TTCCGGAGCC 
GCAGGTGGTG GAGGCGGCTG GAATGATAAC ACTTCCTTGC TCTGGGCCGG AAAGTCTTTG 
CTGGAGGGTG CCGCCGGAGG ACATTCCTGC CCCCAGGCCA TGAAGAAGTG GGGGTGGGAG 
ACAAGAGGGG GTTTCGGAGG GGGTGGAGGG GGGTGCTCCT CAGGTGGAGG AGGCGGAGGA 
TATATAGGTG GCAACGCAGC ATCAAACAAT GACCCCGAAA TGGATGGGGA AGATGGGGTT 
TCCTTCATCA GTCCATTGGG TATCCTGTAC ACCCCGGCCT TAAAAGTGAT GGAGGGCCAC 
GGGGAAGTGA ATATCAAGCA TTATCTAAAC TGCAGTCACT GCGAGGTAGA CGAATGTCAC 
ATGGACCCCG AGAGCCACAA AGTCATCTGC TTCTGTGATC ATGGGACCGT GCTGGCTGAT 
GATGGTGTCT CCTGCATTGT GTCACCCACC CCGGAGCCCC ACCTGCCGCT CTCATTGATC 
CTCTCCGTCG TGACCTCTGC CCTGGTGGCT GCCCTTGTTC TGGCATTCTC CGGCATCATG 
ATTGTGTACC GTCGGAAGCA CCAGGAGTTG CAGGCTATGC AGATGGAACT GCAGAGCCCC 
GAGTATAAGC TGAGCAAGCT ACGGACCTCG ACCATCATGA CCGACTACAA CCCCAACTAC 
TGCTTCGCTG GCAAGACTTC CTCCATCAGT GACCTGAAAG AAGTGCCACG GAAAAACATC 
ACACTCATCC GGGGCCTAGG CCATGGCGCA TTTGGGGAGG TGTATGAAGG CCAGGTGTCT 
GGAATGCCCA ATGACCCAAG CCCTCTACAA GTGGCTGTAA AGACGCTGCC AGAAGTGTGT 
TCAGAACAAG ATGAGCTGGA CTTTCTCATG GAAGCTCTGA TCATCAGCAA ATTCAACCAC 
CAGAATATTG TTCGCTGCAT CGGGGTGAGT CTACAAGCCC TGCCCCGCTT CATCCTGCTG 
GAACTCATGG CTGGCGGAGA CCTCAAGTCC TTCCTCAGGG AGACACGCCC TCGCCCGAAC 
CAACCCACCT CCCTGGCCAT GCTGGACCTT CTGCATGTGG CTCGGGACAT TGCCTGTGGC 
TGTCAGTACC TAGAGGAGAA TCACTTTATC CACCGGGATA TTGCTGCTAG AAACTGTCTG 
TTGACCTGCC CAGGAGCTGG AAGAATAGCA AAGATTGGAG ACTTTGGGAT GGCCCGAGAT 
ATCTACAGGG CCAGCTACTA CCGAAAGGGA GGCTGCGCCA TGCTGCCGGT CAAGTGGATG 
CCCCCTGAAG CCTTCATGGA AGGGATATTT ACCTCTAAAA CAGACACATG GTCTTTTGGA 
GTGTTGCTAT GGGAAATATT TTCTCTTGGA TATATGCCGT ACCCCAGCAA GAGCAACCAG 
GAAGTTCTGG AGTTTGTCAC CAGCGGAGGA CGGATGGACC CGCCTAAGAA CTGCCCCGGG 
CCTGTATACC GGATAATGAC GCAGTGCTGG CAGCATCAGC CTGAAGACAG ACCCAACTTC 
GCCATCATTT TGGAGAGGAT CGAATACTGC ACCCAGGACC CCGATGTGAT CAACACAGCT 
CTGCCCATCG AATACGGTCC AGTAGTAGAA GAGGAGGAGA AAGTGCCCAT GCGCCCCAAA 
GACCCCGAGG GGATGCCACC TTTGCTGGTG TCTCCCCAGC CTGCGAAGCA CGAGGAGGCG 
TCCGCAGCTC CCCAGCCCGC AGCCCTGACG GCACCAGGCC CATCGGTGAA GAAGCCCCCG 
GGTGCGGGTG CGGGCGCGGG CGCGGGTGCG GGTGCCGGCC CGGTGCCCCG AGGTGCGGCC 
GATCGGGGCC ACGTGAACAT GGCTTTCTCT CAGCCCAACC CTCCCCCGGA GCTGCACAAA 
GGCCCGGGAT CCAGAAACAA GCCGACCAGC CTGTGGAACC CCACCTACGG CTCGTGGTTC 
ACCGAGAAGC CTGCCAAAAA GACCCATCCT CCGCCAGGCG CCGAGCCGCA GGCGCGGGCA 
GGAGCGGCCG AGGGTGGCTG GACCGGGCCG GGCGCGGGGC CCCGCAGAGC CGAGGCAGCG 
CTGCTGCTAG AGCCATCGGC GCTGAGCGCC ACCATGAAGG AGGTGCCGCT GTTCAGGCTG 
CGCCACTTCC CCTGCGGCAA TGTCAACTAT GGTTACCAGC AACAGGGTCT CCCCTTGGAA 
GCCACAGCCG CGCCAGGGGA CACCATGCTG AAAAGCAAGA ATAAGGTCAC CCAGCCGGGG 
CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.
Oncogene(2018 Jan)
Lopez-Delisle L,Pierre-Eug?ne C,Louis-Brennetot C,Surdez D,Raynal V,Baulande S,Boeva V,Grosset?te-Lalami S,Combaret V,Peuchmaur M,Delattre O,Janoueix-Lerosey I

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

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Alk cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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