Akr1b3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akr1b3
Entrez Gene ID	11677
Full Name	aldo-keto reductase family 1, member B3 (aldose reductase)
Synonyms	ALR2,AR,Ahr-1,Ahr1,Akr1b1,Aldor1,Aldr1
General protein information	Preferred Names aldo-keto reductase family 1, member B3 (aldose reductase) Names aldose reductase aldehyde reductase 1 aldo-keto reductase family 1, member B1 (aldose reductase)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 14.87 cM\|6 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_009658.3	NP_033788.3	aldo-keto reductase family 1 member B1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	AKR1B1	NP_001012537.1
Rattus norvegicus (Norway rat)	Akr1b1	NP_036630.1
Pan troglodytes (chimpanzee)	AKR1B1	XP_001138232.2
Mus musculus (house mouse)	Akr1b3	NP_033788.3
Danio rerio (zebrafish)	akr1b1	NP_001002048.1
Homo sapiens (human)	AKR1B1	NP_001619.1
	AKR1B1	XP_001100679.1
Canis lupus familiaris (dog)	AKR1B1	NP_001239345.1
Danio rerio (zebrafish)	si:dkey-180p18.9	NP_001070715.1
Xenopus tropicalis (tropical clawed frog)	akr1b1	NP_001011130.1

Gene Ontology
Bibliography

Related articles in PubMed

Aldose reductase (AKR1B) deficiency promotes phagocytosis in bone marrow derived mouse macrophages.
Singh M, Kapoor A, McCracken J, Hill B, Bhatnagar A
Chemico-biological interactions26516-23(2017 Mar)

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell40(4)331-341.e4(2017 02)

Aldose reductase modulates acute activation of mesenchymal markers via the ?-catenin pathway during cardiac ischemia-reperfusion.
Thiagarajan D, O' Shea K, Sreejit G, Ananthakrishnan R, Quadri N, Li Q, Schmidt AM, Gabbay K, Ramasamy R
PloS one12(11)e0188981(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

modulation of macrophage metabolism by inhibition of AR might represent a novel strategy to modulate host defense responses and to modify metabolism to promote macrophage hypertrophy and phagocytosis under inflammatory conditions
Title: Aldose reductase (AKR1B) deficiency promotes phagocytosis in bone marrow derived mouse macrophages.

AR overexpression elevates retinal microglia activation in retina.
Title: Aldose reductase mediates retinal microglia activation.

Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.
Title: Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice.

Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53.
Title: Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.

Data indicate that inhibition of AR alleviates the MCD diet-induced liver inflammation and fibrosis in db/db mice, probably through dampening CYP2E1 mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines.
Title: Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.

The following Akr1b3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akr1b3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04597	NM_009658.3 Latest version!	Mus musculus aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akr1b3 ( NM_009658.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033788.3 Mus musculus aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), mRNA.

Price & Availability↑

CloneID	OMu04597
Clone ID Related Accession (Same CDS sequence)	NM_009658.3
Accession Version	NM_009658.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 951bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	aldo-keto reductase family 1 member B1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY749711.1, AK164682.1 and AV301527.1. On Nov 20, 2007 this sequence version replaced NM_009658.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC021655.1, AK153949.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133, SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAGCC ATCTGGAACT CAACAACGGC ACCAAGATGC CCACCCTGGG CCTGGGCACC 
TGGAAGTCCC CTCCTGGCCA GGTGACTGAG GCCGTGAAAG TTGCTATTGA CTTGGGGTAC 
CGCCACATTG ACTGCGCCCA GGTGTACCAG AATGAGAAGG AGGTGGGAGT GGCCCTCCAG 
GAGAAGCTCA AGGAGCAGGT GGTGAAGCGG CAGGATCTCT TCATTGTCAG CAAGCTGTGG 
TGCACGTTCC ATGACAAGAG CATGGTGAAA GGAGCCTTCC AGAAGACACT GAGCGACCTG 
CAGCTGGACT ACCTGGATCT CTACCTTATT CACTGGCCAA CGGGGTTCAA GCCTGGGCCC 
GACTATTTCC CACTGGATGC CTCAGGGAAC GTGATACCTA GTGACACCGA TTTTGTGGAC 
ACTTGGACGG CTATGGAACA ACTAGTGGAT GAAGGTTTGG TGAAAACAAT CGGTGTCTCC 
AACTTCAACC CTCTTCAGAT TGAGAGGATC TTGAACAAAC CTGGCTTAAA ATATAAGCCT 
GCGGTGAACC AGATCGAGTG CCACCCGTAC CTAACTCAGG AGAAGCTGAT TGAATACTGC 
CACAGCAAAG GCATCGTGGT GACAGCATAT AGTCCCCTTG GTTCTCCTGA CAGGCCCTGG 
GCCAAGCCTG AAGATCCGTC TCTCCTGGAG GATCCCAGGA TCAAAGCAAT TGCAGCCAAG 
TACAATAAAA CTACAGCCCA GGTGCTGATC CGGTTCCCCA TTCAGAGGAA CTTGGTAGTG 
ATCCCCAAGT CTGTGACACC AGTGCGCATT GCTGAGAACT TGAAGGTCTT TGACTTTGAG 
GTGAGCAGCG AGGACATGGC CACTCTACTC AGCTACAACA GGAACTGGAG GGTGTGCGCC 
TTGATGAGCT GTGCCAAACA CAAGGATTAC CCCTTCCACG CCGAAGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033788.3
CDS	85..1035
Translation	MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV

Target ORF information:

RefSeq Version	NM_009658.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus aldo-keto reductase family 1, member B3 (aldose reductase) (Akr1b3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009658.3

ORF Insert Sequence:

ATGGCCAGCC ATCTGGAACT CAACAACGGC ACCAAGATGC CCACCCTGGG CCTGGGCACC 
TGGAAGTCCC CTCCTGGCCA GGTGACTGAG GCCGTGAAAG TTGCTATTGA CTTGGGGTAC 
CGCCACATTG ACTGCGCCCA GGTGTACCAG AATGAGAAGG AGGTGGGAGT GGCCCTCCAG 
GAGAAGCTCA AGGAGCAGGT GGTGAAGCGG CAGGATCTCT TCATTGTCAG CAAGCTGTGG 
TGCACGTTCC ATGACAAGAG CATGGTGAAA GGAGCCTTCC AGAAGACACT GAGCGACCTG 
CAGCTGGACT ACCTGGATCT CTACCTTATT CACTGGCCAA CGGGGTTCAA GCCTGGGCCC 
GACTATTTCC CACTGGATGC CTCAGGGAAC GTGATACCTA GTGACACCGA TTTTGTGGAC 
ACTTGGACGG CTATGGAACA ACTAGTGGAT GAAGGTTTGG TGAAAACAAT CGGTGTCTCC 
AACTTCAACC CTCTTCAGAT TGAGAGGATC TTGAACAAAC CTGGCTTAAA ATATAAGCCT 
GCGGTGAACC AGATCGAGTG CCACCCGTAC CTAACTCAGG AGAAGCTGAT TGAATACTGC 
CACAGCAAAG GCATCGTGGT GACAGCATAT AGTCCCCTTG GTTCTCCTGA CAGGCCCTGG 
GCCAAGCCTG AAGATCCGTC TCTCCTGGAG GATCCCAGGA TCAAAGCAAT TGCAGCCAAG 
TACAATAAAA CTACAGCCCA GGTGCTGATC CGGTTCCCCA TTCAGAGGAA CTTGGTAGTG 
ATCCCCAAGT CTGTGACACC AGTGCGCATT GCTGAGAACT TGAAGGTCTT TGACTTTGAG 
GTGAGCAGCG AGGACATGGC CACTCTACTC AGCTACAACA GGAACTGGAG GGTGTGCGCC 
TTGATGAGCT GTGCCAAACA CAAGGATTAC CCCTTCCACG CCGAAGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aldose reductase (AKR1B) deficiency promotes phagocytosis in bone marrow derived mouse macrophages.
Chemico-biological interactions26516-23(2017 Mar)
Singh M,Kapoor A,McCracken J,Hill B,Bhatnagar A

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Developmental cell40(4)331-341.e4(2017 02)
Bulusu V,Prior N,Snaebjornsson MT,Kuehne A,Sonnen KF,Kress J,Stein F,Schultz C,Sauer U,Aulehla A

Aldose reductase modulates acute activation of mesenchymal markers via the ?-catenin pathway during cardiac ischemia-reperfusion.
PloS one12(11)e0188981(2017)
Thiagarajan D,O' Shea K,Sreejit G,Ananthakrishnan R,Quadri N,Li Q,Schmidt AM,Gabbay K,Ramasamy R

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Akr1b3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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